Grant Number:	2U01CA118444-06 Interpret this number
Primary Investigator:	Slager, Susan
Organization:	Mayo Clinic Rochester
Project Title:	Genetic Epidemiology of Chronic Lymphocytic Leukemia
Fiscal Year:	2011

DESCRIPTION (provided by applicant): Chronic lymphocytic leukemia (CLL) is an incurable neoplasm of the blood and is one of the most common B-cell malignancies in Caucasians in the United States. It has a strong genetic contribution to etiology, with one of the highest familial risks of disease among cancers. During the initial funding period, we have made substantial contributions to the genetic etiology of CLL through genome-wide association (GWA) studies and linkage studies. We have identified and confirmed susceptibility loci of CLL in the IRF8 gene on chromosome 16q24.1, as well as within the HLA region on chromosome 6p21.3. We also replicated previous GWA findings, including those within the IRF4 gene. One striking feature of our work and others is that several of the GWA findings appear to act in determining B-cell development (e.g., IRF4./IRF8). Further, our finding within the HLA region was only observed in our homogenous sample of familial CLL cases. In this renewal application, we take our GWA findings to the next step to further refine the location of the associated signals and to expand upon IRF4/IRF8 findings. Specifically, we propose to (Aim1) identify and validate new genetic variants of CLL risk by comprehensively genotyping genetic variants in genes related to IRF4/IRF8 genes. (Aim 2) to characterize our IRF8 region located on chromosome 16q24.1 through targeted deep sequencing and validation in larger sample of CLL cases and controls. (Aim 3) to characterize our HLA region located on chromosome 6p21.3 in discovery and validation samples of familial CLL cases and controls. We will carry-out our Aims using our unique ongoing resource of high-risk CLL pedigrees that are collected through the Genetic Epidemiology of CLL (GEC) Consortium led by Drs. Slager and Caporaso, as well as the Mayo Clinic CLL case-control study, Mayo Clinic Biobank, and the InterLymph Consortium. Our proposed application is the logical next step following a GWA study, and given our preliminary data, it has a high probability of success. We have a strong collaborative multicenter, multidisciplinary team of investigators who have the combined expertise to successfully carry out the Aims of this proposal. At the completion of this project, we expect to identify additional novel loci influencing CLL risk that could not have been identified through GWA studies. We will also provide a more thorough evaluation of our GWA loci in order to further refine the location of the associated signal. Collectively, our findings will provide for a better understanding of CLL pathobiology and may lead to novel therapeutic approaches to treating CLL and improve our counseling to relatives of CLL patients. PUBLIC HEALTH RELEVANCE: Genes for Chronic Lymphocytic Leukemia (CLL) predispose men and women to increased risk of CLL. Identifying and understanding these genes will inform our limited biology of CLL, as well as improve risk prediction and stratification, and may enable identification of patients who will benefit from early prevention strategies.




The inherited genetic contribution and polygenic risk score for risk of CLL and MBL: a narrative review.
Authors: Kleinstern G. , Slager S.L. .
Source: Leukemia & Lymphoma, 2022-12-28 00:00:00.0; , p. 1-11.
EPub date: 2022-12-28 00:00:00.0.
PMID: 36576061
Related Citations

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.
Authors: Berndt S.I. , Vijai J. , Benavente Y. , Camp N.J. , Nieters A. , Wang Z. , Smedby K.E. , Kleinstern G. , Hjalgrim H. , Besson C. , et al. .
Source: Leukemia, 2022-10-22 00:00:00.0; , .
EPub date: 2022-10-22 00:00:00.0.
PMID: 36273105
Related Citations

Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families.
Authors: Slager S.L. , Lanasa M.C. , Marti G.E. , Achenbach S.J. , Camp N.J. , Abbasi F. , Kay N.E. , Vachon C.M. , Cerhan J.R. , Johnston J.B. , et al. .
Source: Blood, 2021-04-15 00:00:00.0; 137(15), p. 2046-2056.
PMID: 33512457
Related Citations

Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
Authors: Moore A. , Machiela M.J. , Machado M. , Wang S.S. , Kane E. , Slager S.L. , Zhou W. , Carrington M. , Lan Q. , Milne R.L. , et al. .
Source: Journal Of Translational Genetics And Genomics, 2021; 5, p. 200-217.
EPub date: 2021-06-17 00:00:00.0.
PMID: 34622145
Related Citations

Lipid Trait Variants and the Risk of Non-Hodgkin Lymphoma Subtypes: A Mendelian Randomization Study.
Authors: Kleinstern G. , Camp N.J. , Berndt S.I. , Birmann B.M. , Nieters A. , Bracci P.M. , McKay J.D. , Ghesquières H. , Lan Q. , Hjalgrim H. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020 May; 29(5), p. 1074-1078.
EPub date: 2020-02-27 00:00:00.0.
PMID: 32108027
Related Citations

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
Authors: Din L. , Sheikh M. , Kosaraju N. , Smedby K.E. , Bernatsky S. , Berndt S.I. , Skibola C.F. , Nieters A. , Wang S. , McKay J.D. , et al. .
Source: Genetic Epidemiology, 2019-08-13 00:00:00.0; , .
EPub date: 2019-08-13 00:00:00.0.
PMID: 31407831
Related Citations

Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
Authors: Clay-Gilmour A.I. , Rishi A.R. , Goldin L.R. , Greenberg-Worisek A.J. , Achenbach S.J. , Rabe K.G. , Maurer M.J. , Kay N.E. , Shanafelt T.D. , Call T.G. , et al. .
Source: Blood Cancer Journal, 2019-08-05 00:00:00.0; 9(8), p. 59.
EPub date: 2019-08-05 00:00:00.0.
PMID: 31383849
Related Citations

Identification of factors associated with duplicate rate in ChIP-seq data.
Authors: Tian S. , Peng S. , Kalmbach M. , Gaonkar K.S. , Bhagwate A. , Ding W. , Eckel-Passow J. , Yan H. , Slager S.L. .
Source: Plos One, 2019; 14(4), p. e0214723.
EPub date: 2019-04-03 00:00:00.0.
PMID: 30943272
Related Citations

Comparative analysis of de novo assemblers for variation discovery in personal genomes.
Authors: Tian S. , Yan H. , Klee E.W. , Kalmbach M. , Slager S.L. .
Source: Briefings In Bioinformatics, 2018-09-28 00:00:00.0; 19(5), p. 893-904.
PMID: 28407084
Related Citations

HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes.
Authors: Wang S.S. , Carrington M. , Berndt S.I. , Slager S.L. , Bracci P.M. , Voutsinas J. , Cerhan J.R. , Smedby K.E. , Hjalgrim H. , Vijai J. , et al. .
Source: Cancer Research, 2018-07-15 00:00:00.0; 78(14), p. 4086-4096.
EPub date: 2018-05-07 00:00:00.0.
PMID: 29735552
Related Citations

Combined somatic mutation and copy number analysis in the survival of familial CLL.
Authors: Zhou W. , Goldin L. , Wang M. , McMaster M.L. , Jones K. , Burdett L. , Chanock S.J. , Yeager M. , Dean M. , Caporaso N.E. .
Source: British Journal Of Haematology, 2018 Jun; 181(5), p. 604-613.
EPub date: 2018-04-24 00:00:00.0.
PMID: 29687880
Related Citations

Genome-wide Association Analysis Implicates Dysregulation Of Immunity Genes In Chronic Lymphocytic Leukaemia
Authors: Law P.J. , Berndt S.I. , Speedy H.E. , Camp N.J. , Sava G.P. , Skibola C.F. , Holroyd A. , Joseph V. , Sunter N.J. , Nieters A. , et al. .
Source: Nature Communications, 2017-02-06 00:00:00.0; 8, p. 14175.
PMID: 28165464
Related Citations

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.
Authors: Bernatsky S. , Velásquez García H.A. , Spinelli J.J. , Gaffney P. , Smedby K.E. , Ramsey-Goldman R. , Wang S.S. , Adami H.O. , Albanes D. , Angelucci E. , et al. .
Source: Lupus Science & Medicine, 2017; 4(1), p. e000187.
EPub date: 2017-11-12 00:00:00.0.
PMID: 29214033
Related Citations

Impact Of Post-alignment Processing In Variant Discovery From Whole Exome Data
Authors: Tian S. , Yan H. , Kalmbach M. , Slager S.L. .
Source: Bmc Bioinformatics, 2016-10-03 00:00:00.0; 17(1), p. 403.
PMID: 27716037
Related Citations

An Analytical Workflow For Accurate Variant Discovery In Highly Divergent Regions
Authors: Tian S. , Yan H. , Neuhauser C. , Slager S.L. .
Source: Bmc Genomics, 2016-09-02 00:00:00.0; 17, p. 703.
PMID: 27590916
Related Citations

Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes.
Authors: Machiela M.J. , Lan Q. , Slager S.L. , Vermeulen R.C. , Teras L.R. , Camp N.J. , Cerhan J.R. , Spinelli J.J. , Wang S.S. , Nieters A. , et al. .
Source: Human Molecular Genetics, 2016-04-15 00:00:00.0; 25(8), p. 1663-76.
EPub date: 2016-04-15 00:00:00.0.
PMID: 27008888
Related Citations

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
Authors: Berndt S.I. , Camp N.J. , Skibola C.F. , Vijai J. , Wang Z. , Gu J. , Nieters A. , Kelly R.S. , Smedby K.E. , Monnereau A. , et al. .
Source: Nature Communications, 2016-03-09 00:00:00.0; 7, p. 10933.
EPub date: 2016-03-09 00:00:00.0.
PMID: 26956414
Related Citations

Familial Predisposition And Genetic Risk Factors For Lymphoma
Authors: Cerhan J.R. , Slager S.L. .
Source: Blood, 2015-11-12 00:00:00.0; 126(20), p. 2265-73.
PMID: 26405224
Related Citations

Base Resolution Methylome Profiling: Considerations In Platform Selection, Data Preprocessing And Analysis
Authors: Sun Z. , Cunningham J. , Slager S. , Kocher J.P. .
Source: Epigenomics, 2015 Aug; 7(5), p. 813-28.
PMID: 26366945
Related Citations

Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project.
Authors: Morton L.M. , Sampson J.N. , Cerhan J.R. , Turner J.J. , Vajdic C.M. , Wang S.S. , Smedby K.E. , de Sanjosé S. , Monnereau A. , Benavente Y. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 1-14.
PMID: 25174022
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for diffuse large B-cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Cerhan J.R. , Kricker A. , Paltiel O. , Flowers C.R. , Wang S.S. , Monnereau A. , Blair A. , Dal Maso L. , Kane E.V. , Nieters A. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 15-25.
PMID: 25174023
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Linet M.S. , Vajdic C.M. , Morton L.M. , de Roos A.J. , Skibola C.F. , Boffetta P. , Cerhan J.R. , Flowers C.R. , de Sanjosé S. , Monnereau A. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 26-40.
PMID: 25174024
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for chronic lymphocytic leukemia/small lymphocytic lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Slager S.L. , Benavente Y. , Blair A. , Vermeulen R. , Cerhan J.R. , Costantini A.S. , Monnereau A. , Nieters A. , Clavel J. , Call T.G. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 41-51.
PMID: 25174025
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for marginal zone lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Bracci P.M. , Benavente Y. , Turner J.J. , Paltiel O. , Slager S.L. , Vajdic C.M. , Norman A.D. , Cerhan J.R. , Chiu B.C. , Becker N. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 52-65.
PMID: 25174026
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for peripheral T-cell lymphomas: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Wang S.S. , Flowers C.R. , Kadin M.E. , Chang E.T. , Hughes A.M. , Ansell S.M. , Feldman A.L. , Lightfoot T. , Boffetta P. , Melbye M. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 66-75.
PMID: 25174027
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for mantle cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Smedby K.E. , Sampson J.N. , Turner J.J. , Slager S.L. , Maynadié M. , Roman E. , Habermann T.M. , Flowers C.R. , Berndt S.I. , Bracci P.M. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 76-86.
PMID: 25174028
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Vajdic C.M. , Landgren O. , McMaster M.L. , Slager S.L. , Brooks-Wilson A. , Smith A. , Staines A. , Dogan A. , Ansell S.M. , Sampson J.N. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 87-97.
PMID: 25174029
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for mycosis fungoides and Sézary syndrome: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Aschebrook-Kilfoy B. , Cocco P. , La Vecchia C. , Chang E.T. , Vajdic C.M. , Kadin M.E. , Spinelli J.J. , Morton L.M. , Kane E.V. , Sampson J.N. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 98-105.
PMID: 25174030
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for sporadic Burkitt lymphoma/leukemia: the Interlymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Mbulaiteye S.M. , Morton L.M. , Sampson J.N. , Chang E.T. , Costas L. , de Sanjosé S. , Lightfoot T. , Kelly J. , Friedberg J.W. , Cozen W. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 106-14.
PMID: 25174031
Related Citations

Medical history, lifestyle, and occupational risk factors for hairy cell leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Monnereau A. , Slager S.L. , Hughes A.M. , Smith A. , Glimelius B. , Habermann T.M. , Berndt S.I. , Staines A. , Norman A.D. , Cerhan J.R. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 115-24.
PMID: 25174032
Related Citations

Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Skibola C.F. , Slager S.L. , Berndt S.I. , Lightfoot T. , Sampson J.N. , Morton L.M. , Weisenburger D.D. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 125-9.
PMID: 25174033
Related Citations

Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
Authors: Morton L.M. , Slager S.L. , Cerhan J.R. , Wang S.S. , Vajdic C.M. , Skibola C.F. , Bracci P.M. , de Sanjosé S. , Smedby K.E. , Chiu B.C. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2014 Aug; 2014(48), p. 130-44.
PMID: 25174034
Related Citations

Incidence Of Chronic Lymphocytic Leukemia And High-count Monoclonal B-cell Lymphocytosis Using The 2008 Guidelines
Authors: Call T.G. , Norman A.D. , Hanson C.A. , Achenbach S.J. , Kay N.E. , Zent C.S. , Ding W. , Cerhan J.R. , Rabe K.G. , Vachon C.M. , et al. .
Source: Cancer, 2014-07-01 00:00:00.0; 120(13), p. 2000-5.
PMID: 24711224
Related Citations

Genetic Susceptibility To Chronic Lymphocytic Leukemia
Authors: Slager S.L. , Caporaso N.E. , de Sanjose S. , Goldin L.R. .
Source: Seminars In Hematology, 2013 Oct; 50(4), p. 296-302.
PMID: 24246697
Related Citations

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Authors: Berndt S.I. , Skibola C.F. , Joseph V. , Camp N.J. , Nieters A. , Wang Z. , Cozen W. , Monnereau A. , Wang S.S. , Kelly R.S. , et al. .
Source: Nature Genetics, 2013 Aug; 45(8), p. 868-76.
PMID: 23770605
Related Citations

Why precursors matter.
Authors: Caporaso N.E. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2013 Apr; 22(4), p. 518-20.
PMID: 23549394
Related Citations

Mapping Of The Irf8 Gene Identifies A 3'utr Variant Associated With Risk Of Chronic Lymphocytic Leukemia But Not Other Common Non-hodgkin Lymphoma Subtypes
Authors: Slager S.L. , Achenbach S.J. , Asmann Y.W. , Camp N.J. , Rabe K.G. , Goldin L.R. , Call T.G. , Shanafelt T.D. , Kay N.E. , Cunningham J.M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2013 Mar; 22(3), p. 461-6.
PMID: 23307532
Related Citations

Genetic Evidence Of Ptpn22 Effects On Chronic Lymphocytic Leukemia
Authors: Hebbring S.J. , Slager S.L. , Epperla N. , Mazza J.J. , Ye Z. , Zhou Z. , Achenbach S.J. , Vasco D.A. , Call T.G. , Rabe K.G. , et al. .
Source: Blood, 2013-01-03 00:00:00.0; 121(1), p. 237-8.
PMID: 23287625
Related Citations

Common Variants Within 6p21.31 Locus Are Associated With Chronic Lymphocytic Leukaemia And, Potentially, Other Non-hodgkin Lymphoma Subtypes
Authors: Slager S.L. , Camp N.J. , Conde L. , Shanafelt T.D. , Achenbach S.J. , Rabe K.G. , Kay N.E. , Novak A.J. , Call T.G. , Bracci P.M. , et al. .
Source: British Journal Of Haematology, 2012 Dec; 159(5), p. 572-6.
PMID: 23025533
Related Citations

Single Nucleotide Polymorphisms And Inherited Risk Of Chronic Lymphocytic Leukemia Among African Americans
Authors: Coombs C.C. , Rassenti L.Z. , Falchi L. , Slager S.L. , Strom S.S. , Ferrajoli A. , Weinberg J.B. , Kipps T.J. , Lanasa M.C. .
Source: Blood, 2012-08-23 00:00:00.0; 120(8), p. 1687-90.
PMID: 22745306
Related Citations

A Comprehensive Study Of Polymorphisms In The Abcb1, Abcc2, Abcg2, Nr1i2 Genes And Lymphoma Risk
Authors: Campa D. , Butterbach K. , Slager S.L. , Skibola C.F. , de Sanjosé S. , Benavente Y. , Becker N. , Foretova L. , Maynadie M. , Cocco P. , et al. .
Source: International Journal Of Cancer, 2012-08-15 00:00:00.0; 131(4), p. 803-12.
PMID: 21918980
Related Citations

Common Variation At 6p21.31 (bak1) Influences The Risk Of Chronic Lymphocytic Leukemia
Authors: Slager S.L. , Skibola C.F. , Di Bernardo M.C. , Conde L. , Broderick P. , McDonnell S.K. , Goldin L.R. , Croft N. , Holroyd A. , Harris S. , et al. .
Source: Blood, 2012-07-26 00:00:00.0; 120(4), p. 843-6.
PMID: 22700719
Related Citations

Immunophenotypic And Gene Expression Analysis Of Monoclonal B-cell Lymphocytosis Shows Biologic Characteristics Associated With Good Prognosis Cll
Authors: Lanasa M.C. , Allgood S.D. , Slager S.L. , Dave S.S. , Love C. , Marti G.E. , Kay N.E. , Hanson C.A. , Rabe K.G. , Achenbach S.J. , et al. .
Source: Leukemia, 2011 Sep; 25(9), p. 1459-66.
PMID: 21617698
Related Citations

Immunologic Aspects Of Monoclonal B-cell Lymphocytosis
Authors: Lanasa M.C. , Weinberg J.B. .
Source: Immunologic Research, 2011 Apr; 49(1-3), p. 269-80.
PMID: 21161696
Related Citations

Gwas Of Follicular Lymphoma Reveals Allelic Heterogeneity At 6p21.32 And Suggests Shared Genetic Susceptibility With Diffuse Large B-cell Lymphoma
Authors: Smedby K.E. , Foo J.N. , Skibola C.F. , Darabi H. , Conde L. , Hjalgrim H. , Kumar V. , Chang E.T. , Rothman N. , Cerhan J.R. , et al. .
Source: Plos Genetics, 2011 Apr; 7(4), p. e1001378.
PMID: 21533074
Related Citations

Genome-wide Association Study Identifies A Novel Susceptibility Locus At 6p21.3 Among Familial Cll
Authors: Slager S.L. , Rabe K.G. , Achenbach S.J. , Vachon C.M. , Goldin L.R. , Strom S.S. , Lanasa M.C. , Spector L.G. , Rassenti L.Z. , Leis J.F. , et al. .
Source: Blood, 2011-02-10 00:00:00.0; 117(6), p. 1911-6.
PMID: 21131588
Related Citations

Evaluating The Influence Of Quality Control Decisions And Software Algorithms On Snp Calling For The Affymetrix 6.0 Snp Array Platform
Authors: de Andrade M. , Atkinson E.J. , Bamlet W.R. , Matsumoto M.E. , Maharjan S. , Slager S.L. , Vachon C.M. , Cunningham J.M. , Kardia S.L. .
Source: Human Heredity, 2011; 71(4), p. 221-33.
PMID: 21734406
Related Citations

Common Occurrence Of Monoclonal B-cell Lymphocytosis Among Members Of High-risk Cll Families
Authors: Goldin L.R. , Lanasa M.C. , Slager S.L. , Cerhan J.R. , Vachon C.M. , Strom S.S. , Camp N.J. , Spector L.G. , Leis J.F. , Morrison V.A. , et al. .
Source: British Journal Of Haematology, 2010 Oct; 151(2), p. 152-8.
PMID: 20738309
Related Citations

Genome-wide Association Study Of Follicular Lymphoma Identifies A Risk Locus At 6p21.32
Authors: Conde L. , Halperin E. , Akers N.K. , Brown K.M. , Smedby K.E. , Rothman N. , Nieters A. , Slager S.L. , Brooks-Wilson A. , Agana L. , et al. .
Source: Nature Genetics, 2010 Aug; 42(8), p. 661-4.
PMID: 20639881
Related Citations

Familial Chronic Lymphocytic Leukemia
Authors: Goldin L.R. , Slager S.L. , Caporaso N.E. .
Source: Current Opinion In Hematology, 2010 Jul; 17(4), p. 350-5.
PMID: 20389242
Related Citations