Grant Details
Grant Number: |
5R01CA118567-05 Interpret this number |
Primary Investigator: |
Spiegel, David |
Organization: |
Stanford University |
Project Title: |
Sleep, Circadian, Hormonal Dysregulation, and Breast Cancer Survival |
Fiscal Year: |
2010 |
Abstract
DESCRIPTION (provided by applicant): Recent research provides evidence that disrupted circadian rhythms, including hormonal patterns and sleep, are associated with increased risk of breast cancer incidence and faster progression to mortality. We have observed that loss of normal diurnal cortisol rhythm associated with more awakenings during the night predicts early mortality with metastatic breast cancer. Other recent studies have shown that nighttime shift work is associated with higher breast cancer incidence, and in a murine model disrupting circadian cortisol cycles produced a doubling of implanted tumor growth. There is also recent evidence that abnormal clock genes are associated with cancer. However, it is not clear whether sleep disruption per se affects breast cancer progression, or whether such an effect is mediated by hormonal and immune dysregulation of this prevalent and hormone-mediated cancer. We propose to study sleep disruption as a prognostic factor in the progression of metastatic breast cancer. We will also examine sleep patterns in association with disrupted circadian rhythms of cortisol, CRF, ACTH, and melatonin as well as measures of immune function known to be salient to breast cancer progression. These are natural killer cell cytotoxicity and specific cytokines: tumor necrosis factor alpha and nuclear factor kappa B. We plan to recruit 117 women 55 and older with metastatic breast cancer and 63 age and SES-matched controls for a two-week at home sleep study using Actiwatch and one night of in-home EEG monitoring, followed by 32 hours of EEG sleep monitoring and continuous blood sampling in the General Clinical Research Center. This will provide full circadian hormone assessment associated with thorough assessment of sleep patterns. We will relate these measures to the subsequent course of breast cancer progression. Results of this study will provide specific evidence regarding how improved sleep management may affect the course of breast cancer.
Publications
Evening salivary cortisol as a single stress marker in women with metastatic breast cancer.
Authors: Allende S.
, Medina J.L.
, Spiegel D.
, Zeitzer J.M.
.
Source: Psychoneuroendocrinology, 2020 05; 115, p. 104648.
EPub date: 2020-03-08 00:00:00.0.
PMID: 32171899
Related Citations
Serotonin transporter polymorphism, depressive symptoms, and emotional impulsivity among advanced breast cancer patients.
Authors: Kim Y.
, Carver C.S.
, Hallmayer J.F.
, Zeitzer J.M.
, Palesh O.
, Neri E.
, Nouriani B.
, Spiegel D.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2018 Apr; 26(4), p. 1181-1188.
EPub date: 2017-10-31 00:00:00.0.
PMID: 29090386
Related Citations
Physical Activity and Survival in Women With Advanced Breast Cancer.
Authors: Palesh O.
, Kamen C.
, Sharp S.
, Golden A.
, Neri E.
, Spiegel D.
, Koopman C.
.
Source: Cancer Nursing, 2017-07-19 00:00:00.0; , .
EPub date: 2017-07-19 00:00:00.0.
PMID: 28727578
Related Citations
Aberrant Nocturnal Cortisol And Disease Progression In Women With Breast Cancer
Authors: Zeitzer J.M.
, Nouriani B.
, Rissling M.B.
, Sledge G.W.
, Kaplan K.A.
, Aasly L.
, Palesh O.
, Jo B.
, Neri E.
, Dhabhar F.S.
, et al.
.
Source: Breast Cancer Research And Treatment, 2016 Jul; 158(1), p. 43-50.
PMID: 27314577
Related Citations
Posttraumatic Growth And Diurnal Cortisol Slope Among Women With Metastatic Breast Cancer
Authors: Diaz M.
, Aldridge-Gerry A.
, Spiegel D.
.
Source: Psychoneuroendocrinology, 2014 Jun; 44, p. 83-7.
PMID: 24767622
Related Citations
Actigraphy-measured Sleep Disruption As A Predictor Of Survival Among Women With Advanced Breast Cancer
Authors: Palesh O.
, Aldridge-Gerry A.
, Zeitzer J.M.
, Koopman C.
, Neri E.
, Giese-Davis J.
, Jo B.
, Kraemer H.
, Nouriani B.
, Spiegel D.
.
Source: Sleep, 2014 May; 37(5), p. 837-42.
PMID: 24790261
Related Citations
Bedtime Misalignment And Progression Of Breast Cancer
Authors: Hahm B.J.
, Jo B.
, Dhabhar F.S.
, Palesh O.
, Aldridge-Gerry A.
, Bajestan S.N.
, Neri E.
, Nouriani B.
, Spiegel D.
, Zeitzer J.M.
.
Source: Chronobiology International, 2014 Mar; 31(2), p. 214-21.
PMID: 24156520
Related Citations
Correspondence Of Plasma And Salivary Cortisol Patterns In Women With Breast Cancer
Authors: Zeitzer J.M.
, Nouriani B.
, Neri E.
, Spiegel D.
.
Source: Neuroendocrinology, 2014; 100(2-3), p. 153-61.
PMID: 25228297
Related Citations
Psychosocial Correlates Of Sleep Quality And Architecture In Women With Metastatic Breast Cancer
Authors: Aldridge-Gerry A.
, Zeitzer J.M.
, Palesh O.G.
, Jo B.
, Nouriani B.
, Neri E.
, Spiegel D.
.
Source: Sleep Medicine, 2013 Nov; 14(11), p. 1178-86.
PMID: 24074694
Related Citations
Mind Matters In Cancer Survival
Authors: Spiegel D.
.
Source: Psycho-oncology, 2012 Jun; 21(6), p. 588-93.
PMID: 22438289
Related Citations
Mind matters in cancer survival.
Authors: Spiegel D.
.
Source: Jama, 2011-02-02 00:00:00.0; 305(5), p. 502-3.
PMID: 21285429
Related Citations
Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis.
Authors: Giese-Davis J.
, Collie K.
, Rancourt K.M.
, Neri E.
, Kraemer H.C.
, Spiegel D.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2011-02-01 00:00:00.0; 29(4), p. 413-20.
EPub date: 2011-02-01 00:00:00.0.
PMID: 21149651
Related Citations
Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype.
Authors: Lanius R.A.
, Vermetten E.
, Loewenstein R.J.
, Brand B.
, Schmahl C.
, Bremner J.D.
, Spiegel D.
.
Source: The American Journal Of Psychiatry, 2010 Jun; 167(6), p. 640-7.
PMID: 20360318
Related Citations
Hypnotizability, posttraumatic stress, and depressive symptoms in metastatic breast cancer.
Authors: Keuroghlian A.S.
, Butler L.D.
, Neri E.
, Spiegel D.
.
Source: The International Journal Of Clinical And Experimental Hypnosis, 2010 Jan; 58(1), p. 39-52.
PMID: 20183737
Related Citations
Use And Misuse Of The Consolidated Standards Of Reporting Trials (consort) Guidelines To Assess Research Findings: Comment On Coyne, Stefanek, And Palmer (2007)
Authors: Kraemer H.C.
, Kuchler T.
, Spiegel D.
.
Source: Psychological Bulletin, 2009 Mar; 135(2), p. 173-8; discussion 179-82.
PMID: 19254073
Related Citations
Vagal Regulation, Cortisol, And Sleep Disruption In Women With Metastatic Breast Cancer
Authors: Palesh O.
, Zeitzer J.M.
, Conrad A.
, Giese-Davis J.
, Mustian K.M.
, Popek V.
, Nga K.
, Spiegel D.
.
Source: Journal Of Clinical Sleep Medicine : Jcsm : Official Publication Of The American Academy Of Sleep Medicine, 2008-10-15 00:00:00.0; 4(5), p. 441-9.
PMID: 18853702
Related Citations
Losing Sleep Over Cancer
Authors: Spiegel D.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2008-05-20 00:00:00.0; 26(15), p. 2431-2.
PMID: 18487562
Related Citations
A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer.
Authors: Palesh O.G.
, Collie K.
, Batiuchok D.
, Tilston J.
, Koopman C.
, Perlis M.L.
, Butler L.D.
, Carlson R.
, Spiegel D.
.
Source: Biological Psychology, 2007 Apr; 75(1), p. 37-44.
PMID: 17166646
Related Citations