Grant Details
Grant Number: |
5R01CA109650-05 Interpret this number |
Primary Investigator: |
Ganz, Patricia |
Organization: |
University Of California Los Angeles |
Project Title: |
Cognitive Functioning After Breast Cancer Treatment |
Fiscal Year: |
2010 |
Abstract
DESCRIPTION (provided by applicant): Cognitive complaints have been anecdotally reported among women receiving adjuvant chemotherapy for breast cancer, and recently this has been subjected to more rigorous study. Cerebral functioning can be assessed by self-report, standardized neuropsychological testing, and through examination of brain metabolism (all of which have been studied in our laboratory). The literature suggests a relationship between chemotherapy exposure and poorer performance on neurocognitive testing; however, patients with cognitive complaints do not necessarily test poorly and their complaints are often associated with symptoms of depression and anxiety. Preliminary work in our laboratory suggests that hormonal changes associated with menopause and adjuvant endocrine therapy for breast cancer also influence the effects of chemotherapy on cognitive functioning. Little is known about the potential mechanisms by which adjuvant endocrine therapy influences cerebral functioning after breast cancer treatment, and in this study we will address this question by studying women who have recently completed their primary breast cancer treatments (surgery, radiation, chemotherapy) and who are about to initiate adjuvant endocrine therapy (with tamoxifen or aromatase inhibitors). We will examine the potential mechanisms by which endocrine therapy affects cerebral functioning, by consideration of a comprehensive framework that includes the role of constitutional symptoms (fatigue, depression, anxiety), and immune alterations, in addition to specific cancer treatments (chemotherapy, hormonal treatments), and endogenous endocrine exposures (estrogen, cortisol). In this longitudinal, observational cohort study, we propose the following specific aims: 1)To evaluate the effects of adjuvant endocrine therapy on cognitive functioning through standardized questionnaires and neuropsychological assessments in 260 breast cancer patients at the end of primary treatment (baseline) when endocrine treatment is initiated, and one year later (follow-up). 2)To examine the association between cognitive functioning and measures of cerebral metabolism by obtaining positron emission tomography (PET) brain imaging, at rest and with a memory challenge, in close temporal proximity to the baseline assessment of cognitive functioning in a subset of 60 women, with a follow-up assessment one year later. 3)To explore the biopsychosocial mechanisms by which adjuvant endocrine therapy influences cerebral functioning by examining changes in cognitive functioning and brain metabolism, and their relationship to immune and endocrine function, mood and symptoms between the baseline and follow-up assessment one year later. Lay summary: Breast cancer is the most common cancer in women. After treatments for breast cancer, some women complain of difficulty in concentrating and thinking. This study will examine the effects of breast cancer treatments on cognitive, psychological, immune and endocrine function to try to understand the biological mechanisms of these complaints so that they may be better prevented or treated in the future.
Publications
Validating the PROMIS cognitive function short form in cancer survivors.
Authors: Henneghan A.M.
, Van Dyk K.
, Zhou X.
, Moore R.C.
, Root J.C.
, Ahles T.A.
, Nakamura Z.M.
, Mandeblatt J.
, Ganz P.A.
.
Source: Breast Cancer Research And Treatment, 2023-06-17 00:00:00.0; , .
EPub date: 2023-06-17 00:00:00.0.
PMID: 37330430
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Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease.
Authors: Jun G.R.
, You Y.
, Zhu C.
, Meng G.
, Chung J.
, Panitch R.
, Hu J.
, Xia W.
, Alzheimer's Disease Genetics Consortium
, Bennett D.A.
, et al.
.
Source: Alzheimer's & Dementia : The Journal Of The Alzheimer's Association, 2022-02-09 00:00:00.0; , .
EPub date: 2022-02-09 00:00:00.0.
PMID: 35142023
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Association of APOE4 genotype and treatment with cognitive outcomes in breast cancer survivors over time.
Authors: Van Dyk K.
, Crespi C.M.
, Bower J.E.
, Carroll J.E.
, Petersen L.
, Ganz P.A.
.
Source: Npj Breast Cancer, 2021-09-03 00:00:00.0; 7(1), p. 112.
EPub date: 2021-09-03 00:00:00.0.
PMID: 34480030
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Executive Functioning and Depressive Symptoms After Cancer: The Mediating Role of Coping.
Authors: Radin A.
, Ganz P.A.
, Van Dyk K.
, Stanton A.L.
, Bower J.E.
.
Source: Psychosomatic Medicine, 2021-04-01 00:00:00.0; 83(3), p. 291-299.
PMID: 33657085
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Goal disturbance in early-stage breast cancer survivors.
Authors: Haydon M.D.
, Stanton A.L.
, Ganz P.A.
, Bower J.E.
.
Source: Journal Of Psychosocial Oncology, 2019 Jul-Aug; 37(4), p. 478-493.
EPub date: 2019-01-25 00:00:00.0.
PMID: 30681035
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The cognitive effects of endocrine therapy in survivors of breast cancer: A prospective longitudinal study up to 6 years after treatment.
Authors: Van Dyk K.
, Crespi C.M.
, Bower J.E.
, Castellon S.A.
, Petersen L.
, Ganz P.A.
.
Source: Cancer, 2018-11-28 00:00:00.0; , .
EPub date: 2018-11-28 00:00:00.0.
PMID: 30485399
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Cognitive performance in survivors of breast cancer and markers of biological aging.
Authors: Carroll J.E.
, Van Dyk K.
, Bower J.E.
, Scuric Z.
, Petersen L.
, Schiestl R.
, Irwin M.R.
, Ganz P.A.
.
Source: Cancer, 2018-11-26 00:00:00.0; , .
EPub date: 2018-11-26 00:00:00.0.
PMID: 30474160
Related Citations
Fatigue after breast cancer treatment: Biobehavioral predictors of fatigue trajectories.
Authors: Bower J.E.
, Wiley J.
, Petersen L.
, Irwin M.R.
, Cole S.W.
, Ganz P.A.
.
Source: Health Psychology : Official Journal Of The Division Of Health Psychology, American Psychological Association, 2018 Nov; 37(11), p. 1025-1034.
PMID: 30321021
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Cognitive function following breast cancer treatment and associations with concurrent symptoms.
Authors: Van Dyk K.
, Bower J.E.
, Crespi C.M.
, Petersen L.
, Ganz P.A.
.
Source: Npj Breast Cancer, 2018; 4, p. 25.
EPub date: 2018-08-17 00:00:00.0.
PMID: 30131974
Related Citations
Inflammation and attentional bias in breast cancer survivors.
Authors: Boyle C.C.
, Ganz P.A.
, Van Dyk K.M.
, Bower J.E.
.
Source: Brain, Behavior, And Immunity, 2017 Nov; 66, p. 85-88.
EPub date: 2017-05-22 00:00:00.0.
PMID: 28546059
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Evaluating cognitive complaints in breast cancer survivors with the FACT-Cog and quantitative electroencephalography.
Authors: Van Dyk K.
, Hunter A.M.
, Ercoli L.
, Petersen L.
, Leuchter A.F.
, Ganz P.A.
.
Source: Breast Cancer Research And Treatment, 2017 Nov; 166(1), p. 157-166.
EPub date: 2017-07-13 00:00:00.0.
PMID: 28707203
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Measuring cognitive complaints in breast cancer survivors: psychometric properties of the patient's assessment of own functioning inventory.
Authors: Van Dyk K.
, Ganz P.A.
, Ercoli L.
, Petersen L.
, Crespi C.M.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2016 Dec; 24(12), p. 4939-4949.
PMID: 27432402
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Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer.
Authors: Dooley L.N.
, Ganz P.A.
, Cole S.W.
, Crespi C.M.
, Bower J.E.
.
Source: Journal Of Affective Disorders, 2016 Jun; 197, p. 43-50.
PMID: 26967918
Related Citations
Comparison Of Neurocognitive Function After Anthracycline-based Chemotherapy Vs Nonanthracycline-based Chemotherapy
Authors: Van Dyk K.
, Petersen L.
, Ganz P.A.
.
Source: Jama Oncology, 2016-04-21 00:00:00.0; , .
PMID: 27100156
Related Citations
Impact Of Adjuvant Endocrine Therapy On Quality Of Life And Symptoms: Observational Data Over 12 Months From The Mind-body Study
Authors: Ganz P.A.
, Petersen L.
, Bower J.E.
, Crespi C.M.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-03-10 00:00:00.0; 34(8), p. 816-24.
PMID: 26786934
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Positive Affect And Inflammatory Activity In Breast Cancer Survivors: Examining The Role Of Affective Arousal
Authors: Moreno P.I.
, Moskowitz A.L.
, Ganz P.A.
, Bower J.E.
.
Source: Psychosomatic Medicine, 2016-02-18 00:00:00.0; , .
PMID: 26867077
Related Citations
Posttraumatic Growth In Breast Cancer Survivors: Does Age Matter?
Authors: Boyle C.C.
, Stanton A.L.
, Ganz P.A.
, Bower J.E.
.
Source: Psycho-oncology, 2016-02-18 00:00:00.0; , .
PMID: 26893237
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Cognitive Function After The Initiation Of Adjuvant Endocrine Therapy In Early-stage Breast Cancer: An Observational Cohort Study
Authors: Ganz P.A.
, Petersen L.
, Castellon S.A.
, Bower J.E.
, Silverman D.H.
, Cole S.W.
, Irwin M.R.
, Belin T.R.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2014-11-01 00:00:00.0; 32(31), p. 3559-67.
PMID: 25267747
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Childhood Adversity And Inflammation In Breast Cancer Survivors
Authors: Crosswell A.D.
, Bower J.E.
, Ganz P.A.
.
Source: Psychosomatic Medicine, 2014 Apr; 76(3), p. 208-14.
PMID: 24632893
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The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer.
Authors: Pomykala K.L.
, Ganz P.A.
, Bower J.E.
, Kwan L.
, Castellon S.A.
, Mallam S.
, Cheng I.
, Ahn R.
, Breen E.C.
, Irwin M.R.
, et al.
.
Source: Brain Imaging And Behavior, 2013 Dec; 7(4), p. 511-23.
PMID: 23835929
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Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance.
Authors: Ganz P.A.
, Kwan L.
, Castellon S.A.
, Oppenheim A.
, Bower J.E.
, Silverman D.H.
, Cole S.W.
, Irwin M.R.
, Ancoli-Israel S.
, Belin T.R.
.
Source: Journal Of The National Cancer Institute, 2013-06-05 00:00:00.0; 105(11), p. 791-801.
EPub date: 2013-06-05 00:00:00.0.
PMID: 23606729
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Cytokine genetic variations and fatigue among patients with breast cancer.
Authors: Bower J.E.
, Ganz P.A.
, Irwin M.R.
, Castellon S.
, Arevalo J.
, Cole S.W.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2013-05-01 00:00:00.0; 31(13), p. 1656-61.
EPub date: 2013-05-01 00:00:00.0.
PMID: 23530106
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Sleep disturbance, inflammation and depression risk in cancer survivors.
Authors: Irwin M.R.
, Olmstead R.E.
, Ganz P.A.
, Haque R.
.
Source: Brain, Behavior, And Immunity, 2013 Mar; 30 Suppl, p. S58-67.
PMID: 22634367
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Does Tumor Necrosis Factor-alpha (tnf-¿) Play A Role In Post-chemotherapy Cerebral Dysfunction?
Authors: Ganz P.A.
, Bower J.E.
, Kwan L.
, Castellon S.A.
, Silverman D.H.
, Geist C.
, Breen E.C.
, Irwin M.R.
, Cole S.W.
.
Source: Brain, Behavior, And Immunity, 2013 Mar; 30 Suppl, p. S99-108.
PMID: 22884417
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Examining The Influence Of Beta Blockers And Ace Inhibitors On The Risk For Breast Cancer Recurrence: Results From The Lace Cohort
Authors: Ganz P.A.
, Habel L.A.
, Weltzien E.K.
, Caan B.J.
, Cole S.W.
.
Source: Breast Cancer Research And Treatment, 2011 Sep; 129(2), p. 549-56.
PMID: 21479924
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Missing Data: What A Little Can Do, And What Researchers Can Do In Response
Authors: Belin T.R.
.
Source: American Journal Of Ophthalmology, 2009 Dec; 148(6), p. 820-2.
PMID: 19932803
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Chronic Inflammation And Breast Cancer Recurrence
Authors: Cole,S.W.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2009-07-20 00:00:00.0; 27(21), p. 3418-9.
PMID: 19470918
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