Grant Number:	1R01CA166084-01A1 Interpret this number
Primary Investigator:	Hershman, Dawn
Organization:	Columbia University Health Sciences
Project Title:	Using Swog-Medicare Database to Evaluate Long-Term Toxicities of Cancer Survivors
Fiscal Year:	2013

DESCRIPTION (provided by applicant): There are over 12 million cancer survivors in the UC. Cancer survivorship and understanding late effects of cancer therapy is a high priority area. The linkage of the powerful SWOG clinical trial database to Medicare claims data provides a unique opportunity to evaluate late effects of therapy, and may establish a mechanism for identifying differences in outcomes between treatment groups after the clinical trial follow-up ends. We propose to use a database that has linked patients enrolled on SWOG clinical treatment and prevention trials where detailed information on demographics, tumor details, prognostic factors, clinical factors, treatment type (intravenous, subcutaneous and oral) and dose received, short term toxicities during the treatment period, recurrence and survival outcomes are captured with Medicare claims data (based on ICD-9, HCPCS, and CPT codes) which can provide long-term follow-up with underlying illnesses, comorbid conditions, new diagnoses, subsequent treatment, hospitalizations and costs/resource utilization associated with treatment. For the specific aims of our proposal, we will use the SWOG-Medicare linked database to determine the long term cardiovascular, hematologic, gastrointestinal, renal, endocrinologic and neurologic complications of (a) patients with prostate cancer randomized to continuous vs intermittent androgen deprivation (b) patients with prostate cancer treated with and without androgen deprivation (c) patients with breast and prostate cancer treated with and without taxanes (d) patients with non-small cell lung cancer treated with and without platinum agents (e) patients with pelvic cancer treated with chemotherapy and radiation vs. radiation alone. For each of these sub-aims, we will examine how these complications vary by pre-existing co-morbidities, such as diabetes and hypertension, as well as clinical and demographic factors, and examine the relationship between short term toxicities assessed during therapy on a clinical trial, as characterized by the Common Toxicity Criteria (CTC-AE), and long-term toxicities. Using the unique and valuable linked Medicare claims database with the NCI clinical trials database of the Southwest Oncology Group, we can perform analyses that overcome limitations of previously conduced population based research that utilized the SEER-Medicare database alone. If we can better predict who is at greatest risk for late toxicity, and who is not, we can improve long term outcomes for the growing population of cancer survivors




FOLFOX and FOLFIRI Use in Stage IV Colon Cancer: Analysis of SEER-Medicare Data.
Authors: Neugut A.I. , Lin A. , Raab G.T. , Hillyer G.C. , Keller D. , O'Neil D.S. , Accordino M.K. , Kiran R.P. , Wright J. , Hershman D.L. .
Source: Clinical Colorectal Cancer, 2019 06; 18(2), p. 133-140.
EPub date: 2019-01-31 00:00:00.0.
PMID: 30878317
Related Citations

Use of Bisphosphonates in Elderly Patients With Newly Diagnosed Multiple Myeloma.
Authors: Leng S. , Chen Y. , Tsai W.Y. , Bhutani D. , Hillyer G.C. , Lim E. , Accordino M.K. , Wright J.D. , Hershman D.L. , Lentzsch S. , et al. .
Source: Journal Of The National Comprehensive Cancer Network : Jnccn, 2019 Jan; 17(1), p. 22-28.
PMID: 30659126
Related Citations

Characteristics and outcomes of reproductive-aged women with early-stage cervical cancer: trachelectomy vs hysterectomy.
Authors: Machida H. , Mandelbaum R.S. , Mikami M. , Enomoto T. , Sonoda Y. , Grubbs B.H. , Paulson R.J. , Roman L.D. , Wright J.D. , Matsuo K. .
Source: American Journal Of Obstetrics And Gynecology, 2018 Nov; 219(5), p. 461.e1-461.e18.
EPub date: 2018-08-21 00:00:00.0.
PMID: 30138618
Related Citations

Use and Outcomes of Minimally Invasive Hysterectomy for Women with Non-Endometrioid Endometrial Cancers.
Authors: Nieto V.L. , Huang Y. , Hou J.Y. , Tergas A.I. , St Clair C.M. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: American Journal Of Obstetrics And Gynecology, 2018-08-04 00:00:00.0; , .
EPub date: 2018-08-04 00:00:00.0.
PMID: 30086293
Related Citations

Characteristics associated with prolonged length of stay after hysterectomy for benign gynecologic conditions.
Authors: Agrawal S. , Chen L. , Tergas A.I. , Hou J.Y. , St Clair C.M. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: American Journal Of Obstetrics And Gynecology, 2018 07; 219(1), p. 89.e1-89.e15.
EPub date: 2018-05-08 00:00:00.0.
PMID: 29750957
Related Citations

Changes in Surgical Volume and Outcomes Over Time for Women Undergoing Hysterectomy for Endometrial Cancer.
Authors: Wright J.D. , Ruiz M.P. , Chen L. , Gabor L.R. , Tergas A.I. , St Clair C.M. , Hou J.Y. , Ananth C.V. , Neugut A.I. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2018-06-06 00:00:00.0; , .
EPub date: 2018-06-06 00:00:00.0.
PMID: 29889759
Related Citations

Identifying modifiable and non-modifiable risk factors associated with prolonged length of stay after hysterectomy for uterine cancer.
Authors: Agrawal S. , Chen L. , Tergas A.I. , Hou J.Y. , St Clair C.M. , Ananth C.V. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2018 06; 149(3), p. 545-553.
EPub date: 2018-03-17 00:00:00.0.
PMID: 29559171
Related Citations

Outcomes of Hysterectomy Performed by Very Low-Volume Surgeons.
Authors: Ruiz M.P. , Chen L. , Hou J.Y. , Tergas A.I. , St Clair C.M. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Obstetrics And Gynecology, 2018-05-07 00:00:00.0; , .
EPub date: 2018-05-07 00:00:00.0.
PMID: 29742669
Related Citations

Trends in Use and Survival Associated With Fertility-Sparing Trachelectomy for Young Women With Early-Stage Cervical Cancer.
Authors: Cui R.R. , Chen L. , Tergas A.I. , Hou J.Y. , St Clair C.M. , Neugut A.I. , Ananth C.V. , Hershman D.L. , Wright J.D. .
Source: Obstetrics And Gynecology, 2018-05-07 00:00:00.0; , .
EPub date: 2018-05-07 00:00:00.0.
PMID: 29742670
Related Citations

Trends in Sentinel Lymph Node Mapping and Adjuvant Therapy in Endometrial Carcinoma.
Authors: Gómez-Hidalgo N.R. , Chen L. , Hou J.Y. , Tergas A.I. , St Clair C.M. , Ananth C.V. , Hershman D.L. , Wright J.D. .
Source: Cancer Investigation, 2018-03-16 00:00:00.0; 36(3), p. 190-198.
EPub date: 2018-03-22 00:00:00.0.
PMID: 29565689
Related Citations

Impact of hospital volume on racial disparities and outcomes for endometrial cancer.
Authors: Buskwofie A. , Huang Y. , Tergas A.I. , Hou J.Y. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2018-03-02 00:00:00.0; , .
EPub date: 2018-03-02 00:00:00.0.
PMID: 29506862
Related Citations

Use and impact of herpes zoster prophylaxis in myeloma patients treated with proteasome inhibitors.
Authors: Leng S. , Lentzsch S. , Shen Y. , Tsai W.Y. , Wright J.D. , Hershman D.L. , Neugut A.I. .
Source: Leukemia & Lymphoma, 2018-02-02 00:00:00.0; , p. 1-5.
EPub date: 2018-02-02 00:00:00.0.
PMID: 29390929
Related Citations

Racial disparities in young women with endometrial cancer.
Authors: Mukerji B. , Baptiste C. , Chen L. , Tergas A.I. , Hou J.Y. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2018-01-04 00:00:00.0; , .
EPub date: 2018-01-04 00:00:00.0.
PMID: 29307452
Related Citations

Cost of Care for the Initial Management of Ovarian Cancer.
Authors: Bercow A.S. , Chen L. , Chatterjee S. , Tergas A.I. , Hou J.Y. , Burke W.M. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Obstetrics And Gynecology, 2017 Dec; 130(6), p. 1269-1275.
PMID: 29112648
Related Citations

Adherence to treatment recommendations and outcomes for women with ovarian cancer at first recurrence.
Authors: Champer M. , Huang Y. , Hou J.Y. , Tergas A.I. , Burke W.M. , Hillyer G.C. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2017-11-15 00:00:00.0; , .
EPub date: 2017-11-15 00:00:00.0.
PMID: 29153542
Related Citations

Association between survival time with metastatic breast cancer and aggressive end-of-life care.
Authors: Accordino M.K. , Wright J.D. , Vasan S. , Neugut A.I. , Gross T. , Hillyer G.C. , Hershman D.L. .
Source: Breast Cancer Research And Treatment, 2017 Nov; 166(2), p. 549-558.
EPub date: 2017-07-27 00:00:00.0.
PMID: 28752188
Related Citations

National Trends in Extended Procedures for Ovarian Cancer Debulking Surgery.
Authors: Jones N.L. , Chen L. , Chatterjee S. , Tergas A.I. , Burke W.M. , Hou J.Y. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society, 2017-09-22 00:00:00.0; , .
EPub date: 2017-09-22 00:00:00.0.
PMID: 28953134
Related Citations

Association of Hospital Volume and Quality of Care With Survival for Ovarian Cancer.
Authors: Wright J.D. , Chen L. , Hou J.Y. , Burke W.M. , Tergas A.I. , Ananth C.V. , Neugut A.I. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2017 Sep; 130(3), p. 545-553.
PMID: 28796677
Related Citations

All-cause mortality in young women with endometrial cancer receiving progesterone therapy.
Authors: Ruiz M.P. , Huang Y. , Hou J.Y. , Tergas A.I. , Burke W.M. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: American Journal Of Obstetrics And Gynecology, 2017-08-24 00:00:00.0; , .
EPub date: 2017-08-24 00:00:00.0.
PMID: 28844824
Related Citations

Trends in end-of-life care and health care spending in women with uterine cancer.
Authors: Margolis B. , Chen L. , Accordino M.K. , Hillyer G.C. , Hou J.Y. , Tergas A.I. , Burke W.M. , Neugut A.I. , Ananth C.V. , Hershman D.L. , et al. .
Source: American Journal Of Obstetrics And Gynecology, 2017-07-11 00:00:00.0; , .
EPub date: 2017-07-11 00:00:00.0.
PMID: 28709581
Related Citations

Utilization of gynecologic services in women with breast cancer receiving hormonal therapy.
Authors: Wright J.D. , Desai V.B. , Chen L. , Burke W.M. , Tergas A.I. , Hou J.Y. , Accordino M. , Ananth C.V. , Neugut A.I. , Hershman D.L. .
Source: American Journal Of Obstetrics And Gynecology, 2017 Jul; 217(1), p. 59.e1-59.e12.
EPub date: 2017-03-21 00:00:00.0.
PMID: 28341383
Related Citations

Patterns of Specialty-Based Referral and Perioperative Outcomes for Women With Endometrial Cancer Undergoing Hysterectomy.
Authors: Wright J.D. , Chen L. , Gabor L. , Burke W.M. , Tergas A.I. , Hou J.Y. , Ananth C.V. , Neugut A.I. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2017 Jul; 130(1), p. 81-90.
PMID: 28594765
Related Citations

Utility of radiation therapy for early-stage uterine papillary serous carcinoma.
Authors: Cham S. , Huang Y. , Tergas A.I. , Hou J.Y. , Burke W.M. , Deutsch I. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2017 05; 145(2), p. 269-276.
EPub date: 2017-03-23 00:00:00.0.
PMID: 28343693
Related Citations

Factors and Costs Associated With Delay in Treatment Initiation and Prolonged Length of Stay With Inpatient EPOCH Chemotherapy in Patients With Hematologic Malignancies.
Authors: Accordino M.K. , Wright J.D. , Vasan S. , Neugut A.I. , Hillyer G.C. , Hershman D.L. .
Source: Cancer Investigation, 2017-03-16 00:00:00.0; 35(3), p. 202-214.
EPub date: 2017-02-06 00:00:00.0.
PMID: 28165774
Related Citations

Disparities In The Management Of Ectopic Pregnancy
Authors: Hsu J.Y. , Chen L. , Gumer A.R. , Tergas A.I. , Hou J.Y. , Burke W.M. , Ananth C.V. , Hershman D.L. , Wright J.D. .
Source: American Journal Of Obstetrics And Gynecology, 2017-03-10 00:00:00.0; , .
PMID: 28288792
Related Citations

Predictors of Interventional Treatment Use for Venous Thromboembolism in Cancer Patients.
Authors: Yoon L. , Clarke Hillyer G. , Chen L. , Hu J.C. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Cancer Investigation, 2016-09-13 00:00:00.0; 34(8), p. 408-14.
EPub date: 2016-09-13 00:00:00.0.
PMID: 27624740
Related Citations

Effect of Regional Hospital Competition and Hospital Financial Status on the Use of Robotic-Assisted Surgery.
Authors: Wright J.D. , Tergas A.I. , Hou J.Y. , Burke W.M. , Chen L. , Hu J.C. , Neugut A.I. , Ananth C.V. , Hershman D.L. .
Source: Jama Surgery, 2016-07-01 00:00:00.0; 151(7), p. 612-20.
PMID: 26886156
Related Citations

Underuse of BRCA testing in patients with breast and ovarian cancer.
Authors: Wright J.D. , Chen L. , Tergas A.I. , Accordino M. , Ananth C.V. , Neugut A.I. , Hershman D.L. .
Source: American Journal Of Obstetrics And Gynecology, 2016 06; 214(6), p. 761-3.
EPub date: 2016-02-11 00:00:00.0.
PMID: 26875946
Related Citations

Prescription of extended-duration thromboprophylaxis after high-risk, abdominopelvic cancer surgery.
Authors: Wright J.D. , Chen L. , Jorge S. , Burke W.M. , Tergas A.I. , Hou J.Y. , Hu J.C. , Neugut A.I. , Ananth C.V. , Hershman D.L. .
Source: Gynecologic Oncology, 2016 Jun; 141(3), p. 531-7.
PMID: 27032377
Related Citations

Utilization and Toxicity of Alternative Delivery Methods of Adjuvant Chemotherapy for Ovarian Cancer.
Authors: Wright J.D. , Hou J.Y. , Burke W.M. , Tergas A.I. , Chen L. , Hu J.C. , Ananth C.V. , Neugut A.I. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2016 Jun; 127(6), p. 985-91.
PMID: 27159764
Related Citations

Adverse Health Events Following Intermittent and Continuous Androgen Deprivation in Patients With Metastatic Prostate Cancer.
Authors: Hershman D.L. , Unger J.M. , Wright J.D. , Ramsey S. , Till C. , Tangen C.M. , Barlow W.E. , Blanke C. , Thompson I.M. , Hussain M. .
Source: Jama Oncology, 2016 Apr; 2(4), p. 453-61.
PMID: 26720308
Related Citations

Measurement and validation of frailty as a predictor of outcomes in women undergoing major gynaecological surgery.
Authors: George E.M. , Burke W.M. , Hou J.Y. , Tergas A.I. , Chen L. , Neugut A.I. , Ananth C.V. , Hershman D.L. , Wright J.D. .
Source: Bjog : An International Journal Of Obstetrics And Gynaecology, 2016 Feb; 123(3), p. 455-61.
PMID: 26301606
Related Citations

Utilization and Outcomes of Ovarian Conservation in Premenopausal Women With Endometrial Cancer.
Authors: Wright J.D. , Jorge S. , Tergas A.I. , Hou J.Y. , Burke W.M. , Huang Y. , Hu J.C. , Ananth C.V. , Neugut A.I. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2016 Jan; 127(1), p. 101-8.
PMID: 26646128
Related Citations

Influence of Lymphadenectomy on Survival for Early-Stage Endometrial Cancer.
Authors: Wright J.D. , Huang Y. , Burke W.M. , Tergas A.I. , Hou J.Y. , Hu J.C. , Neugut A.I. , Ananth C.V. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2016 Jan; 127(1), p. 109-18.
PMID: 26646130
Related Citations

Safety, Utilization, and Cost of Image-Guided Percutaneous Liver Biopsy Among Cancer Patients.
Authors: Cui Z. , Wright J.D. , Accordino M.K. , Buono D. , Neugut A.I. , Hu J.C. , Hershman D.L. .
Source: Cancer Investigation, 2016; 34(4), p. 189-96.
PMID: 27065211
Related Citations

Influence of treatment center and hospital volume on survival for locally advanced cervical cancer.
Authors: Wright J.D. , Huang Y. , Ananth C.V. , Tergas A.I. , Duffy C. , Deutsch I. , Burke W.M. , Hou J.Y. , Neugut A.I. , Hershman D.L. .
Source: Gynecologic Oncology, 2015 Dec; 139(3), p. 506-12.
PMID: 26177552
Related Citations

Population-level trends in relative survival for cervical cancer.
Authors: Wright J.D. , Chen L. , Tergas A.I. , Burke W.M. , Hou J.Y. , Neugut A.I. , Ananth C.V. , Hershman D.L. .
Source: American Journal Of Obstetrics And Gynecology, 2015 Nov; 213(5), p. 670.e1-7.
PMID: 26210758
Related Citations

Long-term mortality among women with epithelial ovarian cancer.
Authors: Dinkelspiel H.E. , Champer M. , Hou J. , Tergas A. , Burke W.M. , Huang Y. , Neugut A.I. , Ananth C.V. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2015 Aug; 138(2), p. 421-8.
PMID: 26050923
Related Citations

Risk stratification and outcomes of women undergoing surgery for ovarian cancer.
Authors: Patankar S. , Burke W.M. , Hou J.Y. , Tergas A.I. , Huang Y. , Ananth C.V. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2015 Jul; 138(1), p. 62-9.
PMID: 25976399
Related Citations

Trends in relative survival for ovarian cancer from 1975 to 2011.
Authors: Wright J.D. , Chen L. , Tergas A.I. , Patankar S. , Burke W.M. , Hou J.Y. , Neugut A.I. , Ananth C.V. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2015 Jun; 125(6), p. 1345-52.
PMID: 26000505
Related Citations

Trends in use and safety of image-guided transthoracic needle biopsies in patients with cancer.
Authors: Accordino M.K. , Wright J.D. , Buono D. , Neugut A.I. , Hershman D.L. .
Source: Journal Of Oncology Practice / American Society Of Clinical Oncology, 2015 May; 11(3), p. e351-9.
PMID: 25604594
Related Citations

Use of Electric Power Morcellation and Prevalence of Underlying Cancer in Women Who Undergo Myomectomy.
Authors: Wright J.D. , Tergas A.I. , Cui R. , Burke W.M. , Hou J.Y. , Ananth C.V. , Chen L. , Richards C. , Neugut A.I. , Hershman D.L. .
Source: Jama Oncology, 2015 Apr; 1(1), p. 69-77.
PMID: 26182307
Related Citations

High versus low-dose rate brachytherapy for cervical cancer.
Authors: Patankar S.S. , Tergas A.I. , Deutsch I. , Burke W.M. , Hou J.Y. , Ananth C.V. , Huang Y. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2015 Mar; 136(3), p. 534-41.
PMID: 25575481
Related Citations

Relationship between surgical oncologic outcomes and publically reported hospital quality and satisfaction measures.
Authors: Wright J.D. , Tergas A.I. , Ananth C.V. , Burke W.M. , Chen L. , Neugut A.I. , Richards C.A. , Hershman D.L. .
Source: Journal Of The National Cancer Institute, 2015 Mar; 107(3), .
PMID: 25618899
Related Citations

Factors associated with 30-day hospital readmission after hysterectomy.
Authors: Dessources K. , Hou J.Y. , Tergas A.I. , Burke W.M. , Ananth C.V. , Prendergast E. , Chen L. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Obstetrics And Gynecology, 2015 Feb; 125(2), p. 461-70.
PMID: 25569007
Related Citations

Quality and Outcomes of Treatment of Hypercalcemia of Malignancy.
Authors: Wright J.D. , Tergas A.I. , Ananth C.V. , Burke W.M. , Hou J.Y. , Chen L. , Neugut A.I. , Richards C.A. , Hershman D.L. .
Source: Cancer Investigation, 2015; 33(8), p. 331-9.
PMID: 26068056
Related Citations

Comparative effectiveness of robotically assisted compared with laparoscopic adnexal surgery for benign gynecologic disease.
Authors: Wright J.D. , Kostolias A. , Ananth C.V. , Burke W.M. , Tergas A.I. , Prendergast E. , Ramsey S.D. , Neugut A.I. , Hershman D.L. .
Source: Obstetrics And Gynecology, 2014 Nov; 124(5), p. 886-96.
PMID: 25437715
Related Citations

Safety and tolerance of radical hysterectomy for cervical cancer in the elderly.
Authors: George E.M. , Tergas A.I. , Ananth C.V. , Burke W.M. , Lewin S.N. , Prendergast E. , Neugut A.I. , Hershman D.L. , Wright J.D. .
Source: Gynecologic Oncology, 2014 Jul; 134(1), p. 36-41.
PMID: 24768851
Related Citations