Grant Details
Grant Number: |
5R01CA126857-06 Interpret this number |
Primary Investigator: |
Kiecolt-Glaser, Janice |
Organization: |
Ohio State University |
Project Title: |
Breast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress |
Fiscal Year: |
2012 |
Abstract
DESCRIPTION (provided by applicant): Breast cancer survivors confront a number of post-treatment problems including fatigue, decreased physical function, fears of recurrence, and treatment-related sequelae. Persistent fatigue, the most common and distressing problem, appears to be related in part to overactivation of the inflammatory network. Higher levels of depressive symptoms can effectively prime the inflammatory response, promoting larger NF-kappa B and proinflammatory responses to stressors. Physical activity interventions that simultaneously enhance physical performance and reduce depressive symptoms can reduce fatigue-related symptoms, as well as inflammation. This project provides the opportunity to examine mechanistic connections among fatigue, stressors, depressive symptoms, and proinflammatory cytokines both cross-section ally and longitudinally in a randomized clinical trial, building on preliminary studies that have demonstrated anti-inflammatory changes associated with yoga. A total of 200 stage I, II, and Ilia breast cancer survivors will be recruited, ages 40 and older; the women will have completed cancer treatment within the past year (except for tarnoxifen/aromatase inhibitors), and will be at least two months post surgery or adjuvant therapy or radiation, whichever occurred last. All of the women will have received chemotherapy as part of their treatment. Using a block-randomized design, participants will be assigned to either a 1 2-week (twice-weekly) hatha yoga intervention or a delayed intervention arm that receives the yoga intervention after a 6-month observation period. Differences between the two arms will be assessed at 3 months (at the conclusion of the 12-week intervention), and at 6 months (3 months after the formal intervention), controlling for any baseline (pre-randomization) measures. NF-kappa B and proinflammatory cytokine responses to a laboratory stressor will be assessed at baseline and 3 months. AIMS: (1) The primary aim is to determine if the yoga intervention will decrease inflammation, fatigue, and depressive symptoms relative to the wait-list controls. Additional aims are (2) to ascertain the extent to which the intervention modulates psychological, behavioral, and physical functioning; (3) to evaluate the relationship between depressive symptoms and the magnitude of the physiological responses elicited by a laboratory stressor, as well as the relationship of both to fatigue; and (4) to assess the extent to which the yoga intervention wiII decrease physiological stress responses.
Publications
Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship.
Authors: Madison A.A.
, Andridge R.
, Kantaras A.H.
, Renna M.E.
, Bennett J.M.
, Alfano C.M.
, Povoski S.P.
, Agnese D.M.
, Lustberg M.
, Wesolowski R.
, et al.
.
Source: Cancers, 2023-09-04 00:00:00.0; 15(17), .
EPub date: 2023-09-04 00:00:00.0.
PMID: 37686689
Related Citations
Distress disorder histories predict HRV trajectories during and after stress.
Authors: Renna M.E.
, Shrout M.R.
, Madison A.A.
, Bennett J.M.
, Malarkey W.B.
, Emery C.F.
, Kiecolt-Glaser J.K.
.
Source: Psychoneuroendocrinology, 2022 01; 135, p. 105575.
EPub date: 2021-10-26 00:00:00.0.
PMID: 34741982
Related Citations
Frequent Interpersonal Stress and Inflammatory Reactivity Predict Depressive-Symptom Increases: Two Tests of the Social-Signal-Transduction Theory of Depression.
Authors: Madison A.A.
, Andridge R.
, Shrout M.R.
, Renna M.E.
, Bennett J.M.
, Jaremka L.M.
, Fagundes C.P.
, Belury M.A.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Psychological Science, 2022 01; 33(1), p. 152-164.
EPub date: 2021-12-21 00:00:00.0.
PMID: 34932407
Related Citations
Stress Reactivity: What Pushes Us Higher, Faster, and Longer - and Why It Matters.
Authors: Kiecolt-Glaser J.K.
, Renna M.E.
, Shrout M.R.
, Madison A.A.
.
Source: Current Directions In Psychological Science, 2020-10-01 00:00:00.0; 29(5), p. 492-498.
EPub date: 2020-09-09 00:00:00.0.
PMID: 33758478
Related Citations
Cognitive problems of breast cancer survivors on proton pump inhibitors.
Authors: Madison A.A.
, Woody A.
, Bailey B.
, Lustberg M.B.
, Ramaswamy B.
, Wesolowski R.
, Williams N.
, Reinbolt R.
, VanDeusen J.B.
, Sardesai S.
, et al.
.
Source: Journal Of Cancer Survivorship : Research And Practice, 2020 Apr; 14(2), p. 226-234.
EPub date: 2020-01-13 00:00:00.0.
PMID: 31933149
Related Citations
Marriage and Gut (Microbiome) Feelings: Tracing Novel Dyadic Pathways to Accelerated Aging.
Authors: Kiecolt-Glaser J.K.
, Wilson S.J.
, Madison A.
.
Source: Psychosomatic Medicine, 2018-10-10 00:00:00.0; , .
EPub date: 2018-10-10 00:00:00.0.
PMID: 30308579
Related Citations
Yoga And Self-reported Cognitive Problems In Breast Cancer Survivors: A Randomized Controlled Trial
Authors: Derry H.M.
, Jaremka L.M.
, Bennett J.M.
, Peng J.
, Andridge R.
, Shapiro C.
, Malarkey W.B.
, Emery C.F.
, Layman R.
, Mrozek E.
, et al.
.
Source: Psycho-oncology, 2015 Aug; 24(8), p. 958-66.
PMID: 25336068
Related Citations
Cognitive problems among breast cancer survivors: loneliness enhances risk.
Authors: Jaremka L.M.
, Peng J.
, Bornstein R.
, Alfano C.M.
, Andridge R.R.
, Povoski S.P.
, Lipari A.M.
, Agnese D.M.
, Farrar W.B.
, Yee L.D.
, et al.
.
Source: Psycho-oncology, 2014 Dec; 23(12), p. 1356-64.
PMID: 24729533
Related Citations
Omega-3 fatty acids and stress-induced immune dysregulation: implications for wound healing.
Authors: Kiecolt-Glaser J.K.
, Glaser R.
, Christian L.M.
.
Source: Military Medicine, 2014 Nov; 179(11 Suppl), p. 129-33.
PMID: 25373096
Related Citations
Attachment anxiety is related to Epstein-Barr virus latency.
Authors: Fagundes C.P.
, Jaremka L.M.
, Glaser R.
, Alfano C.M.
, Povoski S.P.
, Lipari A.M.
, Agnese D.M.
, Yee L.D.
, Carson W.E.
, Farrar W.B.
, et al.
.
Source: Brain, Behavior, And Immunity, 2014 Oct; 41, p. 232-8.
PMID: 24945717
Related Citations
Attachment style and respiratory sinus arrhythmia predict post-treatment quality of life in breast cancer survivors.
Authors: Fagundes C.P.
, Jaremka L.M.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Psycho-oncology, 2014 Jul; 23(7), p. 820-6.
PMID: 24532423
Related Citations
Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial.
Authors: Kiecolt-Glaser J.K.
, Bennett J.M.
, Andridge R.
, Peng J.
, Shapiro C.L.
, Malarkey W.B.
, Emery C.F.
, Layman R.
, Mrozek E.E.
, Glaser R.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2014-04-01 00:00:00.0; 32(10), p. 1040-9.
EPub date: 2014-04-01 00:00:00.0.
PMID: 24470004
Related Citations
Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients.
Authors: Lindgren M.E.
, Fagundes C.P.
, Alfano C.M.
, Povoski S.P.
, Agnese D.M.
, Arnold M.W.
, Farrar W.B.
, Yee L.D.
, Carson W.E.
, Schmidt C.R.
, et al.
.
Source: Psycho-oncology, 2013 Aug; 22(8), p. 1889-94.
PMID: 23255459
Related Citations
Loneliness Predicts Pain, Depression, And Fatigue: Understanding The Role Of Immune Dysregulation
Authors: Jaremka L.M.
, Fagundes C.P.
, Glaser R.
, Bennett J.M.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Psychoneuroendocrinology, 2013 Aug; 38(8), p. 1310-7.
PMID: 23273678
Related Citations
Depressive symptoms enhance stress-induced inflammatory responses.
Authors: Fagundes C.P.
, Glaser R.
, Hwang B.S.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Brain, Behavior, And Immunity, 2013 Jul; 31, p. 172-6.
PMID: 22634107
Related Citations
Loneliness promotes inflammation during acute stress.
Authors: Jaremka L.M.
, Fagundes C.P.
, Peng J.
, Bennett J.M.
, Glaser R.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Psychological Science, 2013-07-01 00:00:00.0; 24(7), p. 1089-97.
EPub date: 2013-07-01 00:00:00.0.
PMID: 23630220
Related Citations
Synergistic relationships among stress, depression, and troubled relationships: insights from psychoneuroimmunology.
Authors: Jaremka L.M.
, Lindgren M.E.
, Kiecolt-Glaser J.K.
.
Source: Depression And Anxiety, 2013 Apr; 30(4), p. 288-96.
PMID: 23412999
Related Citations
Childhood adversity and herpesvirus latency in breast cancer survivors.
Authors: Fagundes C.P.
, Glaser R.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2013 Mar; 32(3), p. 337-44.
PMID: 22746260
Related Citations
Long lasting effects of smoking: breast cancer survivors' inflammatory responses to acute stress differ by smoking history.
Authors: Bennett J.M.
, Glaser R.
, Andridge R.R.
, Peng J.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Psychoneuroendocrinology, 2013 Feb; 38(2), p. 179-87.
PMID: 22727479
Related Citations
Stressful early life experiences and immune dysregulation across the lifespan.
Authors: Fagundes C.P.
, Glaser R.
, Kiecolt-Glaser J.K.
.
Source: Brain, Behavior, And Immunity, 2013 Jan; 27(1), p. 8-12.
PMID: 22771426
Related Citations
Adiponectin, Leptin, And Yoga Practice
Authors: Kiecolt-Glaser J.K.
, Christian L.M.
, Andridge R.
, Hwang B.S.
, Malarkey W.B.
, Belury M.A.
, Emery C.F.
, Glaser R.
.
Source: Physiology & Behavior, 2012-12-05 00:00:00.0; 107(5), p. 809-13.
PMID: 22306535
Related Citations
Inflammation and reactivation of latent herpesviruses in older adults.
Authors: Bennett J.M.
, Glaser R.
, Malarkey W.B.
, Beversdorf D.Q.
, Peng J.
, Kiecolt-Glaser J.K.
.
Source: Brain, Behavior, And Immunity, 2012 Jul; 26(5), p. 739-46.
PMID: 22155500
Related Citations
The impact of psychological stress on wound healing: methods and mechanisms.
Authors: Gouin J.P.
, Kiecolt-Glaser J.K.
.
Source: Critical Care Nursing Clinics Of North America, 2012 Jun; 24(2), p. 201-13.
PMID: 22548859
Related Citations
Child maltreatment and breast cancer survivors: social support makes a difference for quality of life, fatigue and cancer stress.
Authors: Fagundes C.P.
, Lindgren M.E.
, Shapiro C.L.
, Kiecolt-Glaser J.K.
.
Source: European Journal Of Cancer (oxford, England : 1990), 2012 Mar; 48(5), p. 728-36.
PMID: 21752636
Related Citations
Fatigue and herpesvirus latency in women newly diagnosed with breast cancer.
Authors: Fagundes C.P.
, Glaser R.
, Alfano C.M.
, Bennett J.M.
, Povoski S.P.
, Lipari A.M.
, Agnese D.M.
, Yee L.D.
, Carson W.E.
, Farrar W.B.
, et al.
.
Source: Brain, Behavior, And Immunity, 2012 Mar; 26(3), p. 394-400.
PMID: 21988771
Related Citations
Social support and socioeconomic status interact to predict Epstein-Barr virus latency in women awaiting diagnosis or newly diagnosed with breast cancer.
Authors: Fagundes C.P.
, Bennett J.M.
, Alfano C.M.
, Glaser R.
, Povoski S.P.
, Lipari A.M.
, Agnese D.M.
, Yee L.D.
, Carson W.E.
, Farrar W.B.
, et al.
.
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2012 Jan; 31(1), p. 11-9.
PMID: 22004465
Related Citations
Relationships and Inflammation across the Lifespan: Social Developmental Pathways to Disease.
Authors: Fagundes C.P.
, Bennett J.M.
, Derry H.M.
, Kiecolt-Glaser J.K.
.
Source: Social And Personality Psychology Compass, 2011 Nov; 5(11), p. 891-903.
PMID: 22125580
Related Citations
ß-Blockers and survival among Danish patients with malignant melanoma: a population-based cohort study.
Authors: Lemeshow S.
, Sørensen H.T.
, Phillips G.
, Yang E.V.
, Antonsen S.
, Riis A.H.
, Lesinski G.B.
, Jackson R.
, Glaser R.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2011 Oct; 20(10), p. 2273-9.
PMID: 21933972
Related Citations
Sympathetic and parasympathetic activity in cancer-related fatigue: more evidence for a physiological substrate in cancer survivors.
Authors: Fagundes C.P.
, Murray D.M.
, Hwang B.S.
, Gouin J.P.
, Thayer J.F.
, Sollers J.J.
, Shapiro C.L.
, Malarkey W.B.
, Kiecolt-Glaser J.K.
.
Source: Psychoneuroendocrinology, 2011 Sep; 36(8), p. 1137-47.
PMID: 21388744
Related Citations
The impact of psychological stress on wound healing: methods and mechanisms.
Authors: Gouin J.P.
, Kiecolt-Glaser J.K.
.
Source: Immunology And Allergy Clinics Of North America, 2011 Feb; 31(1), p. 81-93.
PMID: 21094925
Related Citations
Close relationships, inflammation, and health.
Authors: Kiecolt-Glaser J.K.
, Gouin J.P.
, Hantsoo L.
.
Source: Neuroscience And Biobehavioral Reviews, 2010 Sep; 35(1), p. 33-8.
PMID: 19751761
Related Citations
Psychological stress, telomeres, and telomerase.
Authors: Kiecolt-Glaser J.K.
, Glaser R.
.
Source: Brain, Behavior, And Immunity, 2010 May; 24(4), p. 529-30.
PMID: 20167271
Related Citations
Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge.
Authors: Kiecolt-Glaser J.K.
.
Source: Psychosomatic Medicine, 2010 May; 72(4), p. 365-9.
PMID: 20410248
Related Citations
Psychoneuroimmunology: Psychology's Gateway to the Biomedical Future.
Authors: Kiecolt-Glaser J.K.
.
Source: Perspectives On Psychological Science : A Journal Of The Association For Psychological Science, 2009 Jul; 4(4), p. 367-9.
PMID: 19750133
Related Citations
Immune Dysregulation And Chronic Stress Among Older Adults: A Review
Authors: Gouin J.P.
, Hantsoo L.
, Kiecolt-Glaser J.K.
.
Source: Neuroimmunomodulation, 2008; 15(4-6), p. 251-9.
PMID: 19047802
Related Citations