Grant Number:	5R01CA109767-06 Interpret this number
Primary Investigator:	Bracci, Paige
Organization:	University Of California, San Francisco
Project Title:	Molecular Epidemiology of Pancreatic Cancer
Fiscal Year:	2010

DESCRIPTION (provided by applicant): This application is 100% related to PC. Recent studies show that factors associated with abnormal glucose metabolism are important in PC development. We hypothesize that insulin resistance (IR) is a growth-promoting factor in PC etiology. Also, genetic variation in insulin, glucose, and lipid metabolism and in candidate genes for IR are related to PC risk. A clinic-based case-control study will include 600 patients and 600 controls obtained from UCSF clinics. Detailed history of diet, body mass index, obesity, physical activity, diabetes and other factors including medication use and smoking will be collected during interviews. Blood will be collected from eligible participants. UCSF's Molecular Epidemiology Core will process all bloods and extract DMA for use in molecular/ genetic studies. SNPs will be examined in candidate genes related to IR and metabolism, and lipid metabolism. Genetic testing will be done using UCSF's Genome Core facilities and personnel. Main effects for exposures and SNPs will be evaluated as will gene-environment and gene-gene interactions when sample sizes permit. We will work with NCI on the PC consortium development and combine new data with data from our earlier population-based PC study (N=2,233) to conduct analyses. We will collaborate with Seattle and Mayo clinic PC studies to pool data and increase power to study rare exposures and factors within small groups. Major strengths are: 1. Large number of PC cases will allow analyses by sex, ethnicity and race; 2. Innovative hypotheses to advance PC research (e.g. SNPs); 3. Expertise of lab faculty and facilities; 4. No proxy interviews; 5. Clinic-based cases will diminish case loss due to poor survival; 6. Studies of diabetes, IR, diet, obesity, physical activity and SNPs are innovative and new to large studies of PC; 7. Blood samples will be banked for future genetic studies and data will be pooled for greater statistical power.




Smoking modifies pancreatic cancer risk loci on 2q21.3.
Authors: Mocci E. , Kundu P. , Wheeler W. , Arslan A.A. , Beane Freeman L.E. , Bracci P.M. , Brennan P. , Canzian F. , Du M. , Gallinger S. , et al. .
Source: Cancer Research, 2021-02-11 00:00:00.0; , .
EPub date: 2021-02-11 00:00:00.0.
PMID: 33574088
Related Citations

Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk.
Authors: Yuan F. , Hung R.J. , Walsh N. , Zhang H. , Platz E.A. , Wheeler W. , Song L. , Arslan A.A. , Beane Freeman L.E. , Bracci P. , et al. .
Source: Cancer Research, 2020-07-08 00:00:00.0; , .
EPub date: 2020-07-08 00:00:00.0.
PMID: 32641412
Related Citations

Genome-Wide Gene-Diabetes and Gene-Obesity Interaction Scan in 8,255 Cases and 11,900 Controls from PanScan and PanC4 Consortia.
Authors: Tang H. , Jiang L. , Stolzenberg-Solomon R.Z. , Arslan A.A. , Beane Freeman L.E. , Bracci P.M. , Brennan P. , Canzian F. , Du M. , Gallinger S. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-06-16 00:00:00.0; , .
EPub date: 2020-06-16 00:00:00.0.
PMID: 32546605
Related Citations

Analysis of heritability and genetic architecture of Pancreatic Cancer: A PanC4 Study.
Authors: Chen F. , Childs E.J. , Mocci E. , Bracci P.M. , Gallinger S. , Li D. , Neale R.E. , Olson S.H. , Scelo G. , Bamlet W.R. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019-04-23 00:00:00.0; , .
EPub date: 2019-04-23 00:00:00.0.
PMID: 31015203
Related Citations

Pancreatic Cancer Risk is Modulated by Inflammatory Potential of Diet and ABO Genotype: A Consortia-based Evaluation and Replication Study.
Authors: Antwi S.O. , Bamlet W.R. , Pedersen K.S. , Chaffee K.G. , Risch H.A. , Shivappa N. , Steck S.E. , Anderson K.E. , Bracci P.M. , Polesel J. , et al. .
Source: Carcinogenesis, 2018-05-25 00:00:00.0; , .
EPub date: 2018-05-25 00:00:00.0.
PMID: 29800239
Related Citations

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Authors: Klein A.P. , Wolpin B.M. , Risch H.A. , Stolzenberg-Solomon R.Z. , Mocci E. , Zhang M. , Canzian F. , Childs E.J. , Hoskins J.W. , Jermusyk A. , et al. .
Source: Nature Communications, 2018-02-08 00:00:00.0; 9(1), p. 556.
EPub date: 2018-02-08 00:00:00.0.
PMID: 29422604
Related Citations

Menstrual and Reproductive Factors, Hormone Use, and Risk of Pancreatic Cancer: Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Lujan-Barroso L. , Zhang W. , Olson S.H. , Gao Y.T. , Yu H. , Baghurst P.A. , Bracci P.M. , Bueno-de-Mesquita H.B. , Foretová L. , Gallinger S. , et al. .
Source: Pancreas, 2016 Nov; 45(10), p. 1401-1410.
PMID: 27088489
Related Citations

Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis.
Authors: McWilliams R.R. , Maisonneuve P. , Bamlet W.R. , Petersen G.M. , Li D. , Risch H.A. , Yu H. , Fontham E.T. , Luckett B. , Bosetti C. , et al. .
Source: Pancreas, 2016 Feb; 45(2), p. 311-6.
PMID: 26646264
Related Citations

Cigarette Smoking And Risk Of Pancreatic Cancer: A Clinic-based Case-control Study In The San Francisco Bay Area
Authors: Lea C.S. , Holly E.A. , Bracci P.M. .
Source: Annals Of Epidemiology, 2015 Nov; 25(11), p. 816-23.
PMID: 26475980
Related Citations

Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
Authors: Waterhouse M. , Risch H.A. , Bosetti C. , Anderson K.E. , Petersen G.M. , Bamlet W.R. , Cotterchio M. , Cleary S.P. , Ibiebele T.I. , La Vecchia C. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2015 Aug; 26(8), p. 1776-83.
PMID: 25977560
Related Citations

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Authors: Childs E.J. , Mocci E. , Campa D. , Bracci P.M. , Gallinger S. , Goggins M. , Li D. , Neale R.E. , Olson S.H. , Scelo G. , et al. .
Source: Nature Genetics, 2015 Aug; 47(8), p. 911-6.
PMID: 26098869
Related Citations

Statin Use And Risk Of Pancreatic Cancer: Results From A Large, Clinic-based Case-control Study
Authors: Walker E.J. , Ko A.H. , Holly E.A. , Bracci P.M. .
Source: Cancer, 2015-04-15 00:00:00.0; 121(8), p. 1287-94.
PMID: 25649483
Related Citations

Metformin Use Among Type 2 Diabetics And Risk Of Pancreatic Cancer In A Clinic-based Case-control Study
Authors: Walker E.J. , Ko A.H. , Holly E.A. , Bracci P.M. .
Source: International Journal Of Cancer, 2015-03-15 00:00:00.0; 136(6), p. E646-53.
PMID: 25091126
Related Citations

Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium.
Authors: Bosetti C. , Rosato V. , Li D. , Silverman D. , Petersen G.M. , Bracci P.M. , Neale R.E. , Muscat J. , Anderson K. , Gallinger S. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2014 Oct; 25(10), p. 2065-72.
PMID: 25057164
Related Citations

Genes-environment interactions in obesity- and diabetes-associated pancreatic cancer: a GWAS data analysis.
Authors: Tang H. , Wei P. , Duell E.J. , Risch H.A. , Olson S.H. , Bueno-de-Mesquita H.B. , Gallinger S. , Holly E.A. , Petersen G.M. , Bracci P.M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Jan; 23(1), p. 98-106.
PMID: 24136929
Related Citations

Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bosetti C. , Lucenteforte E. , Bracci P.M. , Negri E. , Neale R.E. , Risch H.A. , Olson S.H. , Gallinger S. , Miller A.B. , Bueno-de-Mesquita H.B. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2013 Nov; 24(11), p. 2903-10.
PMID: 23970016
Related Citations

Allergies and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
Authors: Olson S.H. , Hsu M. , Satagopan J.M. , Maisonneuve P. , Silverman D.T. , Lucenteforte E. , Anderson K.E. , Borgida A. , Bracci P.M. , Bueno-de-Mesquita H.B. , et al. .
Source: American Journal Of Epidemiology, 2013-09-01 00:00:00.0; 178(5), p. 691-700.
EPub date: 2013-09-01 00:00:00.0.
PMID: 23820785
Related Citations

An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
Authors: Klein A.P. , Lindström S. , Mendelsohn J.B. , Steplowski E. , Arslan A.A. , Bueno-de-Mesquita H.B. , Fuchs C.S. , Gallinger S. , Gross M. , Helzlsouer K. , et al. .
Source: Plos One, 2013; 8(9), p. e72311.
PMID: 24058443
Related Citations

Obesity and survival in population-based patients with pancreatic cancer in the San Francisco Bay Area.
Authors: Gong Z. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2012 Dec; 23(12), p. 1929-37.
PMID: 23015286
Related Citations

Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
Authors: Bracci P.M. , Zhou M. , Young S. , Wiemels J. .
Source: Cancer, 2012-11-01 00:00:00.0; 118(21), p. 5384-94.
EPub date: 2012-11-01 00:00:00.0.
PMID: 22517435
Related Citations

Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Duell E.J. , Lucenteforte E. , Olson S.H. , Bracci P.M. , Li D. , Risch H.A. , Silverman D.T. , Ji B.T. , Gallinger S. , Holly E.A. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2012 Nov; 23(11), p. 2964-70.
PMID: 22767586
Related Citations

Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4).
Authors: Bosetti C. , Lucenteforte E. , Silverman D.T. , Petersen G. , Bracci P.M. , Ji B.T. , Negri E. , Li D. , Risch H.A. , Olson S.H. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2012 Jul; 23(7), p. 1880-8.
PMID: 22104574
Related Citations

Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.
Authors: Li D. , Duell E.J. , Yu K. , Risch H.A. , Olson S.H. , Kooperberg C. , Wolpin B.M. , Jiao L. , Dong X. , Wheeler B. , et al. .
Source: Carcinogenesis, 2012 Jul; 33(7), p. 1384-90.
PMID: 22523087
Related Citations

Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Lucenteforte E. , La Vecchia C. , Silverman D. , Petersen G.M. , Bracci P.M. , Ji B.T. , Bosetti C. , Li D. , Gallinger S. , Miller A.B. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2012 Feb; 23(2), p. 374-82.
PMID: 21536662
Related Citations

Mitochondrial DNA sequence variation and risk of pancreatic cancer.
Authors: Lam E.T. , Bracci P.M. , Holly E.A. , Chu C. , Poon A. , Wan E. , White K. , Kwok P.Y. , Pawlikowska L. , Tranah G.J. .
Source: Cancer Research, 2012-02-01 00:00:00.0; 72(3), p. 686-95.
EPub date: 2012-02-01 00:00:00.0.
PMID: 22174369
Related Citations

Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms.
Authors: Bracci P.M. .
Source: Molecular Carcinogenesis, 2012 Jan; 51(1), p. 53-63.
PMID: 22162231
Related Citations

Survival in population-based pancreatic cancer patients: San Francisco Bay area, 1995-1999.
Authors: Gong Z. , Holly E.A. , Bracci P.M. .
Source: American Journal Of Epidemiology, 2011-12-15 00:00:00.0; 174(12), p. 1373-81.
EPub date: 2011-12-15 00:00:00.0.
PMID: 22047824
Related Citations

Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Authors: Bertuccio P. , La Vecchia C. , Silverman D.T. , Petersen G.M. , Bracci P.M. , Negri E. , Li D. , Risch H.A. , Olson S.H. , Gallinger S. , et al. .
Source: Annals Of Oncology : Official Journal Of The European Society For Medical Oncology / Esmo, 2011 Jun; 22(6), p. 1420-6.
PMID: 21245160
Related Citations

Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay Area.
Authors: Tranah G.J. , Holly E.A. , Wang F. , Bracci P.M. .
Source: Bmc Cancer, 2011-04-15 00:00:00.0; 11, p. 138.
EPub date: 2011-04-15 00:00:00.0.
PMID: 21496267
Related Citations

Diabetes and risk of pancreatic cancer: a pooled analysis of three large case-control studies.
Authors: Li D. , Tang H. , Hassan M.M. , Holly E.A. , Bracci P.M. , Silverman D.T. .
Source: Cancer Causes & Control : Ccc, 2011 Feb; 22(2), p. 189-97.
PMID: 21104117
Related Citations

Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay area.
Authors: Zablotska L.B. , Gong Z. , Wang F. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2011 Jan; 22(1), p. 91-100.
PMID: 21072578
Related Citations

Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area.
Authors: Gong Z. , Holly E.A. , Wang F. , Chan J.M. , Bracci P.M. .
Source: International Journal Of Cancer, 2010-10-15 00:00:00.0; 127(8), p. 1893-904.
PMID: 20104522
Related Citations

Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study.
Authors: Gupta S. , Wang F. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2010 Jul; 21(7), p. 1047-59.
PMID: 20349126
Related Citations

Pancreatitis and pancreatic cancer in two large pooled case-control studies.
Authors: Bracci P.M. , Wang F. , Hassan M.M. , Gupta S. , Li D. , Holly E.A. .
Source: Cancer Causes & Control : Ccc, 2009 Nov; 20(9), p. 1723-1731.
PMID: 19760029
Related Citations

Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study.
Authors: Gong Z. , Holly E.A. , Bracci P.M. .
Source: Cancer Causes & Control : Ccc, 2009 Oct; 20(8), p. 1317-25.
PMID: 19415507
Related Citations

Pancreatic cancer and medical history in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Ko A.H. , Wang F. , Holly E.A. .
Source: Cancer Causes & Control : Ccc, 2007 Oct; 18(8), p. 809-19.
PMID: 17632765
Related Citations

Diabetes mellitus and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California.
Authors: Wang F. , Gupta S. , Holly E.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2006 Aug; 15(8), p. 1458-63.
PMID: 16896032
Related Citations