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Grant Details

Grant Number: 5R01CA120562-05 Interpret this number
Primary Investigator: Boudreau, Denise
Organization: Kaiser Foundation Health Plan Of Washington
Project Title: Commonly Used Medications and Breast Cancer Recurrence
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): Breast cancer is the most frequently diagnosed cancer in women and it is the second most common cause of cancer mortality. Breast cancer incidence rates have continued to rise since 1980, while mortality rates have declined. As a result, more women are at risk for breast cancer recurrences. Recurrences have important negative consequences requiring a variety of palliative treatments and often lead to death. Numerous commonly used medications such as such as, statins, antihypertensives, antidepressants, and antibiotics have been hypothesized to alter breast cancer risk, in many cases, there is strong biologic evidence to support these hypotheses. However, no studies have examined how these commonly used medications are associated with risk of breast cancer recurrence. We propose to test the hypotheses that use of statins and ACE inhibitors will be associated with a reduced risk of recurrence, and use of antidepressants, antibiotics, calcium channel blockers, and diuretics will be associated with an increased risk of recurrence. To test these hypotheses, we will conduct a retrospective cohort study among approximately 4,550 women diagnosed between 1990 and 2008 with incident early stage invasive breast carcinoma, while enrolled at Group Health Cooperative, a large Health Maintenance Organization in western Washington State. We will use medical records and automated administrative data to follow women an average of 10 years to assess risk of breast cancer recurrence and to collect information on medication use and indication for use, primary therapy, and co-morbidities. Determining whether use of these drugs impacts breast cancer recurrence is of considerable public health importance given the widespread and increasing use of the medications under study and the burden of breast cancer in our nation. The hypotheses we are seeking to test are in line with the National Cancer Institute's 2015 goals of eliminating the suffering and death due to cancer. Learning more about whether there are factors that influence recurrence will help us with the secondary prevention of breast cancer and will lead to a reduction in breast cancer morbidity and mortality.

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Publications

Diabetes and differences in detection of incident invasive breast cancer.
Authors: Calip G.S. , Yu O. , Boudreau D.M. , Shao H. , Oratz R. , Richardson S.B. , Gold H.T. .
Source: Cancer causes & control : CCC, 2019 May; 30(5), p. 435-441.
EPub date: 2019-04-04.
PMID: 30949885
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Risk of second breast cancer events with chronic opioid use in breast cancer survivors.
Authors: Boudreau D.M. , Chen L. , Yu O. , Bowles E.J.A. , Chubak J. .
Source: Pharmacoepidemiology and drug safety, 2019 May; 28(5), p. 740-753.
EPub date: 2019-04-03.
PMID: 30945381
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Inflation of type I error rates due to differential misclassification in EHR-derived outcomes: Empirical illustration using breast cancer recurrence.
Authors: Chen Y. , Wang J. , Chubak J. , Hubbard R.A. .
Source: Pharmacoepidemiology and drug safety, 2019 Feb; 28(2), p. 264-268.
EPub date: 2018-10-30.
PMID: 30375122
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An Electronic Health Record-based Algorithm to Ascertain the Date of Second Breast Cancer Events.
Authors: Chubak J. , Onega T. , Zhu W. , Buist D.S.M. , Hubbard R.A. .
Source: Medical care, 2017 12; 55(12), p. e81-e87.
PMID: 29135770
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Evidence for Detection Bias by Medication Use in a Cohort Study of Breast Cancer Survivors.
Authors: Wirtz H.S. , Calip G.S. , Buist D.S.M. , Gralow J.R. , Barlow W.E. , Gray S. , Boudreau D.M. .
Source: American journal of epidemiology, 2017-04-15; 185(8), p. 661-672.
PMID: 28338879
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Characteristics associated with nonadherence to medications for hypertension, diabetes, and dyslipidemia among breast cancer survivors.
Authors: Calip G.S. , Elmore J.G. , Boudreau D.M. .
Source: Breast cancer research and treatment, 2017 01; 161(1), p. 161-172.
EPub date: 2016-11-08.
PMID: 27826756
Related Citations

Breast cancer recurrence in relation to antidepressant use.
Authors: Chubak J. , Bowles E.J. , Yu O. , Buist D.S. , Fujii M. , Boudreau D.M. .
Source: Cancer causes & control : CCC, 2016 Jan; 27(1), p. 125-36.
EPub date: 2015-10-30.
PMID: 26518198
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Associations between diabetes medication use and risk of second breast cancer events and mortality.
Authors: Calip G.S. , Yu O. , Hoskins K.F. , Boudreau D.M. .
Source: Cancer causes & control : CCC, 2015 Aug; 26(8), p. 1065-77.
EPub date: 2015-05-09.
PMID: 25956271
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Adherence to oral diabetes medications and glycemic control during and following breast cancer treatment.
Authors: Calip G.S. , Hubbard R.A. , Stergachis A. , Malone K.E. , Gralow J.R. , Boudreau D.M. .
Source: Pharmacoepidemiology and drug safety, 2015 Jan; 24(1), p. 75-85.
EPub date: 2014-06-13.
PMID: 24923811
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Metabolic syndrome and outcomes following early-stage breast cancer.
Authors: Calip G.S. , Malone K.E. , Gralow J.R. , Stergachis A. , Hubbard R.A. , Boudreau D.M. .
Source: Breast cancer research and treatment, 2014 Nov; 148(2), p. 363-77.
EPub date: 2014-10-10.
PMID: 25301086
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Comparative safety of cardiovascular medication use and breast cancer outcomes among women with early stage breast cancer.
Authors: Boudreau D.M. , Yu O. , Chubak J. , Wirtz H.S. , Bowles E.J. , Fujii M. , Buist D.S. .
Source: Breast cancer research and treatment, 2014 Apr; 144(2), p. 405-16.
EPub date: 2014-02-21.
PMID: 24557337
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Using natural language processing to improve efficiency of manual chart abstraction in research: the case of breast cancer recurrence.
Authors: Carrell D.S. , Halgrim S. , Tran D.T. , Buist D.S. , Chubak J. , Chapman W.W. , Savova G. .
Source: American journal of epidemiology, 2014-03-15; 179(6), p. 749-58.
EPub date: 2014-01-30.
PMID: 24488511
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Factors associated with long-term adherence to annual surveillance mammography among breast cancer survivors.
Authors: Wirtz H.S. , Boudreau D.M. , Gralow J.R. , Barlow W.E. , Gray S. , Bowles E.J. , Buist D.S. .
Source: Breast cancer research and treatment, 2014 Feb; 143(3), p. 541-50.
EPub date: 2014-01-10.
PMID: 24407530
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Threats to validity of nonrandomized studies of postdiagnosis exposures on cancer recurrence and survival.
Authors: Chubak J. , Boudreau D.M. , Wirtz H.S. , McKnight B. , Weiss N.S. .
Source: Journal of the National Cancer Institute, 2013-10-02; 105(19), p. 1456-62.
EPub date: 2013-08-12.
PMID: 23940288
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Outcomes among chronically ill adults in a medical home prototype.
Authors: Liss D.T. , Fishman P.A. , Rutter C.M. , Grembowski D. , Ross T.R. , Johnson E.A. , Reid R.J. .
Source: The American journal of managed care, 2013-10-01; 19(10), p. e348-58.
EPub date: 2013-10-01.
PMID: 24304182
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Frequent antibiotic use and second breast cancer events.
Authors: Wirtz H.S. , Buist D.S. , Gralow J.R. , Barlow W.E. , Gray S. , Chubak J. , Yu O. , Bowles E.J. , Fujii M. , Boudreau D.M. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013 Sep; 22(9), p. 1588-99.
EPub date: 2013-07-05.
PMID: 23833124
Related Citations

Time scale in follow-up studies: considering disease prognosis.
Authors: Chubak J. , Yu O. , Buist D.S. , Wirtz H.S. , Boudreau D.M. .
Source: Epidemiology (Cambridge, Mass.), 2013 Jul; 24(4), p. 628-9.
PMID: 23732747
Related Citations

Bone mineral density screening among women with a history of breast cancer treated with aromatase inhibitors.
Authors: Spangler L. , Yu O. , Loggers E. , Boudreau D.M. .
Source: Journal of women's health (2002), 2013 Feb; 22(2), p. 132-40.
EPub date: 2013-01-30.
PMID: 23362883
Related Citations

Changes in adherence to statins and subsequent lipid profiles during and following breast cancer treatment.
Authors: Calip G.S. , Boudreau D.M. , Loggers E.T. .
Source: Breast cancer research and treatment, 2013 Feb; 138(1), p. 225-33.
EPub date: 2013-01-29.
PMID: 23358904
Related Citations

Patient-reported discontinuation of endocrine therapy and related adverse effects among women with early-stage breast cancer.
Authors: Aiello Bowles E.J. , Boudreau D.M. , Chubak J. , Yu O. , Fujii M. , Chestnut J. , Buist D.S. .
Source: Journal of oncology practice, 2012 Nov; 8(6), p. e149-57.
EPub date: 2012-07-17.
PMID: 23598850
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Administrative data algorithms to identify second breast cancer events following early-stage invasive breast cancer.
Authors: Chubak J. , Yu O. , Pocobelli G. , Lamerato L. , Webster J. , Prout M.N. , Ulcickas Yood M. , Barlow W.E. , Buist D.S. .
Source: Journal of the National Cancer Institute, 2012-06-20; 104(12), p. 931-40.
EPub date: 2012-04-30.
PMID: 22547340
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Endocrine therapy initiation from 2001 to 2008 varies by age at breast cancer diagnosis and tumor size.
Authors: Bowles E.J. , Buist D.S. , Chubak J. , Yu O. , Johnson J. , Chestnut J. , Boudreau D.M. .
Source: Journal of oncology practice, 2012 Mar; 8(2), p. 113-20.
EPub date: 2012-02-21.
PMID: 23077439
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Cost of breast-related care in the year following false positive screening mammograms.
Authors: Chubak J. , Boudreau D.M. , Fishman P.A. , Elmore J.G. .
Source: Medical care, 2010 Sep; 48(9), p. 815-20.
PMID: 20706161
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Statin use and cancer risk: a comprehensive review.
Authors: Boudreau D.M. , Yu O. , Johnson J. .
Source: Expert opinion on drug safety, 2010 Jul; 9(4), p. 603-21.
PMID: 20377474
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