Grant Details

Grant Number: |
5R01CA160736-03 Interpret this number |

Primary Investigator: |
Baladandayuthapani, Veerabhadran |

Organization: |
University Of Tx Md Anderson Can Ctr |

Project Title: |
Integrative Methods for High-Dimensional Genomics Data |

Fiscal Year: |
2013 |

Abstract

DESCRIPTION (provided by applicant): The primary objective of this proposal is to develop adaptive and exible statistical models for analyses of multivariate, functional and spatial data from high-throughput biomedical studies. These studies raise computational, modeling, and inferential challenges with respect to high-dimensionality as well as structured dependency induced by the various aspects of the processes generating the data. Our work is motivated by, and will be applied to, data from a variety of high- throughput cancer-related studies that were conducted by our biomedical collaborators, in genomics, epigenomics and transcriptomics; although our methods are generally applicable to other contexts. The short-term objective of this research is to develop novel statistical methods and computational tools for statistical and probabilistic modeling of such high-throughput data with particular emphasis on integrative methods to combine information within and across dierent assays as well as clinical data to answer important biological questions. Our long-term goal is to improve risk prediction and treatment selection in cancer prevention, diagnosis and prognosis. We will accomplish the objective of this application by pursuing the following ve specic aims (1) develop new methodology for Bayesian adaptive generalized functional linear mixed models, allowing for local and nonlinear association structures between scalar responses and functional predictors (2) develop hierarchical Bayesian joint models for integrating diverse types of multivariate and functional data. (3) develop Bayesian spatial-functional process models for spatially indexed high-dimensional functional data, methods for data requiring a broader class of within-function and between-function covariance structures using exible families of covariance functions. (4) develop multivariate Bayesian spatial-functional models for joint modeling of multiple spatially indexed functional data. (5) develop ecient, user-friendly and freely available software for the proposed methods.

Publications

**Identification Of Differentially Methylated Loci Using Wavelet-based Functional Mixed Models**

**Authors:**Lee W. , Morris J.S. .

**Source:**Bioinformatics (oxford, England), 2016-03-01 00:00:00.0; 32(5), p. 664-72.

**PMID:**26559505

Related Citations

**Integrative Bayesian Analysis Of Neuroimaging-genetic Data With Application To Cocaine Dependence**

**Authors:**Azadeh S. , Hobbs B.P. , Ma L. , Nielsen D.A. , Moeller F.G. , Baladandayuthapani V. .

**Source:**Neuroimage, 2016-01-15 00:00:00.0; 125, p. 813-24.

**PMID:**26484829

Related Citations

**Demarcate: Density-based Magnetic Resonance Image Clustering For Assessing Tumor Heterogeneity In Cancer**

**Authors:**Saha A. , Banerjee S. , Kurtek S. , Narang S. , Lee J. , Rao G. , Martinez J. , Bharath K. , Rao A.U. , Baladandayuthapani V. .

**Source:**Neuroimage. Clinical, 2016; 12, p. 132-43.

**PMID:**27408798

Related Citations

**Dingo: Differential Network Analysis In Genomics**

**Authors:**Ha M.J. , Baladandayuthapani V. , Do K.A. .

**Source:**Bioinformatics (oxford, England), 2015-11-01 00:00:00.0; 31(21), p. 3413-20.

**PMID:**26148744

Related Citations

**Bayesian Function-on-function Regression For Multilevel Functional Data**

**Authors:**Meyer M.J. , Coull B.A. , Versace F. , Cinciripini P. , Morris J.S. .

**Source:**Biometrics, 2015 Sep; 71(3), p. 563-74.

**PMID:**25787146

Related Citations

**Bayesian Nonlinear Model Selection For Gene Regulatory Networks**

**Authors:**Ni Y. , Stingo F.C. , Baladandayuthapani V. .

**Source:**Biometrics, 2015 Sep; 71(3), p. 585-95.

**PMID:**25854759

Related Citations

**A Two-sample Test For Equality Of Means In High Dimension**

**Authors:**Gregory K.B. , Carroll R.J. , Baladandayuthapani V. , Lahiri S.N. .

**Source:**Journal Of The American Statistical Association, 2015-06-01 00:00:00.0; 110(510), p. 837-849.

**PMID:**26279594

Related Citations

**Prognostic Gene Signature Identification Using Causal Structure Learning: Applications In Kidney Cancer**

**Authors:**Ha M.J. , Baladandayuthapani V. , Do K.A. .

**Source:**Cancer Informatics, 2015; 14(Suppl 1), p. 23-35.

**PMID:**25861215

Related Citations

**Latent Feature Decompositions For Integrative Analysis Of Multi-platform Genomic Data**

**Authors:**Gregory K.B. , Momin A.A. , Coombes K.R. , Baladandayuthapani V. .

**Source:**Ieee/acm Transactions On Computational Biology And Bioinformatics / Ieee, Acm, 2014 Nov-Dec; 11(6), p. 984-94.

**PMID:**26146492

Related Citations

**Bayesian Hierarchical Structured Variable Selection Methods With Application To Mip Studies In Breast Cancer**

**Authors:**Zhang L. , Baladandayuthapani V. , Mallick B.K. , Manyam G.C. , Thompson P.A. , Bondy M.L. , Do K.A. .

**Source:**Journal Of The Royal Statistical Society. Series C, Applied Statistics, 2014 Aug; 63(4), p. 595-620.

**PMID:**25705056

Related Citations

**Bayesian Sparse Graphical Models And Their Mixtures**

**Authors:**Talluri R. , Baladandayuthapani V. , Mallick B.K. .

**Source:**Stat, 2014-01-01 00:00:00.0; 3(1), p. 109-125.

**PMID:**24948842

Related Citations

**Integrative Bayesian Network Analysis Of Genomic Data**

**Authors:**Ni Y. , Stingo F.C. , Baladandayuthapani V. .

**Source:**Cancer Informatics, 2014; 13(Suppl 2), p. 39-48.

**PMID:**25288878

Related Citations

**Bayesian Disease Classification Using Copy Number Data**

**Authors:**Guha S. , Ji Y. , Baladandayuthapani V. .

**Source:**Cancer Informatics, 2014; 13(Suppl 2), p. 83-91.

**PMID:**25336897

Related Citations

**Bayesian Joint Selection Of Genes And Pathways: Applications In Multiple Myeloma Genomics**

**Authors:**Zhang L. , Morris J.S. , Zhang J. , Orlowski R.Z. , Baladandayuthapani V. .

**Source:**Cancer Informatics, 2014; 13(Suppl 2), p. 113-23.

**PMID:**25520554

Related Citations

**Ibag: Integrative Bayesian Analysis Of High-dimensional Multiplatform Genomics Data**

**Authors:**Wang W. , Baladandayuthapani V. , Morris J.S. , Broom B.M. , Manyam G. , Do K.A. .

**Source:**Bioinformatics (oxford, England), 2013-01-15 00:00:00.0; 29(2), p. 149-59.

**PMID:**23142963

Related Citations

**Integrating Multi-platform Genomic Data Using Hierarchical Bayesian Relevance Vector Machines**

**Authors:**Srivastava S. , Wang W. , Manyam G. , Ordonez C. , Baladandayuthapani V. .

**Source:**Eurasip Journal On Bioinformatics & Systems Biology, 2013; 2013(1), p. 9.

**PMID:**23809014

Related Citations

**Bayesian Methods For Expression-based Integration Of Various Types Of Genomics Data**

**Authors:**Jennings E.M. , Morris J.S. , Carroll R.J. , Manyam G.C. , Baladandayuthapani V. .

**Source:**Eurasip Journal On Bioinformatics & Systems Biology, 2013; 2013(1), p. 13.

**PMID:**24053265

Related Citations

**Integrative Network-based Bayesian Analysis Of Diverse Genomics Data**

**Authors:**Wang W. , Baladandayuthapani V. , Holmes C.C. , Do K.A. .

**Source:**Bmc Bioinformatics, 2013; 14 Suppl 13, p. S8.

**PMID:**24267288

Related Citations