Grant Number:	5R01CA140002-04 Interpret this number
Primary Investigator:	Slattery, Martha Or Marty
Organization:	University Of Utah
Project Title:	Disparities in Breast Cancer: Development and Survival in Hispanic and Nhw Women
Fiscal Year:	2011

DESCRIPTION (provided by applicant): The incidence rates of breast cancer vary more than two-fold between Hispanic and non-Hispanic white (NHW) women; Hispanic women have worse survival after diagnosis than NHW women. We propose to evaluate these health disparities in breast cancer development and survival along the continuation of American Indian to NHW women utilizing existing resources from the 4 Corner's States, California, and Mexico City. Existing resources utilized will be behavioral and social lifestyle exposure data along with DNA obtained at the time of interview. Survival data has been ongoing and will continue to be monitored via local SEER and CDC tumor registries. Genetic and lifestyle data are available from approximately 8039 Hispanic and NHW cases of breast cancer and population-based controls. By pooling resources from three studies, we will efficiently examine a biological pathway that we believe is important to breast cancer development and survival and that influences differences in breast cancer rates among Hispanic and NHW women. Evaluation of genetic factors will focus on a pathway that appears to work in conjunction with insulin-, estrogen-, and inflammation-related pathways and represents a point of convergence. This pathway, which we call the Convergence of Hormones, Inflammation, and Energy Functioning (CHIEF) Signaling Pathway has not been studied comprehensively in either Hispanic or non-Hispanic white women and will include genes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, & S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform. Breast cancer associations will be tested between genetic polymorphisms and haplotypes of these genes in Hispanic and NHW women and by proportion of American Indian ancestry. Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined. These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women. PUBLIC HEALTH RELEVANCE: This study will advance our understanding of breast cancer etiology in Hispanic and American Indian women as well as women overall. The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy.




A Pooled Analysis of Breastfeeding and Breast Cancer Risk by Hormone Receptor Status in Parous Hispanic Women.
Authors: Sangaramoorthy M. , Hines L.M. , Torres-Mejía G. , Phipps A.I. , Baumgartner K.B. , Wu A.H. , Koo J. , Ingles S.A. , Slattery M.L. , John E.M. .
Source: Epidemiology (cambridge, Mass.), 2019 05; 30(3), p. 449-457.
PMID: 30964816
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Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer: the Breast Cancer Health Disparities Study.
Authors: Xia Z. , Baumgartner K.B. , Baumgartner R.N. , Boone S.D. , Hines L.M. , John E.M. , Wolff R. , Slattery M.L. , Connor A.E. .
Source: Breast Cancer Research And Treatment, 2017-11-30 00:00:00.0; , .
EPub date: 2017-11-30 00:00:00.0.
PMID: 29190005
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Pre-diagnostic Breastfeeding, Adiposity, And Mortality Among Parous Hispanic And Non-hispanic White Women With Invasive Breast Cancer: The Breast Cancer Health Disparities Study
Authors: Connor A.E. , Visvanathan K. , Baumgartner K.B. , Baumgartner R.N. , Boone S.D. , Hines L.M. , Wolff R.K. , John E.M. , Slattery M.L. .
Source: Breast Cancer Research And Treatment, 2016-11-11 00:00:00.0; , .
PMID: 27837379
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Ethnic differences in the relationships between diabetes, early age adiposity and mortality among breast cancer survivors: the Breast Cancer Health Disparities Study.
Authors: Connor A.E. , Visvanathan K. , Baumgartner K.B. , Baumgartner R.N. , Boone S.D. , Hines L.M. , Wolff R.K. , John E.M. , Slattery M.L. .
Source: Breast Cancer Research And Treatment, 2016 05; 157(1), p. 167-78.
EPub date: 2016-04-26 00:00:00.0.
PMID: 27116186
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Red meat, poultry, and fish intake and breast cancer risk among Hispanic and Non-Hispanic white women: The Breast Cancer Health Disparities Study.
Authors: Kim A.E. , Lundgreen A. , Wolff R.K. , Fejerman L. , John E.M. , Torres-Mejía G. , Ingles S.A. , Boone S.D. , Connor A.E. , Hines L.M. , et al. .
Source: Cancer Causes & Control : Ccc, 2016 Apr; 27(4), p. 527-43.
PMID: 26898200
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Energy homeostasis genes and survival after breast cancer diagnosis: the Breast Cancer Health Disparities Study.
Authors: Pellatt A.J. , Lundgreen A. , Wolff R.K. , Hines L. , John E.M. , Slattery M.L. .
Source: Cancer Causes & Control : Ccc, 2016 Jan; 27(1), p. 47-57.
PMID: 26472474
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Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study.
Authors: Connor A.E. , Baumgartner R.N. , Baumgartner K.B. , Pinkston C.M. , Boone S.D. , John E.M. , Torres-Mejía G. , Hines L.M. , Giuliano A.R. , Wolff R.K. , et al. .
Source: Molecular Carcinogenesis, 2015 Dec; 54(12), p. 1541-53.
PMID: 25339205
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Energy homeostasis genes and breast cancer risk: The influence of ancestry, body size, and menopausal status, the breast cancer health disparities study.
Authors: Slattery M.L. , Lundgreen A. , Hines L. , Wolff R.K. , Torres-Mejia G. , Baumgartner K.N. , John E.M. .
Source: Cancer Epidemiology, 2015 Dec; 39(6), p. 1113-22.
PMID: 26395295
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Interaction between common breast cancer susceptibility variants, genetic ancestry, and nongenetic risk factors in Hispanic women.
Authors: Fejerman L. , Stern M.C. , John E.M. , Torres-Mejía G. , Hines L.M. , Wolff R.K. , Baumgartner K.B. , Giuliano A.R. , Ziv E. , Pérez-Stable E.J. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Nov; 24(11), p. 1731-8.
PMID: 26364163
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Active and passive cigarette smoking and mortality among Hispanic and non-Hispanic white women diagnosed with invasive breast cancer.
Authors: Boone S.D. , Baumgartner K.B. , Baumgartner R.N. , Connor A.E. , John E.M. , Giuliano A.R. , Hines L.M. , Rai S.N. , Riley E.C. , Pinkston C.M. , et al. .
Source: Annals Of Epidemiology, 2015 Nov; 25(11), p. 824-31.
PMID: 26387598
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Overall and abdominal adiposity and premenopausal breast cancer risk among hispanic women: the breast cancer health disparities study.
Authors: John E.M. , Sangaramoorthy M. , Hines L.M. , Stern M.C. , Baumgartner K.B. , Giuliano A.R. , Wolff R.K. , Slattery M.L. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Jan; 24(1), p. 138-47.
PMID: 25352526
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MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: the Breast Cancer Health Disparities Study.
Authors: Slattery M.L. , Lundgreen A. , John E.M. , Torres-Mejia G. , Hines L. , Giuliano A.R. , Baumgartner K.B. , Stern M.C. , Wolff R.K. .
Source: Nutrition And Cancer, 2015; 67(2), p. 292-304.
PMID: 25629224
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Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the Breast Cancer Health Disparities Study.
Authors: Slattery M.L. , Lundgreen A. , Torres-Mejia G. , Wolff R.K. , Hines L. , Baumgartner K. , John E.M. .
Source: Mutation Research, 2014 Dec; 770, p. 19-28.
PMID: 25332681
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Associations between CYP19A1 polymorphisms, Native American ancestry, and breast cancer risk and mortality: the Breast Cancer Health Disparities Study.
Authors: Boone S.D. , Baumgartner K.B. , Baumgartner R.N. , Connor A.E. , Pinkston C.M. , Rai S.N. , Riley E.C. , Hines L.M. , Giuliano A.R. , John E.M. , et al. .
Source: Cancer Causes & Control : Ccc, 2014 Nov; 25(11), p. 1461-71.
PMID: 25088806
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Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study.
Authors: Slattery M.L. , Hines L.H. , Lundgreen A. , Baumgartner K.B. , Wolff R.K. , Stern M.C. , John E.M. .
Source: Cancer Causes & Control : Ccc, 2014 Sep; 25(9), p. 1211-25.
PMID: 24993294
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Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study.
Authors: Slattery M.L. , Herrick J.S. , Torres-Mejia G. , John E.M. , Giuliano A.R. , Hines L.M. , Stern M.C. , Baumgartner K.B. , Presson A.P. , Wolff R.K. .
Source: Carcinogenesis, 2014 Aug; 35(8), p. 1750-9.
PMID: 24670917
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Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study.
Authors: Slattery M.L. , Lundgreen A. , Hines L.M. , Torres-Mejia G. , Wolff R.K. , Stern M.C. , John E.M. .
Source: Breast Cancer Research And Treatment, 2014 Aug; 147(1), p. 145-58.
PMID: 25104439
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The influence of genetic ancestry and ethnicity on breast cancer survival associated with genetic variation in the TGF-ß-signaling pathway: The Breast Cancer Health Disparities Study.
Authors: Slattery M.L. , Lundgreen A. , Stern M.C. , Hines L. , Wolff R.K. , Giuliano A.R. , Baumgartner K.B. , John E.M. .
Source: Cancer Causes & Control : Ccc, 2014 Mar; 25(3), p. 293-307.
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Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: the Breast Cancer Health Disparities Study.
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Source: International Journal Of Cancer, 2014-02-01 00:00:00.0; 134(3), p. 629-44.
EPub date: 2014-02-01 00:00:00.0.
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Genetic Variants And Non-genetic Factors Predict Circulating Vitamin D Levels In Hispanic And Non-hispanic White Women: The Breast Cancer Health Disparities Study
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Source: International Journal Of Molecular Epidemiology And Genetics, 2014; 5(1), p. 31-46.
PMID: 24596595
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Associations between genetic variants in the TGF-ß signaling pathway and breast cancer risk among Hispanic and non-Hispanic white women.
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Source: Breast Cancer Research And Treatment, 2013 Sep; 141(2), p. 287-97.
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Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women.
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Source: Carcinogenesis, 2013 Aug; 34(8), p. 1787-93.
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Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study.
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Source: Breast Cancer Research And Treatment, 2013 Aug; 140(3), p. 587-601.
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Source: Genes, Chromosomes & Cancer, 2013 Jul; 52(7), p. 595-609.
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Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study.
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Source: International Journal Of Cancer, 2013-06-15 00:00:00.0; 132(12), p. 2928-39.
EPub date: 2013-06-15 00:00:00.0.
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Differences between Hispanic and non-Hispanic white women with breast cancer for clinical characteristics and their correlates.
Authors: Connor A.E. , Baumgartner R.N. , Yang D. , Slattery M.L. , Giuliano A.R. , Risendal B.C. , Abdel-Maksoud M.M. , Baumgartner K.B. .
Source: Annals Of Epidemiology, 2013 Apr; 23(4), p. 227-32.
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Matrix Metalloproteinase Genes Are Associated With Breast Cancer Risk And Survival: The Breast Cancer Health Disparities Study
Authors: Slattery M.L. , John E. , Torres-Mejia G. , Stern M. , Lundgreen A. , Hines L. , Giuliano A. , Baumgartner K. , Herrick J. , Wolff R.K. .
Source: Plos One, 2013; 8(5), p. e63165.
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Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.
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ADRB2 G-G haplotype associated with breast cancer risk among Hispanic and non-Hispanic white women: interaction with type 2 diabetes and obesity.
Authors: Connor A. , Baumgartner R.N. , Kerber R.A. , O'Brien E. , Rai S.N. , Wolff R.K. , Slattery M.L. , Giuliano A.R. , Risendal B.C. , Byers T.E. , et al. .
Source: Cancer Causes & Control : Ccc, 2012 Oct; 23(10), p. 1653-63.
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Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.
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Source: Carcinogenesis, 2012 Aug; 33(8), p. 1512-21.
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Vitamin D intake, vitamin D receptor polymorphisms, and breast cancer risk among women living in the southwestern U.S.
Authors: Rollison D.E. , Cole A.L. , Tung K.H. , Slattery M.L. , Baumgartner K.B. , Byers T. , Wolff R.K. , Giuliano A.R. .
Source: Breast Cancer Research And Treatment, 2012 Apr; 132(2), p. 683-91.
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Behavioral risk factors and their relationship to tumor characteristics in Hispanic and non-Hispanic white long-term breast cancer survivors.
Authors: Abdel-Maksoud M.F. , Risendal B.C. , Slattery M.L. , Giuliano A.R. , Baumgartner K.B. , Byers T.E. .
Source: Breast Cancer Research And Treatment, 2012 Jan; 131(1), p. 169-76.
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Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States.
Authors: Slattery M.L. , Baumgartner K.B. , Giuliano A.R. , Byers T. , Herrick J.S. , Wolff R.K. .
Source: Breast Cancer Research And Treatment, 2011 Sep; 129(2), p. 531-9.
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Comparative analysis of breast cancer risk factors among Hispanic and non-Hispanic white women.
Authors: Hines L.M. , Risendal B. , Slattery M.L. , Baumgartner K.B. , Giuliano A.R. , Sweeney C. , Rollison D.E. , Byers T. .
Source: Cancer, 2010-07-01 00:00:00.0; 116(13), p. 3215-23.
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