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Grant Details

Grant Number: 5R01CA101963-10 Interpret this number
Primary Investigator: Ellerbeck, Edward
Organization: University Of Kansas Medical Center
Project Title: Centralized Disease Management for Rural Hospitalized Smokers
Fiscal Year: 2013
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DESCRIPTION (provided by applicant): Hospitalized smokers are at high risk for complications related to continued tobacco use. Although national attention has been directed at smoking cessation for hospitalized patients, rural hospitals have been unable to implement the complete components of effective smoking cessation programs. In this competitive renewal to Kan Quit, our experienced, multidisciplinary team will build upon our strong foundation of research on smoking cessation in rural communities. Kan Quit, directed at smokers in all stages of readiness to quit, demonstrated that disease management, in which free pharmacotherapy was combined with pharmacotherapy management, could engage 78% of smokers in effective treatment. Unfortunately, free pharmacotherapy for smoking cessation is not universally available. State smoking cessation programs have limited supplies and offer limited choices; although prescription coverage for pharmacotherapy is increasingly available, it is underutilized, particularly among the high-risk population of hospitalized smokers. Grounded in the Chronic Care Model, our revised disease management program is designed to provide counseling and disease management while increasing utilization of pharmacotherapy and enhancing support from healthcare providers. In contrast to Kan Quit, our revised disease management program will take advantage of resources for pharmacotherapy already available in the community. Our specific objectives are to 1) evaluate the effectiveness of Centralized Disease Management (CDM) for smoking cessation among hospitalized rural smokers; 2) test the impact of CDM on utilization of pharmacotherapy and discussions with health care providers; 3) clarify how utilization of these elements may mediate the effect of CDM on smoking cessation; and 4) examine the marginal cost effectiveness of CDM for smoking cessation. This study will be conducted in 30 rural critical access hospitals in Kansas. The primary outcome is 7-day point prevalence abstinence confirmed by salivary cotinine. Hospitalized rural smokers will be randomized to either CDM or counseling (C) alone (303 in each arm). All participants will receive in-hospital telephone counseling with telephone follow-up at days 3, 7, 21, and 90. A second effort will be made to re-engage persistent or relapsed smokers 6 months later. For CDM participants, our Tobacco Treatment Specialist will also provide telephone-based disease management during the hospitalization and after discharge, including supplemental support for pharmacotherapy that is consistent with their insurance plan and guidance on establishing effective discussions with their health care provider. The Tobacco Treatment Specialist will also fax treatment recommendations, prescription requests, and counseling suggestions to the healthcare provider. The proposed research will enhance our understanding of disease management for smoking cessation and, if successful, has the potential for immediate implementation in rural critical access hospitals.

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Impact of Adding Telephone-Based Care Coordination to Standard Telephone-Based Smoking Cessation Counseling Post-hospital Discharge: a Randomized Controlled Trial.
Authors: Ellerbeck E.F. , Cox L.S. , Hui S.A. , Keighley J. , Hutcheson T.D. , Fitzgerald S.A. , Cupertino A.P. , Greiner K.A. , Rigotti N.A. , Miller N.H. , et al. .
Source: Journal of general internal medicine, 2019 12; 34(12), p. 2804-2811.
EPub date: 2019-07-31.
PMID: 31367875
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Impact of Telephone-Based Care Coordination on Use of Cessation Medications Posthospital Discharge: A Randomized Controlled Trial.
Authors: Tague C. , Richter K.P. , Cox L.S. , Keighley J. , Hutcheson T. , Fitzgerald S.A. , Ellerbeck E.F. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017-03-01; 19(3), p. 299-306.
PMID: 27194545
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Modeling and validating Bayesian accrual models on clinical data and simulations using adaptive priors.
Authors: Jiang Y. , Simon S. , Mayo M.S. , Gajewski B.J. .
Source: Statistics in medicine, 2015-02-20; 34(4), p. 613-29.
EPub date: 2014-11-06.
PMID: 25376910
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Ongoing self-engagement in quit attempts and cessation outcomes among rural smokers who were unable to quit after 2 years of repeated interventions.
Authors: Hui S.K. , Nazir N. , Faseru B. , Ellerbeck E.F. .
Source: The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association, 2013 Winter; 29(1), p. 106-12.
EPub date: 2012-05-31.
PMID: 23289661
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Simultaneous evaluation of abstinence and relapse using a Markov chain model in smokers enrolled in a two-year randomized trial.
Authors: Yeh H.W. , Ellerbeck E.F. , Mahnken J.D. .
Source: BMC medical research methodology, 2012-07-07; 12, p. 95.
EPub date: 2012-07-07.
PMID: 22770436
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Change in self-efficacy, autonomous and controlled motivation predicting smoking.
Authors: Cupertino A.P. , Berg C. , Gajewski B. , Hui S.K. , Richter K. , Catley D. , Ellerbeck E.F. .
Source: Journal of health psychology, 2012 Jul; 17(5), p. 640-52.
EPub date: 2011-11-10.
PMID: 22076554
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Predictors of early versus late smoking abstinence within a 24-month disease management program.
Authors: Cox L.S. , Wick J.A. , Nazir N. , Cupertino A.P. , Mussulman L.M. , Ahluwalia J.S. , Ellerbeck E.F. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011 Mar; 13(3), p. 215-20.
EPub date: 2011-01-13.
PMID: 21233256
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The impact of repeated cycles of pharmacotherapy on smoking cessation: a longitudinal cohort study.
Authors: Cupertino A.P. , Wick J.A. , Richter K.P. , Mussulman L. , Nazir N. , Ellerbeck E.F. .
Source: Archives of internal medicine, 2009-11-09; 169(20), p. 1928-30.
PMID: 19901150
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Effect of varying levels of disease management on smoking cessation: a randomized trial.
Authors: Ellerbeck E.F. , Mahnken J.D. , Cupertino A.P. , Cox L.S. , Greiner K.A. , Mussulman L.M. , Nazir N. , Shireman T.I. , Resnicow K. , Ahluwalia J.S. .
Source: Annals of internal medicine, 2009-04-07; 150(7), p. 437-46.
PMID: 19349629
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Design and baseline characteristics from the KAN-QUIT disease management intervention for rural smokers in primary care.
Authors: Cox L.S. , Cupertino A.P. , Mussulman L.M. , Nazir N. , Greiner K.A. , Mahnken J.D. , Ahluwalia J.S. , Ellerbeck E.F. .
Source: Preventive medicine, 2008 Aug; 47(2), p. 200-5.
EPub date: 2008-05-03.
PMID: 18544464
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Correlates of self-efficacy among rural smokers.
Authors: Berg C.J. , Sanderson Cox L. , Mahnken J.D. , Greiner K.A. , Ellerbeck E.F. .
Source: Journal of health psychology, 2008 Apr; 13(3), p. 416-21.
PMID: 18420774
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Understanding smoking cessation in rural communities.
Authors: Hutcheson T.D. , Greiner K.A. , Ellerbeck E.F. , Jeffries S.K. , Mussulman L.M. , Casey G.N. .
Source: The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association, 2008 Spring; 24(2), p. 116-24.
PMID: 18397444
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Smoking cessation pharmacotherapy preferences in rural primary care.
Authors: Cupertino P.A. , Richter K.P. , Cox L.S. , Nazir N. , Greiner A.K. , Ahluwalia J.S. , Ellerbeck E.F. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008 Feb; 10(2), p. 301-7.
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NF-kappaB: a potential target for cancer chemoprevention and therapy.
Authors: Sarkar F.H. , Li Y. .
Source: Frontiers in bioscience : a journal and virtual library, 2008-01-01; 13, p. 2950-9.
EPub date: 2008-01-01.
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Long-term engagement in smoking cessation counseling among rural smokers.
Authors: Cupertino A.P. , Mahnken J.D. , Richter K. , Cox L.S. , Casey G. , Resnicow K. , Ellerbeck E.F. .
Source: Journal of health care for the poor and underserved, 2007 Nov; 18(4 Suppl), p. 39-51.
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A relative color approach to color discrimination for malignant melanoma detection in dermoscopy images.
Authors: Stanley R.J. , Stoecker W.V. , Moss R.H. .
Source: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2007 Feb; 13(1), p. 62-72.
PMID: 17250534
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Correlates of home smoking restrictions among rural smokers.
Authors: Berg C.J. , Cox L.S. , Nazir N. , Mussulman L.M. , Ahluwalia J.S. , Ellerbeck E.F. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006 Jun; 8(3), p. 353-60.
PMID: 16801293
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