Grant Details
Grant Number: |
5R01CA138556-05 Interpret this number |
Primary Investigator: |
Irwin, Melinda |
Organization: |
Yale University |
Project Title: |
Impact of Exercise on Ovarian Cancer Prognosis |
Fiscal Year: |
2013 |
Abstract
Ovarian cancer results in more deaths than any other cancer of the female reproductive system. However,
improvements in surgical techniques and chemotherapy have led to an increase in the 5-year survival rate
from 37% in 1976 to 45% in 2006. Because of advances in therapeutic modalities, the number of ovarian
cancer survivors for whom primary goals are to maximize disease-free survival and maintain quality of life
(QOL) is growing. As such, survivorship issues are becoming increasingly important. Various studies report
poor QOL in ovarian cancer patients. Research is needed to develop and test interventions to improve QOL in
ovarian cancer survivors. Currently, the American Cancer Society recommends a physically active lifestyle for
cancer survivors to increase disease-free survival from cancer and other chronic diseases, and to improve
quality of life. Studies of a strong benefit of physical activity on improving QOL following other types of cancer
treatment, e.g., breast cancer, are well documented in the literature; yet very few studies of physical activity
and QOL after a diagnosis of ovarian cancer have been published. There are also no published data
examining whether physical activity may improve ovarian cancer survival or surrogate markers of survival.
Although the impact of exercise on ovarian cancer survival is unknown, it may play a role via weight control,
since obesity has been shown in some studies, but not all, to be negatively associated with survival. Results
from observational studies also suggest an inverse association between physical activity and risk of ovarian
cancer. Possible biological explanations for the associations between obesity and low levels of physical
inactivity and ovarian cancer risk and mortality involve the potential role of estrogens, insulin, insulin-like
growth factors (IGFs) C-reactive protein (CRP), leptin, CA-125, prolactin, osteopontin, and macrophage
inhibitory factor. Given the promising results from our randomized trials of exercise interventions in healthy
women and breast cancer survivors, and our QOL interventions in ovarian cancer survivors, a trial examining
the impact of exercise in improving QOL and surrogate markers of prognosis in ovarian cancer survivors is
warranted. We propose to evaluate, in 230 sedentary women diagnosed with Stage I-III ovarian cancer, the
impact of a 6-month, moderate-intensity, aerobic exercise intervention vs. attention control upon QOL and
surrogate markers of prognosis. Women will be randomized to an exercise program or attention control group.
Women randomized to exercise will participate in 150 minutes of aerobic exercise per week (e.g., five 30-min
sessions/wk). We will conduct baseline and 6-month clinic visits to evaluate the effect of exercise on QOL and
surrogate markers. Our study, the largest exercise trial in cancer survivors, could be a "proof of principal" and
will provide critical information in understanding the potential mechanisms through which physical activity may
impact ovarian cancer risk and prognosis.
Publications
Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Authors: Cao A.
, Cartmel B.
, Li F.Y.
, Gottlieb L.T.
, Harrigan M.
, Ligibel J.A.
, Gogoi R.
, Schwartz P.E.
, Esserman D.A.
, Irwin M.L.
, et al.
.
Source: Jama Network Open, 2023-08-01 00:00:00.0; 6(8), p. e2326463.
EPub date: 2023-08-01 00:00:00.0.
PMID: 37526937
Related Citations
Randomized trial of exercise on cancer-related blood biomarkers and survival in women with ovarian cancer.
Authors: Cartmel B.
, Li F.Y.
, Zhou Y.
, Gottlieb L.
, Lu L.
, Mszar R.
, Harrigan M.
, Ligibel J.A.
, Gogoi R.
, Schwartz P.E.
, et al.
.
Source: Cancer Medicine, 2023-06-03 00:00:00.0; , .
EPub date: 2023-06-03 00:00:00.0.
PMID: 37269192
Related Citations
Exercise adherence in a randomized controlled trial of exercise on quality of life in ovarian cancer survivors.
Authors: Cao A.
, Cartmel B.
, Li F.Y.
, Gottlieb L.T.
, Harrigan M.
, Ligibel J.A.
, Gogoi R.
, Schwartz P.E.
, Irwin M.L.
, Ferrucci L.M.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2023 Apr; 17(2), p. 535-543.
EPub date: 2022-12-23 00:00:00.0.
PMID: 36550261
Related Citations
Effect of exercise on body composition among women with ovarian cancer.
Authors: Cao A.
, Cartmel B.
, Li F.Y.
, Gottlieb L.T.
, Harrigan M.
, Ligibel J.A.
, Gogoi R.
, Schwartz P.E.
, Irwin M.L.
, Ferrucci L.M.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2022-04-04 00:00:00.0; , .
EPub date: 2022-04-04 00:00:00.0.
PMID: 35377104
Related Citations
Randomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC).
Authors: Cartmel B.
, Hughes M.
, Ercolano E.A.
, Gottlieb L.
, Li F.
, Zhou Y.
, Harrigan M.
, Ligibel J.A.
, von Gruenigen V.E.
, Gogoi R.
, et al.
.
Source: Gynecologic Oncology, 2021 May; 161(2), p. 587-594.
EPub date: 2021-03-26 00:00:00.0.
PMID: 33773809
Related Citations
Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity.
Authors: Iyer N.S.
, Cartmel B.
, Friedman L.
, Li F.
, Zhou Y.
, Ercolano E.
, Harrigan M.
, Gottlieb L.
, McCorkle R.
, Schwartz P.E.
, et al.
.
Source: Cancer, 2018-05-01 00:00:00.0; 124(9), p. 1929-1937.
EPub date: 2018-02-13 00:00:00.0.
PMID: 29437202
Related Citations
Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors - I.
Authors: Zhou Y.
, Irwin M.L.
, Ferrucci L.M.
, McCorkle R.
, Ercolano E.A.
, Li F.
, Stein K.
, Cartmel B.
.
Source: Gynecologic Oncology, 2016 Jun; 141(3), p. 543-9.
PMID: 27072805
Related Citations
Exercise improves body fat, lean mass, and bone mass in breast cancer survivors.
Authors: Irwin M.L.
, Alvarez-Reeves M.
, Cadmus L.
, Mierzejewski E.
, Mayne S.T.
, Yu H.
, Chung G.G.
, Jones B.
, Knobf M.T.
, DiPietro L.
.
Source: Obesity (silver Spring, Md.), 2009 Aug; 17(8), p. 1534-41.
PMID: 19629060
Related Citations
Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship study.
Authors: Irwin M.L.
, Varma K.
, Alvarez-Reeves M.
, Cadmus L.
, Wiley A.
, Chung G.G.
, Dipietro L.
, Mayne S.T.
, Yu H.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Jan; 18(1), p. 306-13.
PMID: 19124513
Related Citations