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Grant Details

Grant Number: 5U01CA136859-06 Interpret this number
Primary Investigator: Rogers, Laura
Organization: University Of Alabama At Birmingham
Project Title: Enhancing Physical Activity After Breast Cancer Diagnosis: Randomized Trial
Fiscal Year: 2014


Abstract

DESCRIPTION (provided by applicant): Most breast cancer survivors do not engage in regular physical activity (PA). Our piloted PA behavior change intervention for breast cancer survivors significantly improved PA and health outcomes post-intervention. Testing in additional sites with longer follow-up is warranted to confirm program effectiveness short and longer term. Importantly, the pilot intervention resulted in changes in PA and social cognitive theory constructs, enhancing our potential for testing mechanisms mediating PA behavior change. Therefore, we propose a multi- center, randomized controlled trial enrolling 256 breast cancer survivors with the following study aims: Primary study aim: To examine intervention effectiveness, the primary study aim is to compare the effects of the BEAT Cancer PA behavior change intervention to usual care on short and longer term PA adherence among breast cancer survivors. We hypothesize that, compared with usual care, the intervention will result in a significant increase in PA adherence post-intervention that will be maintained 3 and 9 months post- intervention. Secondary study aim #1: To better understand the mechanisms of PA behavior change, secondary study aim #1 is to compare the effects of the BEAT Cancer PA behavior change intervention to usual care on social cognitive factors and examine if such changes mediate PA behavior change. We hypothesize that, compared with usual care, the intervention will result in significant improvements in social cognitive factors targeted by the intervention. We also hypothesize that social cognitive factors will mediate the intervention effect on PA with selected factors mediating the intervention effect on self-efficacy and the effect of self-efficacy on PA. Secondary study aim #2: Although the primary focus of this proposal is to achieve and understand PA behavior change, we also aim to compare the short and longer term health effects of the BEAT Cancer PA behavior change intervention when compared with usual care. We hypothesize that, compared with usual care, the intervention will result in significant improvements in fitness, muscle strength, waist-to-hip ratio, quality of life, fatigue, sleep quality, and joint dysfunction. Outcome measures obtained at baseline, 3 months (i.e., immediately post-intervention), 6 months, and 12 months will include accelerometer (PA and sleep), survey (social cognitive factors, quality of life, fatigue, perceived sleep, and joint dysfunction), submaximal treadmill test (fitness), dynamometer (muscle strength), and waist-to-hip ratio. The study aims will be analyzed with mixed-model analysis of variance (ANOVA) with the secondary study aim #1 also utilizing multivariate analysis of variance (MANOVA) and Freedman- Schatzkin difference-in-coefficients test of mediation. Identifying the effects and underlying mechanisms of PA behavior change interventions will facilitate translation to community settings for improving the health and well- being of breast cancer survivors.



Publications

Inverse association between changes in energetic cost of walking and vertical accelerations in non-metastatic breast cancer survivors.
Authors: Carter S.J. , Rogers L.Q. , Bowles H.R. , Norian L.A. , Hunter G.R. .
Source: European journal of applied physiology, 2019 Dec; 119(11-12), p. 2457-2464.
EPub date: 2019-09-13.
PMID: 31520215
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Gut microbiota diversity is associated with cardiorespiratory fitness in post-primary treatment breast cancer survivors.
Authors: Carter S.J. , Hunter G.R. , Blackston J.W. , Liu N. , Lefkowitz E.J. , Van Der Pol W.J. , Morrow C.D. , Paulsen J.A. , Rogers L.Q. .
Source: Experimental physiology, 2019 04; 104(4), p. 529-539.
EPub date: 2019-02-27.
PMID: 30763983
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Acceptability of a Mobile Phone App for Measuring Time Use in Breast Cancer Survivors (Life in a Day): Mixed-Methods Study.
Authors: Ainsworth M.C. , Pekmezi D. , Bowles H. , Ehlers D. , McAuley E. , Courneya K.S. , Rogers L.Q. .
Source: JMIR cancer, 2018-05-14; 4(1), p. e9.
EPub date: 2018-05-14.
PMID: 29759953
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Ease of walking associates with greater free-living physical activity and reduced depressive symptomology in breast cancer survivors: pilot randomized trial.
Authors: Carter S.J. , Hunter G.R. , Norian L.A. , Turan B. , Rogers L.Q. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018 May; 26(5), p. 1675-1683.
EPub date: 2017-12-14.
PMID: 29243165
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Effects of BEAT Cancer randomized physical activity trial on subjective memory impairments in breast cancer survivors.
Authors: Ehlers D.K. , Rogers L.Q. , Courneya K.S. , Robbs R.S. , McAuley E. .
Source: Psycho-oncology, 2018 02; 27(2), p. 687-690.
EPub date: 2017-05-11.
PMID: 28414894
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Effects of a multicomponent physical activity behavior change intervention on fatigue, anxiety, and depressive symptomatology in breast cancer survivors: randomized trial.
Authors: Rogers L.Q. , Courneya K.S. , Anton P.M. , Verhulst S. , Vicari S.K. , Robbs R.S. , McAuley E. .
Source: Psycho-oncology, 2017 Nov; 26(11), p. 1901-1906.
EPub date: 2016-09-06.
PMID: 27530961
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Physical Activity and Sleep Quality in Breast Cancer Survivors: A Randomized Trial.
Authors: Rogers L.Q. , Courneya K.S. , Oster R.A. , Anton P.M. , Robbs R.S. , Forero A. , McAuley E. .
Source: Medicine and science in sports and exercise, 2017 Oct; 49(10), p. 2009-2015.
PMID: 28538261
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Gut microbiota composition associated with alterations in cardiorespiratory fitness and psychosocial outcomes among breast cancer survivors.
Authors: Paulsen J.A. , Ptacek T.S. , Carter S.J. , Liu N. , Kumar R. , Hyndman L. , Lefkowitz E.J. , Morrow C.D. , Rogers L.Q. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017 05; 25(5), p. 1563-1570.
EPub date: 2017-01-07.
PMID: 28064384
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Lower rate-pressure product during submaximal walking: a link to fatigue improvement following a physical activity intervention among breast cancer survivors.
Authors: Carter S.J. , Hunter G.R. , McAuley E. , Courneya K.S. , Anton P.M. , Rogers L.Q. .
Source: Journal of cancer survivorship : research and practice, 2016 10; 10(5), p. 927-34.
EPub date: 2016-04-09.
PMID: 27061740
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Effects of a multicomponent physical activity behavior change intervention on breast cancer survivor health status outcomes in a randomized controlled trial.
Authors: Rogers L.Q. , Courneya K.S. , Carter S.J. , Anton P.M. , Verhulst S. , Vicari S.K. , Robbs R.S. , McAuley E. .
Source: Breast cancer research and treatment, 2016 Sep; 159(2), p. 283-91.
EPub date: 2016-08-18.
PMID: 27539586
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Effects of the BEAT Cancer physical activity behavior change intervention on physical activity, aerobic fitness, and quality of life in breast cancer survivors: a multicenter randomized controlled trial.
Authors: Rogers L.Q. , Courneya K.S. , Anton P.M. , Hopkins-Price P. , Verhulst S. , Vicari S.K. , Robbs R.S. , Mocharnuk R. , McAuley E. .
Source: Breast cancer research and treatment, 2015 Jan; 149(1), p. 109-19.
EPub date: 2014-11-23.
PMID: 25417174
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Effects of a physical activity behavior change intervention on inflammation and related health outcomes in breast cancer survivors: pilot randomized trial.
Authors: Rogers L.Q. , Fogleman A. , Trammell R. , Hopkins-Price P. , Vicari S. , Rao K. , Edson B. , Verhulst S. , Courneya K.S. , Hoelzer K. .
Source: Integrative cancer therapies, 2013 Jul; 12(4), p. 323-35.
EPub date: 2012-07-24.
PMID: 22831916
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Diet components associated with perceived fatigue in breast cancer survivors.
Authors: Guest D.D. , Evans E.M. , Rogers L.Q. .
Source: European journal of cancer care, 2013 Jan; 22(1), p. 51-9.
EPub date: 2012-06-05.
PMID: 22672363
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Better exercise adherence after treatment for cancer (BEAT Cancer) study: rationale, design, and methods.
Authors: Rogers L.Q. , McAuley E. , Anton P.M. , Courneya K.S. , Vicari S. , Hopkins-Price P. , Verhulst S. , Mocharnuk R. , Hoelzer K. .
Source: Contemporary clinical trials, 2012 Jan; 33(1), p. 124-37.
EPub date: 2011-09-29.
PMID: 21983625
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Reduced barriers mediated physical activity maintenance among breast cancer survivors.
Authors: Rogers L.Q. , Markwell S. , Hopkins-Price P. , Vicari S. , Courneya K.S. , Hoelzer K. , Verhulst S. .
Source: Journal of sport & exercise psychology, 2011 Apr; 33(2), p. 235-54.
PMID: 21558582
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Physical activity type and intensity among rural breast cancer survivors: patterns and associations with fatigue and depressive symptoms.
Authors: Rogers L.Q. , Markwell S.J. , Courneya K.S. , McAuley E. , Verhulst S. .
Source: Journal of cancer survivorship : research and practice, 2011 Mar; 5(1), p. 54-61.
EPub date: 2010-11-26.
PMID: 21110134
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Lessons learned in the trenches: facilitating exercise adherence among breast cancer survivors in a group setting.
Authors: Rogers L.Q. , Vicari S. , Courneya K.S. .
Source: Cancer nursing, 2010 Nov-Dec; 33(6), p. E10-7.
PMID: 20562618
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Objective monitoring of physical activity after a cancer diagnosis: challenges and opportunities for enhancing cancer control.
Authors: Rogers L.Q. .
Source: Physical therapy reviews : PTR, 2010-06-01; 15(3), p. 224-237.
PMID: 21603254
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