Grant Details
Grant Number: |
5R01CA126841-05 Interpret this number |
Primary Investigator: |
Moysich, Kirsten |
Organization: |
Roswell Park Cancer Institute Corp |
Project Title: |
Regulatory T Cell Function in Ovarian Cancer |
Fiscal Year: |
2013 |
Abstract
Abstract
Etiologic and prognostic factors in ovarian cancer remain poorly understood, although emerging
evidence suggests that factors related to immune response play important roles in the
development and clinical treatment of this disease. Recent evidence has revealed that a subset
of T cells with immunosuppressive properties, referred to as regulatory T cells (Treg), are
essential for the development and maintenance of self-tolerance. There is a very consistent
body of literature that points to an important role of these Treg cells in human health. These
studies have shown that lower peripheral Treg cells expression is associated with autoimmune
disease, allergy, and adverse transplantation outcomes, indicating that insufficient Treg cell
stimulated immune suppression might lead to the development of these auto reactive health
conditions. On the other hand, elevated Treg cell expression has been consistently reported in
patients with a wide variety of malignancies, suggesting that Treg cell-mediated suppression
might interfere with an adequate immune response to tumor associated antigens. Our group
and others also provided direct evidence linking elevated Treg cell expression to greater risk of
ovarian cancer and poorer prognosis. Thus, the role of Treg cells in cancer etiology and
prognosis is an area of emerging interest, as high Treg activity might a) prevent an adequate
immune response at the time of cancer initiation and progression, b) prevent an adequate
immune response after initial treatment of the tumor; and c) result in lower responsiveness to
tumor immunotherapy. To date, we are unaware of any comprehensive epidemiological study
that has focused on the role Treg cells in human cancer in general or ovarian carcinogenesis in
particular. Thus, we propose to evaluate the role of Treg cell burden as well as a panel of
candidate genetic polymorphisms, directly relevant to Treg cell activity, in the etiology and
prognosis of ovarian cancer. We hypothesize in Aim 1 that women with ovarian cancer will have
higher blood Treg cell levels than healthy controls. We also expect in Aim 2 that women with a
genetically determined high activity Treg cell profile will be less effective in mounting an immune
response toward tumor cells in the initiation and progression phase of ovarian carcinogenesis.
We further hypothesize in Aim 3 that ovarian cancer patients with a genetically determined high
activity Treg cell profile will be less effective in battling residual disease. We also seek to
determine in Aim 4 if genetic variability in Treg cell function can predict Treg cell expression in
ovarian tumors. We propose to utilize data and specimens from core resources at our institute
and from a population-based case-control study of ovarian cancer. For Aim 1, we will newly
recruit 100 ovarian cancer patients and 100 controls via our institute's Biorepository to collect
fresh blood samples required for Treg cell measurements. In the case-control study we recently
recruited over 900 ovarian cancer patients and 1800 community controls (Specific Aim 2) from
the Buffalo, NY, Pittsburgh PA, and Cleveland, OH areas. We propose to follow-up the ovarian
cancer patient group and assess relevant clinical outcomes (recurrence, survival; Specific Aim
3). We will also select 630 patients with advanced stage disease with available blood and tumor
samples from our institute's Ovarian Cancer Specimen Bank (Specific Aim 4). For the laboratory
analyses, we will utilize Illumina Golden Gate assays and flow-cytometry techniques for the
genotype and Treg cell assessment, respectively. Our statistical and genetic analyses will be
carried out by a trained genetic epidemiologist.
Publications
Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk.
Authors: Barnes D.R.
, Tyrer J.P.
, Dennis J.
, Leslie G.
, Bolla M.K.
, Lush M.
, Aeilts A.M.
, Aittomäki K.
, Andrieu N.
, Andrulis I.L.
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-03-04 00:00:00.0; , .
EPub date: 2024-03-04 00:00:00.0.
PMID: 38496424
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A framework for assessing interactions for risk stratification models: the example of ovarian cancer.
Authors: Phung M.T.
, Lee A.W.
, McLean K.
, Anton-Culver H.
, Bandera E.V.
, Carney M.E.
, Chang-Claude J.
, Cramer D.W.
, Doherty J.A.
, Fortner R.T.
, et al.
.
Source: Journal Of The National Cancer Institute, 2023-11-08 00:00:00.0; 115(11), p. 1420-1426.
PMID: 37436712
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Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case-Control Study from the Ovarian Cancer Association Consortium.
Authors: Gersekowski K.
, Ibiebele T.I.
, Australian Ovarian Cancer Study Group
, Doherty J.A.
, Harris H.R.
, Goodman M.T.
, Terry K.L.
, Wu A.H.
, Bandera E.V.
, Qin B.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-08-01 00:00:00.0; 32(8), p. 1087-1096.
PMID: 37220873
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Clinical parameters affecting survival outcomes in patients with low-grade serous ovarian carcinoma: an international multicentre analysis.
Authors: May T.
, Bernardini M.
, Lheureux S.
, Aben K.K.H.
, Bandera E.V.
, Beckmann M.W.
, Benitez J.
, Berchuck A.
, Bjørge L.
, Carney M.E.
, et al.
.
Source: Canadian Journal Of Surgery. Journal Canadien De Chirurgie, 2023 May-Jun; 66(3), p. E310-E320.
EPub date: 2023-06-27 00:00:00.0.
PMID: 37369443
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Lifestyle and personal factors associated with having macroscopic residual disease after ovarian cancer primary cytoreductive surgery.
Authors: Phung M.T.
, Webb P.M.
, DeFazio A.
, Fereday S.
, Lee A.W.
, Bowtell D.D.L.
, Fasching P.A.
, Goode E.L.
, Goodman M.T.
, Karlan B.Y.
, et al.
.
Source: Gynecologic Oncology, 2023 Jan; 168, p. 68-75.
EPub date: 2022-11-17 00:00:00.0.
PMID: 36401943
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Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.
Authors: DeVries A.A.
, Dennis J.
, Tyrer J.P.
, Peng P.C.
, Coetzee S.G.
, Reyes A.L.
, Plummer J.T.
, Davis B.D.
, Chen S.S.
, Dezem F.S.
, et al.
.
Source: Journal Of The National Cancer Institute, 2022-11-14 00:00:00.0; 114(11), p. 1533-1544.
PMID: 36210504
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Effects of risk factors for ovarian cancer in women with and without endometriosis.
Authors: Phung M.T.
, Muthukumar A.
, Trabert B.
, Webb P.M.
, Jordan S.J.
, Terry K.L.
, Cramer D.W.
, Titus L.J.
, Risch H.A.
, Doherty J.A.
, et al.
.
Source: Fertility And Sterility, 2022 Nov; 118(5), p. 960-969.
EPub date: 2022-09-29 00:00:00.0.
PMID: 36182623
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Reproductive Factors Do Not Influence Survival with Ovarian Cancer.
Authors: Phung M.T.
, Alimujiang A.
, Berchuck A.
, Anton-Culver H.
, Schildkraut J.M.
, Bandera E.V.
, Chang-Claude J.
, Chase A.
, Doherty J.A.
, Grout B.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-04-01 00:00:00.0; 31(4), p. 909-913.
PMID: 35064059
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High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival.
Authors: Brieger K.K.
, Phung M.T.
, Mukherjee B.
, Bakulski K.M.
, Anton-Culver H.
, Bandera E.V.
, Bowtell D.D.L.
, Cramer D.W.
, DeFazio A.
, Doherty J.A.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022 02; 31(2), p. 443-452.
EPub date: 2021-11-17 00:00:00.0.
PMID: 34789471
Related Citations
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas.
Authors: Heinze K.
, Nazeran T.M.
, Lee S.
, Krämer P.
, Cairns E.S.
, Chiu D.S.
, Leung S.C.
, Kang E.Y.
, Meagher N.S.
, Kennedy C.J.
, et al.
.
Source: The Journal Of Pathology, 2021-12-13 00:00:00.0; , .
EPub date: 2021-12-13 00:00:00.0.
PMID: 34897700
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MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma.
Authors: Kang E.Y.
, Millstein J.
, Popovic G.
, Meagher N.S.
, Bolithon A.
, Talhouk A.
, Chiu D.S.
, Anglesio M.S.
, Leung B.
, Tang K.
, et al.
.
Source: Virchows Archiv : An International Journal Of Pathology, 2021-11-15 00:00:00.0; , .
EPub date: 2021-11-15 00:00:00.0.
PMID: 34782936
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Identification of a Locus Near ULK1 Associated With Progression-Free Survival in Ovarian Cancer.
Authors: Quinn M.C.J.
, McCue K.
, Shi W.
, Johnatty S.E.
, Beesley J.
, Civitarese A.
, O'Mara T.A.
, Glubb D.M.
, Tyrer J.P.
, Armasu S.M.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-06-23 00:00:00.0; , .
EPub date: 2021-06-23 00:00:00.0.
PMID: 34162658
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Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.
Authors: Song H.
, Dicks E.M.
, Tyrer J.
, Intermaggio M.
, Chenevix-Trench G.
, Bowtell D.D.
, Traficante N.
, Group A.
, Brenton J.
, Goranova T.
, et al.
.
Source: Journal Of Medical Genetics, 2021 May; 58(5), p. 305-313.
EPub date: 2020-06-16 00:00:00.0.
PMID: 32546565
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Depot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of Progestins.
Authors: Phung M.T.
, Lee A.W.
, Wu A.H.
, Berchuck A.
, Cho K.R.
, Cramer D.W.
, Doherty J.A.
, Goodman M.T.
, Hanley G.E.
, Harris H.R.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021 05; 30(5), p. 927-935.
EPub date: 2021-02-22 00:00:00.0.
PMID: 33619020
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Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.
Authors: Modugno F.
, Fu Z.
, Jordan S.J.
, Group A.
, Chang-Claude J.
, Fortner R.T.
, Goodman M.T.
, Moysich K.B.
, Schildkraut J.M.
, Berchuck A.
, et al.
.
Source: European Journal Of Epidemiology, 2020-09-21 00:00:00.0; , .
EPub date: 2020-09-21 00:00:00.0.
PMID: 32959149
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Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival.
Authors: Brieger K.K.
, Peterson S.
, Lee A.W.
, Mukherjee B.
, Bakulski K.M.
, Alimujiang A.
, Anton-Culver H.
, Anglesio M.S.
, Bandera E.V.
, Berchuck A.
, et al.
.
Source: Gynecologic Oncology, 2020 Sep; 158(3), p. 702-709.
EPub date: 2020-07-06 00:00:00.0.
PMID: 32641237
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Identification of novel epithelial ovarian cancer loci in women of African ancestry.
Authors: Manichaikul A.
, Peres L.C.
, Wang X.Q.
, Barnard M.E.
, Chyn D.
, Sheng X.
, Du Z.
, Tyrer J.
, Dennis J.
, Schwartz A.G.
, et al.
.
Source: International Journal Of Cancer, 2019-08-30 00:00:00.0; , .
EPub date: 2019-08-30 00:00:00.0.
PMID: 31469419
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Association between Cigarette Smoking and Histotype-Specific Epithelial Ovarian Cancer: A Review of Epidemiologic Studies.
Authors: Zhou A.
, Minlikeeva A.N.
, Khan S.
, Moysich K.B.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019 Jul; 28(7), p. 1103-1116.
EPub date: 2019-05-01 00:00:00.0.
PMID: 31043418
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An aspirin a day keeps ovarian cancer at bay?
Authors: Minlikeeva A.N.
, Moysich K.B.
.
Source: Expert Review Of Anticancer Therapy, 2019 Jul; 19(7), p. 541-542.
EPub date: 2019-06-05 00:00:00.0.
PMID: 31159617
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Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
Authors: Lawrenson K.
, Song F.
, Hazelett D.J.
, Kar S.P.
, Tyrer J.
, Phelan C.M.
, Corona R.I.
, Rodríguez-Malavé N.I.
, Seo J.H.
, Adler E.
, et al.
.
Source: Gynecologic Oncology, 2019 05; 153(2), p. 343-355.
EPub date: 2019-03-19 00:00:00.0.
PMID: 30898391
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Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium.
Authors: Minlikeeva A.N.
, Cannioto R.
, Jensen A.
, Kjaer S.K.
, Jordan S.J.
, Diergaarde B.
, Szender J.B.
, Odunsi K.
, Almohanna H.
, Mayor P.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2019 May; 30(5), p. 537-547.
EPub date: 2019-03-23 00:00:00.0.
PMID: 30905014
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Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.
Authors: Grant D.J.
, Manichaikul A.
, Alberg A.J.
, Bandera E.V.
, Barnholtz-Sloan J.
, Bondy M.
, Cote M.L.
, Funkhouser E.
, Moorman P.G.
, Peres L.C.
, et al.
.
Source: Cancer Medicine, 2019 May; 8(5), p. 2503-2513.
EPub date: 2019-04-18 00:00:00.0.
PMID: 31001917
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Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.
Authors: Buckley M.A.
, Woods N.T.
, Tyrer J.P.
, Mendoza-Fandiño G.
, Lawrenson K.
, Hazelett D.J.
, Najafabadi H.S.
, Gjyshi A.
, Carvalho R.S.
, Lyra P.C.
, et al.
.
Source: Cancer Research, 2019-02-01 00:00:00.0; 79(3), p. 467-481.
EPub date: 2018-11-28 00:00:00.0.
PMID: 30487138
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Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.
Authors: Yang Y.
, Wu L.
, Shu X.
, Lu Y.
, Shu X.O.
, Cai Q.
, Beeghly-Fadiel A.
, Li B.
, Ye F.
, Berchuck A.
, et al.
.
Source: Cancer Research, 2019-02-01 00:00:00.0; 79(3), p. 505-517.
EPub date: 2018-12-17 00:00:00.0.
PMID: 30559148
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Shared heritability and functional enrichment across six solid cancers.
Authors: Jiang X.
, Finucane H.K.
, Schumacher F.R.
, Schmit S.L.
, Tyrer J.P.
, Han Y.
, Michailidou K.
, Lesseur C.
, Kuchenbaecker K.B.
, Dennis J.
, et al.
.
Source: Nature Communications, 2019-01-25 00:00:00.0; 10(1), p. 431.
EPub date: 2019-01-25 00:00:00.0.
PMID: 30683880
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Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.
Authors: Rambau P.F.
, Vierkant R.A.
, Intermaggio M.P.
, Kelemen L.E.
, Goodman M.T.
, Herpel E.
, Pharoah P.D.
, Kommoss S.
, Jimenez-Linan M.
, Karlan B.Y.
, et al.
.
Source: The Journal Of Pathology. Clinical Research, 2018-07-30 00:00:00.0; , .
EPub date: 2018-07-30 00:00:00.0.
PMID: 30062862
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A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk.
Authors: Lu Y.
, Beeghly-Fadiel A.
, Wu L.
, Guo X.
, Li B.
, Schildkraut J.M.
, Im H.K.
, Chen Y.A.
, Permuth J.B.
, Reid B.M.
, et al.
.
Source: Cancer Research, 2018-07-27 00:00:00.0; , .
EPub date: 2018-07-27 00:00:00.0.
PMID: 30054336
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Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.
Authors: Ong J.S.
, Hwang L.D.
, Cuellar-Partida G.
, Martin N.G.
, Chenevix-Trench G.
, Quinn M.C.J.
, Cornelis M.C.
, Gharahkhani P.
, Webb P.M.
, MacGregor S.
, et al.
.
Source: International Journal Of Epidemiology, 2018-04-01 00:00:00.0; 47(2), p. 450-459.
PMID: 29186515
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Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.
Authors: Liu G.
, Mukherjee B.
, Lee S.
, Lee A.W.
, Wu A.H.
, Bandera E.V.
, Jensen A.
, Rossing M.A.
, Moysich K.B.
, Chang-Claude J.
, et al.
.
Source: American Journal Of Epidemiology, 2018-02-01 00:00:00.0; 187(2), p. 366-377.
PMID: 28633381
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Anthropometric characteristics and ovarian cancer risk and survival.
Authors: Minlikeeva A.N.
, Moysich K.B.
, Mayor P.C.
, Etter J.L.
, Cannioto R.A.
, Ness R.B.
, Starbuck K.
, Edwards R.P.
, Segal B.H.
, Lele S.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2018 Feb; 29(2), p. 201-212.
EPub date: 2018-01-11 00:00:00.0.
PMID: 29327114
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Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Authors: Earp M.
, Tyrer J.P.
, Winham S.J.
, Lin H.Y.
, Chornokur G.
, Dennis J.
, Aben K.K.H.
, Anton-Culver H.
, Antonenkova N.
, Bandera E.V.
, et al.
.
Source: Plos One, 2018; 13(7), p. e0197561.
EPub date: 2018-07-06 00:00:00.0.
PMID: 29979793
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History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
Authors: Minlikeeva A.N.
, Freudenheim J.L.
, Cannioto R.A.
, Eng K.H.
, Szender J.B.
, Mayor P.
, Etter J.L.
, Cramer D.W.
, Diergaarde B.
, Doherty J.A.
, et al.
.
Source: British Journal Of Cancer, 2017-09-26 00:00:00.0; 117(7), p. 1063-1069.
EPub date: 2017-08-17 00:00:00.0.
PMID: 28817835
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Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.
Authors: Glubb D.M.
, Johnatty S.E.
, Quinn M.C.J.
, O'Mara T.A.
, Tyrer J.P.
, Gao B.
, Fasching P.A.
, Beckmann M.W.
, Lambrechts D.
, Vergote I.
, et al.
.
Source: Oncotarget, 2017-09-12 00:00:00.0; 8(39), p. 64670-64684.
EPub date: 2017-06-15 00:00:00.0.
PMID: 29029385
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History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium.
Authors: Minlikeeva A.N.
, Freudenheim J.L.
, Eng K.H.
, Cannioto R.A.
, Friel G.
, Szender J.B.
, Segal B.
, Odunsi K.
, Mayor P.
, Diergaarde B.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 09; 26(9), p. 1470-1473.
PMID: 28864456
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History Of Hypertension, Heart Disease, And Diabetes And Ovarian Cancer Patient Survival: Evidence From The Ovarian Cancer Association Consortium
Authors: Minlikeeva A.N.
, Freudenheim J.L.
, Cannioto R.A.
, Szender J.B.
, Eng K.H.
, Modugno F.
, Ness R.B.
, LaMonte M.J.
, Friel G.
, Segal B.H.
, et al.
.
Source: Cancer Causes & Control : Ccc, 2017 May; 28(5), p. 469-486.
PMID: 28293802
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Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.
Authors: Dixon S.C.
, Nagle C.M.
, Wentzensen N.
, Trabert B.
, Beeghly-Fadiel A.
, Schildkraut J.M.
, Moysich K.B.
, deFazio A.
, Australian Ovarian Cancer Study Group
, Risch H.A.
, et al.
.
Source: British Journal Of Cancer, 2017-04-25 00:00:00.0; 116(9), p. 1223-1228.
EPub date: 2017-03-28 00:00:00.0.
PMID: 28350790
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No Evidence That Genetic Variation In The Myeloid-derived Suppressor Cell Pathway Influences Ovarian Cancer Survival
Authors: Sucheston-Campbell L.E.
, Cannioto R.
, Clay A.I.
, Etter J.L.
, Eng K.H.
, Liu S.
, Battaglia S.
, Hu Q.
, Szender J.B.
, Minlikeeva A.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 Mar; 26(3), p. 420-424.
PMID: 27677730
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Enrichment Of Putative Pax8 Target Genes At Serous Epithelial Ovarian Cancer Susceptibility Loci
Authors: Kar S.P.
, Adler E.
, Tyrer J.
, Hazelett D.
, Anton-Culver H.
, Bandera E.V.
, Beckmann M.W.
, Berchuck A.
, Bogdanova N.
, Brinton L.
, et al.
.
Source: British Journal Of Cancer, 2017-02-14 00:00:00.0; 116(4), p. 524-535.
PMID: 28103614
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The Association Of Peripheral Blood Regulatory T-cell Concentrations With Epithelial Ovarian Cancer: A Brief Report
Authors: Cannioto R.A.
, Sucheston-Campbell L.E.
, Hampras S.
, Goode E.L.
, Knutson K.
, Ness R.
, Modugno F.
, Wallace P.K.
, Szender J.B.
, Mayor P.
, et al.
.
Source: International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society, 2017 Jan; 27(1), p. 11-16.
PMID: 27759594
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A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.
Authors: Lee A.W.
, Bomkamp A.
, Bandera E.V.
, Jensen A.
, Ramus S.J.
, Goodman M.T.
, Rossing M.A.
, Modugno F.
, Moysich K.B.
, Chang-Claude J.
, et al.
.
Source: International Journal Of Cancer, 2016-12-15 00:00:00.0; 139(12), p. 2646-2654.
EPub date: 2016-09-16 00:00:00.0.
PMID: 27420401
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Inherited Variants Affecting Rna Editing May Contribute To Ovarian Cancer Susceptibility: Results From A Large-scale Collaboration
Authors: Permuth J.B.
, Reid B.
, Earp M.
, Chen Y.A.
, Monteiro A.N.
, Chen Z.
, AOCS Study Group
, Chenevix-Trench G.
, Fasching P.A.
, Beckmann M.W.
, et al.
.
Source: Oncotarget, 2016-11-08 00:00:00.0; 7(45), p. 72381-72394.
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