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Grant Details

Grant Number: 5R01CA114379-05 Interpret this number
Primary Investigator: Nemesure, Barbara
Organization: State University New York Stony Brook
Project Title: Prostate Cancer in a Black Population
Fiscal Year: 2011
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Abstract

DESCRIPTION (provided by applicant): Prostate cancer (PC) disproportionately affects African-Americans (AA). This study proposes to identify new genetic and obesity-related factors contributing to PC risk in persons of African descent, in a setting that offers special opportunities for such research. Results would be based on 960 histologically-confirmed nationwide incident cases and 960 population-based control men from Barbados, West Indies, -94% being African-Barbadians (AB). Study results have high applicability to AA. The AA and AB populations share the same ancestral origin and have similar PC patterns. These similarities suggest a role for inherited susceptibility in AA/AB, which could be due to ancestral genetic variants. Detection of these variants would be enhanced in AB because of lower admixture; results would be replicated in AA samples. We hypothesize a multigenic model of susceptibility involving insulin-related and steroid hormone pathways, which also may be mediated by environmental influences; central adiposity patterns would notably affect risk. AIM 1: To evaluate the contribution of body size to PC risk. This aim would be achieved by ascertaining relationships with anthropometric indices (which differ in AA/AB vs. others), weight history and other factors. AIM 2: To evaluate the relationship of PC to common genetic variants in hypothesized pathways, using a staged genotyping approach. Stage 1: we will genotype and analyze 800 SNPs (2kb SNP map) within select candidate genes involved in the insulin/IGF axis and steroid metabolism and regulation pathways among 900 AB PC cases and 900 AB controls. We will determine the haplotype block structure of these genes and subsequently determine risk estimates associated with PC for alleles at individual SNPs and haplotypes. Stage 2: we will validate the top 1% of all SNPs/haplotypes and all coding SNPs among the top 5% of SNPs in a set of 800 AA PC cases and 800 controls. The study has high public health relevance to AA. It would clarify reasons for PC risk in AA, by identifying new genetic and other risk factors. The study will use novel multigenic and multistage approaches, involving data on AA, and focus on relevant PC pathways. It will also determine the role of obesity-related factors, with results having potential for preventive interventions. Study data will allow comparisons of PC risk across the African diaspora, as well as being a resource to advance PC research in AA.

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Publications

Distribution of Duffy Antigen Receptor for Chemokines (DARC) and Risk of Prostate Cancer in Barbados, West Indies.
Authors: Nemesure B. , Wu S.Y. , Hennis A. , Leske M.C. .
Source: Journal of immigrant and minority health, 2015 Jun; 17(3), p. 679-83.
PMID: 24399209
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8q24 risk alleles and prostate cancer in African-Barbadian men.
Authors: Cropp C.D. , Robbins C.M. , Sheng X. , Hennis A.J. , Carpten J.D. , Waterman L. , Worrell R. , Schwantes-An T.H. , Trent J.M. , Haiman C.A. , et al. .
Source: The Prostate, 2014 Dec; 74(16), p. 1579-88.
EPub date: 2014-09-22.
PMID: 25252079
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Family history of prostate cancer in a black population.
Authors: Nemesure B. , Wu S.Y. , Hennis A. , Leske M.C. .
Source: Journal of immigrant and minority health, 2013 Dec; 15(6), p. 1107-12.
PMID: 22936456
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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Authors: Monda K.L. , Chen G.K. , Taylor K.C. , Palmer C. , Edwards T.L. , Lange L.A. , Ng M.C. , Adeyemo A.A. , Allison M.A. , Bielak L.F. , et al. .
Source: Nature genetics, 2013 Jun; 45(6), p. 690-6.
EPub date: 2013-04-14.
PMID: 23583978
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Factors influencing prostate cancer healthcare practices in Barbados, West Indies.
Authors: Ng P. , Schoenfeld E.R. , Hennis A. , Wu S.Y. , Leske M.C. , Nemesure B. .
Source: Journal of immigrant and minority health, 2013 Jun; 15(3), p. 653-60.
PMID: 22669639
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Urologic characteristics and sexual behaviors associated with prostate cancer in an african-Caribbean population in barbados, west indies.
Authors: Hennis A.J. , Wu S.Y. , Nemesure B. , Leske M.C. .
Source: Prostate cancer, 2013; 2013, p. 682750.
EPub date: 2013-02-25.
PMID: 23533778
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Central adiposity and Prostate Cancer in a Black Population.
Authors: Nemesure B. , Wu S.Y. , Hennis A. , Leske M.C. , Prostate Cancer in a Black Population (PCBP) Study Group .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012 May; 21(5), p. 851-8.
EPub date: 2012-03-08.
PMID: 22402288
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Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
Authors: Haiman C.A. , Chen G.K. , Blot W.J. , Strom S.S. , Berndt S.I. , Kittles R.A. , Rybicki B.A. , Isaacs W.B. , Ingles S.A. , Stanford J.L. , et al. .
Source: Nature genetics, 2011 Jun; 43(6), p. 570-3.
EPub date: 2011-05-22.
PMID: 21602798
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Validation of a quantitative FFQ for the Barbados National Cancer Study.
Authors: Pakseresht M. , Sharma S. , Cao X. , Harris R. , Caberto C. , Wilkens L.R. , Hennis A.J. , Wu S.Y. , Nemesure B. , Leske M.C. , et al. .
Source: Public health nutrition, 2011 Mar; 14(3), p. 426-34.
EPub date: 2010-09-15.
PMID: 20843400
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Prostate cancer incidence and mortality in barbados, west indies.
Authors: Hennis A.J. , Hambleton I.R. , Wu S.Y. , Skeete D.H. , Nemesure B. , Leske M.C. .
Source: Prostate cancer, 2011; 2011, p. 565230.
EPub date: 2011-04-17.
PMID: 22110989
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Body size and breast cancer in a black population--the Barbados National Cancer Study.
Authors: Nemesure B. , Wu S.Y. , Hennis A. , Leske M.C. , Barbados National Cancer Study Group .
Source: Cancer causes & control : CCC, 2009 Apr; 20(3), p. 387-94.
EPub date: 2008-11-06.
PMID: 18987981
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Breast cancer incidence and mortality in a Caribbean population: comparisons with African-Americans.
Authors: Hennis A.J. , Hambleton I.R. , Wu S.Y. , Leske M.C. , Nemesure B. , Barbados National Cancer Study Group .
Source: International journal of cancer, 2009-01-15; 124(2), p. 429-33.
PMID: 18844211
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Risk factors for breast cancer in a black population--the Barbados National Cancer Study.
Authors: Nemesure B. , Wu S.Y. , Hambleton I.R. , Leske M.C. , Hennis A.J. , Barbados National Cancer Study Group .
Source: International journal of cancer, 2009-01-01; 124(1), p. 174-9.
PMID: 18814239
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Assessing dietary patterns in Barbados highlights the need for nutritional intervention to reduce risk of chronic disease.
Authors: Sharma S. , Cao X. , Harris R. , Hennis A.J. , Wu S.Y. , Leske M.C. , Barbados National Cancer Study Group .
Source: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2008 Apr; 21(2), p. 150-8.
PMID: 18339055
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Admixture and population stratification in African Caribbean populations.
Authors: Benn-Torres J. , Bonilla C. , Robbins C.M. , Waterman L. , Moses T.Y. , Hernandez W. , Santos E.R. , Bennett F. , Aiken W. , Tullock T. , et al. .
Source: Annals of human genetics, 2008 Jan; 72(Pt 1), p. 90-8.
EPub date: 2006-10-01.
PMID: 17908263
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African-Caribbean cancer consortium for the study of viral, genetic and environmental cancer risk factors.
Authors: Ragin C.C. , Taioli E. , McFarlane-Anderson N. , Avery G. , Bennett F. , Bovell-Benjamin A. , Thompson A.B. , Carrington A. , Campbell-Everett L. , Ford J. , et al. .
Source: Infectious agents and cancer, 2007-09-24; 2, p. 17.
EPub date: 2007-09-24.
PMID: 17892589
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Nutritional composition of the commonly consumed composite dishes for the Barbados National Cancer Study.
Authors: Sharma S. , Harris R. , Cao X. , Hennis A.J. , Leske M.C. , Wu S.Y. , Barbados National Cancer Study Group .
Source: International journal of food sciences and nutrition, 2007 Sep; 58(6), p. 461-74.
PMID: 17710590
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Dietary intake and development of a quantitative food-frequency questionnaire for the Barbados National Cancer Study.
Authors: Sharma S. , Cao X. , Harris R. , Hennis A.J. , Leske M.C. , Wu S.Y. , Barbados National Cancer Study Group .
Source: Public health nutrition, 2007 May; 10(5), p. 464-70.
PMID: 17411466
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