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Grant Details

Grant Number: 4R03CA167771-02 Interpret this number
Primary Investigator: Mccormack, Valerie
Organization: International Agency For Res On Cancer
Project Title: International Pooling Project of Mammographic Density
Fiscal Year: 2013


DESCRIPTION (provided by applicant): Women with a high percentage of fibroglandular tissue in their breast, as opposed to fatty tissue, have an increased breast cancer risk (up to 5-fold higher) in the subsequent 10 or more years. This attribute, known as mammographic density (MD), varies between women and can change within the same woman over time. Having both genetic and environmental determinants, between-country differences in MD may account for the over 6-fold international variations in breast cancer incidence rates. Only one study has investigated this to date, i.e. a US/Hawaii/Japanese comparison (Maskarinec et al. 2007). We aim to initiate a more widespread International Pooling Project of Mammographic Density to: (i) pool and obtain standardised comparable data on MD from countries spanning the breast cancer incidence range; (ii) describe international variations in overall and age-specific MD distributions and assess whether they are explained by individual-level risk factors for MD; (iii) quantify the extent to which international variations in MD correlated with corresponding breast cancer incidence rates and Pike's proposed model of breast tissue ageing; (iv) assess a range of MD metrics (absolute/relative/age-specific/cumulative); (v) continue and expand this pooled resource into the future. The International Pooling Project of Mammographic Density would be the first such initiative for MD, which could later be expanded to include new methods of MD measurement, imaging modalities and a broader range of determinants. Being led by the International Agency for Research on Cancer, we emphasize an international perspective for this marker, especially urgent as breast cancer is now the most common cancer in women in almost every country worldwide. If MD does underpin international variations in breast cancer incidence, the monitoring of MD-distributions would become an important early indicator of changes in breast cancer risk.


The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.
Authors: Ward S.V. , Burton A. , Tamimi R.M. , Pereira A. , Garmendia M.L. , Pollan M. , Boyd N. , Dos-Santos-Silva I. , Maskarinec G. , Perez-Gomez B. , et al. .
Source: Breast cancer research : BCR, 2022-07-14; 24(1), p. 49.
EPub date: 2022-07-14.
PMID: 35836268
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Authors: Ayeni O.A. , Norris S.A. , Joffe M. , Cubasch H. , Nietz S. , Buccimazza I. , Singh U. , Čačala S. , Stopforth L. , Chen W.C. , et al. .
Source: International journal of cancer, 2020-07-15; 147(2), p. 361-374.
EPub date: 2019-10-25.
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Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide.
Authors: Burton A. , Maskarinec G. , Perez-Gomez B. , Vachon C. , Miao H. , Lajous M. , López-Ridaura R. , Rice M. , Pereira A. , Garmendia M.L. , et al. .
Source: PLoS medicine, 2017 Jun; 14(6), p. e1002335.
EPub date: 2017-06-30.
PMID: 28666001
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Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems.
Authors: Burton A. , Byrnes G. , Stone J. , Tamimi R.M. , Heine J. , Vachon C. , Ozmen V. , Pereira A. , Garmendia M.L. , Scott C. , et al. .
Source: Breast cancer research : BCR, 2016-12-19; 18(1), p. 130.
EPub date: 2016-12-19.
PMID: 27993168
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International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries.
Authors: McCormack V.A. , Burton A. , dos-Santos-Silva I. , Hipwell J.H. , Dickens C. , Salem D. , Kamal R. , Hartman M. , Lee C.P. , Chia K.S. , et al. .
Source: Cancer epidemiology, 2016 Feb; 40, p. 141-51.
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