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Grant Details

Grant Number: 1R01CA170128-01 Interpret this number
Primary Investigator: Fredrickson, Barbara
Organization: Univ Of North Carolina Chapel Hill
Project Title: Promoting Cancer-Related Behavior Change Through Positive Emotions (PQ4)
Fiscal Year: 2012


DESCRIPTION (provided by applicant): The American Cancer Society estimates that 62% of all cancers could be prevented altogether through lifestyle change. Despite good intentions, people's attempts to alter their behaviors known to increase cancer risk - related to diet, physica activity, tobacco and alcohol use - often fail, which ultimately increases their risks for various cancers. In response to NCI's Provocative Question 4, the overarching goal of the proposed research is to investigate the role of positive emotions in facilitating successful lifestyle chang, defined as long-term adherence to cancer- preventive behaviors (e.g., nutritious eating, physical activity, tobacco, and alcohol use). An innovative upward spiral model of lifestyle change integrates multiple streams of research in basic behavioral and brain sciences to position positive emotions as key active ingredients that not only seed non-conscious motivational pulls toward newly-adopted cancer-preventive behaviors, but also reshape key biopsychosocial resources in ways that increase the subsequent positive emotion yield of multiple cancer-preventive behaviors, creating a self- sustaining dynamic system. A longitudinal, dual-blind, placebo-controlled field experiment tests this new model by targeting three Specific Aims. These aims are: (1) to identify biopsychosocial resources that moderate the link between cancer-preventive behaviors and their positive emotion yield; (2) to test whether and how positive emotions, experienced in daily life, produce a psychological propensity for wellness through the combined presence of (a) increases in non-conscious motives for cancer-preventive behaviors and (b) increases in biopsychosocial resources; and (3) to test whether positive emotions and a psychological propensity for wellness predict increasing and sustained cancer-preventive behaviors and improved health-related outcomes at 18-month follow-up. The proposed study tests the novel upward spiral model in daily life with densely repeated measures and physiological, behavioral, endocrine, and self- report indices of health-related outcomes. This program of translational research stands to reshape public health interventions and unlock hidden opportunities to drastically reduce the incidence of cancer. PUBLIC HEALTH RELEVANCE: Unhealthy lifestyles contribute to many cancers and other costly chronic diseases. Lifestyle change is thus vital to reduce cancer incidence, yet most attempts at lifestyle change fail. Understanding how positive emotions create non-conscious motives for long-term adherence to cancer-preventive behaviors is needed to unlock evidence-based health interventions to promote health and save money and lives.


Penalized Estimation and Forecasting of Multiple Subject Intensive Longitudinal Data.
Authors: Fisher Z.F. , Kim Y. , Fredrickson B.L. , Pipiras V. .
Source: Psychometrika, 2022 06; 87(2), p. 1-29.
EPub date: 2022-01-21.
PMID: 35060013
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A Square-Root Second-Order Extended Kalman Filtering Approach for Estimating Smoothly Time-Varying Parameters.
Authors: Fisher Z.F. , Chow S.M. , Molenaar P.C.M. , Fredrickson B.L. , Pipiras V. , Gates K.M. .
Source: Multivariate behavioral research, 2022 Jan-Feb; 57(1), p. 134-152.
EPub date: 2020-10-07.
PMID: 33025834
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More Than a Momentary Blip in the Universe? Investigating the Link Between Religiousness and Perceived Meaning in Life.
Authors: Prinzing M. , Van Cappellen P. , Fredrickson B.L. .
Source: Personality & social psychology bulletin, 2021-12-29; , p. 1461672211060136.
EPub date: 2021-12-29.
PMID: 34964385
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The Psychometric Properties of the Prioritizing Positivity Scale.
Authors: Catalino L.I. , Boulton A.J. .
Source: Journal of personality assessment, 2021 Sep-Oct; 103(5), p. 705-715.
EPub date: 2020-11-09.
PMID: 33166185
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Understanding Engagement in and Affective Experiences During Physical Activity: The Role of Meditation Interventions.
Authors: Don B.P. , Van Cappellen P. , Fredrickson B.L. .
Source: Psychosomatic medicine, 2021 Jul-Aug 01; 83(6), p. 592-601.
PMID: 34213861
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Specifying exogeneity and bilinear effects in data-driven model searches.
Authors: Arizmendi C. , Gates K. , Fredrickson B. , Wright A. .
Source: Behavior research methods, 2021 06; 53(3), p. 1276-1288.
PMID: 33037600
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Same-day, cross-day, and upward spiral relations between positive affect and positive health behaviours.
Authors: Fredrickson B.L. , Arizmendi C. , Van Cappellen P. .
Source: Psychology & health, 2021 04; 36(4), p. 444-460.
EPub date: 2020-06-13.
PMID: 32538212
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Perceived social integration predicts future physical activity through positive affect and spontaneous thoughts.
Authors: Rice E.L. , Adair K.C. , Tepper S.J. , Fredrickson B.L. .
Source: Emotion (Washington, D.C.), 2020 Sep; 20(6), p. 1074-1083.
EPub date: 2019-07-01.
PMID: 31259591
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Well-Being Correlates of Perceived Positivity Resonance: Evidence From Trait and Episode-Level Assessments.
Authors: Major B.C. , Le Nguyen K.D. , Lundberg K.B. , Fredrickson B.L. .
Source: Personality & social psychology bulletin, 2018 12; 44(12), p. 1631-1647.
EPub date: 2018-05-13.
PMID: 29756547
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Reflections on Positive Emotions and Upward Spirals.
Authors: Fredrickson B.L. , Joiner T. .
Source: Perspectives on psychological science : a journal of the Association for Psychological Science, 2018 03; 13(2), p. 194-199.
PMID: 29592643
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Evidence for the Upward Spiral Stands Steady: A Response to Nickerson (2018).
Authors: Fredrickson B.L. , Kok B.E. .
Source: Psychological science, 2018 03; 29(3), p. 467-470.
EPub date: 2018-01-24.
PMID: 29364775
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Positive affective processes underlie positive health behaviour change.
Authors: Van Cappellen P. , Rice E.L. , Catalino L.I. , Fredrickson B.L. .
Source: Psychology & health, 2018 01; 33(1), p. 77-97.
EPub date: 2017-05-12.
PMID: 28498722
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Positive Emotion Correlates of Meditation Practice: A Comparison of Mindfulness Meditation and Loving-kindness Meditation.
Authors: Fredrickson B.L. , Boulton A.J. , Firestine A.M. , Van Cappellen P. , Algoe S.B. , Brantley M.M. , Kim S.L. , Brantley J. , Salzberg S. .
Source: Mindfulness, 2017 Dec; 8(6), p. 1623-1633.
EPub date: 2017-05-29.
PMID: 29201247
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Being present and enjoying it: Dispositional mindfulness and savoring the moment are distinct, interactive predictors of positive emotions and psychological health.
Authors: Kiken L.G. , Lundberg K.B. , Fredrickson B.L. .
Source: Mindfulness, 2017 Oct; 8(5), p. 1280-1290.
EPub date: 2017-03-29.
PMID: 29312472
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Do positive spontaneous thoughts function as incentive salience?
Authors: Rice E.L. , Fredrickson B.L. .
Source: Emotion (Washington, D.C.), 2017 08; 17(5), p. 840-855.
EPub date: 2017-02-16.
PMID: 28206793
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Of passions and positive spontaneous thoughts.
Authors: Rice E.L. , Fredrickson B.L. .
Source: Cognitive therapy and research, 2017 Jun; 41(3), p. 350-361.
EPub date: 2016-02-03.
PMID: 35655861
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Common variant in OXTR predicts growth in positive emotions from loving-kindness training.
Authors: Isgett S.F. , Algoe S.B. , Boulton A.J. , Way B.M. , Fredrickson B.L. .
Source: Psychoneuroendocrinology, 2016 11; 73, p. 244-251.
EPub date: 2016-08-11.
PMID: 27543885
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Beyond emotional benefits: physical activity and sedentary behaviour affect psychosocial resources through emotions.
Authors: Hogan C.L. , Catalino L.I. , Mata J. , Fredrickson B.L. .
Source: Psychology & health, 2015; 30(3), p. 354-69.
EPub date: 2014-11-06.
PMID: 25307453
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Prioritizing positivity: an effective approach to pursuing happiness?
Authors: Catalino L.I. , Algoe S.B. , Fredrickson B.L. .
Source: Emotion (Washington, D.C.), 2014 Dec; 14(6), p. 1155-61.
PMID: 25401290
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Updated thinking on positivity ratios.
Authors: Fredrickson B.L. .
Source: The American psychologist, 2013 Dec; 68(9), p. 814-22.
EPub date: 2013-07-15.
PMID: 23855895
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