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Grant Details

Grant Number: 5R01CA142081-04 Interpret this number
Primary Investigator: Schildkraut, Joellen
Organization: Duke University
Project Title: Epidemiology of Ovarian Cancer in African-American Women
Fiscal Year: 2013
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Abstract

DESCRIPTION (provided by applicant): Ovarian cancer is the most lethal of gynecologic malignancies. Although African-American women have lower incidence rates than white women, their five-year survival rates are lower. To date, there has been little research on ovarian cancer in African-American women. In 1993, an analysis involving 110 cases and 365 controls was the first published report describing ovarian cancer risk factors in African-American women. An editorial accompanying this report called for further research on ovarian cancer in African-Americans, however there has been little progress in this area in the past fifteen years. In the international Ovarian Cancer Association Consortium, women of African descent comprise fewer than 300 of the more than 12,000 cases from 18 case-control studies, including 144 cases from our North Carolina Ovarian Cancer Study (NCOCS). Within the NCOCS, we have found evidence suggesting differences between African-Americans and whites in certain ovarian cancer risk factors including CAG repeats in the androgen receptor (AR) gene and anthropometric characteristics. Although these findings are intriguing, we have been unable to confirm them because of the paucity of data on African-American women in other studies. The purpose of this application is to establish a multi-center case-control study involving nine geographic regions within the United States to study the etiology of ovarian cancer in African Americans. The specific aims are: 1. To establish the infrastructure to recruit 1000 African-American women with invasive epithelial ovarian cancer and an equal number of age-matched controls. 2. To determine how risk factors for ovarian cancer in African-American women are similar or different to established risk factors for white women. We will calculate population attributable fractions to determine if differences in the prevalence of risk factors (e.g. reproductive characteristics or obesity) can account for racial differences in ovarian cancer incidence. 3. To evaluate genetic risk factors for ovarian cancer, focusing on concordance or discordance of results with genes that have been reported to be associated with ovarian cancer in white women in studies from large consortia or genome-wide association studies (GWAS). 4. To obtain information on treatment and outcome for ovarian cancer cases. We will analyze patterns of care and assess factors associated with obtaining treatment consistent with recommended standards for therapy. We also will be positioning ourselves to study predictors of survival among African-American ovarian cancer patients. The proposed study will fill an important gap in research on ovarian cancer in African-American women. Not only will we explore risk factors and prognostic characteristics that have been established as important in white women, we will investigate associations with factors that may be specific to African Americans. The large sample size and the diverse populations represented will provide critical insight into the similarities and differences in ovarian cancer risk factors between African-American and white women and may contribute to a better understanding of the poorer survival experienced by African Americans. PUBLIC HEALTH RELEVANCE: Although the epidemiology of ovarian cancer has been well-studied among Caucasian women there is very little known about risk factors for ovarian cancer among African-Americans. This is largely due to the sparse enrollment of African Americans in existing epidemiologic studies. The purpose of this study is to enroll 1,000 ovarian cancer cases and 1,000 controls of African American ethnicity from 9 geographic regions in the U.S. to comprehensively evaluate known and suspected epidemiologic and genetic factors for ovarian cancer in this population. The collection of treatment and follow-up data will set the stage to address the disparity in ovarian cancer survival among African-American women diagnosed with ovarian cancer compared to whites. This study will provide new insight into both the etiology and prognosis of ovarian cancer in African-American women.

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Publications

Recreational physical activity and survival in African-American women with ovarian cancer.
Authors: Abbott S.E. , Camacho F. , Peres L.C. , Alberg A.J. , Bandera E.V. , Bondy M. , Cote M.L. , Funkhouser E. , Moorman P.G. , Peters E.S. , et al. .
Source: Cancer causes & control : CCC, 2018 Jan; 29(1), p. 77-86.
EPub date: 2017-11-29.
PMID: 29188593
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Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.
Authors: Peres L.C. , Risch H. , Terry K.L. , Webb P.M. , Goodman M.T. , Wu A.H. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M.L. , et al. .
Source: International journal of epidemiology, 2017-12-02; , .
EPub date: 2017-12-02.
PMID: 29211900
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Tubal ligation and ovarian cancer risk in African American women.
Authors: McNamara C. , Abbott S.E. , Bandera E.V. , Qin B. , Peres L.C. , Camacho F. , Moorman P.G. , Alberg A.J. , Barnholtz-Sloan J.S. , Bondy M. , et al. .
Source: Cancer causes & control : CCC, 2017 Oct; 28(10), p. 1033-1041.
EPub date: 2017-09-04.
PMID: 28871344
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Engaging African Americans in Research: The Recruiter's Perspective.
Authors: Barrett N.J. , Ingraham K.L. , Vann Hawkins T. , Moorman P.G. .
Source: Ethnicity & disease, 2017 Fall; 27(4), p. 453-462.
EPub date: 2017-12-07.
PMID: 29225447
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Challenges and Opportunities in Studying the Epidemiology of Ovarian Cancer Subtypes.
Authors: Doherty J.A. , Peres L.C. , Wang C. , Way G.P. , Greene C.S. , Schildkraut J.M. .
Source: Current Epidemiology Reports, 2017 Sep; 4(3), p. 211-220.
EPub date: 2017-07-10 00:00:00.0.
PMID: 29226065
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Cigarette smoking and the association with serous ovarian cancer in African American women: African American Cancer Epidemiology Study (AACES).
Authors: Kelemen L.E. , Abbott S. , Qin B. , Peres L.C. , Moorman P.G. , Wallace K. , Bandera E.V. , Barnholtz-Sloan J.S. , Bondy M. , Cartmell K. , et al. .
Source: Cancer Causes & Control : Ccc, 2017 Jul; 28(7), p. 699-708.
EPub date: 2017-05-02 00:00:00.0.
PMID: 28466107
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Dietary Quality and Ovarian Cancer Risk in African-American Women.
Authors: Qin B. , Moorman P.G. , Kelemen L.E. , Alberg A.J. , Barnholtz-Sloan J.S. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E.S. , Schwartz A.G. , et al. .
Source: American Journal Of Epidemiology, 2017-05-23 00:00:00.0; , p. 1-9.
EPub date: 2017-05-23 00:00:00.0.
PMID: 28535290
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Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women.
Authors: Peres L.C. , Moorman P.G. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E.S. , Schwartz A.G. , et al. .
Source: Cancer Causes & Control : Ccc, 2017 May; 28(5), p. 405-414.
PMID: 28251458
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Premenopausal Hysterectomy and Risk of Ovarian Cancer in African-American Women.
Authors: Peres L.C. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M. , Cote M.L. , Funkhouser E. , Moorman P.G. , Peters E.S. , Schwartz A.G. , et al. .
Source: American Journal Of Epidemiology, 2017-04-21 00:00:00.0; , p. 1-8.
EPub date: 2017-04-21 00:00:00.0.
PMID: 28444120
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Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women.
Authors: Terry P.D. , Qin B. , Camacho F. , Moorman P.G. , Alberg A.J. , Barnholtz-Sloan J.S. , Bondy M. , Cote M.L. , Funkhouser E. , Guertin K.A. , et al. .
Source: The Journal Of Nutrition, 2017 Apr; 147(4), p. 621-627.
EPub date: 2017-02-15 00:00:00.0.
PMID: 28202637
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Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.
Authors: Peres L.C. , Bandera E.V. , Qin B. , Guertin K.A. , Shivappa N. , Hebert J.R. , Abbott S.E. , Alberg A.J. , Barnholtz-Sloan J. , Bondy M. , et al. .
Source: International Journal Of Cancer, 2017-02-01 00:00:00.0; 140(3), p. 535-543.
EPub date: 2017-02-01 00:00:00.0.
PMID: 27727481
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Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.
Authors: Qin B. , Moorman P.G. , Alberg A.J. , Barnholtz-Sloan J.S. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E.S. , Schwartz A.G. , Terry P. , et al. .
Source: British Journal Of Cancer, 2016-10-25 00:00:00.0; 115(9), p. 1122-1130.
EPub date: 2016-10-25 00:00:00.0.
PMID: 27632371
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Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES).
Authors: Schildkraut J.M. , Abbott S.E. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J.S. , Bondy M.L. , Cote M.L. , Funkhouser E. , Peres L.C. , Peters E.S. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016 Oct; 25(10), p. 1411-1417.
PMID: 27197282
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Reproductive factors and ovarian cancer risk in African-American women.
Authors: Moorman P.G. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E.S. , Schwartz A.G. , Terry P. , et al. .
Source: Annals Of Epidemiology, 2016 Sep; 26(9), p. 654-62.
PMID: 27528178
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Socioeconomic Status in Relation to the Risk of Ovarian Cancer in African-American Women: A Population-Based Case-Control Study.
Authors: Alberg A.J. , Moorman P.G. , Crankshaw S. , Wang F. , Bandera E.V. , Barnholtz-Sloan J.S. , Bondy M. , Cartmell K.B. , Cote M.L. , Ford M.E. , et al. .
Source: American Journal Of Epidemiology, 2016-08-15 00:00:00.0; 184(4), p. 274-83.
EPub date: 2016-08-15 00:00:00.0.
PMID: 27492896
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Obesity, weight gain, and ovarian cancer risk in African American women.
Authors: Bandera E.V. , Qin B. , Moorman P.G. , Alberg A.J. , Barnholtz-Sloan J.S. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E.S. , Schwartz A.G. , et al. .
Source: International Journal Of Cancer, 2016-08-01 00:00:00.0; 139(3), p. 593-600.
EPub date: 2016-08-01 00:00:00.0.
PMID: 27038123
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The Association Between Body Mass Index and Presenting Symptoms in African American Women with Ovarian Cancer.
Authors: Erondu C.O. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E. , Schwartz A.G. , Terry P.D. , et al. .
Source: Journal Of Women's Health (2002), 2016 Jun; 25(6), p. 571-8.
EPub date: 2016-02-17 00:00:00.0.
PMID: 26886855
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Analgesic medication use and risk of epithelial ovarian cancer in African American women.
Authors: Peres L.C. , Camacho F. , Abbott S.E. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M. , Cote M.L. , Crankshaw S. , Funkhouser E. , et al. .
Source: British Journal Of Cancer, 2016-03-29 00:00:00.0; 114(7), p. 819-25.
EPub date: 2016-03-29 00:00:00.0.
PMID: 26908324
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Dietary carbohydrate intake, glycaemic load, glycaemic index and ovarian cancer risk in African-American women.
Authors: Qin B. , Moorman P.G. , Alberg A.J. , Barnholtz-Sloan J.S. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E.S. , Schwartz A.G. , Terry P. , et al. .
Source: The British Journal Of Nutrition, 2016-02-28 00:00:00.0; 115(4), p. 694-702.
EPub date: 2016-02-28 00:00:00.0.
PMID: 26669283
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A multi-center population-based case-control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES).
Authors: Schildkraut J.M. , Alberg A.J. , Bandera E.V. , Barnholtz-Sloan J. , Bondy M. , Cote M.L. , Funkhouser E. , Peters E. , Schwartz A.G. , Terry P. , et al. .
Source: Bmc Cancer, 2014-09-22 00:00:00.0; 14, p. 688.
EPub date: 2014-09-22 00:00:00.0.
PMID: 25242549
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Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women.
Authors: Grant D.J. , Hoyo C. , Akushevich L. , Iversen E.S. , Whitaker R. , Marks J. , Berchuck A. , Schildkraut J.M. .
Source: Gynecologic Oncology, 2013 Apr; 129(1), p. 173-8.
PMID: 23262379
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Global ovarian cancer health disparities.
Authors: Chornokur G. , Amankwah E.K. , Schildkraut J.M. , Phelan C.M. .
Source: Gynecologic Oncology, 2013 Apr; 129(1), p. 258-64.
PMID: 23266352
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Recreational Physical Activity And Ovarian Cancer Risk In African American Women
Authors: Abbott S.E. , Bandera E.V. , Qin B. , Peres L.C. , Moorman P.G. , Barnholtz-Sloan J. , Schwartz A.G. , Funkhouser E. , Peters E.S. , Cote M.L. , et al. .
Source: Cancer Medicine, 2016 06; 5(6), p. 1319-27.
PMID: 26923432
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