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Grant Details

Grant Number: 5R01CA129091-06 Interpret this number
Primary Investigator: Houston, Thomas
Organization: Univ Of Massachusetts Med Sch Worcester
Project Title: QUIT-PRIMO:WEB-DELIVERED Clinical Microsystem Intervention for Tobacco Control
Fiscal Year: 2012


DESCRIPTION (provided by applicant): This is our first resubmission of a randomized trial of QUIT-PRIMO Quality Improvement in Tobacco - Provider Referrals & Internet-delivered Microsystem Optimization in response to PA-06-226 Information Technologies and the Internet in Health Services and Intervention Delivery. Our Overall Goal is to advance science related to the use and impact of the Internet in health services delivery, specifically smoking cessation, by targeting primary care clinical microsystems. A clinical microsystem is defined as the smallest functional healthcare unit. A clinical microsystem is not simply equivalent to a clinical team doctors and nurses, but also includes the panel of patients cared for by the providers and the processes of care that are used. The Institute for Healthcare Improvement (IHI) states interventions targeted to clinical microsystems are a crucial component in improving health care quality. We have the following Specific AIMS: Aim 1. Randomize 160 community- based primary care microsystems into a trial comparing the QUIT-PRIMO with a paper- based information prescription; Aim 2. Evaluate the impact of QUIT-PRIMO on referral rates using patient-reported measures; Aim 3. Evaluate the impact of QUIT- PRIMO on six-month smoking cessation of primary care patients. The QUIT-PRIIMO Intervention is a multi-component Internet-delivered clinical microsystem intervention with: 1. Refer2Quit A point-of-care patient referral portal providers can use to enroll patients into a self-management system, with summary reports of provider and patient activity, and secure messaging templates providers can use to efficiently encourage patients to quit during follow-up; AND 2. Decide2Quit A patient self-management portal organizing interactive, tailored, patient education, cessation planning, links to other high-quality web ( and offline resources (1-800-QUIT-NOW), and secure messaging patients can use. The Control is a paper-based information prescription providers print to refer patients to a previously developed patient self-management website not linked into the clinical microsystem. The significance of the proposed study is that it will be the first Internet-delivered Intervention targeted to the clinical microsystem with the specific purpose of increasing smoking cessation. Our intervention is also unique among web resources for smoking cessation because a major goal is to enhance follow-up and increase treatment-seeking. QUIT-PRIMO builds upon our previous NCI-funded R21 (Ford, PI), where we our control self-management system for this study.


Exploring Online Asynchronous Counseling With Tobacco Treatment Specialists in the QUIT-PRIMO and National Dental PBRN HI-QUIT Studies: Who Uses It and What Do They Say?
Authors: Williams J.H. , DeLaughter K. , Volkman J.E. , Sadasivam R.S. , Ray M.N. , Gilbert G.H. , Houston T.K. , QUIT-PRIMO and National Dental PBRN Collaborative Groups .
Source: American journal of health promotion : AJHP, 2018 Jun; 32(5), p. 1170-1177.
EPub date: 2016-10-10.
PMID: 29848011
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Online tobacco websites and online communities-who uses them and do users quit smoking? The quit-primo and national dental practice-based research network Hi-Quit studies.
Authors: Cutrona S.L. , Sadasivam R.S. , DeLaughter K. , Kamberi A. , Volkman J.E. , Cobb N. , Gilbert G.H. , Ray M.N. , Houston T.K. , National Dental PBRN Collaborative Group comprises practitioners, faculty and staff who contributed to this activity. A list of these persons is at .
Source: Translational behavioral medicine, 2016 Dec; 6(4), p. 546-557.
PMID: 27379777
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Impact of a Collective Intelligence Tailored Messaging System on Smoking Cessation: The Perspect Randomized Experiment.
Authors: Sadasivam R.S. , Borglund E.M. , Adams R. , Marlin B.M. , Houston T.K. .
Source: Journal of medical Internet research, 2016-11-08; 18(11), p. e285.
EPub date: 2016-11-08.
PMID: 27826134
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Crave-Out: A Distraction/Motivation Mobile Game to Assist in Smoking Cessation.
Authors: DeLaughter K.L. , Sadasivam R.S. , Kamberi A. , English T.M. , Seward G.L. , Chan S.W. , Volkman J.E. , Amante D.J. , Houston T.K. .
Source: JMIR serious games, 2016-05-26; 4(1), p. e3.
EPub date: 2016-05-26.
PMID: 27229772
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Collective-Intelligence Recommender Systems: Advancing Computer Tailoring for Health Behavior Change Into the 21st Century.
Authors: Sadasivam R.S. , Cutrona S.L. , Kinney R.L. , Marlin B.M. , Mazor K.M. , Lemon S.C. , Houston T.K. .
Source: Journal of medical Internet research, 2016-03-07; 18(3), p. e42.
EPub date: 2016-03-07.
PMID: 26952574
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Evaluating the QUIT-PRIMO clinical practice ePortal to increase smoker engagement with online cessation interventions: a national hybrid type 2 implementation study.
Authors: Houston T.K. , Sadasivam R.S. , Allison J.J. , Ash A.S. , Ray M.N. , English T.M. , Hogan T.P. , Ford D.E. .
Source: Implementation science : IS, 2015-11-02; 10, p. 154.
EPub date: 2015-11-02.
PMID: 26525410
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An observational study of social and emotional support in smoking cessation Twitter accounts: content analysis of tweets.
Authors: Rocheleau M. , Sadasivam R.S. , Baquis K. , Stahl H. , Kinney R.L. , Pagoto S.L. , Houston T.K. .
Source: Journal of medical Internet research, 2015-01-14; 17(1), p. e18.
EPub date: 2015-01-14.
PMID: 25589009
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Quitters referring smokers: a quitline chain-referral pilot study.
Authors: DeLaughter K.L. , Volkman J.E. , Phillips B.D. , Houston T.K. .
Source: BMC research notes, 2014-05-05; 7, p. 282.
EPub date: 2014-05-05.
PMID: 24886693
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Implementing point of care "e-referrals" in 137 clinics to increase access to a quit smoking internet system: the Quit-Primo and National Dental PBRN HI-QUIT Studies.
Authors: Sadasivam R.S. , Hogan T.P. , Volkman J.E. , Smith B.M. , Coley H.L. , Williams J.H. , Delaughter K. , Ray M.N. , Gilbert G.H. , Ford D.E. , et al. .
Source: Translational behavioral medicine, 2013 Dec; 3(4), p. 370-8.
PMID: 24294325
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Crowdsourced peer- versus expert-written smoking-cessation messages.
Authors: Coley H.L. , Sadasivam R.S. , Williams J.H. , Volkman J.E. , Schoenberger Y.M. , Kohler C.L. , Sobko H. , Ray M.N. , Allison J.J. , Ford D.E. , et al. .
Source: American journal of preventive medicine, 2013 Nov; 45(5), p. 543-50.
PMID: 24139766
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Who participates in Web-assisted tobacco interventions? The QUIT-PRIMO and National Dental Practice-Based Research Network Hi-Quit studies.
Authors: Sadasivam R.S. , Kinney R.L. , Delaughter K. , Rao S.R. , Williams J.H. , Coley H.L. , Ray M.N. , Gilbert G.H. , Allison J.J. , Ford D.E. , et al. .
Source: Journal of medical Internet research, 2013-05-01; 15(5), p. e77.
EPub date: 2013-05-01.
PMID: 23635417
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Web-based smoking cessation intervention that transitions from inpatient to outpatient: study protocol for a randomized controlled trial.
Authors: Harrington K.F. , McDougal J.A. , Pisu M. , Zhang B. , Sadasivam R.S. , Houston T.K. , Bailey W.C. , CHART Collaborative Group .
Source: Trials, 2012-08-01; 13, p. 123.
EPub date: 2012-08-01.
PMID: 22852802
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Using a resource effect study pre-pilot to inform a large randomized trial: the Decide2Quit.Org Web-assisted tobacco intervention.
Authors: Sadasivam R.S. , Allison J.J. , Ray M.N. , Ford D.E. , Houston T.K. .
Source: AMIA ... Annual Symposium proceedings. AMIA Symposium, 2012; 2012, p. 789-98.
EPub date: 2012-11-03.
PMID: 23304353
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Development of an interactive, Web-delivered system to increase provider-patient engagement in smoking cessation.
Authors: Sadasivam R.S. , Delaughter K. , Crenshaw K. , Sobko H.J. , Williams J.H. , Coley H.L. , Ray M.N. , Ford D.E. , Allison J.J. , Houston T.K. .
Source: Journal of medical Internet research, 2011-10-18; 13(4), p. e87.
EPub date: 2011-10-18.
PMID: 22011394
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