Grant Details
Grant Number: |
1R01CA160427-01A1 Interpret this number |
Primary Investigator: |
Bower, Julienne |
Organization: |
University Of California Los Angeles |
Project Title: |
Biobehavioral Predictors of Fatigue in Newly-Diagnosed Breast Cancer Patients |
Fiscal Year: |
2012 |
Abstract
DESCRIPTION (provided by applicant): Fatigue is one of the most common and distressing side effects of breast cancer treatment and may persist for months or years after successful treatment completion. Approximately one-third of breast cancer survivors report moderate to severe symptoms of fatigue, which has a negative impact on all aspects of quality of life. Although the prevalence and impact of cancer-related fatigue has now been well established, very little is known about predictors and mechanisms for the development and persistence of fatigue post-treatment. Accordingly, the primary goal of this prospective, longitudinal study is to identify biological and psychological risk factors for post-treatment fatigue, with intensive evaluation of mechanisms, in women newly diagnosed with early stage breast cancer. In particular, this application focuses on vulnerability factors that increase risk for inflammatory processes given evidence suggesting an inflammatory basis for cancer-related fatigue. Specific aims are to: 1) determine whether inflammatory risk genes, hypothalamic-pituitary-adrenal axis dysregulation, and body mass index at treatment onset predict post-treatment fatigue in breast cancer patients assessed longitudinally for 18 months after treatment completion; 2) evaluate whether history of depression and early life stress at treatment onset predict post-treatment fatigue in breast cancer patients assessed longitudinally for 18 months after treatment onset; 3) investigate the contribution of measured proinflammatory cytokine activity to the association between biological and psychological risk factors and post-treatment fatigue. We will recruit 360 women with newly-diagnosed, early-stage breast cancer before initiation of treatment with radiation, chemotherapy, trastuzumab or endocrine therapy. At baseline, participants will complete self-report questionnaires, diagnostic interview for depression, blood draw for cytokine gene polymorphisms and markers of inflammation, and saliva samples for diurnal cortisol slope. Follow-up assessments conducted at treatment completion and at 6, 12, and 18 months post-treatment will determine the trajectory of post-treatment fatigue and associated changes in inflammatory processes. This research is a critical next step in the early identification of patients who are at risk for persistent fatigue as a long term side effect of cancer treatment and for the development and implementation of targeted interventions to prevent and treat this disabling symptom.
PUBLIC HEALTH RELEVANCE: With advances in detection and treatment, the number of women who survive breast cancer has increased significantly in recent years. Many of these women will experience persistent, debilitating fatigue after completing cancer treatment. This research will identify risk factors for post-treatment fatigue and illuminate the biological underpinnings of this symptom, facilitating the early identification of vulnerable patients and the development and implementation of targeted therapies.
Publications
Type I interferons, inflammation, and fatigue in a longitudinal RNA study of women with breast cancer.
Authors: Bower J.E.
, Ganz P.A.
, Irwin M.R.
, Crespi C.M.
, Petersen L.
, Asher A.
, Hurvitz S.A.
, Cole S.W.
.
Source: Brain, Behavior, And Immunity, 2024 May; 118, p. 312-317.
EPub date: 2024-02-05 00:00:00.0.
PMID: 38325563
Related Citations
Acute health-related quality of life outcomes and systemic inflammatory markers following contemporary breast cancer surgery.
Authors: Radin A.S.
, Bower J.E.
, Irwin M.R.
, Asher A.
, Hurvitz S.A.
, Cole S.W.
, Crespi C.M.
, Ganz P.A.
.
Source: Npj Breast Cancer, 2022-08-08 00:00:00.0; 8(1), p. 91.
EPub date: 2022-08-08 00:00:00.0.
PMID: 35941136
Related Citations
Younger women are more susceptible to inflammation: A longitudinal examination of the role of aging in inflammation and depressive symptoms.
Authors: Kuhlman K.R.
, Irwin M.R.
, Ganz P.A.
, Cole S.W.
, Manigault A.W.
, Crespi C.M.
, Bower J.E.
.
Source: Journal Of Affective Disorders, 2022-08-01 00:00:00.0; 310, p. 328-336.
EPub date: 2022-05-11 00:00:00.0.
PMID: 35561889
Related Citations
Psychosocial Resilience to Inflammation-Associated Depression: A Prospective Study of Breast-Cancer Survivors.
Authors: Manigault A.W.
, Kuhlman K.R.
, Irwin M.R.
, Cole S.W.
, Ganz P.A.
, Crespi C.M.
, Bower J.E.
.
Source: Psychological Science, 2022 08; 33(8), p. 1328-1339.
EPub date: 2022-08-05 00:00:00.0.
PMID: 35930691
Related Citations
Acute and Chronic Effects of Adjuvant Therapy on Inflammatory Markers in Breast Cancer Patients.
Authors: Bower J.E.
, Ganz P.A.
, Irwin M.R.
, Cole S.W.
, Carroll J.
, Kuhlman K.R.
, Petersen L.
, Garet D.
, Asher A.
, Hurvitz S.A.
, et al.
.
Source: Jnci Cancer Spectrum, 2022-07-01 00:00:00.0; 6(4), .
PMID: 35900175
Related Citations
Socioeconomic Status and Inflammation in Women with Early-stage Breast Cancer: Mediation by Body Mass Index.
Authors: Pageot Y.K.
, Stanton A.L.
, Ganz P.A.
, Irwin M.R.
, Cole S.W.
, Crespi C.M.
, Breen E.C.
, Kuhlman K.R.
, Bower J.E.
.
Source: Brain, Behavior, And Immunity, 2022 01; 99, p. 307-316.
EPub date: 2021-10-18 00:00:00.0.
PMID: 34673177
Related Citations
Vulnerability to inflammation-related depressive symptoms: Moderation by stress in women with breast cancer.
Authors: Manigault A.W.
, Kuhlman K.R.
, Irwin M.R.
, Cole S.W.
, Ganz P.A.
, Crespi C.M.
, Bower J.E.
.
Source: Brain, Behavior, And Immunity, 2021 May; 94, p. 71-78.
EPub date: 2021-03-09 00:00:00.0.
PMID: 33705868
Related Citations
Do all patients with cancer experience fatigue? a longitudinal study of fatigue trajectories in women with breast cancer.
Authors: Bower J.E.
, Ganz P.A.
, Irwin M.R.
, Cole S.W.
, Garet D.
, Petersen L.
, Asher A.
, Hurvitz S.A.
, Crespi C.M.
.
Source: Cancer, 2021-02-19 00:00:00.0; , .
EPub date: 2021-02-19 00:00:00.0.
PMID: 33606273
Related Citations
Childhood maltreatment and monocyte gene expression among women with breast cancer.
Authors: Bower J.E.
, Kuhlman K.R.
, Ganz P.A.
, Irwin M.R.
, Crespi C.M.
, Cole S.W.
.
Source: Brain, Behavior, And Immunity, 2020 08; 88, p. 396-402.
EPub date: 2020-04-02 00:00:00.0.
PMID: 32247915
Related Citations
The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients.
Authors: Sehl M.E.
, Carroll J.E.
, Horvath S.
, Bower J.E.
.
Source: Npj Breast Cancer, 2020; 6, p. 23.
EPub date: 2020-06-12 00:00:00.0.
PMID: 32566744
Related Citations
Cultivating a healthy neuro-immune network: A health psychology approach.
Authors: Bower J.E.
, Kuhlman K.R.
, Haydon M.D.
, Boyle C.C.
, Radin A.
.
Source: Social And Personality Psychology Compass, 2019 Sep; 13(9), .
EPub date: 2019-09-09 00:00:00.0.
PMID: 37008404
Related Citations
Inflammation and dimensions of reward processing following exposure to the influenza vaccine.
Authors: Boyle C.C.
, Kuhlman K.R.
, Dooley L.N.
, Haydon M.D.
, Robles T.F.
, Ang Y.S.
, Pizzagalli D.A.
, Bower J.E.
.
Source: Psychoneuroendocrinology, 2019 Apr; 102, p. 16-23.
EPub date: 2018-11-20 00:00:00.0.
PMID: 30496908
Related Citations
Testing a biobehavioral model of fatigue before adjuvant therapy in women with breast cancer.
Authors: Bower J.E.
, Asher A.
, Garet D.
, Petersen L.
, Ganz P.A.
, Irwin M.R.
, Cole S.W.
, Hurvitz S.A.
, Crespi C.M.
.
Source: Cancer, 2019-02-15 00:00:00.0; 125(4), p. 633-641.
EPub date: 2018-12-18 00:00:00.0.
PMID: 30561795
Related Citations
Communicating Risks of Adjuvant Chemotherapy for Breast Cancer: Getting Beyond the Laundry List.
Authors: Brauer E.R.
, Long E.F.
, Melnikow J.
, Ravdin P.M.
, Ganz P.A.
.
Source: Journal Of Oncology Practice, 2019 Feb; 15(2), p. e98-e109.
EPub date: 2018-12-14 00:00:00.0.
PMID: 30550372
Related Citations
The role of neuro-immune interactions in cancer-related fatigue: Biobehavioral risk factors and mechanisms.
Authors: Bower J.E.
.
Source: Cancer, 2019-02-01 00:00:00.0; 125(3), p. 353-364.
EPub date: 2019-01-02 00:00:00.0.
PMID: 30602059
Related Citations
Prometastatic Molecular Profiles in Breast Tumors From Socially Isolated Women.
Authors: Bower J.E.
, Shiao S.L.
, Sullivan P.
, Lamkin D.M.
, Atienza R.
, Mercado F.
, Arevalo J.
, Asher A.
, Ganz P.A.
, Cole S.W.
.
Source: Jnci Cancer Spectrum, 2018 Jul; 2(3), p. pky029.
EPub date: 2018-07-19 00:00:00.0.
PMID: 30057973
Related Citations
Childhood maltreatment, psychological resources, and depressive symptoms in women with breast cancer.
Authors: Kuhlman K.R.
, Boyle C.C.
, Irwin M.R.
, Ganz P.A.
, Crespi C.M.
, Asher A.
, Petersen L.
, Bower J.E.
.
Source: Child Abuse & Neglect, 2017-09-07 00:00:00.0; 72, p. 360-369.
EPub date: 2017-09-07 00:00:00.0.
PMID: 28888809
Related Citations
Cortisol Awakening Response as a Prospective Risk Factor for Depressive Symptoms in Women After Treatment for Breast Cancer.
Authors: Kuhlman K.R.
, Irwin M.R.
, Ganz P.A.
, Crespi C.M.
, Petersen L.
, Asher A.
, Bower J.E.
.
Source: Psychosomatic Medicine, 2017 Sep; 79(7), p. 763-769.
PMID: 28570439
Related Citations
Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer.
Authors: Dooley L.N.
, Ganz P.A.
, Cole S.W.
, Crespi C.M.
, Bower J.E.
.
Source: Journal Of Affective Disorders, 2016 Jun; 197, p. 43-50.
PMID: 26967918
Related Citations
Mind-body therapies and control of inflammatory biology: A descriptive review.
Authors: Bower J.E.
, Irwin M.R.
.
Source: Brain, Behavior, And Immunity, 2016 Jan; 51, p. 1-11.
PMID: 26116436
Related Citations
Cancer-related fatigue--mechanisms, risk factors, and treatments.
Authors: Bower J.E.
.
Source: Nature Reviews. Clinical Oncology, 2014 Oct; 11(10), p. 597-609.
PMID: 25113839
Related Citations
Low heart rate variability and cancer-related fatigue in breast cancer survivors.
Authors: Crosswell A.D.
, Lockwood K.G.
, Ganz P.A.
, Bower J.E.
.
Source: Psychoneuroendocrinology, 2014 Jul; 45, p. 58-66.
PMID: 24845177
Related Citations
Childhood Adversity and Cumulative Life Stress: Risk Factors for Cancer-Related Fatigue.
Authors: Bower J.E.
, Crosswell A.D.
, Slavich G.M.
.
Source: Clinical Psychological Science : A Journal Of The Association For Psychological Science, 2014 Jan; 2(1), .
PMID: 24377083
Related Citations
Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications.
Authors: Bower J.E.
, Lamkin D.M.
.
Source: Brain, Behavior, And Immunity, 2013 Mar; 30 Suppl, p. S48-57.
PMID: 22776268
Related Citations