Skip to main content
An official website of the United States government
Grant Details

Grant Number: 5R01CA126841-05 Interpret this number
Primary Investigator: Moysich, Kirsten
Organization: Roswell Park Cancer Institute Corp
Project Title: Regulatory T Cell Function in Ovarian Cancer
Fiscal Year: 2013


Abstract

Abstract Etiologic and prognostic factors in ovarian cancer remain poorly understood, although emerging evidence suggests that factors related to immune response play important roles in the development and clinical treatment of this disease. Recent evidence has revealed that a subset of T cells with immunosuppressive properties, referred to as regulatory T cells (Treg), are essential for the development and maintenance of self-tolerance. There is a very consistent body of literature that points to an important role of these Treg cells in human health. These studies have shown that lower peripheral Treg cells expression is associated with autoimmune disease, allergy, and adverse transplantation outcomes, indicating that insufficient Treg cell stimulated immune suppression might lead to the development of these auto reactive health conditions. On the other hand, elevated Treg cell expression has been consistently reported in patients with a wide variety of malignancies, suggesting that Treg cell-mediated suppression might interfere with an adequate immune response to tumor associated antigens. Our group and others also provided direct evidence linking elevated Treg cell expression to greater risk of ovarian cancer and poorer prognosis. Thus, the role of Treg cells in cancer etiology and prognosis is an area of emerging interest, as high Treg activity might a) prevent an adequate immune response at the time of cancer initiation and progression, b) prevent an adequate immune response after initial treatment of the tumor; and c) result in lower responsiveness to tumor immunotherapy. To date, we are unaware of any comprehensive epidemiological study that has focused on the role Treg cells in human cancer in general or ovarian carcinogenesis in particular. Thus, we propose to evaluate the role of Treg cell burden as well as a panel of candidate genetic polymorphisms, directly relevant to Treg cell activity, in the etiology and prognosis of ovarian cancer. We hypothesize in Aim 1 that women with ovarian cancer will have higher blood Treg cell levels than healthy controls. We also expect in Aim 2 that women with a genetically determined high activity Treg cell profile will be less effective in mounting an immune response toward tumor cells in the initiation and progression phase of ovarian carcinogenesis. We further hypothesize in Aim 3 that ovarian cancer patients with a genetically determined high activity Treg cell profile will be less effective in battling residual disease. We also seek to determine in Aim 4 if genetic variability in Treg cell function can predict Treg cell expression in ovarian tumors. We propose to utilize data and specimens from core resources at our institute and from a population-based case-control study of ovarian cancer. For Aim 1, we will newly recruit 100 ovarian cancer patients and 100 controls via our institute's Biorepository to collect fresh blood samples required for Treg cell measurements. In the case-control study we recently recruited over 900 ovarian cancer patients and 1800 community controls (Specific Aim 2) from the Buffalo, NY, Pittsburgh PA, and Cleveland, OH areas. We propose to follow-up the ovarian cancer patient group and assess relevant clinical outcomes (recurrence, survival; Specific Aim 3). We will also select 630 patients with advanced stage disease with available blood and tumor samples from our institute's Ovarian Cancer Specimen Bank (Specific Aim 4). For the laboratory analyses, we will utilize Illumina Golden Gate assays and flow-cytometry techniques for the genotype and Treg cell assessment, respectively. Our statistical and genetic analyses will be carried out by a trained genetic epidemiologist.



Publications

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk.
Authors: Barnes D.R. , Tyrer J.P. , Dennis J. , Leslie G. , Bolla M.K. , Lush M. , Aeilts A.M. , Aittomäki K. , Andrieu N. , Andrulis I.L. , et al. .
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-03-04 00:00:00.0; , .
EPub date: 2024-03-04 00:00:00.0.
PMID: 38496424
Related Citations

A framework for assessing interactions for risk stratification models: the example of ovarian cancer.
Authors: Phung M.T. , Lee A.W. , McLean K. , Anton-Culver H. , Bandera E.V. , Carney M.E. , Chang-Claude J. , Cramer D.W. , Doherty J.A. , Fortner R.T. , et al. .
Source: Journal Of The National Cancer Institute, 2023-11-08 00:00:00.0; 115(11), p. 1420-1426.
PMID: 37436712
Related Citations

Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case-Control Study from the Ovarian Cancer Association Consortium.
Authors: Gersekowski K. , Ibiebele T.I. , Australian Ovarian Cancer Study Group , Doherty J.A. , Harris H.R. , Goodman M.T. , Terry K.L. , Wu A.H. , Bandera E.V. , Qin B. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-08-01 00:00:00.0; 32(8), p. 1087-1096.
PMID: 37220873
Related Citations

Clinical parameters affecting survival outcomes in patients with low-grade serous ovarian carcinoma: an international multicentre analysis.
Authors: May T. , Bernardini M. , Lheureux S. , Aben K.K.H. , Bandera E.V. , Beckmann M.W. , Benitez J. , Berchuck A. , Bjørge L. , Carney M.E. , et al. .
Source: Canadian Journal Of Surgery. Journal Canadien De Chirurgie, 2023 May-Jun; 66(3), p. E310-E320.
EPub date: 2023-06-27 00:00:00.0.
PMID: 37369443
Related Citations

Lifestyle and personal factors associated with having macroscopic residual disease after ovarian cancer primary cytoreductive surgery.
Authors: Phung M.T. , Webb P.M. , DeFazio A. , Fereday S. , Lee A.W. , Bowtell D.D.L. , Fasching P.A. , Goode E.L. , Goodman M.T. , Karlan B.Y. , et al. .
Source: Gynecologic Oncology, 2023 Jan; 168, p. 68-75.
EPub date: 2022-11-17 00:00:00.0.
PMID: 36401943
Related Citations

Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.
Authors: DeVries A.A. , Dennis J. , Tyrer J.P. , Peng P.C. , Coetzee S.G. , Reyes A.L. , Plummer J.T. , Davis B.D. , Chen S.S. , Dezem F.S. , et al. .
Source: Journal Of The National Cancer Institute, 2022-11-14 00:00:00.0; 114(11), p. 1533-1544.
PMID: 36210504
Related Citations

Effects of risk factors for ovarian cancer in women with and without endometriosis.
Authors: Phung M.T. , Muthukumar A. , Trabert B. , Webb P.M. , Jordan S.J. , Terry K.L. , Cramer D.W. , Titus L.J. , Risch H.A. , Doherty J.A. , et al. .
Source: Fertility And Sterility, 2022 Nov; 118(5), p. 960-969.
EPub date: 2022-09-29 00:00:00.0.
PMID: 36182623
Related Citations

Reproductive Factors Do Not Influence Survival with Ovarian Cancer.
Authors: Phung M.T. , Alimujiang A. , Berchuck A. , Anton-Culver H. , Schildkraut J.M. , Bandera E.V. , Chang-Claude J. , Chase A. , Doherty J.A. , Grout B. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-04-01 00:00:00.0; 31(4), p. 909-913.
PMID: 35064059
Related Citations

High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival.
Authors: Brieger K.K. , Phung M.T. , Mukherjee B. , Bakulski K.M. , Anton-Culver H. , Bandera E.V. , Bowtell D.D.L. , Cramer D.W. , DeFazio A. , Doherty J.A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022 02; 31(2), p. 443-452.
EPub date: 2021-11-17 00:00:00.0.
PMID: 34789471
Related Citations

Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas.
Authors: Heinze K. , Nazeran T.M. , Lee S. , Krämer P. , Cairns E.S. , Chiu D.S. , Leung S.C. , Kang E.Y. , Meagher N.S. , Kennedy C.J. , et al. .
Source: The Journal Of Pathology, 2021-12-13 00:00:00.0; , .
EPub date: 2021-12-13 00:00:00.0.
PMID: 34897700
Related Citations

MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma.
Authors: Kang E.Y. , Millstein J. , Popovic G. , Meagher N.S. , Bolithon A. , Talhouk A. , Chiu D.S. , Anglesio M.S. , Leung B. , Tang K. , et al. .
Source: Virchows Archiv : An International Journal Of Pathology, 2021-11-15 00:00:00.0; , .
EPub date: 2021-11-15 00:00:00.0.
PMID: 34782936
Related Citations

Identification of a Locus Near ULK1 Associated With Progression-Free Survival in Ovarian Cancer.
Authors: Quinn M.C.J. , McCue K. , Shi W. , Johnatty S.E. , Beesley J. , Civitarese A. , O'Mara T.A. , Glubb D.M. , Tyrer J.P. , Armasu S.M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-06-23 00:00:00.0; , .
EPub date: 2021-06-23 00:00:00.0.
PMID: 34162658
Related Citations

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.
Authors: Song H. , Dicks E.M. , Tyrer J. , Intermaggio M. , Chenevix-Trench G. , Bowtell D.D. , Traficante N. , Group A. , Brenton J. , Goranova T. , et al. .
Source: Journal Of Medical Genetics, 2021 May; 58(5), p. 305-313.
EPub date: 2020-06-16 00:00:00.0.
PMID: 32546565
Related Citations

Depot-Medroxyprogesterone Acetate Use Is Associated with Decreased Risk of Ovarian Cancer: The Mounting Evidence of a Protective Role of Progestins.
Authors: Phung M.T. , Lee A.W. , Wu A.H. , Berchuck A. , Cho K.R. , Cramer D.W. , Doherty J.A. , Goodman M.T. , Hanley G.E. , Harris H.R. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021 05; 30(5), p. 927-935.
EPub date: 2021-02-22 00:00:00.0.
PMID: 33619020
Related Citations

Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.
Authors: Modugno F. , Fu Z. , Jordan S.J. , Group A. , Chang-Claude J. , Fortner R.T. , Goodman M.T. , Moysich K.B. , Schildkraut J.M. , Berchuck A. , et al. .
Source: European Journal Of Epidemiology, 2020-09-21 00:00:00.0; , .
EPub date: 2020-09-21 00:00:00.0.
PMID: 32959149
Related Citations

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival.
Authors: Brieger K.K. , Peterson S. , Lee A.W. , Mukherjee B. , Bakulski K.M. , Alimujiang A. , Anton-Culver H. , Anglesio M.S. , Bandera E.V. , Berchuck A. , et al. .
Source: Gynecologic Oncology, 2020 Sep; 158(3), p. 702-709.
EPub date: 2020-07-06 00:00:00.0.
PMID: 32641237
Related Citations

Identification of novel epithelial ovarian cancer loci in women of African ancestry.
Authors: Manichaikul A. , Peres L.C. , Wang X.Q. , Barnard M.E. , Chyn D. , Sheng X. , Du Z. , Tyrer J. , Dennis J. , Schwartz A.G. , et al. .
Source: International Journal Of Cancer, 2019-08-30 00:00:00.0; , .
EPub date: 2019-08-30 00:00:00.0.
PMID: 31469419
Related Citations

Association between Cigarette Smoking and Histotype-Specific Epithelial Ovarian Cancer: A Review of Epidemiologic Studies.
Authors: Zhou A. , Minlikeeva A.N. , Khan S. , Moysich K.B. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019 Jul; 28(7), p. 1103-1116.
EPub date: 2019-05-01 00:00:00.0.
PMID: 31043418
Related Citations

An aspirin a day keeps ovarian cancer at bay?
Authors: Minlikeeva A.N. , Moysich K.B. .
Source: Expert Review Of Anticancer Therapy, 2019 Jul; 19(7), p. 541-542.
EPub date: 2019-06-05 00:00:00.0.
PMID: 31159617
Related Citations

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.
Authors: Lawrenson K. , Song F. , Hazelett D.J. , Kar S.P. , Tyrer J. , Phelan C.M. , Corona R.I. , Rodríguez-Malavé N.I. , Seo J.H. , Adler E. , et al. .
Source: Gynecologic Oncology, 2019 05; 153(2), p. 343-355.
EPub date: 2019-03-19 00:00:00.0.
PMID: 30898391
Related Citations

Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium.
Authors: Minlikeeva A.N. , Cannioto R. , Jensen A. , Kjaer S.K. , Jordan S.J. , Diergaarde B. , Szender J.B. , Odunsi K. , Almohanna H. , Mayor P. , et al. .
Source: Cancer Causes & Control : Ccc, 2019 May; 30(5), p. 537-547.
EPub date: 2019-03-23 00:00:00.0.
PMID: 30905014
Related Citations

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.
Authors: Grant D.J. , Manichaikul A. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M. , Cote M.L. , Funkhouser E. , Moorman P.G. , Peres L.C. , et al. .
Source: Cancer Medicine, 2019 May; 8(5), p. 2503-2513.
EPub date: 2019-04-18 00:00:00.0.
PMID: 31001917
Related Citations

Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.
Authors: Buckley M.A. , Woods N.T. , Tyrer J.P. , Mendoza-Fandiño G. , Lawrenson K. , Hazelett D.J. , Najafabadi H.S. , Gjyshi A. , Carvalho R.S. , Lyra P.C. , et al. .
Source: Cancer Research, 2019-02-01 00:00:00.0; 79(3), p. 467-481.
EPub date: 2018-11-28 00:00:00.0.
PMID: 30487138
Related Citations

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.
Authors: Yang Y. , Wu L. , Shu X. , Lu Y. , Shu X.O. , Cai Q. , Beeghly-Fadiel A. , Li B. , Ye F. , Berchuck A. , et al. .
Source: Cancer Research, 2019-02-01 00:00:00.0; 79(3), p. 505-517.
EPub date: 2018-12-17 00:00:00.0.
PMID: 30559148
Related Citations

Shared heritability and functional enrichment across six solid cancers.
Authors: Jiang X. , Finucane H.K. , Schumacher F.R. , Schmit S.L. , Tyrer J.P. , Han Y. , Michailidou K. , Lesseur C. , Kuchenbaecker K.B. , Dennis J. , et al. .
Source: Nature Communications, 2019-01-25 00:00:00.0; 10(1), p. 431.
EPub date: 2019-01-25 00:00:00.0.
PMID: 30683880
Related Citations

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.
Authors: Rambau P.F. , Vierkant R.A. , Intermaggio M.P. , Kelemen L.E. , Goodman M.T. , Herpel E. , Pharoah P.D. , Kommoss S. , Jimenez-Linan M. , Karlan B.Y. , et al. .
Source: The Journal Of Pathology. Clinical Research, 2018-07-30 00:00:00.0; , .
EPub date: 2018-07-30 00:00:00.0.
PMID: 30062862
Related Citations

A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk.
Authors: Lu Y. , Beeghly-Fadiel A. , Wu L. , Guo X. , Li B. , Schildkraut J.M. , Im H.K. , Chen Y.A. , Permuth J.B. , Reid B.M. , et al. .
Source: Cancer Research, 2018-07-27 00:00:00.0; , .
EPub date: 2018-07-27 00:00:00.0.
PMID: 30054336
Related Citations

Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.
Authors: Ong J.S. , Hwang L.D. , Cuellar-Partida G. , Martin N.G. , Chenevix-Trench G. , Quinn M.C.J. , Cornelis M.C. , Gharahkhani P. , Webb P.M. , MacGregor S. , et al. .
Source: International Journal Of Epidemiology, 2018-04-01 00:00:00.0; 47(2), p. 450-459.
PMID: 29186515
Related Citations

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.
Authors: Liu G. , Mukherjee B. , Lee S. , Lee A.W. , Wu A.H. , Bandera E.V. , Jensen A. , Rossing M.A. , Moysich K.B. , Chang-Claude J. , et al. .
Source: American Journal Of Epidemiology, 2018-02-01 00:00:00.0; 187(2), p. 366-377.
PMID: 28633381
Related Citations

Anthropometric characteristics and ovarian cancer risk and survival.
Authors: Minlikeeva A.N. , Moysich K.B. , Mayor P.C. , Etter J.L. , Cannioto R.A. , Ness R.B. , Starbuck K. , Edwards R.P. , Segal B.H. , Lele S. , et al. .
Source: Cancer Causes & Control : Ccc, 2018 Feb; 29(2), p. 201-212.
EPub date: 2018-01-11 00:00:00.0.
PMID: 29327114
Related Citations

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Authors: Earp M. , Tyrer J.P. , Winham S.J. , Lin H.Y. , Chornokur G. , Dennis J. , Aben K.K.H. , Anton-Culver H. , Antonenkova N. , Bandera E.V. , et al. .
Source: Plos One, 2018; 13(7), p. e0197561.
EPub date: 2018-07-06 00:00:00.0.
PMID: 29979793
Related Citations

History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
Authors: Minlikeeva A.N. , Freudenheim J.L. , Cannioto R.A. , Eng K.H. , Szender J.B. , Mayor P. , Etter J.L. , Cramer D.W. , Diergaarde B. , Doherty J.A. , et al. .
Source: British Journal Of Cancer, 2017-09-26 00:00:00.0; 117(7), p. 1063-1069.
EPub date: 2017-08-17 00:00:00.0.
PMID: 28817835
Related Citations

Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.
Authors: Glubb D.M. , Johnatty S.E. , Quinn M.C.J. , O'Mara T.A. , Tyrer J.P. , Gao B. , Fasching P.A. , Beckmann M.W. , Lambrechts D. , Vergote I. , et al. .
Source: Oncotarget, 2017-09-12 00:00:00.0; 8(39), p. 64670-64684.
EPub date: 2017-06-15 00:00:00.0.
PMID: 29029385
Related Citations

History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium.
Authors: Minlikeeva A.N. , Freudenheim J.L. , Eng K.H. , Cannioto R.A. , Friel G. , Szender J.B. , Segal B. , Odunsi K. , Mayor P. , Diergaarde B. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 09; 26(9), p. 1470-1473.
PMID: 28864456
Related Citations

History Of Hypertension, Heart Disease, And Diabetes And Ovarian Cancer Patient Survival: Evidence From The Ovarian Cancer Association Consortium
Authors: Minlikeeva A.N. , Freudenheim J.L. , Cannioto R.A. , Szender J.B. , Eng K.H. , Modugno F. , Ness R.B. , LaMonte M.J. , Friel G. , Segal B.H. , et al. .
Source: Cancer Causes & Control : Ccc, 2017 May; 28(5), p. 469-486.
PMID: 28293802
Related Citations

Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.
Authors: Dixon S.C. , Nagle C.M. , Wentzensen N. , Trabert B. , Beeghly-Fadiel A. , Schildkraut J.M. , Moysich K.B. , deFazio A. , Australian Ovarian Cancer Study Group , Risch H.A. , et al. .
Source: British Journal Of Cancer, 2017-04-25 00:00:00.0; 116(9), p. 1223-1228.
EPub date: 2017-03-28 00:00:00.0.
PMID: 28350790
Related Citations

No Evidence That Genetic Variation In The Myeloid-derived Suppressor Cell Pathway Influences Ovarian Cancer Survival
Authors: Sucheston-Campbell L.E. , Cannioto R. , Clay A.I. , Etter J.L. , Eng K.H. , Liu S. , Battaglia S. , Hu Q. , Szender J.B. , Minlikeeva A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017 Mar; 26(3), p. 420-424.
PMID: 27677730
Related Citations

Enrichment Of Putative Pax8 Target Genes At Serous Epithelial Ovarian Cancer Susceptibility Loci
Authors: Kar S.P. , Adler E. , Tyrer J. , Hazelett D. , Anton-Culver H. , Bandera E.V. , Beckmann M.W. , Berchuck A. , Bogdanova N. , Brinton L. , et al. .
Source: British Journal Of Cancer, 2017-02-14 00:00:00.0; 116(4), p. 524-535.
PMID: 28103614
Related Citations

The Association Of Peripheral Blood Regulatory T-cell Concentrations With Epithelial Ovarian Cancer: A Brief Report
Authors: Cannioto R.A. , Sucheston-Campbell L.E. , Hampras S. , Goode E.L. , Knutson K. , Ness R. , Modugno F. , Wallace P.K. , Szender J.B. , Mayor P. , et al. .
Source: International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society, 2017 Jan; 27(1), p. 11-16.
PMID: 27759594
Related Citations

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.
Authors: Lee A.W. , Bomkamp A. , Bandera E.V. , Jensen A. , Ramus S.J. , Goodman M.T. , Rossing M.A. , Modugno F. , Moysich K.B. , Chang-Claude J. , et al. .
Source: International Journal Of Cancer, 2016-12-15 00:00:00.0; 139(12), p. 2646-2654.
EPub date: 2016-09-16 00:00:00.0.
PMID: 27420401
Related Citations

Inherited Variants Affecting Rna Editing May Contribute To Ovarian Cancer Susceptibility: Results From A Large-scale Collaboration
Authors: Permuth J.B. , Reid B. , Earp M. , Chen Y.A. , Monteiro A.N. , Chen Z. , AOCS Study Group , Chenevix-Trench G. , Fasching P.A. , Beckmann M.W. , et al. .
Source: Oncotarget, 2016-11-08 00:00:00.0; 7(45), p. 72381-72394.
PMID: 27911851
Related Citations

Assessment Of Variation In Immunosuppressive Pathway Genes Reveals Tgfbr2 To Be Associated With Risk Of Clear Cell Ovarian Cancer
Authors: Hampras S.S. , Sucheston-Campbell L.E. , Cannioto R. , Chang-Claude J. , Modugno F. , Dörk T. , Hillemanns P. , Preus L. , Knutson K.L. , Wallace P.K. , et al. .
Source: Oncotarget, 2016-10-25 00:00:00.0; 7(43), p. 69097-69110.
PMID: 27533245
Related Citations

Risk Prediction For Epithelial Ovarian Cancer In 11 United States-based Case-control Studies: Incorporation Of Epidemiologic Risk Factors And 17 Confirmed Genetic Loci
Authors: Clyde M.A. , Palmieri Weber R. , Iversen E.S. , Poole E.M. , Doherty J.A. , Goodman M.T. , Ness R.B. , Risch H.A. , Rossing M.A. , Terry K.L. , et al. .
Source: American Journal Of Epidemiology, 2016-10-15 00:00:00.0; 184(8), p. 579-589.
PMID: 27698005
Related Citations

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.
Authors: Ong J.S. , Cuellar-Partida G. , Lu Y. , Australian Ovarian Cancer Study , Fasching P.A. , Hein A. , Burghaus S. , Beckmann M.W. , Lambrechts D. , Van Nieuwenhuysen E. , et al. .
Source: International Journal Of Epidemiology, 2016 10; 45(5), p. 1619-1630.
EPub date: 2016-09-04 00:00:00.0.
PMID: 27594614
Related Citations

Functional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p13.1 Breast-ovarian Cancer Susceptibility Locus
Authors: Lawrenson K. , Kar S. , McCue K. , Kuchenbaeker K. , Michailidou K. , Tyrer J. , Beesley J. , Ramus S.J. , Li Q. , Delgado M.K. , et al. .
Source: Nature Communications, 2016-09-07 00:00:00.0; 7, p. 12675.
PMID: 27601076
Related Citations

Exome Genotyping Arrays To Identify Rare And Low Frequency Variants Associated With Epithelial Ovarian Cancer Risk
Authors: Permuth J.B. , Pirie A. , Ann Chen Y. , Lin H.Y. , Reid B.M. , Chen Z. , Monteiro A. , Dennis J. , Mendoza-Fandino G. , AOCS Study Group , et al. .
Source: Human Molecular Genetics, 2016-07-04 00:00:00.0; , .
PMID: 27378695
Related Citations

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.
Authors: Cuellar-Partida G. , Lu Y. , Dixon S.C. , Australian Ovarian Cancer Study , Fasching P.A. , Hein A. , Burghaus S. , Beckmann M.W. , Lambrechts D. , Van Nieuwenhuysen E. , et al. .
Source: Human Genetics, 2016 Jul; 135(7), p. 741-56.
PMID: 27075448
Related Citations

Recreational Physical Inactivity And Mortality In Women With Invasive Epithelial Ovarian Cancer: Evidence From The Ovarian Cancer Association Consortium
Authors: Cannioto R.A. , LaMonte M.J. , Kelemen L.E. , Risch H.A. , Eng K.H. , Minlikeeva A.N. , Hong C.C. , Szender J.B. , Sucheston-Campbell L. , Joseph J.M. , et al. .
Source: British Journal Of Cancer, 2016-06-28 00:00:00.0; 115(1), p. 95-101.
PMID: 27299959
Related Citations

No Clinical Utility Of Kras Variant Rs61764370 For Ovarian Or Breast Cancer
Authors: Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2 , Hollestelle A. , van der Baan F.H. , Berchuck A. , Johnatty S.E. , Aben K.K. , Agnarsson B.A. , Aittomäki K. , Alducci E. , Andrulis I.L. , et al. .
Source: Gynecologic Oncology, 2016 May; 141(2), p. 386-401.
PMID: 25940428
Related Citations

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk.
Authors: Lee A.W. , Ness R.B. , Roman L.D. , Terry K.L. , Schildkraut J.M. , Chang-Claude J. , Doherty J.A. , Menon U. , Cramer D.W. , Gayther S.A. , et al. .
Source: Obstetrics And Gynecology, 2016 May; 127(5), p. 828-36.
PMID: 27054934
Related Citations



Back to Top