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Grant Details

Grant Number: 5R01CA160744-02 Interpret this number
Primary Investigator: Kim, Jane
Organization: Harvard School Of Public Health
Project Title: Comparative and Cost-Effectiveness of Preventing HPV-Related Diseases
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): Each year, more than 25,000 cases of invasive cancer attributable to human papillomavirus (HPV) infection occur in the United States; nearly 50% are cervical cancer, while the rest involve the oral cavity/oropharynx, anus, vulva, penis, and vagina. Collectively, these account for substantial morbidity and mortality, contribute to health disparities, and are associated with high economic costs. Advancements in HPV-related cancer epidemiology, coupled with new (e.g., HPV-16,-18 vaccines, HPV DNA testing) and emerging (e.g., biomarkers, therapeutic vaccines) technologies provide a remarkable opportunity to improve cancer prevention efforts. However, critical challenges remain with respect to clinical decision-making and prevention policy, pertaining to knowledge gaps and heterogeneities in the natural history of different cancers, uncertainties in HPV type distribution following HPV-16,-18 vaccination, and the real-world clinical effectiveness of emerging technologies. We propose to employ a decision-analytic approach, developing a flexible modeling framework that will allow us to synthesize the best available data; evaluate the health and economic consequences of alternative strategies; explore the uncertainty around their outcomes; explicitly quantify the tradeoffs associated with different approaches; and inform timely clinical and policy questions. By achieving our aims, we expect to have an impact on (1) the analytic methods of decision science; (2) the equitable distribution and rationale use of new technology; (3) the effectiveness of strategies for cancer prevention through clinical guidelines and national policies; (4) HPV-related cancer outcomes, including reduced incidence, enhanced quality of life, improved survival, and reduced disparities; and (5) the financial and economic profile of delivering cancer-related health services.

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Publications

Choosing wisely: a model-based analysis evaluating the trade-offs in cancer benefit and diagnostic referrals among alternative HPV testing strategies in Norway.
Authors: Burger E.A. , Pedersen K. , Sy S. , Kristiansen I.S. , Kim J.J. .
Source: British Journal Of Cancer, 2017-09-05 00:00:00.0; 117(6), p. 783-790.
EPub date: 2017-08-03 00:00:00.0.
PMID: 28772279
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Age of acquiring causal human papillomavirus (HPV) infections: Leveraging simulation models to explore the natural history of HPV-induced cervical cancer.
Authors: Burger E.A. , Kim J.J. , Sy S. , Castle P.E. .
Source: Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America, 2017-05-20 00:00:00.0; , .
EPub date: 2017-05-20 00:00:00.0.
PMID: 28531261
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The Cost-effectiveness Of Cervical Self-sampling To Improve Routine Cervical Cancer Screening: The Importance Of Respondent Screening History And Compliance
Authors: Burger E.A. , Sy S. , Nygård M. , Kim J.J. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016-09-13 00:00:00.0; , .
PMID: 27624639
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Cost-effective Management Of Women With Minor Cervical Lesions: Revisiting The Application Of Hpv Dna Testing
Authors: Pedersen K. , Burger E.A. , Sy S. , Kristiansen I.S. , Kim J.J. .
Source: Gynecologic Oncology, 2016-08-16 00:00:00.0; , .
PMID: 27542966
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Racial And Ethnic Disparities In Human Papillomavirus-associated Cancer Burden With First-generation And Second-generation Human Papillomavirus Vaccines
Authors: Burger E.A. , Lee K. , Saraiya M. , Thompson T.D. , Chesson H.W. , Markowitz L.E. , Kim J.J. .
Source: Cancer, 2016-04-28 00:00:00.0; , .
PMID: 27124396
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Cervical Cancer Screening In Low-resource Settings: A Cost-effectiveness Framework For Valuing Tradeoffs Between Test Performance And Program Coverage
Authors: Campos N.G. , Castle P.E. , Wright T.C. , Kim J.J. .
Source: International Journal Of Cancer, 2015-11-01 00:00:00.0; 137(9), p. 2208-19.
PMID: 25943074
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Too Late To Vaccinate? The Incremental Benefits And Cost-effectiveness Of A Delayed Catch-up Program Using The 4-valent Human Papillomavirus Vaccine In Norway
Authors: Burger E.A. , Sy S. , Nygård M. , Kristiansen I.S. , Kim J.J. .
Source: The Journal Of Infectious Diseases, 2015-01-15 00:00:00.0; 211(2), p. 206-15.
PMID: 25057044
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The value of improving failures within a cervical cancer screening program: an example from Norway.
Authors: Burger E.A. , Kim J.J. .
Source: International Journal Of Cancer, 2014-10-15 00:00:00.0; 135(8), p. 1931-9.
EPub date: 2014-10-15 00:00:00.0.
PMID: 24615416
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Practice-based evidence for primary HPV testing in the United States.
Authors: Kim J.J. .
Source: Journal Of The National Cancer Institute, 2014 Aug; 106(8), .
PMID: 25038468
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Prevention of HPV-related cancers in Norway: cost-effectiveness of expanding the HPV vaccination program to include pre-adolescent boys.
Authors: Burger E.A. , Sy S. , Nygård M. , Kristiansen I.S. , Kim J.J. .
Source: Plos One, 2014; 9(3), p. e89974.
PMID: 24651645
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Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
Source: Vaccine, 2013-12-31 00:00:00.0; 31 Suppl 7, p. H1-31.
PMID: 24332295
Related Citations

Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
Source: Vaccine, 2013-12-30 00:00:00.0; 31 Suppl 6, p. G1-31.
PMID: 24331817
Related Citations

Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
Source: Vaccine, 2013-12-29 00:00:00.0; 31 Suppl 5, p. F1-31.
PMID: 24331745
Related Citations

Comprehensive control of human papillomavirus infections and related diseases.
Authors: Bosch F.X. , Broker T.R. , Forman D. , Moscicki A.B. , Gillison M.L. , Doorbar J. , Stern P.L. , Stanley M. , Arbyn M. , Poljak M. , et al. .
Source: Vaccine, 2013-11-22 00:00:00.0; 31 Suppl 8, p. I1-31.
PMID: 24229716
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Cost-effectiveness Of Surveillance Strategies After Treatment For High-grade Anal Dysplasia In High-risk Patients
Authors: Assoumou S.A. , Mayer K.H. , Panther L. , Linas B.P. , Kim J. .
Source: Sexually Transmitted Diseases, 2013 Apr; 40(4), p. 298-303.
PMID: 23486494
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Modeling preventative strategies against human papillomavirus-related disease in developed countries.
Authors: Canfell K. , Chesson H. , Kulasingam S.L. , Berkhof J. , Diaz M. , Kim J.J. .
Source: Vaccine, 2012-11-20 00:00:00.0; 30 Suppl 5, p. F157-67.
PMID: 23199959
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Optimal Cervical Cancer Screening in Women Vaccinated Against Human Papillomavirus.
Authors: Kim J.J. , Burger E.A. , Sy S. , Campos N.G. .
Source: Journal Of The National Cancer Institute, 2017 02; 109(2), .
EPub date: 2016-10-18 00:00:00.0.
PMID: 27754955
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