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Grant Details

Grant Number: 5U01CA155309-02 Interpret this number
Primary Investigator: Scelo, Ghislaine
Organization: International Agency For Res On Cancer
Project Title: Pooled Genome-Wide Analysis of Kidney Cancer Risk
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): Renal cell carcinoma (RCC) is the 8th most common cancer in the US and the 10th most common form of cancer death, with over 34,000 cases and 12,000 deaths each year. A sharp increase in the incidence of RCC was observed in recent decades with some of the greatest increases happening in Central Europe and among the black population in the US. Apart from smoking, obesity and hypertension, much of the etiology of this disease remains to be identified. There is increasing evidence that genetic factors influence susceptibility to RCC, although this hypothesis has been understudied. We have recently completed a genome-wide association study (GWAS) of RCC comprising 3,800 cases and 8,500 controls. We now propose to extend this study by incorporating an additional 3,800 cases and 4,800 controls from a series of population based case-control and cohort studies. Inclusion of cohort studies has been facilitated via the NCI cohort consortium initiative. In addition to its size, our study will be unique in several ways: (1) extensive clinicopathological information and survival of cases will be collected; (2) genome-wide analyses for the association between genetic variants and RCC will be conducted for both disease onset and survival; (3) a comprehensive biorepository of germline DNA and tumor DNA and RNA on at least 2,000 cases will be developed; (4) whole-genome gene expression profiling on fresh renal tissue and tumor tissue will be obtained to complement results obtained from the germline genotyping analyses.

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Publications

Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Authors: Scelo G. , Purdue M.P. , Brown K.M. , Johansson M. , Wang Z. , Eckel-Passow J.E. , Ye Y. , Hofmann J.N. , Choi J. , Foll M. , et al. .
Source: Nature Communications, 2017-06-09 00:00:00.0; 8, p. 15724.
EPub date: 2017-06-09 00:00:00.0.
PMID: 28598434
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A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus.
Authors: Mobuchon L. , Battistella A. , Bardel C. , Scelo G. , Renoud A. , Houy A. , Cassoux N. , Milder M. , Cancel-Tassin G. , Cussenot O. , et al. .
Source: Npj Genomic Medicine, 2017; 2, .
EPub date: 2017-03-10 00:00:00.0.
PMID: 28781888
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Aristolochic acid exposure in Romania and implications for renal cell carcinoma.
Authors: Turesky R.J. , Yun B.H. , Brennan P. , Mates D. , Jinga V. , Harnden P. , Banks R.E. , Blanche H. , Bihoreau M.T. , Chopard P. , et al. .
Source: British Journal Of Cancer, 2016-01-12 00:00:00.0; 114(1), p. 76-80.
EPub date: 2016-01-12 00:00:00.0.
PMID: 26657656
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Circulating 25-hydroxyvitamin D3 and survival after diagnosis with kidney cancer.
Authors: Muller D.C. , Scelo G. , Zaridze D. , Janout V. , Holcatova I. , Navratilova M. , Mates D. , Midttun . , Ueland P.M. , Brennan P. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Aug; 24(8), p. 1277-81.
PMID: 26021552
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Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study.
Authors: Muller D.C. , Johansson M. , Zaridze D. , Moukeria A. , Janout V. , Holcatova I. , Navratilova M. , Mates D. , Midttun . , Ueland P.M. , et al. .
Source: Plos One, 2015; 10(10), p. e0140677.
PMID: 26506437
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Integrative genome-wide gene expression profiling of clear cell renal cell carcinoma in Czech Republic and in the United States.
Authors: Wozniak M.B. , Le Calvez-Kelm F. , Abedi-Ardekani B. , Byrnes G. , Durand G. , Carreira C. , Michelon J. , Janout V. , Holcatova I. , Foretova L. , et al. .
Source: Plos One, 2013; 8(3), p. e57886.
PMID: 23526956
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