Skip to main content

COVID-19 Resources

What people with cancer should know:

Guidance for cancer researchers:

Get the latest public health information from CDC:

Get the latest research information from NIH:

Grant Details

Grant Number: 5R01CA129539-02 Interpret this number
Primary Investigator: Cerhan, James
Organization: Mayo Clinic Rochester
Project Title: Molecular Epidemiology of Non-Hodgkin Lymphoma Survival
Fiscal Year: 2010


In 2008, over 66,000 people in the US will be diagnosed with Non-Hodgkin lymphoma (NHL), and over 19,000 will die of this cancer. Survival rates have only recently begun to improve, and the current 5-year survival rate is 66%. We have identified a number of candidate host (inherited) immune genes and DNA repair genes that individually and in aggregate predict survival for follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) beyond classic clinical and demographic prognostic factors. We have also found that pre-diagnosis smoking and obesity are associated with poorer overall NHL survival. We propose to replicate and extend these provocative findings. Furthermore, building off these findings, we will evaluate whether the association of host genetics is independent of tumor molecular markers, as well as begin to explore whether there are host–tumor interactions that impact disease progression and survival. The overall goal of this study is to identify host genetic and tumor molecular markers that predict event-free and overall survival in order to improve prognostication, better understand NHL pathophysiology, and ultimately help identify approaches to improve the survival of NHL patients. Our specific aims are: 1) To evaluate the association of polymorphisms in immune and DNA repair genes with event-free and overall survival from FL and DLBCL; 2) To evaluate the association of tumor molecular markers with event-free and overall survival from FL and DLBCL; and 3) To develop multivariate prediction models for FL and DLBCL that integrate standard demographic and clinical characteristics, treatment, host genetic variation (Aim 1) and tumor molecular markers (Aim 2) to predict eventfree and overall survival. In a secondary aim, we will evaluate the role of pre-diagnosis lifestyle factors with event-free and overall survival from NHL. To achieve these aims, we will use the Lymphoma Molecular Epidemiology Resource, an ongoing, prospective prognostic cohort study of newly diagnosed cases from the Mayo Clinic and the University of Iowa initiated in 2002. This resource has several methodologic strengths, including large sample size (>2200cases), central pathology review and classification, availability of tumor tissue, detailed baseline clinical prognostic data, initial and subsequent treatments, and a large patient population treated in the immunochemotherapy (rituximab) era. We have systematically collected detailed outcome data, which will allow us to evaluate both event-free and overall survival. We will also be able to evaluate host genetic and tumor molecular prognostic factors in the context of established demographic and clinical prognostic factors, as well as all treatment(s). Upon completion of these aims, we will have simultaneously evaluated the role of host genetic variation and molecular tumor markers in the prognosis of FL and DLBCL. If host genetic factors are confirmed as robust predictors of outcome, this could lead to a fundamental shift in how patient prognosis is evaluated by incorporating host genotype into prognostic models. Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients.


Lipid Trait Variants and the Risk of Non-Hodgkin Lymphoma Subtypes: A Mendelian Randomization Study.
Authors: Kleinstern G. , Camp N.J. , Berndt S.I. , Birmann B.M. , Nieters A. , Bracci P.M. , McKay J.D. , Ghesquières H. , Lan Q. , Hjalgrim H. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020 05; 29(5), p. 1074-1078.
EPub date: 2020-02-27.
PMID: 32108027
Related Citations

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
Authors: Din L. , Sheikh M. , Kosaraju N. , Smedby K.E. , Bernatsky S. , Berndt S.I. , Skibola C.F. , Nieters A. , Wang S. , McKay J.D. , et al. .
Source: Genetic epidemiology, 2019 10; 43(7), p. 844-863.
EPub date: 2019-08-13.
PMID: 31407831
Related Citations

Host genetic variation in tumor necrosis factor and nuclear factor-κB pathways and overall survival in mantle cell lymphoma: A discovery and replication study.
Authors: Wang Y. , Habermann T.M. , Wang S.S. , Maurer M.J. , Sarangi V. , Link B.K. , Feldman A.L. , Inwards D.J. , Witzig T.E. , Cozen W. , et al. .
Source: American journal of hematology, 2019 06; 94(6), p. E153-E155.
EPub date: 2019-03-15.
PMID: 30815899
Related Citations

Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
Authors: Kleinstern G. , Camp N.J. , Goldin L.R. , Vachon C.M. , Vajdic C.M. , de Sanjose S. , Weinberg J.B. , Benavente Y. , Casabonne D. , Liebow M. , et al. .
Source: Blood, 2018-06-07; 131(23), p. 2541-2551.
EPub date: 2018-04-19.
PMID: 29674426
Related Citations

A susceptibility locus for classical Hodgkin lymphoma at 8q24 near MYC/PVT1 predicts patient outcome in two independent cohorts.
Authors: Ghesquières H. , Larrabee B.R. , Casasnovas O. , Maurer M.J. , McKay J.D. , Ansell S.M. , Montgomery D. , Asmann Y.W. , Farrell K. , Verney A. , et al. .
Source: British journal of haematology, 2018 01; 180(2), p. 286-290.
EPub date: 2016-09-09.
PMID: 27716907
Related Citations

Cohort Profile: The Lymphoma Specialized Program of Research Excellence (SPORE) Molecular Epidemiology Resource (MER) Cohort Study.
Authors: Cerhan J.R. , Link B.K. , Habermann T.M. , Maurer M.J. , Feldman A.L. , Syrbu S.I. , Thompson C.A. , Farooq U. , Novak A.J. , Slager S.L. , et al. .
Source: International journal of epidemiology, 2017-12-01; 46(6), p. 1753-1754i.
PMID: 29025017
Related Citations

FCGR3A/2A polymorphisms and diffuse large B-cell lymphoma outcome treated with immunochemotherapy: a meta-analysis on 1134 patients from two prospective cohorts.
Authors: Ghesquières H. , Larrabee B.R. , Haioun C. , Link B.K. , Verney A. , Slager S.L. , Ketterer N. , Ansell S.M. , Delarue R. , Maurer M.J. , et al. .
Source: Hematological oncology, 2017 Dec; 35(4), p. 447-455.
EPub date: 2016-06-10.
PMID: 27282998
Related Citations

Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.
Authors: Ghesquieres H. , Slager S.L. , Jardin F. , Veron A.S. , Asmann Y.W. , Maurer M.J. , Fest T. , Habermann T.M. , Bene M.C. , Novak A.J. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-11-20; 33(33), p. 3930-7.
EPub date: 2015-10-12.
PMID: 26460308
Related Citations

A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Authors: Vijai J. , Wang Z. , Berndt S.I. , Skibola C.F. , Slager S.L. , de Sanjose S. , Melbye M. , Glimelius B. , Bracci P.M. , Conde L. , et al. .
Source: Nature communications, 2015-01-08; 6, p. 5751.
EPub date: 2015-01-08.
PMID: 25569183
Related Citations

Elevated monoclonal and polyclonal serum immunoglobulin free light chain as prognostic factors in B- and T-cell non-Hodgkin lymphoma.
Authors: Witzig T.E. , Maurer M.J. , Habermann T.M. , Link B.K. , Micallef I.N. , Nowakowski G.S. , Ansell S.M. , Colgan J.P. , Inwards D.J. , Porrata L.F. , et al. .
Source: American journal of hematology, 2014 Dec; 89(12), p. 1116-20.
EPub date: 2014-09-26.
PMID: 25228125
Related Citations

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Authors: Cerhan J.R. , Berndt S.I. , Vijai J. , Ghesquières H. , McKay J. , Wang S.S. , Wang Z. , Yeager M. , Conde L. , de Bakker P.I. , et al. .
Source: Nature genetics, 2014 Nov; 46(11), p. 1233-8.
EPub date: 2014-09-28.
PMID: 25261932
Related Citations

Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma.
Authors: Gustafson H.L. , Yao S. , Goldman B.H. , Lee K. , Spier C.M. , LeBlanc M.L. , Rimsza L.M. , Cerhan J.R. , Habermann T.M. , Link B.K. , et al. .
Source: American journal of hematology, 2014 Jun; 89(6), p. 639-45.
EPub date: 2014-04-12.
PMID: 24633940
Related Citations

Elevated serum monoclonal and polyclonal free light chains and interferon inducible protein-10 predicts inferior prognosis in untreated diffuse large B-cell lymphoma.
Authors: Witzig T.E. , Maurer M.J. , Stenson M.J. , Allmer C. , Macon W. , Link B. , Katzmann J.A. , Gupta M. .
Source: American journal of hematology, 2014 Apr; 89(4), p. 417-22.
EPub date: 2014-02-10.
PMID: 24382707
Related Citations

CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis.
Authors: Charbonneau B. , Wang A.H. , Maurer M.J. , Asmann Y.W. , Zent C.S. , Link B.K. , Ansell S.M. , Weiner G.J. , Ozsan N. , Feldman A.L. , et al. .
Source: Cancer immunology, immunotherapy : CII, 2013 Sep; 62(9), p. 1475-84.
EPub date: 2013-06-28.
PMID: 23812490
Related Citations

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Authors: Berndt S.I. , Skibola C.F. , Joseph V. , Camp N.J. , Nieters A. , Wang Z. , Cozen W. , Monnereau A. , Wang S.S. , Kelly R.S. , et al. .
Source: Nature genetics, 2013 Aug; 45(8), p. 868-76.
EPub date: 2013-06-16.
PMID: 23770605
Related Citations

Germline variation in complement genes and event-free survival in follicular and diffuse large B-cell lymphoma.
Authors: Charbonneau B. , Maurer M.J. , Fredericksen Z.S. , Zent C.S. , Link B.K. , Novak A.J. , Ansell S.M. , Weiner G.J. , Wang A.H. , Witzig T.E. , et al. .
Source: American journal of hematology, 2012 Sep; 87(9), p. 880-5.
EPub date: 2012-06-20.
PMID: 22718493
Related Citations

LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era.
Authors: Cerhan J.R. , Natkunam Y. , Morton L.M. , Maurer M.J. , Asmann Y. , Habermann T.M. , Vasef M.A. , Cozen W. , Lynch C.F. , Allmer C. , et al. .
Source: Leukemia & lymphoma, 2012 Jun; 53(6), p. 1105-12.
EPub date: 2012-01-03.
PMID: 22066713
Related Citations

Host genetics in follicular lymphoma.
Authors: Cerhan J.R. .
Source: Best practice & research. Clinical haematology, 2011 Jun; 24(2), p. 121-34.
EPub date: 2011-05-05.
PMID: 21658613
Related Citations

Back to Top