Grant Number:	2R01CA112243-06 Interpret this number
Primary Investigator:	Thomas, Nancy
Organization:	Univ Of North Carolina Chapel Hill
Project Title:	Melanoma Ras/Braf Mutation: Heterogeneity-Risk-Prognosis
Fiscal Year:	2010

DESCRIPTION (provided by applicant): Melanoma can metastasize at an early stage, and these metastases are typically resistant to medical treatment. In addition, melanoma is rising in incidence and mortality, greatly increasing the need for methods of prevention and treatment. Evidence suggests that chemokines and their receptors are important regulators of tumor immunity, progression, metastasis, and, angiogenesis in many cancers, including melanoma. The activities of chemokines and their receptors have been shown to be altered by polymorphisms but the impact of these changes on melanoma remains to be elucidated. Preliminary work has identified a polymorphism of a single chemokine receptor that influences the risk of melanoma, but as yet no comprehensive investigations of links between melanoma and chemokine or chemokine receptor polymorphisms have been performed. We propose to detail inherited variations in chemokines and their receptors and determine their associations with melanoma risk, survival, and NRAS and BRAF mutational subtypes in the large international population-based Genes, Environment, and Melanoma (GEM) study. We will also determine whether these relationships are modified by age, ultraviolet exposure, phenotypic traits, and polymorphisms in other genes. Few previous studies have simultaneously addressed the 'immunogenicity' of melanoma along with the oncogenic pathways. The results are likely to improve risk prediction and evidence-based recommendations for environmental protection and enable better outcomes prediction and customization of treatment paradigms for affected patients. PUBLIC HEALTH RELEVANCE: The objective of this competitive renewal is to determine whether inherited variants of chemokines and their receptors, which are key modulators of tumor immunity, are associated with melanoma risk, survival, and tumor mutations in melanoma, with a particular focus on covariates of risk: age and ultraviolet radiation. The work will be done in the context of a large international population-based study of over 3,000 melanoma patients. The results should lead to better risk prediction and more evidence-based recommendations for environmental protection and enable better survival prediction and the identification of patient groups most likely to benefit from targeted therapies for melanoma treatment.




Region of Interest Detection in Melanocytic Skin Tumor Whole Slide Images-Nevus and Melanoma.
Authors: Cui Y. , Li Y. , Miedema J.R. , Edmiston S.N. , Farag S.W. , Marron J.S. , Thomas N.E. .
Source: Cancers, 2024-07-23 00:00:00.0; 16(15), .
EPub date: 2024-07-23 00:00:00.0.
PMID: 39123344
Related Citations

Region of Interest Detection in Melanocytic Skin Tumor Whole Slide Images - Nevus & Melanoma.
Authors: Cui Y. , Li Y. , Miedema J.R. , Edmiston S.N. , Farag S. , Marron J.S. , Thomas N.E. .
Source: Arxiv, 2024-05-16 00:00:00.0; , .
EPub date: 2024-05-16 00:00:00.0.
PMID: 38800658
Related Citations

Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death.
Authors: Gibbs D.C. , Thomas N.E. , Kanetsky P.A. , Luo L. , Busam K.J. , Cust A.E. , Anton-Culver H. , Gallagher R.P. , Zanetti R. , Rosso S. , et al. .
Source: Jnci Cancer Spectrum, 2023-08-31 00:00:00.0; 7(5), .
PMID: 37494457
Related Citations

Sex-Specific Associations of MDM2 and MDM4 Variants with Risk of Multiple Primary Melanomas and Melanoma Survival in Non-Hispanic Whites.
Authors: Ward S.V. , Autuori I. , Luo L. , LaPilla E. , Yoo S. , Sharma A. , Busam K.J. , Olilla D.W. , Dwyer T. , Anton-Culver H. , et al. .
Source: Cancers, 2023-05-11 00:00:00.0; 15(10), .
EPub date: 2023-05-11 00:00:00.0.
PMID: 37345045
Related Citations

Association of Melanoma-Risk Variants with Primary Melanoma Tumor Prognostic Characteristics and Melanoma-Specific Survival in the GEM Study.
Authors: Davari D.R. , Orlow I. , Kanetsky P.A. , Luo L. , Busam K.J. , Sharma A. , Kricker A. , Cust A.E. , Anton-Culver H. , Gruber S.B. , et al. .
Source: Current Oncology (toronto, Ont.), 2021-11-16 00:00:00.0; 28(6), p. 4756-4771.
EPub date: 2021-11-16 00:00:00.0.
PMID: 34898573
Related Citations

Disease-Associated Risk Variants in ANRIL are Associated with Tumor-Infiltrating Lymphocytes Presence in Primary Melanomas in the Population-Based GEM Study.
Authors: Davari D.R. , Orlow I. , Kanetsky P.A. , Luo L. , Edmiston S.N. , Conway K. , Parrish E.A. , Hao H. , Busam K.J. , Sharma A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-10-04 00:00:00.0; , .
EPub date: 2021-10-04 00:00:00.0.
PMID: 34607836
Related Citations

Comparison of community pathologists with expert dermatopathologists evaluating Breslow thickness and histopathologic subtype in a large international population-based study of melanoma.
Authors: Yardman-Frank J.M. , Bronner B. , Rosso S. , From L. , Busam K. , Groben P. , Tucker P. , Cust A. , Armstrong B. , Kricker A. , et al. .
Source: Jaad International, 2021 Sep; 4, p. 25-27.
EPub date: 2021-06-01 00:00:00.0.
PMID: 34409386
Related Citations

Differences in Melanoma Between Canada and New South Wales, Australia: A Population-Based Genes, Environment, and Melanoma (GEM) Study.
Authors: Yardman-Frank J.M. , Glassheim E. , Kricker A. , Armstrong B.K. , Marrett L.D. , Luo L. , Cust A.E. , Busam K.J. , Orlow I. , Gallagher R.P. , et al. .
Source: Jid Innovations, 2021 Mar; 1(1), .
EPub date: 2021-01-25 00:00:00.0.
PMID: 33768212
Related Citations

Association of Known Melanoma Risk Factors with Primary Melanoma of the Scalp and Neck.
Authors: Wood R.P. , Heyworth J.S. , McCarthy N.S. , Mauguen A. , Berwick M. , Thomas N.E. , Millward M.J. , Anton-Culver H. , Cust A.E. , Dwyer T. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-08-20 00:00:00.0; , .
EPub date: 2020-08-20 00:00:00.0.
PMID: 32856602
Related Citations

Association of IRF4 single-nucleotide polymorphism rs12203592 with melanoma-specific survival.
Authors: Ward S.V. , Gibbs D.C. , Orlow I. , Thomas N.E. , Kanetsky P.A. , Luo L. , Cust A.E. , Anton-Culver H. , Gruber S.B. , Gallagher R.P. , et al. .
Source: The British Journal Of Dermatology, 2020-01-20 00:00:00.0; , .
EPub date: 2020-01-20 00:00:00.0.
PMID: 31958143
Related Citations

Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma.
Authors: Gibbs D.C. , Orlow I. , Vernali S. , Powell H.B. , Kanetsky P.A. , Luo L. , Busam K.J. , Sharma A. , Kricker A. , Armstrong B.K. , et al. .
Source: The Journal Of Investigative Dermatology, 2019-09-27 00:00:00.0; , .
EPub date: 2019-09-27 00:00:00.0.
PMID: 31568773
Related Citations

A risk prediction model for development of subsequent primary melanoma in a population-based cohort.
Authors: Cust A.E. , Badcock C. , Smith J. , Thomas N.E. , Haydu L.E. , Armstrong B.K. , Law M.H. , Thompson J.F. , Kanetsky P.A. , Begg C.B. , et al. .
Source: The British Journal Of Dermatology, 2019-09-14 00:00:00.0; , .
EPub date: 2019-09-14 00:00:00.0.
PMID: 31520533
Related Citations

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.
Authors: Pellegrini C. , Botta F. , Massi D. , Martorelli C. , Facchetti F. , Gandini S. , Maisonneuve P. , Avril M.F. , Demenais F. , Bressac-de Paillerets B. , et al. .
Source: The Lancet. Child & Adolescent Health, 2019 May; 3(5), p. 332-342.
EPub date: 2019-03-12 00:00:00.0.
PMID: 30872112
Related Citations

Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma Study.
Authors: Miles J.A. , Orlow I. , Kanetsky P.A. , Luo L. , Cust A.E. , Armstrong B.K. , Kricker A. , Anton-Culver H. , Gruber S.B. , Gallagher R.P. , et al. .
Source: The Journal Of Investigative Dermatology, 2018-12-17 00:00:00.0; , .
EPub date: 2018-12-17 00:00:00.0.
PMID: 30571972
Related Citations

Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes.
Authors: Thomas N.E. , Edmiston S.N. , Orlow I. , Kanetsky P.A. , Luo L. , Gibbs D.C. , Parrish E.A. , Hao H. , Busam K.J. , Armstrong B.K. , et al. .
Source: The Journal Of Investigative Dermatology, 2018-05-09 00:00:00.0; , .
EPub date: 2018-05-09 00:00:00.0.
PMID: 29753029
Related Citations

The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.
Authors: Orlow I. , Shi Y. , Kanetsky P.A. , Thomas N.E. , Luo L. , Corrales-Guerrero S. , Cust A.E. , Sacchetto L. , Zanetti R. , Rosso S. , et al. .
Source: Pigment Cell & Melanoma Research, 2018 Mar; 31(2), p. 287-296.
EPub date: 2017-11-05 00:00:00.0.
PMID: 28990310
Related Citations

Associations of MC1R genotype and patient phenotypes with BRAF and NRAS mutations in melanoma.
Authors: Thomas N.E. , Edmiston S.N. , Kanetsky P.A. , Busam K.J. , Kricker A. , Armstrong B.K. , Cust A.E. , Anton-Culver H. , Gruber S.B. , Luo L. , et al. .
Source: The Journal Of Investigative Dermatology, 2017-08-22 00:00:00.0; , .
EPub date: 2017-08-22 00:00:00.0.
PMID: 28842324
Related Citations

Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma.
Authors: Vernali S. , Waxweiler W.T. , Dillon P.M. , Kanetsky P.A. , Orlow I. , Luo L. , Busam K.J. , Kricker A. , Armstrong B.K. , Anton-Culver H. , et al. .
Source: Jama Dermatology, 2017-07-26 00:00:00.0; , .
EPub date: 2017-07-26 00:00:00.0.
PMID: 28746718
Related Citations

No association between prediagnosis exercise and survival in patients with high-risk primary melanoma: A population-based study.
Authors: Schwitzer E. , Orlow I. , Zabor E.C. , Begg C.B. , Berwick M. , Thomas N.E. , Kanetsky P.A. , Jones L.W. , GEM Study Group .
Source: Pigment Cell & Melanoma Research, 2017 Jul; 30(4), p. 424-427.
EPub date: 2017-06-08 00:00:00.0.
PMID: 28397350
Related Citations

Functional melanoma-risk variant IRF4 rs12203592 associated with Breslow thickness: a pooled international study of primary melanomas.
Authors: Gibbs D.C. , Ward S.V. , Orlow I. , Cadby G. , Kanetsky P.A. , Luo L. , Busam K.J. , Kricker A. , Armstrong B.K. , Cust A.E. , et al. .
Source: The British Journal Of Dermatology, 2017-07-01 00:00:00.0; , .
EPub date: 2017-07-01 00:00:00.0.
PMID: 28667740
Related Citations

No prognostic value added by vitamin D pathway SNPs to current prognostic system for melanoma survival.
Authors: Luo L. , Orlow I. , Kanetsky P.A. , Thomas N.E. , Fang S. , Lee J.E. , Berwick M. , Lee J.H. , GEM Study Group .
Source: Plos One, 2017; 12(3), p. e0174234.
EPub date: 2017-03-21 00:00:00.0.
PMID: 28323902
Related Citations

Defining Cancer Subtypes With Distinctive Etiologic Profiles: An Application to the Epidemiology of Melanoma.
Authors: Mauguen A. , Zabor E.C. , Thomas N.E. , Berwick M. , Seshan V.E. , Begg C.B. .
Source: Journal Of The American Statistical Association, 2017; 112(517), p. 54-63.
EPub date: 2017-05-03 00:00:00.0.
PMID: 28603323
Related Citations

Variants In Autophagy-related Genes And Clinical Characteristics In Melanoma: A Population-based Study
Authors: White K.A. , Luo L. , Thompson T.A. , Torres S. , Hu C.A. , Thomas N.E. , Lilyquist J. , Anton-Culver H. , Gruber S.B. , From L. , et al. .
Source: Cancer Medicine, 2016-10-17 00:00:00.0; , .
PMID: 27748080
Related Citations

Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma.
Authors: Taylor N.J. , Thomas N.E. , Anton-Culver H. , Armstrong B.K. , Begg C.B. , Busam K.J. , Cust A.E. , Dwyer T. , From L. , Gallagher R.P. , et al. .
Source: International Journal Of Cancer, 2016-09-15 00:00:00.0; 139(6), p. 1217-22.
EPub date: 2016-09-15 00:00:00.0.
PMID: 27101944
Related Citations

Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways.
Authors: Gibbs D.C. , Orlow I. , Bramson J.I. , Kanetsky P.A. , Luo L. , Kricker A. , Armstrong B.K. , Anton-Culver H. , Gruber S.B. , Marrett L.D. , et al. .
Source: Journal Of The National Cancer Institute, 2016 Jul; 108(7), .
PMID: 26857527
Related Citations

Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study.
Authors: Orlow I. , Reiner A.S. , Thomas N.E. , Roy P. , Kanetsky P.A. , Luo L. , Paine S. , Armstrong B.K. , Kricker A. , Marrett L.D. , et al. .
Source: Carcinogenesis, 2016 Jan; 37(1), p. 30-8.
PMID: 26521212
Related Citations

Appearance Normalization Of Histology Slides
Authors: Vicory J. , Couture H.D. , Thomas N.E. , Borland D. , Marron J.S. , Woosley J. , Niethammer M. .
Source: Computerized Medical Imaging And Graphics : The Official Journal Of The Computerized Medical Imaging Society, 2015 Jul; 43, p. 89-98.
PMID: 25863518
Related Citations

Inherited variation at MC1R and ASIP and association with melanoma-specific survival.
Authors: Taylor N.J. , Reiner A.S. , Begg C.B. , Cust A.E. , Busam K.J. , Anton-Culver H. , Dwyer T. , From L. , Gallagher R.P. , Gruber S.B. , et al. .
Source: International Journal Of Cancer, 2015-06-01 00:00:00.0; 136(11), p. 2659-67.
EPub date: 2015-06-01 00:00:00.0.
PMID: 25382380
Related Citations

Inherited genetic variants associated with occurrence of multiple primary melanoma.
Authors: Gibbs D.C. , Orlow I. , Kanetsky P.A. , Luo L. , Kricker A. , Armstrong B.K. , Anton-Culver H. , Gruber S.B. , Marrett L.D. , Gallagher R.P. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 Jun; 24(6), p. 992-7.
PMID: 25837821
Related Citations

Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma.
Authors: Thomas N.E. , Edmiston S.N. , Alexander A. , Groben P.A. , Parrish E. , Kricker A. , Armstrong B.K. , Anton-Culver H. , Gruber S.B. , From L. , et al. .
Source: Jama Oncology, 2015 Jun; 1(3), p. 359-68.
PMID: 26146664
Related Citations

Il2 Inducible T-cell Kinase, A Novel Therapeutic Target In Melanoma
Authors: Carson C.C. , Moschos S.J. , Edmiston S.N. , Darr D.B. , Nikolaishvili-Feinberg N. , Groben P.A. , Zhou X. , Kuan P.F. , Pandey S. , Chan K.T. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2015-05-01 00:00:00.0; 21(9), p. 2167-76.
PMID: 25934889
Related Citations

Inherited variation at MC1R and histological characteristics of primary melanoma.
Authors: Taylor N.J. , Busam K.J. , From L. , Groben P.A. , Anton-Culver H. , Cust A.E. , Begg C.B. , Dwyer T. , Gallagher R.P. , Gruber S.B. , et al. .
Source: Plos One, 2015; 10(3), p. e0119920.
PMID: 25790105
Related Citations

Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study.
Authors: Thomas N.E. , Kricker A. , Waxweiler W.T. , Dillon P.M. , Busman K.J. , From L. , Groben P.A. , Armstrong B.K. , Anton-Culver H. , Gruber S.B. , et al. .
Source: Jama Dermatology, 2014 Dec; 150(12), p. 1306-314.
PMID: 25162299
Related Citations

Dna Methylation Profiles In Primary Cutaneous Melanomas Are Associated With Clinically Significant Pathologic Features
Authors: Thomas N.E. , Slater N.A. , Edmiston S.N. , Zhou X. , Kuan P.F. , Groben P.A. , Carson C.C. , Hao H. , Parrish E. , Moschos S.J. , et al. .
Source: Pigment Cell & Melanoma Research, 2014 Nov; 27(6), p. 1097-105.
PMID: 24986547
Related Citations

Sun Exposure And Melanoma Survival: A Gem Study
Authors: Berwick M. , Reiner A.S. , Paine S. , Armstrong B.K. , Kricker A. , Goumas C. , Cust A.E. , Thomas N.E. , Groben P.A. , From L. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Oct; 23(10), p. 2145-52.
PMID: 25069694
Related Citations

Validation Of The Ve1 Immunostain For The Braf V600e Mutation In Melanoma
Authors: Pearlstein M.V. , Zedek D.C. , Ollila D.W. , Treece A. , Gulley M.L. , Groben P.A. , Thomas N.E. .
Source: Journal Of Cutaneous Pathology, 2014 Sep; 41(9), p. 724-32.
PMID: 24917033
Related Citations

Occupational sun exposure and risk of melanoma according to anatomical site.
Authors: Vuong K. , McGeechan K. , Armstrong B.K. , AMFS Investigators , GEM Investigators , Cust A.E. .
Source: International Journal Of Cancer, 2014-06-01 00:00:00.0; 134(11), p. 2735-41.
EPub date: 2014-06-01 00:00:00.0.
PMID: 24288300
Related Citations

MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors.
Authors: Berwick M. , MacArthur J. , Orlow I. , Kanetsky P. , Begg C.B. , Luo L. , Reiner A. , Sharma A. , Armstrong B.K. , Kricker A. , et al. .
Source: Pigment Cell & Melanoma Research, 2014 May; 27(3), p. 485-8.
PMID: 24406078
Related Citations

Development Of Dna Damage Response Signaling Biomarkers Using Automated, Quantitative Image Analysis
Authors: Nikolaishvilli-Feinberg N. , Cohen S.M. , Midkiff B. , Zhou Y. , Olorvida M. , Ibrahim J.G. , Omolo B. , Shields J.M. , Thomas N.E. , Groben P.A. , et al. .
Source: The Journal Of Histochemistry And Cytochemistry : Official Journal Of The Histochemistry Society, 2014 Mar; 62(3), p. 185-96.
PMID: 24309508
Related Citations

Solar Ultraviolet Exposure And Mortality From Skin Tumors
Authors: Berwick M. , Pestak C. , Thomas N. .
Source: Advances In Experimental Medicine And Biology, 2014; 810, p. 342-58.
PMID: 25207375
Related Citations

Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study.
Authors: Thomas N.E. , Busam K.J. , From L. , Kricker A. , Armstrong B.K. , Anton-Culver H. , Gruber S.B. , Gallagher R.P. , Zanetti R. , Rosso S. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2013-11-20 00:00:00.0; 31(33), p. 4252-9.
EPub date: 2013-11-20 00:00:00.0.
PMID: 24127443
Related Citations

Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis.
Authors: Raskin L. , Fullen D.R. , Giordano T.J. , Thomas D.G. , Frohm M.L. , Cha K.B. , Ahn J. , Mukherjee B. , Johnson T.M. , Gruber S.B. .
Source: The Journal Of Investigative Dermatology, 2013 Nov; 133(11), p. 2585-92.
PMID: 23633021
Related Citations

Survival for patients with single and multiple primary melanomas: the genes, environment, and melanoma study.
Authors: Kricker A. , Armstrong B.K. , Goumas C. , Thomas N.E. , From L. , Busam K. , Kanetsky P.A. , Gallagher R.P. , Marrett L.D. , Groben P.A. , et al. .
Source: Jama Dermatology, 2013 Aug; 149(8), p. 921-7.
PMID: 23784017
Related Citations

Image And Statistical Analysis Of Melanocytic Histology
Authors: Miedema J. , Marron J.S. , Niethammer M. , Borland D. , Woosley J. , Coposky J. , Wei S. , Reisner H. , Thomas N.E. .
Source: Histopathology, 2012 Sep; 61(3), p. 436-44.
PMID: 22687043
Related Citations

Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers.
Authors: Mukherjee B. , Delancey J.O. , Raskin L. , Everett J. , Jeter J. , Begg C.B. , Orlow I. , Berwick M. , Armstrong B.K. , Kricker A. , et al. .
Source: Journal Of The National Cancer Institute, 2012-06-20 00:00:00.0; 104(12), p. 953-6.
EPub date: 2012-06-20 00:00:00.0.
PMID: 22534780
Related Citations

The Tbx21 Transcription Factor T-1993c Polymorphism Is Associated With Decreased Ifn-¿ And Il-4 Production By Primary Human Lymphocytes
Authors: Fyall K.M. , Fong A.M. , Rao S.B. , Ibrahim J.G. , Waxweiler W.T. , Thomas N.E. .
Source: Human Immunology, 2012 Jun; 73(6), p. 673-6.
PMID: 22521571
Related Citations

Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas.
Authors: Murali R. , Goumas C. , Kricker A. , From L. , Busam K.J. , Begg C.B. , Dwyer T. , Gruber S.B. , Kanetsky P.A. , Orlow I. , et al. .
Source: Annals Of Surgical Oncology, 2012 Mar; 19(3), p. 1024-33.
PMID: 21913010
Related Citations

Vitamin D Receptor Polymorphisms In Patients With Cutaneous Melanoma
Authors: Orlow I. , Roy P. , Reiner A.S. , Yoo S. , Patel H. , Paine S. , Armstrong B.K. , Kricker A. , Marrett L.D. , Millikan R.C. , et al. .
Source: International Journal Of Cancer, 2012-01-15 00:00:00.0; 130(2), p. 405-18.
PMID: 21365644
Related Citations

Melanocortin-1 Receptor, Skin Cancer And Phenotypic Characteristics (m-skip) Project: Study Design And Methods For Pooling Results Of Genetic Epidemiological Studies
Authors: Raimondi S. , Gandini S. , Fargnoli M.C. , Bagnardi V. , Maisonneuve P. , Specchia C. , Kumar R. , Nagore E. , Han J. , Hansson J. , et al. .
Source: Bmc Medical Research Methodology, 2012; 12, p. 116.
PMID: 22862891
Related Citations

How Do Solar Uv Irradiance And Smoking Impact The Diagnosis Of Second Cancers After Diagnosis Of Melanoma?: No Answer Yet
Authors: Berwick,M. .
Source: Dermato-endocrinology, 2012-01-01 00:00:00.0; 4(1), p. 18-9.
PMID: 22870348
Related Citations