Skip to main content
Grant Details

Grant Number: 5P01CA163233-02 Interpret this number
Primary Investigator: Katz, Steven
Organization: University Of Michigan
Project Title: The Challenge of Individualizing Treatments for Patients with Breast Cancer
Fiscal Year: 2013
Back to top


Abstract

DESCRIPTION (provided by applicant): Treatments for cancer impose substantial burden and morbidity but net survival benefit of different strategies is often small and virtually always uncertain. Thus, clinicians may do more harm than good if treatment is too aggressive. There are a number of management strategies for breast cancer aimed at reducing unnecessary morbidity and burden on patients with favorable disease. A key barrier to advancing these initiatives is the need for a better understanding of the challenges of individualizing cancer care The goal of this program is to improve population health by helping clinicians and their patients address the challenges of individualizing treatment of breast cancer for patients with favorable prognosis. Objective 1: To examine the challenges of individualizing treatment for women with breast cancer. Two projects will each undertake an observational study of patients newly diagnosed with breast cancer (including their attending clinicians) who were reported to the SEER registries of Georgia and New Jersey during an 18 month period to examine patient and clinician factors associated with key evaluative tests, treatments, and patient appraisal of decision quality. Project 1 will focus on challenges for surgeons and their patients with regard to locoregional therapy. Project 2 will focus on challenges for medical oncologists and their patients with regard to systemic therapy. Objective 2: To improve treatment decision quality. Project 3 will perform a randomized controlled trial of a practice based online decision tool for patients newly diagnosed with breast cancer in the Detroit and Atlanta SEER regions intended to improve decision quality. Objective 3: To accelerate the dissemination of SEER-based research findings by implementing and evaluating a tailored online portal aimed at all surgeons and medical oncologists who treated the patient samples in P1 and P2 to evaluate whether our research findings can more directly and promptly inform clinicians knowledge and attitudes about individualizing treatment. Objective 4: To advance methods in SEER population translational research focused on quality of cancer care. We propose four shared resource cores that will support program project activities, advance innovative methods in oncology population sciences, and advance team mission and long-term strategic planning.

Back to top


Publications

Surgeon Influence on Variation in Receipt of Contralateral Prophylactic Mastectomy for Women With Breast Cancer.
Authors: Katz S.J. , Hawley S.T. , Hamilton A.S. , Ward K.C. , Morrow M. , Jagsi R. , Hofer T.P. .
Source: Jama Surgery, 2018-01-01 00:00:00.0; 153(1), p. 29-36.
PMID: 28903158
Related Citations

Treatment decisions and employment of breast cancer patients: Results of a population-based survey.
Authors: Jagsi R. , Abrahamse P.H. , Lee K.L. , Wallner L.P. , Janz N.K. , Hamilton A.S. , Ward K.C. , Morrow M. , Kurian A.W. , Friese C.R. , et al. .
Source: Cancer, 2017-10-09 00:00:00.0; , .
EPub date: 2017-10-09 00:00:00.0.
PMID: 28990155
Related Citations

What Factors Influence Women's Perceptions of their Systemic Recurrence Risk after Breast Cancer Treatment?
Authors: Lee K.L. , Janz N.K. , Zikmund-Fisher B.J. , Jagsi R. , Wallner L.P. , Kurian A.W. , Katz S.J. , Abrahamse P. , Hawley S.T. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2017-08-01 00:00:00.0; , p. 272989X17724441.
EPub date: 2017-08-01 00:00:00.0.
PMID: 28814131
Related Citations

Patient Preferences for Primary Care Provider Roles in Breast Cancer Survivorship Care.
Authors: Wallner L.P. , Li Y. , Furgal A.K.C. , Friese C.R. , Hamilton A.S. , Ward K.C. , Jagsi R. , Katz S.J. , Hawley S.T. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-07-12 00:00:00.0; , p. JCO2017731307.
EPub date: 2017-07-12 00:00:00.0.
PMID: 28700276
Related Citations

Oncologists' influence on receipt of adjuvant chemotherapy: does it matter whom you see for treatment of curable breast cancer?
Authors: Katz S.J. , Hawley S.T. , Bondarenko I. , Jagsi R. , Ward K.C. , Hofer T.P. , Kurian A.W. .
Source: Breast Cancer Research And Treatment, 2017-07-08 00:00:00.0; , .
EPub date: 2017-07-08 00:00:00.0.
PMID: 28689364
Related Citations

Surgeon Attitudes and Use of MRI in Patients Newly Diagnosed with Breast Cancer.
Authors: Morrow M. , Hawley S.T. , McLeod M.C. , Hamilton A.S. , Ward K.C. , Katz S.J. , Jagsi R. .
Source: Annals Of Surgical Oncology, 2017 Jul; 24(7), p. 1889-1896.
EPub date: 2017-03-22 00:00:00.0.
PMID: 28332033
Related Citations

Decision-support networks of women newly diagnosed with breast cancer.
Authors: Wallner L.P. , Li Y. , McLeod M.C. , Hamilton A.S. , Ward K.C. , Veenstra C.M. , An L.C. , Janz N.K. , Katz S.J. , Hawley S.T. .
Source: Cancer, 2017-06-22 00:00:00.0; , .
EPub date: 2017-06-22 00:00:00.0.
PMID: 28640360
Related Citations

Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials.
Authors: Taylor C. , Correa C. , Duane F.K. , Aznar M.C. , Anderson S.J. , Bergh J. , Dodwell D. , Ewertz M. , Gray R. , Jagsi R. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-05-20 00:00:00.0; 35(15), p. 1641-1649.
EPub date: 2017-03-20 00:00:00.0.
PMID: 28319436
Related Citations

Gaps in Incorporating Germline Genetic Testing Into Treatment Decision-Making for Early-Stage Breast Cancer.
Authors: Kurian A.W. , Li Y. , Hamilton A.S. , Ward K.C. , Hawley S.T. , Morrow M. , McLeod M.C. , Jagsi R. , Katz S.J. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2017-04-12 00:00:00.0; , p. JCO2016716480.
EPub date: 2017-04-12 00:00:00.0.
PMID: 28402748
Related Citations

Treatment Experiences Of Latinas After Diagnosis Of Breast Cancer
Authors: Katz S.J. , Wallner L.P. , Abrahamse P.H. , Janz N.K. , Martinez K.A. , Shumway D.A. , Hamilton A.S. , Ward K.C. , Resnicow K.A. , Hawley S.T. .
Source: Cancer, 2017-04-11 00:00:00.0; , .
PMID: 28398629
Related Citations

Patient Reactions to Surgeon Recommendations About Contralateral Prophylactic Mastectomy for Treatment of Breast Cancer.
Authors: Katz S.J. , Janz N.K. , Abrahamse P. , Wallner L.P. , Hawley S.T. , An L.C. , Ward K.C. , Hamilton A.S. , Morrow M. , Jagsi R. .
Source: Jama Surgery, 2017-04-05 00:00:00.0; , .
EPub date: 2017-04-05 00:00:00.0.
PMID: 28384687
Related Citations

Contralateral Prophylactic Mastectomy Decisions In A Population-based Sample Of Patients With Early-stage Breast Cancer
Authors: Jagsi R. , Hawley S.T. , Griffith K.A. , Janz N.K. , Kurian A.W. , Ward K.C. , Hamilton A.S. , Morrow M. , Katz S.J. .
Source: Jama Surgery, 2017-03-01 00:00:00.0; 152(3), p. 274-282.
PMID: 28002555
Related Citations

Study protocol: A Randomized Controlled Trial of a Comprehensive Breast Cancer Treatment Patient Decision Tool (iCanDecide).
Authors: Hawley S.T. , Li Y. , Jeanpierre L.A. , Goodell S. , Jagsi R. , Ward K.C. , Sabel M.S. , Katz S.J. .
Source: Contemporary Clinical Trials Communications, 2017 Mar; 5, p. 123-132.
EPub date: 2017-02-03 00:00:00.0.
PMID: 29152598
Related Citations

Genetic Testing And Counseling Among Patients With Newly Diagnosed Breast Cancer
Authors: Kurian A.W. , Griffith K.A. , Hamilton A.S. , Ward K.C. , Morrow M. , Katz S.J. , Jagsi R. .
Source: Jama, 2017-02-07 00:00:00.0; 317(5), p. 531-534.
PMID: 28170472
Related Citations

The Impact Of Doctor-patient Communication On Patients' Perceptions Of Their Risk Of Breast Cancer Recurrence
Authors: Janz N.K. , Li Y. , Zikmund-Fisher B.J. , Jagsi R. , Kurian A.W. , An L.C. , McLeod M.C. , Lee K.L. , Katz S.J. , Hawley S.T. .
Source: Breast Cancer Research And Treatment, 2017 Feb; 161(3), p. 525-535.
PMID: 27943007
Related Citations

Treatment-associated Toxicities Reported By Patients With Early-stage Invasive Breast Cancer
Authors: Friese C.R. , Harrison J.M. , Janz N.K. , Jagsi R. , Morrow M. , Li Y. , Hamilton A.S. , Ward K.C. , Kurian A.W. , Katz S.J. , et al. .
Source: Cancer, 2017-01-24 00:00:00.0; , .
PMID: 28117882
Related Citations

Cultural challenges to engaging patients in shared decision making.
Authors: Hawley S.T. , Morris A.M. .
Source: Patient Education And Counseling, 2017 Jan; 100(1), p. 18-24.
PMID: 27461943
Related Citations

Chemotherapy Decisions And Patient Experience With The Recurrence Score Assay For Early-stage Breast Cancer
Authors: Friese C.R. , Li Y. , Bondarenko I. , Hofer T.P. , Ward K.C. , Hamilton A.S. , Deapen D. , Kurian A.W. , Katz S.J. .
Source: Cancer, 2017-01-01 00:00:00.0; 123(1), p. 43-51.
PMID: 27775837
Related Citations

Second Opinions From Medical Oncologists For Early-stage Breast Cancer: Prevalence, Correlates, And Consequences
Authors: Kurian A.W. , Friese C.R. , Bondarenko I. , Jagsi R. , Li Y. , Hamilton A.S. , Ward K.C. , Katz S.J. .
Source: Jama Oncology, 2016-12-29 00:00:00.0; , .
PMID: 28033448
Related Citations

The Influence Of 21-gene Recurrence Score Assay On Chemotherapy Use In A Population-based Sample Of Breast Cancer Patients
Authors: Li Y. , Kurian A.W. , Bondarenko I. , Taylor J.M. , Jagsi R. , Ward K.C. , Hamilton A.S. , Katz S.J. , Hofer T.P. .
Source: Breast Cancer Research And Treatment, 2016-12-23 00:00:00.0; , .
PMID: 28012085
Related Citations

Recurrence Risk Perception And Quality Of Life Following Treatment Of Breast Cancer
Authors: Hawley S.T. , Janz N.K. , Griffith K.A. , Jagsi R. , Friese C.R. , Kurian A.W. , Hamilton A.S. , Ward K.C. , Morrow M. , Wallner L.P. , et al. .
Source: Breast Cancer Research And Treatment, 2016-12-21 00:00:00.0; , .
PMID: 28004220
Related Citations

Does physician communication style impact patient report of decision quality for breast cancer treatment?
Authors: Martinez K.A. , Resnicow K. , Williams G.C. , Silva M. , Abrahamse P. , Shumway D.A. , Wallner L.P. , Katz S.J. , Hawley S.T. .
Source: Patient Education And Counseling, 2016 Dec; 99(12), p. 1947-1954.
PMID: 27395750
Related Citations

Use Of Online Communication By Patients With Newly Diagnosed Breast Cancer During The Treatment Decision Process
Authors: Wallner L.P. , Martinez K.A. , Li Y. , Jagsi R. , Janz N.K. , Katz S.J. , Hawley S.T. .
Source: Jama Oncology, 2016-12-01 00:00:00.0; 2(12), p. 1654-1656.
PMID: 27468161
Related Citations

Involvement of Primary Care Physicians in the Decision Making and Care of Patients With Breast Cancer.
Authors: Wallner L.P. , Abrahamse P. , Uppal J.K. , Friese C.R. , Hamilton A.S. , Ward K.C. , Katz S.J. , Hawley S.T. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-11-20 00:00:00.0; 34(33), p. 3969-3975.
EPub date: 2016-10-31 00:00:00.0.
PMID: 28440678
Related Citations

Stroke risk stratification in acute dizziness presentations: A prospective imaging-based study.
Authors: Kerber K.A. , Meurer W.J. , Brown D.L. , Burke J.F. , Hofer T.P. , Tsodikov A. , Hoeffner E.G. , Fendrick A.M. , Adelman E.E. , Morgenstern L.B. .
Source: Neurology, 2015-11-24 00:00:00.0; 85(21), p. 1869-78.
EPub date: 2015-11-24 00:00:00.0.
PMID: 26511453
Related Citations

Precision Medicine In Breast Cancer Care: An Early Glimpse Of Impact
Authors: Kurian A.W. , Friese C.R. .
Source: Jama Oncology, 2015 Nov; 1(8), p. 1109-10.
PMID: 26313021
Related Citations

Treatment Decision Making And Genetic Testing For Breast Cancer: Mainstreaming Mutations
Authors: Katz S.J. , Kurian A.W. , Morrow M. .
Source: Jama, 2015-09-08 00:00:00.0; 314(10), p. 997-8.
PMID: 26203642
Related Citations

Psychometric properties of a brief measure of autonomy support in breast cancer patients.
Authors: Shumway D. , Griffith K.A. , Jagsi R. , Gabram S.G. , Williams G.C. , Resnicow K. .
Source: Bmc Medical Informatics And Decision Making, 2015-07-09 00:00:00.0; 15, p. 51.
EPub date: 2015-07-09 00:00:00.0.
PMID: 26155944
Related Citations

How can we best respect patient autonomy in breast cancer treatment decisions?
Authors: Martinez K.A. , Kurian A.W. , Hawley S.T. , Jagsi R. .
Source: Breast Cancer Management, 2015; 4(1), p. 53-64.
PMID: 25733982
Related Citations

Development and psychometric properties of a brief measure of subjective decision quality for breast cancer treatment.
Authors: Resnicow K. , Abrahamse P. , Tocco R.S. , Hawley S. , Griggs J. , Janz N. , Fagerlin A. , Wilson A. , Ward K.C. , Gabram S.G. , et al. .
Source: Bmc Medical Informatics And Decision Making, 2014-12-05 00:00:00.0; 14, p. 110.
EPub date: 2014-12-05 00:00:00.0.
PMID: 25476986
Related Citations

Shared decision making for treatment of cancer: challenges and opportunities.
Authors: Katz S.J. , Belkora J. , Elwyn G. .
Source: Journal Of Oncology Practice / American Society Of Clinical Oncology, 2014 May; 10(3), p. 206-8.
PMID: 24839284
Related Citations

Patient-physician shared decision making--reply.
Authors: Katz S.J. , Hawley S. .
Source: Jama, 2014-02-26 00:00:00.0; 311(8), p. 864.
PMID: 24570256
Related Citations

Treatment decision aids are unlikely to cut healthcare costs.
Authors: Katz S.J. .
Source: Bmj (clinical Research Ed.), 2014-02-05 00:00:00.0; 348, p. g1172.
EPub date: 2014-02-05 00:00:00.0.
PMID: 24500345
Related Citations

Addressing overtreatment in breast cancer: The doctors' dilemma.
Authors: Katz S.J. , Morrow M. .
Source: Cancer, 2013-10-15 00:00:00.0; 119(20), p. 3584-8.
EPub date: 2013-10-15 00:00:00.0.
PMID: 23913512
Related Citations

Contralateral prophylactic mastectomy for breast cancer: addressing peace of mind.
Authors: Katz S.J. , Morrow M. .
Source: Jama, 2013-08-28 00:00:00.0; 310(8), p. 793-4.
PMID: 23907558
Related Citations




Back to Top