Grant Number:	5R01CA134779-02 Interpret this number
Primary Investigator:	Wheeler, Cosette
Organization:	University Of New Mexico Health Scis Ctr
Project Title:	HPV Outcomes: Prevention Epidemiology and Surveillance (HOPES)
Fiscal Year:	2010

New Mexico (NM) is the only state with the capacity to fully monitor cervical cancer screening and human papillomavirus (HPV) prevention using a state-wide woman-based electronic informatics system under mandated reporting. We are uniquely positioned to address gaps in understanding HPV vaccine impact and effectiveness within a mulit-cultural US population suffering many disparities. Our project will accomplish three integrated specific aims required to provide definitive baseline characterizations of the opportunistic cervical cancer screening program in NM. In Aim 1, we will establish the individual HPV genotype distribution of 37 HPV genotypes needed to appropriately monitor expected or unexpected population-based impact of HPV vaccines. Although we have performed a state-wide sampling of over 60,000 cervical samples targeting all women with abnormal Pap tests and a random sample of women with normal Pap tests, our existing resources were limited to HPV genoytping of 40,000 samples. In this Aim we will achieve the targeted sample size by performing the additional 20,000 HPV genotype assays.We will describe the agespecific population-based genotype distribution and determine the genotype-specific risk for CIN2+ outcomes across the 2 year grant period. In Aim 2, we will convene a pathology panel to determine consensus diagnoses for ~8,000 cervical biopsies including >CIN/AIS. The consensus diagnoses will be compared to community-based diagnoses determined for the same specimens through use of the NM HPV Pap Registry (NMHPVPR) data warehouse. We will create a gold standard slide set that will enable standardization of future population-based assessments, a prerequisite for determining the real-world impact and effectiveness of HPV vaccination. In Aim 3 we will develop a shared image resource of the cervical biopsy tissues and validate the use of image-based versus glass-based diagnoses. Because the impact of HPV vaccines is expected to increase over time, longitudinal periodic assessments will be expected to span several decades. Image-based diagnostic standards will be critical to future population evaluations.




Corrigendum To "a Comparison Of Cervical Histopathology Variability Using Whole Slide Digitized Images Versus Glass Slides: Experience With A Statewide Registry" [human Pathology 2013;44:2542-2548]
Authors: Gage J.C. , Joste N. , Ronnett B.M. , Stoler M. , Hunt W.C. , Schiffman M. , Wheeler C.M. .
Source: Human Pathology, 2016 Jun; 52, p. 201.
PMID: 27141825
Related Citations

The Interpretive Variability Of Cervical Biopsies And Its Relationship To Hpv Status
Authors: Stoler M.H. , Ronnett B.M. , Joste N.E. , Hunt W.C. , Cuzick J. , Wheeler C.M. , New Mexico HPV Pap Registry Steering Committee .
Source: The American Journal Of Surgical Pathology, 2015 Jun; 39(6), p. 729-36.
PMID: 25602796
Related Citations

No Evidence For Synergy Between Human Papillomavirus Genotypes For The Risk Of High-grade Squamous Intraepithelial Lesions In A Large Population-based Study
Authors: Wentzensen N. , Nason M. , Schiffman M. , Dodd L. , Hunt W.C. , Wheeler C.M. , New Mexico HPV Pap Registry Steering Committee .
Source: The Journal Of Infectious Diseases, 2014 Mar; 209(6), p. 855-64.
PMID: 24179110
Related Citations

A Comparison Of Cervical Histopathology Variability Using Whole Slide Digitized Images Versus Glass Slides: Experience With A Statewide Registry
Authors: Gage J.C. , Joste N. , Ronnett B.M. , Stoler M. , Hunt W.C. , Schiffman M. , Wheeler C.M. .
Source: Human Pathology, 2013 Nov; 44(11), p. 2542-8.
PMID: 24075599
Related Citations

Cervical Histopathology Variability Among Laboratories: A Population-based Statewide Investigation
Authors: Gage J.C. , Schiffman M. , Hunt W.C. , Joste N. , Ghosh A. , Wentzensen N. , Wheeler C.M. , New Mexico HPV Pap Registry Steering Committee .
Source: American Journal Of Clinical Pathology, 2013 Mar; 139(3), p. 330-5.
PMID: 23429369
Related Citations

A Population-based Study Of Human Papillomavirus Genotype Prevalence In The United States: Baseline Measures Prior To Mass Human Papillomavirus Vaccination
Authors: Wheeler C.M. , Hunt W.C. , Cuzick J. , Langsfeld E. , Pearse A. , Montoya G.D. , Robertson M. , Shearman C.A. , Castle P.E. , New Mexico HPV Pap Registry Steering Committee .
Source: International Journal Of Cancer, 2013-01-01 00:00:00.0; 132(1), p. 198-207.
PMID: 22532127
Related Citations