Skip to main content


Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit

Updates regarding government operating status and resumption of normal operations can be found at

Grant Details

Grant Number: 5R01CA138730-04 Interpret this number
Primary Investigator: Patrick, Kevin
Organization: University Of California San Diego
Project Title: MDIET: a Text Message Intervention for Weight Loss
Fiscal Year: 2013
Back to top


DESCRIPTION (provided by applicant): We propose a randomized controlled trial to evaluate how well a weight loss intervention based primarily on text messages sent to/from mobile phones, mDIET, promotes weight loss and weight loss maintenance in overweight and obese men and women age 21 through 60. This study is based on promising formative research and a pilot randomized controlled trial (RCT) recently concluded among 75 overweight/obese men and women (mean age: 49.9) with the support of an NCI R21. To our knowledge the mDIET pilot study was the first RCT to address overweight/obesity with an intervention that is based primarily on the use of text (SMS) messages. At 16 weeks we found a significant between-group difference in weight with mDIET users losing 3.16% more weight (2.88 kg) than controls and very high acceptability. SMS messaging is becoming increasingly common and can be viewed on essentially all mobile phone platforms. Thus, the population reach of behavioral interventions using this approach can be extensive. In this project we will expand and strengthen the expert system logic underlying mDIET, strengthen content targeted at energy intake behaviors that contribute to weight loss and develop additional content related to physical activity and sedentary behavior -- all changes aimed at enabling mDIET to promote and sustain a 5-10% weight loss at 12 months. We will conduct additional formative research among those whose first language is Spanish, and develop mDIET for both English and Spanish-language speaking men and women. Then, 309 overweight/obese (BMI 25.1-39.9) women and men, age 21-60 will be randomized to one of three 12-month conditions: a) an SMS only version of mDIET; b) An SMS+Phone version of mDIET that includes regular brief counseling calls from a trained weight loss specialist; or c) a usual care Standard Print-based weight intervention. We will enroll approximately 30% in the Spanish language preference group to assure our ability to perform meaningful exploratory analyses in this population. mDIET is based in behavioral theory and can support delivery of tailored messages to each user. The primary outcome will be the effect of mDIET on percent weight loss at 12 months. Secondary outcomes will include assessments at 6 and 12 months of mDIET effects on proportion of each group that lose at least 5% of initial body weight, behavioral, and psychosocial constructs, quality of life & depression, satisfaction with the intervention and process measures related to use of intervention elements.

Back to top


Associations Between Physical Activity And Bmi, Body Fatness, And Visceral Adiposity In Overweight Or Obese Latino And Non-latino Adults
Authors: Cameron N. , Godino J. , Nichols J.F. , Wing D. , Hill L. , Patrick K. .
Source: International Journal Of Obesity (2005), 2017-02-21 00:00:00.0; , .
PMID: 28220040
Related Citations

Exploratory and confirmatory factor analyses and demographic correlate models of the strategies for weight management measure for overweight or obese adults.
Authors: Kolodziejczyk J.K. , Norman G.J. , Roesch S.C. , Rock C.L. , Arredondo E.M. , Madanat H. , Patrick K. .
Source: American Journal Of Health Promotion : Ajhp, 2015 Mar-Apr; 29(4), p. e147-57.
PMID: 24670075
Related Citations

Feasibility And Effectiveness Of An Automated Bilingual Text Message Intervention For Weight Loss: Pilot Study
Authors: Kolodziejczyk J.K. , Norman G.J. , Barrera-Ng A. , Dillon L. , Marshall S. , Arredondo E. , Rock C.L. , Raab F. , Griswold W.G. , Sullivan M. , et al. .
Source: Jmir Research Protocols, 2013-11-06 00:00:00.0; 2(2), p. e48.
PMID: 24200517
Related Citations

Back to Top