Grant Details
Grant Number: |
5R01CA151933-04 Interpret this number |
Primary Investigator: |
Claus, Elizabeth |
Organization: |
Yale University |
Project Title: |
The Meningioma Consortium: Genome-Wide Association Study |
Fiscal Year: |
2013 |
Abstract
Project Summary/ Abstract
Meningioma is the most common primary brain tumor, present in up to one percent of adults, and
although often considered benign, has survival comparable to breast cancer. Information on risk
factors is extremely limited. In an effort to better define such factors, we are conducting a
comprehensive population-based, case/control study of meningioma that includes 1600 cases and
1600 controls drawn from Massachusetts, Connecticut, North Carolina, California and Texas. This
will represent the largest population-based collection of meningioma cases worldwide, with more than
double the number of cases of any existing study. We are currently collecting biological specimens,
and extensive exposure and phenotypic data with funding from the National Institutes of Health (NIH
R01s CA109468, CA109461, CA109745, CA108473, and CA109475). In this application we request
funds to genotype the study subjects to find inherited risk loci for meningioma. Our aims are to 1)
Conduct the first genome wide association study (GWAS) of meningioma using the 1360 Caucasian
cases from our ongoing case/control project and 3420 Caucasian controls drawn from the first half of
three control series a) 600 controls from our ongoing case/control project, b) 1699 controls from
Illumina iControlDB and c) 1121 controls from the Cancer Genetic Markers of Susceptibility (CGEMs)
study, 2) Using 700 additional Caucasian meningioma subjects drawn from our clinical series and the
second half of the above mentioned controls (n=3420), replicate candidates from Aim 1 that yielded
p<10-5 for association with meningioma. Variants with p < 5.0*10-8 will be considered significant for
genome wide association with meningioma risk from combined stage 1 and stage 2 analyses, 3)
Replicate previous associations from the Interphone study8a of meningioma risk with variants in BRIP1
(the breast cancer susceptibility gene (BRCA1)-interacting protein) and ATM (ataxia telangiectasia
mutated gene) and 4) Replicate previous associations from the Tineas Capitas study of meningioma
risk with variants in DNA repair genes (KRAS2, ERCC2, CCND1).107 The proposed genetic analyses
would represent the first GWAS data for meningioma and also provide important replication of
previously observed associations with strong biological plausibility given the established association
between meningioma risk and ionizing radiation. Identification of risk loci for meningioma will likely
have strong etiologic significance with importance for both prevention and treatment.
Publications
Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.
Authors: Muskens I.S.
, Hansen H.M.
, Smirnov I.V.
, Molinaro A.M.
, Bondy M.L.
, Schildkraut J.M.
, Wrensch M.
, Wiemels J.L.
, Claus E.B.
.
Source: Journal of neuro-oncology, 2019 May; 142(3), p. 479-487.
EPub date: 2019-02-22.
PMID: 30796745
Related Citations
Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas.
Authors: Fennell L.
, Dumenil T.
, Wockner L.
, Hartel G.
, Nones K.
, Bond C.
, Borowsky J.
, Liu C.
, McKeone D.
, Bowdler L.
, et al.
.
Source: Cellular and molecular gastroenterology and hepatology, 2019; 8(2), p. 269-290.
EPub date: 2019-04-05.
PMID: 30954552
Related Citations
Quality of life after surgery for intracranial meningioma.
Authors: Benz L.S.
, Wrensch M.R.
, Schildkraut J.M.
, Bondy M.L.
, Warren J.L.
, Wiemels J.L.
, Claus E.B.
.
Source: Cancer, 2018-01-01; 124(1), p. 161-166.
EPub date: 2017-09-13.
PMID: 28902404
Related Citations
Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma.
Authors: Aizer A.A.
, Arvold N.D.
, Catalano P.
, Claus E.B.
, Golby A.J.
, Johnson M.D.
, Al-Mefty O.
, Wen P.Y.
, Reardon D.A.
, Lee E.Q.
, et al.
.
Source: Neuro-oncology, 2014 Nov; 16(11), p. 1547-53.
EPub date: 2014-06-02.
PMID: 24891451
Related Citations
Endogenous and exogenous hormone exposure and the risk of meningioma in men.
Authors: Schildkraut J.M.
, Calvocoressi L.
, Wang F.
, Wrensch M.
, Bondy M.L.
, Wiemels J.L.
, Claus E.B.
.
Source: Journal of neurosurgery, 2014 Apr; 120(4), p. 820-6.
EPub date: 2014-01-31.
PMID: 24484233
Related Citations
Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females.
Authors: Claus E.B.
, Calvocoressi L.
, Bondy M.L.
, Wrensch M.
, Wiemels J.L.
, Schildkraut J.M.
.
Source: Journal of neurosurgery, 2013 Mar; 118(3), p. 649-56.
EPub date: 2012-10-26.
PMID: 23101448
Related Citations
Dental x-rays and risk of meningioma: response to Drs. Calnon, Jorgensen, and White.
Authors: Claus E.B.
, Wiemels J.
, Wrensch M.
.
Source: Cancer, 2013-01-15; 119(2), p. 465-6.
EPub date: 2012-12-18.
PMID: 23254687
Related Citations
Assessment of autoantibodies to meningioma in a population-based study.
Authors: Wiemels J.L.
, Bracci P.M.
, Wrensch M.
, Schildkraut J.
, Bondy M.
, Pfefferle J.
, Zhou M.
, Sison J.
, Calvocoressi L.
, Claus E.B.
.
Source: American journal of epidemiology, 2013-01-01; 177(1), p. 75-83.
EPub date: 2012-12-06.
PMID: 23221727
Related Citations
Dental x-rays and risk of meningioma.
Authors: Claus E.B.
, Calvocoressi L.
, Bondy M.L.
, Schildkraut J.M.
, Wiemels J.L.
, Wrensch M.
.
Source: Cancer, 2012-09-15; 118(18), p. 4530-7.
EPub date: 2012-04-10.
PMID: 22492363
Related Citations
Cigarette smoking and risk of meningioma: the effect of gender.
Authors: Claus E.B.
, Walsh K.M.
, Calvocoressi L.
, Bondy M.L.
, Schildkraut J.M.
, Wrensch M.
, Wiemels J.L.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012 Jun; 21(6), p. 943-50.
EPub date: 2012-04-02.
PMID: 22473761
Related Citations
Family and personal medical history and risk of meningioma.
Authors: Claus E.B.
, Calvocoressi L.
, Bondy M.L.
, Schildkraut J.M.
, Wiemels J.L.
, Wrensch M.
.
Source: Journal of neurosurgery, 2011 Dec; 115(6), p. 1072-7.
EPub date: 2011-07-22.
PMID: 21780859
Related Citations
Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.
Authors: Wiemels J.L.
, Wrensch M.
, Sison J.D.
, Zhou M.
, Bondy M.
, Calvocoressi L.
, Black P.M.
, Yu H.
, Schildkraut J.M.
, Claus E.B.
.
Source: International journal of cancer, 2011-10-15; 129(8), p. 1932-9.
EPub date: 2011-04-25.
PMID: 21520030
Related Citations
Treatment and survival of patients with nonmalignant intracranial meningioma: results from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. Clinical article.
Authors: Cahill K.S.
, Claus E.B.
.
Source: Journal of neurosurgery, 2011 Aug; 115(2), p. 259-67.
EPub date: 2011-04-29.
PMID: 21529132
Related Citations
Epidemiology and etiology of meningioma.
Authors: Wiemels J.
, Wrensch M.
, Claus E.B.
.
Source: Journal of neuro-oncology, 2010 Sep; 99(3), p. 307-14.
EPub date: 2010-09-07.
PMID: 20821343
Related Citations
Specific genes expressed in association with progesterone receptors in meningioma.
Authors: Claus E.B.
, Park P.J.
, Carroll R.
, Chan J.
, Black P.M.
.
Source: Cancer research, 2008-01-01; 68(1), p. 314-22.
PMID: 18172325
Related Citations