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Grant Details

Grant Number: 5R01CA118136-05 Interpret this number
Primary Investigator: Wenzel, Lari
Organization: University Of California-Irvine
Project Title: Stress, Immunity & Cervical Cancer: Biobehavioral Outcomes of a Randomized Trial
Fiscal Year: 2011


Abstract

DESCRIPTION (provided by applicant): The incidence and mortality rates for invasive cervical cancer in minority, low-income, and less educated women exceeds that for white, higher income, and better educated women. In southern California the incidence and mortality rates for cervical cancer are nearly twice that of non-Latina white women. Our preliminary work supports and extends the extant literature, noting that quality of life can be significantly disrupted among cervical cancer survivors, with qualitative differences in how Latina women experience cancer survivorship. However, there is a paucity of literature on interventions designed to assist cervical cancer survivors manage illness-specific stress and improve health behaviors. Our preliminary NCI-funded study provides strong data indicating that a six session psychosocial telephone counseling (PTC) intervention can improve QOL, with accompanying intervention-induced neuroendocrine and immune parameter modulations which may be related to disease endpoints. Specifically, we demonstrated a significant association between the improvement in QOL elicited by PTC and a shift to a more pronounced Th1 immunologic stance. In primary support of these significant biobehavioral findings, the project herein proposes to accomplish the following Specific Aims: 1) Test the efficacy of PTC for cervical cancer survivors, compared to usual care. 2) Evaluate the longitudinal immune and neuroendocrine parameters in cervical cancer patients who have received PTC, compared to usual care. 3) Examine the longitudinal relationship between PTC associated modulations of QOL measures and biologic parameters (immune and neuroendocrine). To achieve these aims we will randomize patients ascertained through the two SEER cancer registries to PTC (N=125) or usual care (N=125), stratifying on English or Spanish language preference. Assessments will occur at baseline (9-20 months post diagnosis), and three and nine months post enrollment/baseline. Assessments will include evaluation of QOL (overall QOL, psychological distress, coping, social support, sexual functioning), health behaviors, neuroendocrine parameters (DHEA-S, cortisol, GH) and immunologic parameters (NK cell activity, IL-5, interferon, HPV E6/E7 peptides, IL-15, IL 10). This project has significant public health relevance for an important unstudied cancer survivor population, many of whom are poor and underserved. If effective, an intervention which could improve quality of life (QOL) and health behaviors, and enhance neuroendocrine and immune responses for women with cervical cancer could have significant implications toward disease recurrence or survival.



Publications

Longitudinal Changes in Sleep: Associations with Shifts in Circulating Cytokines and Emotional Distress in a Cancer Survivor Population.
Authors: Tucker J.A. , Osann K. , Hsieh S. , Wahi A. , Monk B.J. , Wenzel L. , Nelson E.L. .
Source: International journal of behavioral medicine, 2021 Feb; 28(1), p. 140-150.
EPub date: 2021-02-17.
PMID: 33598780
Related Citations

Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.
Authors: Osann K. , Wilford J. , Wenzel L. , Hsieh S. , Tucker J.A. , Wahi A. , Monk B.J. , Nelson E.L. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019 Sep; 27(9), p. 3301-3310.
EPub date: 2019-01-05.
PMID: 30612237
Related Citations

Validation of PROMIS emotional distress short form scales for cervical cancer.
Authors: Wilford J. , Osann K. , Hsieh S. , Monk B. , Nelson E. , Wenzel L. .
Source: Gynecologic oncology, 2018 10; 151(1), p. 111-116.
EPub date: 2018-08-02.
PMID: 30078504
Related Citations

Health Behaviors in Cervical Cancer Survivors and Associations with Quality of Life.
Authors: Iyer N.S. , Osann K. , Hsieh S. , Tucker J.A. , Monk B.J. , Nelson E.L. , Wenzel L. .
Source: Clinical therapeutics, 2016 Mar; 38(3), p. 467-75.
EPub date: 2016-02-27.
PMID: 26926320
Related Citations

Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.
Authors: Wenzel L. , Osann K. , Hsieh S. , Tucker J.A. , Monk B.J. , Nelson E.L. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-04-01; 33(10), p. 1171-9.
EPub date: 2015-02-23.
PMID: 25713429
Related Citations

Cervical cancer survivorship: long-term quality of life and social support.
Authors: Pfaendler K.S. , Wenzel L. , Mechanic M.B. , Penner K.R. .
Source: Clinical therapeutics, 2015-01-01; 37(1), p. 39-48.
PMID: 25592090
Related Citations

Factors associated with poor quality of life among cervical cancer survivors: implications for clinical care and clinical trials.
Authors: Osann K. , Hsieh S. , Nelson E.L. , Monk B.J. , Chase D. , Cella D. , Wenzel L. .
Source: Gynecologic oncology, 2014 Nov; 135(2), p. 266-72.
EPub date: 2014-09-03.
PMID: 25192629
Related Citations

Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention.
Authors: Biegler K.A. , Anderson A.K. , Wenzel L.B. , Osann K. , Nelson E.L. .
Source: Cancer prevention research (Philadelphia, Pa.), 2012 Oct; 5(10), p. 1173-82.
EPub date: 2012-07-24.
PMID: 22827974
Related Citations

Recruitment and retention results for a population-based cervical cancer biobehavioral clinical trial.
Authors: Osann K. , Wenzel L. , Dogan A. , Hsieh S. , Chase D.M. , Sappington S. , Monk B.J. , Nelson E.L. .
Source: Gynecologic oncology, 2011-06-01; 121(3), p. 558-64.
EPub date: 2011-03-12.
PMID: 21402400
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