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Grant Details

Grant Number: 1R03CA156561-01A1 Interpret this number
Primary Investigator: Villano, John
Organization: University Of Kentucky
Project Title: Clinical Characteristics and Patterns of Care for Rare Brain Tumor Sub-Types
Fiscal Year: 2013


DESCRIPTION (provided by applicant): With over 100 different histological subtypes, many rare brain and CNS tumor histologies cannot be adequately assessed for factors that may influence treatment or survival patterns. An estimated 1,000 ependymomas, 1,200 primary CNS lymphomas, 100 choroid plexus tumors, and 100 pineal parenchymal tumors are reported in the United States per year. Because of the small number of individuals who develop these tumors, studies are often restricted and may not provide information representative of the general population. The National Cancer Data Base (NCDB) is the largest clinical database in the world and collects information on all cancers, including all primary brain and CNS tumors, from Commission on Cancer accredited institutions, representing about 70% of all cancer cases diagnosed in the U.S. The NCDB collects a wealth of demographic, tumor characteristic, treatment, and follow-up (survival) data. The goal of this proposal is to describe presenting clinical characteristics and treatment and survival patterns for patients diagnosed with a subset of the rarest brain and CNS tumor subtypes, mainly ependymomas, primary CNS lymphomas, choroid plexus tumors, and pineal parenchymal tumors using data from the NCDB. A second goal of this proposal is to conduct a comprehensive evaluation of clinical or treatment factors that may influence survival time. We anticipate that approximately 7,000 ependymomas, 8,500 primary CNS lymphomas, 600 choroid plexus tumors, and 250 pineal parenchymal tumors will be available for analyses for the years 1998 - 2010, providing a large and diverse data set for analyses of these important tumors.


National cancer database analysis of outcomes in pediatric glioblastoma.
Authors: Liu M. , Thakkar J.P. , Garcia C.R. , Dolecek T.A. , Wagner L.M. , Dressler E.V.M. , Villano J.L. .
Source: Cancer medicine, 2018 Apr; 7(4), p. 1151-1159.
EPub date: 2018-03-13.
PMID: 29532996
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Demographics, patterns of care, and survival in pediatric medulloblastoma.
Authors: Dressler E.V. , Dolecek T.A. , Liu M. , Villano J.L. .
Source: Journal of neuro-oncology, 2017 May; 132(3), p. 497-506.
EPub date: 2017-03-13.
PMID: 28290003
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Incidence of CNS tumors in Appalachian children.
Authors: Huang B. , Luo A. , Durbin E.B. , Lycan E. , Tucker T. , Chen Q. , Horbinski C. , Villano J.L. .
Source: Journal of neuro-oncology, 2017 May; 132(3), p. 507-512.
EPub date: 2017-03-11.
PMID: 28285334
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Epidemiology of meningiomas post-Public Law 107-206: The Benign Brain Tumor Cancer Registries Amendment Act.
Authors: Dolecek T.A. , Dressler E.V. , Thakkar J.P. , Liu M. , Al-Qaisi A. , Villano J.L. .
Source: Cancer, 2015-07-15; 121(14), p. 2400-10.
EPub date: 2015-04-14.
PMID: 25872752
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Epidemiologic and molecular prognostic review of glioblastoma.
Authors: Thakkar J.P. , Dolecek T.A. , Horbinski C. , Ostrom Q.T. , Lightner D.D. , Barnholtz-Sloan J.S. , Villano J.L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014 Oct; 23(10), p. 1985-96.
EPub date: 2014-07-22.
PMID: 25053711
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Analyzing temozolomide medication errors: potentially fatal.
Authors: Letarte N. , Gabay M.P. , Bressler L.R. , Long K.E. , Stachnik J.M. , Villano J.L. .
Source: Journal of neuro-oncology, 2014 Oct; 120(1), p. 111-5.
EPub date: 2014-07-16.
PMID: 25026995
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Age-specific cancer incidence rates increase through the oldest age groups.
Authors: Thakkar J.P. , McCarthy B.J. , Villano J.L. .
Source: The American journal of the medical sciences, 2014 Jul; 348(1), p. 65-70.
PMID: 24805784
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