Grant Number:	5R01CA107028-08 Interpret this number
Primary Investigator:	Luebeck, Georg
Organization:	Fred Hutchinson Cancer Research Center
Project Title:	Biomathematical Evaluation of Colon Cancer Screening and Prevention
Fiscal Year:	2013

Project Summary In spite of the wealth of experimental, clinical and epidemiological data that have helped identify important genetic components and pathways in colorectal cancer (CRC), CRC continues to be the second leading cause of cancer associated death, with close to 50,000 deaths predicted for the year 2008 in the US alone. Because CRC arises predominantly in benign precursors (mainly the adenomatous polyps), which are likely to sojourn for many years before they turn malignant, CRC can be prevented largely through screening and prompt intervention. The goal of this renewal is to further explore, via a biomathematical description of the natural history of CRC, how screening and interventions can be applied most effectively to reduce the mortality associated with CRC




Incremental Benefits Of Screening Colonoscopy Over Sigmoidoscopy In Average-risk Populations: A Model-driven Analysis
Authors: Jeon J. , Meza R. , Hazelton W.D. , Renehan A.G. , Luebeck E.G. .
Source: Cancer Causes & Control : Ccc, 2015 Jun; 26(6), p. 859-70.
PMID: 25783458
Related Citations

Impact of tumor progression on cancer incidence curves.
Authors: Luebeck E.G. , Curtius K. , Jeon J. , Hazelton W.D. .
Source: Cancer Research, 2013-02-01 00:00:00.0; 73(3), p. 1086-96.
EPub date: 2013-02-01 00:00:00.0.
PMID: 23054397
Related Citations

Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers.
Authors: Hazelton W.D. , Goodman G. , Rom W.N. , Tockman M. , Thornquist M. , Moolgavkar S. , Weissfeld J.L. , Feng Z. .
Source: Mathematical Biosciences, 2012 Nov; 240(1), p. 20-34.
PMID: 22705252
Related Citations

Development and characterization of an organotypic model of Barrett's esophagus.
Authors: Kosoff R.E. , Gardiner K.L. , Merlo L.M. , Pavlov K. , Rustgi A.K. , Maley C.C. .
Source: Journal Of Cellular Physiology, 2012 Jun; 227(6), p. 2654-9.
PMID: 21882191
Related Citations

Biomarker-based early cancer detection: is it achievable?
Authors: Hazelton W.D. , Luebeck E.G. .
Source: Science Translational Medicine, 2011-11-16 00:00:00.0; 3(109), p. 109fs9.
PMID: 22089449
Related Citations

Number And Size Distribution Of Colorectal Adenomas Under The Multistage Clonal Expansion Model Of Cancer
Authors: Dewanji A. , Jeon J. , Meza R. , Luebeck E.G. .
Source: Plos Computational Biology, 2011 Oct; 7(10), p. e1002213.
PMID: 22022253
Related Citations

A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma.
Authors: Merlo L.M. , Shah N.A. , Li X. , Blount P.L. , Vaughan T.L. , Reid B.J. , Maley C.C. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2010 Nov; 3(11), p. 1388-97.
PMID: 20947487
Related Citations

Multiscale Estimation Of Cell Kinetics
Authors: Jean L.W. , Suchorolski M.T. , Jeon J. , Luebeck E.G. .
Source: Computational And Mathematical Methods In Medicine, 2010 Sep; 11(3), p. 239-54.
PMID: 20582763
Related Citations

Colorectal Cancer Incidence Trends In The United States And United Kingdom: Evidence Of Right- To Left-sided Biological Gradients With Implications For Screening
Authors: Meza R. , Jeon J. , Renehan A.G. , Luebeck E.G. .
Source: Cancer Research, 2010-07-01 00:00:00.0; 70(13), p. 5419-29.
PMID: 20530677
Related Citations

Age-specific Incidence Of Cancer: Phases, Transitions, And Biological Implications
Authors: Meza R. , Jeon J. , Moolgavkar S.H. , Luebeck E.G. .
Source: Proceedings Of The National Academy Of Sciences Of The United States Of America, 2008-10-21 00:00:00.0; 105(42), p. 16284-9.
PMID: 18936480
Related Citations

Does Folic Acid Supplementation Prevent Or Promote Colorectal Cancer? Results From Model-based Predictions
Authors: Luebeck E.G. , Moolgavkar S.H. , Liu A.Y. , Boynton A. , Ulrich C.M. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Jun; 17(6), p. 1360-7.
PMID: 18539928
Related Citations

Evaluation Of Screening Strategies For Pre-malignant Lesions Using A Biomathematical Approach
Authors: Jeon J. , Meza R. , Moolgavkar S.H. , Luebeck E.G. .
Source: Mathematical Biosciences, 2008 May; 213(1), p. 56-70.
PMID: 18374369
Related Citations