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Grant Details

Grant Number: 5R01CA120061-06 Interpret this number
Primary Investigator: Lukanova, Annekatrin
Organization: German Cancer Research Center
Project Title: Hormone Levels During Pregnancy and Maternal Ovarian Cancer
Fiscal Year: 2010
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Abstract

DESCRIPTION (provided by applicant): A pregnancy completed to term is the strongest known protective factor for ovarian cancer. Older age at the end of child-bearing confers greater protection than younger age and it was proposed that pregnancy may clear the ovaries from cells that have undergone malignant transformation - the wash-out hypothesis. Progesterone is the most likely hormone candidate to mediate the beneficial effect of pregnancy. In a case control study (1,827 cases, 3,654 controls), nested within two large cohorts in Finland and Sweden, we will explore the associations between progesterone and 17alpha-OH progesterone (marker of corpus luteum function and correlate of ovarian synthesis of progesterone) in stored specimens obtained during the first trimester of a last, full-term pregnancy and the subsequent risk of invasive or borderline ovarian cancer in the mother. Specific aims are the following: 1). To investigate prospectively the association of circulating progesterone and 17a-OH progesterone during the first trimester of a last full-term pregnancy with risk of epithelial ovarian cancer in the mother and to explore the effect of age at last full-term pregnancy on these associations. 2). To explore the above hormone-cancer associations according to the histological sub-type of both invasive and borderline epithelial ovarian malignancies. Additionally, the large Nordic cohorts offer the opportunity to address the role of two groups of hormones that have been associated with increased ovarian cancer risk. Two more specific aims are proposed: 3). To examine prospectively the association of IGF-I, IGFBP-3 and placental GH during early pregnancy with maternal risk of ovarian cancer overall, and in subgroups defined by the histological types of the tumors. 4). To examine prospectively the association of testosterone, androstenedione and SHBG during pregnancy with maternal risk of ovarian cancer overall, and in subgroups defined by the histological types of the tumors. The proposed study will be one of the largest studies on ovarian cancer conducted to date. It will gather important new data concerning the role of progesterone in the protection afforded by pregnancies, and the role of the IGF-system and androgens, on ovarian cancer risk. Observations from this study may lead to a better understanding of disease pathogenesis, and, ultimately to development of preventive interventions.

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Publications

Androgens Are Differentially Associated with Ovarian Cancer Subtypes in the Ovarian Cancer Cohort Consortium.
Authors: Ose J. , Poole E.M. , Schock H. , Lehtinen M. , Arslan A.A. , Zeleniuch-Jacquotte A. , Visvanathan K. , Helzlsouer K. , Buring J.E. , Lee I.M. , et al. .
Source: Cancer research, 2017-07-15; 77(14), p. 3951-3960.
EPub date: 2017-04-05.
PMID: 28381542
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Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium.
Authors: Ose J. , Schock H. , Poole E.M. , Lehtinen M. , Visvanathan K. , Helzlsouer K. , Buring J.E. , Lee I.M. , Tjønneland A. , Boutron-Ruault M.C. , et al. .
Source: Cancer causes & control : CCC, 2017 May; 28(5), p. 429-435.
EPub date: 2017-02-16.
PMID: 28205047
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Hormone concentrations throughout uncomplicated pregnancies: a longitudinal study.
Authors: Schock H. , Zeleniuch-Jacquotte A. , Lundin E. , Grankvist K. , Lakso H.Å. , Idahl A. , Lehtinen M. , Surcel H.M. , Fortner R.T. .
Source: BMC pregnancy and childbirth, 2016-07-04; 16(1), p. 146.
EPub date: 2016-07-04.
PMID: 27377060
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Early pregnancy IGF-I and placental GH and risk of epithelial ovarian cancer: A nested case-control study.
Authors: Schock H. , Fortner R.T. , Surcel H.M. , Grankvist K. , Pukkala E. , Lehtinen M. , Lundin E. .
Source: International journal of cancer, 2015-07-15; 137(2), p. 439-47.
EPub date: 2014-12-17.
PMID: 25516257
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Anti-Mullerian hormone and risk of invasive serous ovarian cancer.
Authors: Schock H. , Lundin E. , Vääräsmäki M. , Grankvist K. , Fry A. , Dorgan J.F. , Pukkala E. , Lehtinen M. , Surcel H.M. , Lukanova A. .
Source: Cancer causes & control : CCC, 2014 May; 25(5), p. 583-9.
EPub date: 2014-02-22.
PMID: 24562905
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Free ?-human chorionic gonadotropin, total human chorionic gonadotropin and maternal risk of breast cancer.
Authors: Toriola A.T. , Tolockiene E. , Schock H. , Surcel H.M. , Zeleniuch-Jacquotte A. , Wadell G. , Toniolo P. , Lundin E. , Grankvist K. , Lukanova A. .
Source: Future oncology (London, England), 2014 Feb; 10(3), p. 377-84.
PMID: 24559445
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Early pregnancy sex steroids and maternal risk of epithelial ovarian cancer.
Authors: Schock H. , Surcel H.M. , Zeleniuch-Jacquotte A. , Grankvist K. , Lakso H.Å. , Fortner R.T. , Kaaks R. , Pukkala E. , Lehtinen M. , Toniolo P. , et al. .
Source: Endocrine-related cancer, 2014; 21(6), p. 831-44.
PMID: 25270324
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Circulating estrogens and progesterone during primiparous pregnancies and risk of maternal breast cancer.
Authors: Lukanova A. , Surcel H.M. , Lundin E. , Kaasila M. , Lakso H.A. , Schock H. , Husing A. , Kaaks R. , Koskela P. , Grankvist K. , et al. .
Source: International journal of cancer, 2012-02-15; 130(4), p. 910-20.
EPub date: 2011-05-09.
PMID: 21413009
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Determinants of maternal sex steroids during the first half of pregnancy.
Authors: Toriola A.T. , Vääräsmäki M. , Lehtinen M. , Zeleniuch-Jacquotte A. , Lundin E. , Rodgers K.G. , Lakso H.A. , Chen T. , Schock H. , Hallmans G. , et al. .
Source: Obstetrics and gynecology, 2011 Nov; 118(5), p. 1029-36.
PMID: 22015870
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Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer.
Authors: Toriola A.T. , Lundin E. , Schock H. , Grankvist K. , Pukkala E. , Chen T. , Zeleniuch-Jacquotte A. , Toniolo P. , Lehtinen M. , Surcel H.M. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Aug; 20(8), p. 1798-801.
EPub date: 2011-06-15.
PMID: 21680537
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Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy.
Authors: Toriola A.T. , Surcel H.M. , Husing A. , Grankvist K. , Lakso H.A. , Schock H. , Lundin E. , Lehtinen M. , Lukanova A. .
Source: Cancer causes & control : CCC, 2011 Jun; 22(6), p. 925-8.
EPub date: 2011-03-09.
PMID: 21387179
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Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer.
Authors: Chen T. , Surcel H.M. , Lundin E. , Kaasila M. , Lakso H.A. , Schock H. , Kaaks R. , Koskela P. , Grankvist K. , Hallmans G. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Feb; 20(2), p. 324-36.
EPub date: 2010-12-21.
PMID: 21177423
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Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer.
Authors: Toniolo P. , Grankvist K. , Wulff M. , Chen T. , Johansson R. , Schock H. , Lenner P. , Hallmans G. , Lehtinen M. , Kaaks R. , et al. .
Source: Cancer research, 2010-09-01; 70(17), p. 6779-86.
EPub date: 2010-08-16.
PMID: 20713523
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Maternal hormones during early pregnancy: a cross-sectional study.
Authors: Chen T. , Lundin E. , Grankvist K. , Zeleniuch-Jacquotte A. , Wulff M. , Afanasyeva Y. , Schock H. , Johansson R. , Lenner P. , Hallmans G. , et al. .
Source: Cancer causes & control : CCC, 2010 May; 21(5), p. 719-27.
EPub date: 2010-01-19.
PMID: 20084544
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IGF-I during primiparous pregnancy and maternal risk of breast cancer.
Authors: Chen T. , Lukanova A. , Grankvist K. , Zeleniuch-Jacquotte A. , Wulff M. , Johansson R. , Schock H. , Lenner P. , Hallmans G. , Wadell G. , et al. .
Source: Breast cancer research and treatment, 2010 May; 121(1), p. 169-75.
EPub date: 2009-09-02.
PMID: 19728079
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Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study.
Authors: Lukanova A. , Andersson R. , Wulff M. , Zeleniuch-Jacquotte A. , Grankvist K. , Dossus L. , Afanasyeva Y. , Johansson R. , Arslan A.A. , Lenner P. , et al. .
Source: American journal of epidemiology, 2008-12-01; 168(11), p. 1284-91.
EPub date: 2008-10-20.
PMID: 18936438
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Effect of long-term storage on hormone measurements in samples from pregnant women: the experience of the Finnish Maternity Cohort.
Authors: Holl K. , Lundin E. , Kaasila M. , Grankvist K. , Afanasyeva Y. , Hallmans G. , Lehtinen M. , Pukkala E. , Surcel H.M. , Toniolo P. , et al. .
Source: Acta oncologica (Stockholm, Sweden), 2008; 47(3), p. 406-12.
EPub date: 2007-09-24.
PMID: 17891670
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