Grant Number:	1R01CA148667-01A1 Interpret this number
Primary Investigator:	Zheng, Wei
Organization:	Vanderbilt University
Project Title:	Consortium Study to Identify Breast Cancer Susceptibility Loci
Fiscal Year:	2011

DESCRIPTION (provided by applicant): Breast cancer is the most common malignancy among women in the United States and many other parts of the world. Genetic factors play an important role in the etiology of breast cancer. Recent genome-wide association studies (GWAS) have identified multiple genetic susceptibility loci for breast cancer. However, these newly- identified genetic factors, along with high-penetrance susceptibility genes reported previously (such as the BRCA1 and BRCA2 genes), explain only a small fraction of genetic variation for breast cancer. In this application, we propose two novel projects that will significantly advance our understanding of the genetic basis for breast cancer and the methodology used for genetic epidemiologic research. The first project is a GWAS based on the newly-established Asia Breast Cancer Consortium and will include over 27,000 cases and controls recruited from 11 studies conducted among Asian women living in various parts of the world. Through analyzing GWA scan data from 3,500 cases and 3,500 controls, we will identify and evaluate the top 8,500 SNPs in an independent set of 3,500 cases and 3,500 controls and then validate approximately the top 100 SNPs in 6,700 cases and 6,700 controls. In the second project, we will sequence eight GWAS-mapped regions in 3,000 cases and 3,000 controls with the goal of identifying additional genetic risk variants, particularly low- frequency variants, for breast cancer in these regions. We will select up to 180 promising SNPs for replication in an independent set of 2,500 cases and 2,500 controls and then select the top 30 SNPs for further evaluation in another independent set of 2,500 cases and 2,500 controls. This is the only well-powered GWAS conducted in Asian women, and thus is the only existing GWAS capable of discovering genetic variants for breast cancer that are unlikely or more difficult to identify in other GWAS. The proposed sequencing project represents a new model for future genetic association studies. These two newly-proposed projects will be built upon several well- conducted, NCI-funded studies to generate substantial novel information that will help to not only understand breast cancer biology and genetics, but also to improve risk assessment models and identify high-risk women for cost-efficient prevention of breast cancer. PUBLIC HEALTH RELEVANCE: Genetic factors play a major role in the etiology of breast cancers, yet only a small number of cases are explained by genetic factors identified thus far. The large epidemiologic study we propose will comprehensively evaluate genetic markers in relation to breast cancer risk. This study will generate valuable results for the identification of high-risk women for the primary and secondary prevention of breast cancer.




Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.
Authors: Zanti M. , O'Mahony D.G. , Parsons M.T. , Dorling L. , Dennis J. , Boddicker N.J. , Chen W. , Hu C. , Naven M. , Yiangou K. , et al. .
Source: Nature Communications, 2025-05-25 00:00:00.0; 16(1), p. 4852.
EPub date: 2025-05-25 00:00:00.0.
PMID: 40413188
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Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions.
Authors: Jia G. , Chen Z. , Ping J. , Cai Q. , Tao R. , Li C. , Bauer J.A. , Xie Y. , Ambs S. , Barnard M.E. , et al. .
Source: Nature Genetics, 2025-01-03 00:00:00.0; , .
EPub date: 2025-01-03 00:00:00.0.
PMID: 39753771
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NON-ADDITIVE EFFECTS OF COMMON GENETIC VARIANTS HAVE A NEGLIGENT CONTRIBUTION TO CANCER HERITABILITY.
Authors: Hammermeister Suger A. , Harrison T.A. , Henning B. , Turman C. , Kraft P. , Lindström S. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2024-07-17 00:00:00.0; , .
EPub date: 2024-07-17 00:00:00.0.
PMID: 39018351
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Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel.
Authors: Levi H. , Carmi S. , Rosset S. , Yerushalmi R. , Zick A. , Yablonski-Peretz T. , BCAC Consortium , Wang Q. , Bolla M.K. , Dennis J. , et al. .
Source: Journal Of Medical Genetics, 2023-11-27 00:00:00.0; 60(12), p. 1186-1197.
EPub date: 2023-11-27 00:00:00.0.
PMID: 37451831
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Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival.
Authors: Lopes Cardozo J.M.N. , Andrulis I.L. , Bojesen S.E. , Dörk T. , Eccles D.M. , Fasching P.A. , Hooning M.J. , Keeman R. , Nevanlinna H. , Rutgers E.J.T. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2023-04-01 00:00:00.0; 41(10), p. 1849-1863.
EPub date: 2023-01-23 00:00:00.0.
PMID: 36689693
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Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.
Authors: Mueller S.H. , Lai A.G. , Valkovskaya M. , Michailidou K. , Bolla M.K. , Wang Q. , Dennis J. , Lush M. , Abu-Ful Z. , Ahearn T.U. , et al. .
Source: Genome Medicine, 2023-01-26 00:00:00.0; 15(1), p. 7.
EPub date: 2023-01-26 00:00:00.0.
PMID: 36703164
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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.
Authors: Fernandez-Rozadilla C. , Timofeeva M. , Chen Z. , Law P. , Thomas M. , Schmit S. , Díez-Obrero V. , Hsu L. , Fernandez-Tajes J. , Palles C. , et al. .
Source: Nature Genetics, 2023 Jan; 55(1), p. 89-99.
EPub date: 2022-12-20 00:00:00.0.
PMID: 36539618
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Distinct Reproductive Risk Profiles for Intrinsic-Like Breast Cancer Subtypes: Pooled Analysis of Population-Based Studies.
Authors: Jung A.Y. , Ahearn T.U. , Behrens S. , Middha P. , Bolla M.K. , Wang Q. , Arndt V. , Aronson K.J. , Augustinsson A. , Beane Freeman L.E. , et al. .
Source: Journal Of The National Cancer Institute, 2022-12-08 00:00:00.0; 114(12), p. 1706-1719.
PMID: 35723569
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Genome- and transcriptome-wide association studies of 386,000 Asian and European-ancestry women provide new insights into breast cancer genetics.
Authors: Jia G. , Ping J. , Shu X. , Yang Y. , Cai Q. , Kweon S.S. , Choi J.Y. , Kubo M. , Park S.K. , Bolla M.K. , et al. .
Source: American Journal Of Human Genetics, 2022-11-03 00:00:00.0; , .
EPub date: 2022-11-03 00:00:00.0.
PMID: 36356581
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Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians.
Authors: Ping J. , Yang Y. , Wen W. , Kweon S.S. , Matsuda K. , Jia W.H. , Shin A. , Gao Y.T. , Matsuo K. , Kim J. , et al. .
Source: International Journal Of Cancer, 2022-06-29 00:00:00.0; , .
EPub date: 2022-06-29 00:00:00.0.
PMID: 35765848
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Polygenic risk scores for prediction of breast cancer risk in Asian populations.
Authors: Ho W.K. , Tai M.C. , Dennis J. , Shu X. , Li J. , Ho P.J. , Millwood I.Y. , Lin K. , Jee Y.H. , Lee S.H. , et al. .
Source: Genetics In Medicine : Official Journal Of The American College Of Medical Genetics, 2022 Mar; 24(3), p. 586-600.
EPub date: 2021-12-15 00:00:00.0.
PMID: 34906514
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Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium.
Authors: Morra A. , Jung A.Y. , Behrens S. , Keeman R. , Ahearn T.U. , Anton-Cluver H. , Arndt V. , Augustinsson A. , Auvinen P.K. , Beane Freeman L.E. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-01-26 00:00:00.0; , .
EPub date: 2021-01-26 00:00:00.0.
PMID: 33500318
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Transcriptome-wide association study of breast cancer risk by estrogen-receptor status.
Authors: Feng H. , Gusev A. , Pasaniuc B. , Wu L. , Long J. , Abu-Full Z. , Aittomäki K. , Andrulis I.L. , Anton-Culver H. , Antoniou A.C. , et al. .
Source: Genetic Epidemiology, 2020 07; 44(5), p. 442-468.
EPub date: 2020-03-01 00:00:00.0.
PMID: 32115800
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Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk.
Authors: Liu J. , Prager-van der Smissen W.J.C. , Collée J.M. , Bolla M.K. , Wang Q. , Michailidou K. , Dennis J. , Ahearn T.U. , Aittomäki K. , Ambrosone C.B. , et al. .
Source: Scientific Reports, 2020-06-16 00:00:00.0; 10(1), p. 9688.
EPub date: 2020-06-16 00:00:00.0.
PMID: 32546843
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Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.
Authors: Shu X. , Long J. , Cai Q. , Kweon S.S. , Choi J.Y. , Kubo M. , Park S.K. , Bolla M.K. , Dennis J. , Wang Q. , et al. .
Source: Nature Communications, 2020-03-05 00:00:00.0; 11(1), p. 1217.
EPub date: 2020-03-05 00:00:00.0.
PMID: 32139696
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Genetically Predicted Levels of DNA Methylation Biomarkers and Breast Cancer Risk: Data From 228 951 Women of European Descent.
Authors: Yang Y. , Wu L. , Shu X.O. , Cai Q. , Shu X. , Li B. , Guo X. , Ye F. , Michailidou K. , Bolla M.K. , et al. .
Source: Journal Of The National Cancer Institute, 2020-03-01 00:00:00.0; 112(3), p. 295-304.
PMID: 31143935
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Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians.
Authors: Lu Y. , Kweon S.S. , Cai Q. , Tanikawa C. , Shu X.O. , Jia W.H. , Xiang Y.B. , Huyghe J.R. , Harrison T.A. , Kim J. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020 02; 29(2), p. 477-486.
EPub date: 2019-12-11 00:00:00.0.
PMID: 31826910
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Two truncating variants in FANCC and breast cancer risk.
Authors: Dörk T. , Peterlongo P. , Mannermaa A. , Bolla M.K. , Wang Q. , Dennis J. , Ahearn T. , Andrulis I.L. , Anton-Culver H. , Arndt V. , et al. .
Source: Scientific Reports, 2019-08-29 00:00:00.0; 9(1), p. 12524.
EPub date: 2019-08-29 00:00:00.0.
PMID: 31467304
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Authors: Shi J. , Wu L. , Li B. , Lu Y. , Guo X. , Cai Q. , Long J. , Wen W. , Zheng W. , Shu X.O. .
Source: Reproductive Sciences (thousand Oaks, Calif.), 2019 04; 26(4), p. 496-502.
EPub date: 2018-05-30 00:00:00.0.
PMID: 29848177
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Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
Authors: Lu Y. , Kweon S.S. , Tanikawa C. , Jia W.H. , Xiang Y.B. , Cai Q. , Zeng C. , Schmit S.L. , Shin A. , Matsuo K. , et al. .
Source: Gastroenterology, 2019 Apr; 156(5), p. 1455-1466.
EPub date: 2018-12-06 00:00:00.0.
PMID: 30529582
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Shared heritability and functional enrichment across six solid cancers.
Authors: Jiang X. , Finucane H.K. , Schumacher F.R. , Schmit S.L. , Tyrer J.P. , Han Y. , Michailidou K. , Lesseur C. , Kuchenbaecker K.B. , Dennis J. , et al. .
Source: Nature Communications, 2019-01-25 00:00:00.0; 10(1), p. 431.
EPub date: 2019-01-25 00:00:00.0.
PMID: 30683880
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Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas.
Authors: Hoffman J. , Fejerman L. , Hu D. , Huntsman S. , Li M. , John E.M. , Torres-Mejia G. , Kushi L. , Ding Y.C. , Weitzel J. , et al. .
Source: Breast Cancer Research : Bcr, 2019-01-14 00:00:00.0; 21(1), p. 3.
EPub date: 2019-01-14 00:00:00.0.
PMID: 30642363
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Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.
Authors: Shu X. , Wu L. , Khankari N.K. , Shu X.O. , Wang T.J. , Michailidou K. , Bolla M.K. , Wang Q. , Dennis J. , Milne R.L. , et al. .
Source: International Journal Of Epidemiology, 2018-10-01 00:00:00.0; , .
EPub date: 2018-10-01 00:00:00.0.
PMID: 30277539
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Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
Authors: Schmit S.L. , Edlund C.K. , Schumacher F.R. , Gong J. , Harrison T.A. , Huyghe J.R. , Qu C. , Melas M. , Van Den Berg D.J. , Wang H. , et al. .
Source: Journal Of The National Cancer Institute, 2018-06-16 00:00:00.0; , .
EPub date: 2018-06-16 00:00:00.0.
PMID: 29917119
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A Comprehensive cis-eQTL Analysis Revealed Target Genes in Breast Cancer Susceptibility Loci Identified in Genome-wide Association Studies.
Authors: Guo X. , Lin W. , Bao J. , Cai Q. , Pan X. , Bai M. , Yuan Y. , Shi J. , Sun Y. , Han M.R. , et al. .
Source: American Journal Of Human Genetics, 2018-05-03 00:00:00.0; 102(5), p. 890-903.
PMID: 29727689
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Authors: Milne R.L. , Kuchenbaecker K.B. , Michailidou K. , Beesley J. , Kar S. , Lindström S. , Hui S. , Lemaçon A. , Soucy P. , Dennis J. , et al. .
Source: Nature Genetics, 2017 Dec; 49(12), p. 1767-1778.
EPub date: 2017-10-23 00:00:00.0.
PMID: 29058716
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Association analysis identifies 65 new breast cancer risk loci.
Authors: Michailidou K. , Lindström S. , Dennis J. , Beesley J. , Hui S. , Kar S. , Lemaçon A. , Soucy P. , Glubb D. , Rostamianfar A. , et al. .
Source: Nature, 2017-11-02 00:00:00.0; 551(7678), p. 92-94.
EPub date: 2017-10-23 00:00:00.0.
PMID: 29059683
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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
Authors: Spracklen C.N. , Chen P. , Kim Y.J. , Wang X. , Cai H. , Li S. , Long J. , Wu Y. , Wang Y.X. , Takeuchi F. , et al. .
Source: Human Molecular Genetics, 2017-05-01 00:00:00.0; 26(9), p. 1770-1784.
PMID: 28334899
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Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians.
Authors: Han M.R. , Zheng W. , Cai Q. , Gao Y.T. , Zheng Y. , Bolla M.K. , Michailidou K. , Dennis J. , Wang Q. , Dunning A.M. , et al. .
Source: Carcinogenesis, 2017-05-01 00:00:00.0; 38(5), p. 511-518.
PMID: 28419251
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Estimation of heritability for nine common cancers using data from genome-wide association studies in Chinese population.
Authors: Dai J. , Shen W. , Wen W. , Chang J. , Wang T. , Chen H. , Jin G. , Ma H. , Wu C. , Li L. , et al. .
Source: International Journal Of Cancer, 2017-01-15 00:00:00.0; 140(2), p. 329-336.
EPub date: 2016-10-11 00:00:00.0.
PMID: 27668986
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Prediction Of Breast Cancer Risk Based On Common Genetic Variants In Women Of East Asian Ancestry
Authors: Wen W. , Shu X.O. , Guo X. , Cai Q. , Long J. , Bolla M.K. , Michailidou K. , Dennis J. , Wang Q. , Gao Y.T. , et al. .
Source: Breast Cancer Research : Bcr, 2016-12-08 00:00:00.0; 18(1), p. 124.
PMID: 27931260
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PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Authors: Southey M.C. , Goldgar D.E. , Winqvist R. , Pylkäs K. , Couch F. , Tischkowitz M. , Foulkes W.D. , Dennis J. , Michailidou K. , van Rensburg E.J. , et al. .
Source: Journal Of Medical Genetics, 2016 Dec; 53(12), p. 800-811.
PMID: 27595995
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Age At Menarche And Age At Natural Menopause In East Asian Women: A Genome-wide Association Study
Authors: Shi J. , Zhang B. , Choi J.Y. , Gao Y.T. , Li H. , Lu W. , Long J. , Kang D. , Xiang Y.B. , Wen W. , et al. .
Source: Age (dordrecht, Netherlands), 2016 Dec; 38(5-6), p. 513-523.
PMID: 27629107
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Rs2735383, Located At A Microrna Binding Site In The 3'utr Of Nbs1, Is Not Associated With Breast Cancer Risk
Authors: Liu J. , Lon¿ar I. , Collée J.M. , Bolla M.K. , Dennis J. , Michailidou K. , Wang Q. , Andrulis I.L. , Barile M. , Beckmann M.W. , et al. .
Source: Scientific Reports, 2016-11-15 00:00:00.0; 6, p. 36874.
PMID: 27845421
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Evidence That The 5p12 Variant Rs10941679 Confers Susceptibility To Estrogen-receptor-positive Breast Cancer Through Fgf10 And Mrps30 Regulation
Authors: Ghoussaini M. , French J.D. , Michailidou K. , Nord S. , Beesley J. , Canisus S. , Hillman K.M. , Kaufmann S. , Sivakumaran H. , Moradi Marjaneh M. , et al. .
Source: American Journal Of Human Genetics, 2016-10-06 00:00:00.0; 99(4), p. 903-911.
PMID: 27640304
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Association Between Genetic Risk Score For Telomere Length And Risk Of Breast Cancer
Authors: Luu H.N. , Long J. , Wen W. , Zheng Y. , Cai Q. , Gao Y.T. , Zheng W. , Shu X.O. .
Source: Cancer Causes & Control : Ccc, 2016 Oct; 27(10), p. 1219-28.
PMID: 27581250
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Fine-scale Mapping Of 8q24 Locus Identifies Multiple Independent Risk Variants For Breast Cancer
Authors: Shi J. , Zhang Y. , Zheng W. , Michailidou K. , Ghoussaini M. , Bolla M.K. , Wang Q. , Dennis J. , Lush M. , Milne R.L. , et al. .
Source: International Journal Of Cancer, 2016-09-15 00:00:00.0; 139(6), p. 1303-17.
PMID: 27087578
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Authors: Darabi H. , Beesley J. , Droit A. , Kar S. , Nord S. , Moradi Marjaneh M. , Soucy P. , Michailidou K. , Ghoussaini M. , Fues Wahl H. , et al. .
Source: Scientific Reports, 2016-09-07 00:00:00.0; 6, p. 32512.
PMID: 27600471
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Authors: Lawrenson K. , Kar S. , McCue K. , Kuchenbaeker K. , Michailidou K. , Tyrer J. , Beesley J. , Ramus S.J. , Li Q. , Delgado M.K. , et al. .
Source: Nature Communications, 2016-09-07 00:00:00.0; 7, p. 12675.
PMID: 27601076
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An Intergenic Risk Locus Containing An Enhancer Deletion In 2q35 Modulates Breast Cancer Risk By Deregulating Igfbp5 Expression
Authors: Wyszynski A. , Hong C.C. , Lam K. , Michailidou K. , Lytle C. , Yao S. , Zhang Y. , Bolla M.K. , Wang Q. , Dennis J. , et al. .
Source: Human Molecular Genetics, 2016-09-01 00:00:00.0; 25(17), p. 3863-3876.
PMID: 27402876
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Genome-wide Association Study In East Asians Identifies Two Novel Breast Cancer Susceptibility Loci
Authors: Han M.R. , Long J. , Choi J.Y. , Low S.K. , Kweon S.S. , Zheng Y. , Cai Q. , Shi J. , Guo X. , Matsuo K. , et al. .
Source: Human Molecular Genetics, 2016-08-01 00:00:00.0; 25(15), p. 3361-3371.
PMID: 27354352
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Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Authors: Zeng C. , Guo X. , Long J. , Kuchenbaecker K.B. , Droit A. , Michailidou K. , Ghoussaini M. , Kar S. , Freeman A. , Hopper J.L. , et al. .
Source: Breast Cancer Research : Bcr, 2016-06-21 00:00:00.0; 18(1), p. 64.
EPub date: 2016-06-21 00:00:00.0.
PMID: 27459855
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Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
Authors: Zeng C. , Matsuda K. , Jia W.H. , Chang J. , Kweon S.S. , Xiang Y.B. , Shin A. , Jee S.H. , Kim D.H. , Zhang B. , et al. .
Source: Gastroenterology, 2016 Jun; 150(7), p. 1633-45.
PMID: 26965516
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No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
Authors: Easton D.F. , Lesueur F. , Decker B. , Michailidou K. , Li J. , Allen J. , Luccarini C. , Pooley K.A. , Shah M. , Bolla M.K. , et al. .
Source: Journal Of Medical Genetics, 2016 May; 53(5), p. 298-309.
PMID: 26921362
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Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Authors: Dunning A.M. , Michailidou K. , Kuchenbaecker K.B. , Thompson D. , French J.D. , Beesley J. , Healey C.S. , Kar S. , Pooley K.A. , Lopez-Knowles E. , et al. .
Source: Nature Genetics, 2016 Apr; 48(4), p. 374-86.
PMID: 26928228
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Evaluation Of Potential Regulatory Function Of Breast Cancer Risk Locus At 6q25.1
Authors: Sun Y. , Ye C. , Guo X. , Wen W. , Long J. , Gao Y.T. , Shu X.O. , Zheng W. , Cai Q. .
Source: Carcinogenesis, 2016 Feb; 37(2), p. 163-8.
PMID: 26645718
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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.
Authors: Wen W. , Kato N. , Hwang J.Y. , Guo X. , Tabara Y. , Li H. , Dorajoo R. , Yang X. , Tsai F.J. , Li S. , et al. .
Source: Scientific Reports, 2016-01-20 00:00:00.0; 6, p. 17958.
EPub date: 2016-01-20 00:00:00.0.
PMID: 26785701
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Fine-mapping Of The 1p11.2 Breast Cancer Susceptibility Locus
Authors: Horne H.N. , Chung C.C. , Zhang H. , Yu K. , Prokunina-Olsson L. , Michailidou K. , Bolla M.K. , Wang Q. , Dennis J. , Hopper J.L. , et al. .
Source: Plos One, 2016; 11(8), p. e0160316.
PMID: 27556229
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Integrative genomic analysis reveals functional diversification of APOBEC gene family in breast cancer.
Authors: Zhang Y. , Delahanty R. , Guo X. , Zheng W. , Long J. .
Source: Human Genomics, 2015-12-18 00:00:00.0; 9, p. 34.
EPub date: 2015-12-18 00:00:00.0.
PMID: 26682542
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Tert Gene Harbors Multiple Variants Associated With Pancreatic Cancer Susceptibility
Authors: Campa D. , Rizzato C. , Stolzenberg-Solomon R. , Pacetti P. , Vodicka P. , Cleary S.P. , Capurso G. , Bueno-de-Mesquita H.B. , Werner J. , Gazouli M. , et al. .
Source: International Journal Of Cancer, 2015-11-01 00:00:00.0; 137(9), p. 2175-83.
PMID: 25940397
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