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Grant Details

Grant Number: 5R01CA118711-05 Interpret this number
Primary Investigator: Sherwood, Paula
Organization: University Of Pittsburgh At Pittsburgh
Project Title: Mind-Body Interactions in Neuro-Oncology Family Caregivers
Fiscal Year: 2011


DESCRIPTION (provided by applicant): Persons with a primary malignant brain tumor (PMBT) often suffer significant functional and neurologic morbidity causing family caregivers to assume the care recipient's familial, social, and financial obligations. Research has shown that caregivers of persons with other chronic diseases develop negative consequences as a result of providing care. Despite high morbidity (and mortality) rates for persons with a PMBT, caregiver issues in neuro-oncology have been virtually ignored. In response to PA-05-027, the purposes of this study are to use a multidisciplinary, integrative model, the Pittsburgh Mind Body Center Model, to (1) examine the psycho-behavioral responses (i.e. depressive symptoms and sleep), biologic responses (i.e. blood pressure and ihterleukins) and overall physical health of family members of persons with a PMBT at the time of diagnosis, and (2) to describe how relationships within the model vary over time in response to changes in the care recipient's illness trajectory as the family member transitions to a family caregiver. The specific aims of the project are to: 1) examine how care recipients' disease characteristics and caregivers' psycho- behavioral responses, biologic responses, and overall physical health change over time (from PBMT diagnosis to 12 months after diagnosis); and during this 12-month period, to 2) examine how caregivers' personal characteristics moderate the relationship between care recipients' disease characteristics and caregivers' psycho-behavioral responses; 3) examine how caregiver psycho-behavioral responses mediate the relationship between care recipients' disease characteristics and caregivers' biologic responses; and 4) examine how caregivers' biologic responses mediate the relationship between their psycho-behavioral responses and overall physical health. A descriptive longitudinal design will be used to collect data to address the aims of the project. Linear and logistic regression analysis will be used to model baseline responses. Repeated measures analysis (random coefficients modeling) will be used to examine change over time and latent growth curve modeling will be used to further explore longitudinal data. The relevance of the project to public health is to identify caregivers at specific time-points during the care recipient's disease trajectory who are vulnerable to changes in their emotional and physical health. Improving caregivers' emotional and physical health may improve the delivery of care and quality of life for the care recipient.


Mediating burden and stress over time: Caregivers of patients with primary brain tumor.
Authors: Reblin M. , Small B. , Jim H. , Weimer J. , Sherwood P. .
Source: Psycho-oncology, 2018 02; 27(2), p. 607-612.
EPub date: 2017-08-31.
PMID: 28801927
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Family caregivers' level of mastery predicts survival of patients with glioblastoma: A preliminary report.
Authors: Boele F.W. , Given C.W. , Given B.A. , Donovan H.S. , Schulz R. , Weimer J.M. , Drappatz J. , Lieberman F.S. , Sherwood P.R. .
Source: Cancer, 2017-03-01; 123(5), p. 832-840.
EPub date: 2016-10-27.
PMID: 27787881
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Neuro-oncology family caregivers are at risk for systemic inflammation.
Authors: Sherwood P.R. , Price T.J. , Weimer J. , Ren D. , Donovan H.S. , Given C.W. , Given B.A. , Schulz R. , Prince J. , Bender C. , et al. .
Source: Journal of neuro-oncology, 2016 05; 128(1), p. 109-118.
EPub date: 2016-02-23.
PMID: 26907491
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Risk factors for depression and fatigue among survivors of hematopoietic cell transplantation.
Authors: Jim H.S. , Sutton S.K. , Jacobsen P.B. , Martin P.J. , Flowers M.E. , Lee S.J. .
Source: Cancer, 2016-04-15; 122(8), p. 1290-7.
EPub date: 2016-01-27.
PMID: 26814442
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Symptoms as the Main Predictors of Caregivers' Perception of the Suffering of Patients With Primary Malignant Brain Tumors.
Authors: Zeleníková R. , Ren D. , Schulz R. , Given B. , Sherwood P.R. .
Source: Cancer nursing, 2016 Mar-Apr; 39(2), p. 97-105.
PMID: 25881804
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Depressive symptoms and cytokine levels in Serum and Tumor Tissue in patients with an Astrocytoma: a pilot study.
Authors: Starkweather A.R. , Sherwood P. , Lyon D.E. , Bovbjerg D.H. , Broaddus W.C. , Elswick R.K. , Sturgill J. .
Source: BMC research notes, 2014-07-04; 7, p. 423.
EPub date: 2014-07-04.
PMID: 24997057
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Sleep loss and its effects on health of family caregivers of individuals with primary malignant brain tumors.
Authors: Pawl J.D. , Lee S.Y. , Clark P.C. , Sherwood P.R. .
Source: Research in nursing & health, 2013 Aug; 36(4), p. 386-99.
EPub date: 2013-04-30.
PMID: 23633116
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Exploring spirituality in family caregivers of patients with primary malignant brain tumors across the disease trajectory.
Authors: Newberry A.G. , Choi C.W. , Donovan H.S. , Schulz R. , Bender C. , Given B. , Sherwood P. .
Source: Oncology nursing forum, 2013-05-01; 40(3), p. E119-25.
PMID: 23615145
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Sleep characteristics of family caregivers of individuals with a primary malignant brain tumor.
Authors: Pawl J.D. , Lee S.Y. , Clark P.C. , Sherwood P.R. .
Source: Oncology nursing forum, 2013 Mar; 40(2), p. 171-9.
PMID: 23448742
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Locke-Wallace Short Marital-Adjustment Test: psychometric evaluation in caregivers for persons with primary malignant brain tumor.
Authors: Jiang Y. , Terhorst L. , Donovan H.S. , Weimer J.M. , Choi C.W. , Schulz R. , Given B. , Sherwood P.R. .
Source: Journal of nursing measurement, 2013; 21(3), p. 502-15.
PMID: 24620520
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Group-based trajectory modeling of caregiver psychological distress over time.
Authors: Choi C.W. , Stone R.A. , Kim K.H. , Ren D. , Schulz R. , Given C.W. , Given B.A. , Sherwood P.R. .
Source: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2012 Aug; 44(1), p. 73-84.
PMID: 22585179
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Identifying family members who are likely to perceive benefits from providing care to a person with a primary malignant brain tumor.
Authors: Newberry A. , Kuo J. , Donovan H. , Given B. , Given C.W. , Schulz R. , Sherwood P. .
Source: Oncology nursing forum, 2012-05-01; 39(3), p. E226-32.
PMID: 22543393
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Changes in caregiver perceptions over time in response to providing care for a loved one with a primary malignant brain tumor.
Authors: Hricik A. , Donovan H. , Bradley S.E. , Given B.A. , Bender C.M. , Newberry A. , Hamilton R. , Given C.W. , Sherwood P. .
Source: Oncology nursing forum, 2011 Mar; 38(2), p. 149-55.
PMID: 21356653
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Understanding recruitment and retention in neurological research.
Authors: Newberry A. , Sherwood P. , Hricik A. , Bradley S. , Kuo J. , Crago E. , Hoffman L.A. , Given B.A. .
Source: The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 2010 Feb; 42(1), p. 47-57.
PMID: 20187349
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Perceptions of economic hardship and emotional health in a pilot sample of family caregivers.
Authors: Bradley S.E. , Sherwood P.R. , Kuo J. , Kammerer C.M. , Gettig E.A. , Ren D. , Rohrer W.M. , Donovan H.S. , Hricik A. , Newberry A. , et al. .
Source: Journal of neuro-oncology, 2009 Jul; 93(3), p. 333-42.
EPub date: 2009-01-22.
PMID: 19159080
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