Grant Details
Grant Number: |
5R01CA121197-04 Interpret this number |
Primary Investigator: |
Amos, Christopher |
Organization: |
University Of Tx Md Anderson Can Ctr |
Project Title: |
High Density Association Analysis of Lung Cancer |
Fiscal Year: |
2010 |
Abstract
DESCRIPTION (provided by applicant): The goal of this research is to identify novel susceptibility genes for lung cancer using a systematic genome- wide association-based approach. To achieve this goal, we are applying a two-stage design. This proposal builds upon an extensive resource of lung cancer cases and controls matched for smoking behavior, sex, and ethnicity who have been collected over many years at the U.T. M.D. Anderson Cancer Center, and on a recently approved proposal to the Center for Inherited Disease Research that is performing genotyping of 317,000 markers on 1200 Caucasian ever-smoking lung cancer cases and 1200 controls matched for ethnicity, age, smoking behavior, and sex. Our first aim is to analyze data from the completed first-stage of genotyping. For our second aim, we will complete the two-stage design, which is powered to detect associations with genotypic risk ratios of about 1.4 with a very stringent significance criterion of 1.7 x 10-7. We will genotype and analyze 3380 SNPs on 1200 lung cancer cases and 1200 controls. We will also analyze SNPs from 90 candidate genes identified through a systematic literature search as well as a limited number of SNPs in significant pathways. In our third aim we will genotype 400 never-smoking lung cancer cases and 400 controls for 946 SNP markers. To evaluate possible interethnic differences in the genetic control of lung cancer risk we will analyze 400 African-American lung cancer cases and 400 African- American controls (aim 4) for 946 SNP markers. In these 4 aims we are also including a panel of SNPs to estimate ancestry. In aim 5, we use machine learning approaches to develop models for characterizing gene-gene and gene-environment effects on lung cancer risk. Cases and controls have extensive epidemiological and family history data together with candidate gene and functional DNA repair measures. The end result of our analysis will substantively increase our understanding of the genetic etiology of lung cancer and gene-environment interactions that contribute to its causation. This is an experienced investigative team, using state of the art technology to perform a multistage genome-wide analysis on a large, uniquely well-characterized population of lung cancer cases and matched controls with rich functional data. We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives.
Publications
Precise diagnosis of three top cancers using dbGaP data.
Authors: Liu X.Q.
, Liu X.S.
, Rong J.Y.
, Gao F.
, Wu Y.D.
, Deng C.H.
, Jiang H.Y.
, Li X.F.
, Chen Y.Q.
, Zhao Z.G.
, et al.
.
Source: Scientific Reports, 2021-01-12 00:00:00.0; 11(1), p. 823.
EPub date: 2021-01-12 00:00:00.0.
PMID: 33436913
Related Citations
Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.
Authors: Feng Y.
, Wang Y.
, Liu H.
, Liu Z.
, Mills C.
, Owzar K.
, Xie J.
, Han Y.
, Qian D.C.
, Hung Rj R.J.
, et al.
.
Source: Molecular Carcinogenesis, 2018 Feb; 57(2), p. 216-224.
EPub date: 2017-10-31 00:00:00.0.
PMID: 29071797
Related Citations
Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus.
Authors: Yin J.
, Liu H.
, Liu Z.
, Owzar K.
, Han Y.
, Su L.
, Wei Y.
, Hung R.J.
, Brhane Y.
, McLaughlin J.
, et al.
.
Source: Molecular Carcinogenesis, 2017 Jun; 56(6), p. 1663-1672.
EPub date: 2017-02-23 00:00:00.0.
PMID: 28150878
Related Citations
Functional variants in DCAF4 associated with lung cancer risk in European populations.
Authors: Liu H.
, Liu Z.
, Wang Y.
, Stinchcombe T.E.
, Owzar K.
, Han Y.
, Hung R.J.
, Brhane Y.
, McLaughlin J.
, Brennan P.
, et al.
.
Source: Carcinogenesis, 2017-05-01 00:00:00.0; 38(5), p. 541-551.
PMID: 28383684
Related Citations
Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.
Authors: Feng Y.
, Wang Y.
, Liu H.
, Liu Z.
, Mills C.
, Han Y.
, Hung R.J.
, Brhane Y.
, McLaughlin J.
, Brennan P.
, et al.
.
Source: Scientific Reports, 2017-04-11 00:00:00.0; 7(1), p. 825.
EPub date: 2017-04-11 00:00:00.0.
PMID: 28400551
Related Citations
Susceptibility Loci Of Cnot6 In The General Mrna Degradation Pathway And Lung Cancer Risk-a Re-analysis Of Eight Gwass
Authors: Zhou F.
, Wang Y.
, Liu H.
, Ready N.
, Han Y.
, Hung R.J.
, Brhane Y.
, McLaughlin J.
, Brennan P.
, Bickeböller H.
, et al.
.
Source: Molecular Carcinogenesis, 2017 Apr; 56(4), p. 1227-1238.
PMID: 27805284
Related Citations
Associations Between Genetic Variants In Mrna Splicing-related Genes And Risk Of Lung Cancer: A Pathway-based Analysis From Published Gwass
Authors: Pan Y.
, Liu H.
, Wang Y.
, Kang X.
, Liu Z.
, Owzar K.
, Han Y.
, Su L.
, Wei Y.
, Hung R.J.
, et al.
.
Source: Scientific Reports, 2017-03-17 00:00:00.0; 7, p. 44634.
PMID: 28304396
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Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus.
Authors: Rosenberger A.
, Sohns M.
, Friedrichs S.
, Hung R.J.
, Fehringer G.
, McLaughlin J.
, Amos C.I.
, Brennan P.
, Risch A.
, Brüske I.
, et al.
.
Source: Plos One, 2017; 12(3), p. e0173339.
EPub date: 2017-03-08 00:00:00.0.
PMID: 28273134
Related Citations
Nonsyndromic Cleft Lip With Or Without Cleft Palate And Cancer: Evaluation Of A Possible Common Genetic Background Through The Analysis Of Gwas Data
Authors: Dunkhase E.
, Ludwig K.U.
, Knapp M.
, Skibola C.F.
, Figueiredo J.C.
, Hosking F.J.
, Ellinghaus E.
, Landi M.T.
, Ma H.
, Nakagawa H.
, et al.
.
Source: Genomics Data, 2016 Dec; 10, p. 22-9.
PMID: 27630819
Related Citations
A Novel Genetic Variant In Long Non-coding Rna Gene Nexn-as1 Is Associated With Risk Of Lung Cancer
Authors: Yuan H.
, Liu H.
, Liu Z.
, Owzar K.
, Han Y.
, Su L.
, Wei Y.
, Hung R.J.
, McLaughlin J.
, Brhane Y.
, et al.
.
Source: Scientific Reports, 2016-10-07 00:00:00.0; 6, p. 34234.
PMID: 27713484
Related Citations
Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.
Authors: Patel Y.M.
, Park S.L.
, Han Y.
, Wilkens L.R.
, Bickeböller H.
, Rosenberger A.
, Caporaso N.
, Landi M.T.
, Brüske I.
, Risch A.
, et al.
.
Source: Cancer Research, 2016-10-01 00:00:00.0; 76(19), p. 5768-5776.
EPub date: 2016-10-01 00:00:00.0.
PMID: 27488534
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Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Authors: Fehringer G.
, Kraft P.
, Pharoah P.D.
, Eeles R.A.
, Chatterjee N.
, Schumacher F.R.
, Schildkraut J.M.
, Lindström S.
, Brennan P.
, Bickeböller H.
, et al.
.
Source: Cancer Research, 2016-09-01 00:00:00.0; 76(17), p. 5103-14.
EPub date: 2016-09-01 00:00:00.0.
PMID: 27197191
Related Citations
Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium.
Authors: Wang M.
, Liu H.
, Liu Z.
, Yi X.
, Bickeboller H.
, Hung R.J.
, Brennan P.
, Landi M.T.
, Caporaso N.
, Christiani D.C.
, et al.
.
Source: Carcinogenesis, 2016 Sep; 37(9), p. 888-896.
EPub date: 2016-06-10 00:00:00.0.
PMID: 27288692
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Genetic Risk Can Be Decreased: Quitting Smoking Decreases And Delays Lung Cancer For Smokers With High And Low Chrna5 Risk Genotypes - A Meta-analysis
Authors: Chen L.S.
, Baker T.
, Hung R.J.
, Horton A.
, Culverhouse R.
, Hartz S.
, Saccone N.
, Cheng I.
, Deng B.
, Han Y.
, et al.
.
Source: Ebiomedicine, 2016 Sep; 11, p. 219-226.
PMID: 27543155
Related Citations
Genome-wide Association Study Confirms Lung Cancer Susceptibility Loci On Chromosomes 5p15 And 15q25 In An African-american Population
Authors: Zanetti K.A.
, Wang Z.
, Aldrich M.
, Amos C.I.
, Blot W.J.
, Bowman E.D.
, Burdette L.
, Cai Q.
, Caporaso N.
, Chung C.C.
, et al.
.
Source: Lung Cancer (amsterdam, Netherlands), 2016 Aug; 98, p. 33-42.
PMID: 27393504
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Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.
Authors: Kang X.
, Liu H.
, Onaitis M.W.
, Liu Z.
, Owzar K.
, Han Y.
, Su L.
, Wei Y.
, Hung R.J.
, Brhane Y.
, et al.
.
Source: Carcinogenesis, 2016 Mar; 37(3), p. 280-9.
PMID: 26905588
Related Citations
Deciphering associations for lung cancer risk through imputation and analysis of 12,316 cases and 16,831 controls.
Authors: Wang Y.
, Wei Y.
, Gaborieau V.
, Shi J.
, Han Y.
, Timofeeva M.N.
, Su L.
, Li Y.
, Eisen T.
, Amos C.I.
, et al.
.
Source: European Journal Of Human Genetics : Ejhg, 2015 Dec; 23(12), p. 1723-8.
PMID: 25804397
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CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
Authors: Chen L.S.
, Hung R.J.
, Baker T.
, Horton A.
, Culverhouse R.
, Saccone N.
, Cheng I.
, Deng B.
, Han Y.
, Hansen H.M.
, et al.
.
Source: Journal Of The National Cancer Institute, 2015 May; 107(5), .
PMID: 25873736
Related Citations
Meta-gsa: Combining Findings From Gene-set Analyses Across Several Genome-wide Association Studies
Authors: Rosenberger A.
, Friedrichs S.
, Amos C.I.
, Brennan P.
, Fehringer G.
, Heinrich J.
, Hung R.J.
, Muley T.
, Müller-Nurasyid M.
, Risch A.
, et al.
.
Source: Plos One, 2015; 10(10), p. e0140179.
PMID: 26501144
Related Citations
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
Authors: Wang Y.
, McKay J.D.
, Rafnar T.
, Wang Z.
, Timofeeva M.N.
, Broderick P.
, Zong X.
, Laplana M.
, Wei Y.
, Han Y.
, et al.
.
Source: Nature Genetics, 2014 Jul; 46(7), p. 736-41.
PMID: 24880342
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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Authors: Monda K.L.
, Chen G.K.
, Taylor K.C.
, Palmer C.
, Edwards T.L.
, Lange L.A.
, Ng M.C.
, Adeyemo A.A.
, Allison M.A.
, Bielak L.F.
, et al.
.
Source: Nature Genetics, 2013 Jun; 45(6), p. 690-6.
PMID: 23583978
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Pilot study of CYP2B6 genetic variation to explore the contribution of nitrosamine activation to lung carcinogenesis.
Authors: Wassenaar C.A.
, Dong Q.
, Amos C.I.
, Spitz M.R.
, Tyndale R.F.
.
Source: International Journal Of Molecular Sciences, 2013-04-16 00:00:00.0; 14(4), p. 8381-92.
EPub date: 2013-04-16 00:00:00.0.
PMID: 23591849
Related Citations
Role Of Selected Genetic Variants In Lung Cancer Risk In African Americans
Authors: Spitz M.R.
, Amos C.I.
, Land S.
, Wu X.
, Dong Q.
, Wenzlaff A.S.
, Schwartz A.G.
.
Source: Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer, 2013 Apr; 8(4), p. 391-7.
PMID: 23454887
Related Citations
Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.
Authors: Walsh K.M.
, Gorlov I.P.
, Hansen H.M.
, Wu X.
, Spitz M.R.
, Zhang H.
, Lu E.Y.
, Wenzlaff A.S.
, Sison J.D.
, Wei C.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2013 Feb; 22(2), p. 251-60.
PMID: 23221128
Related Citations
Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.
Authors: Wang L.E.
, Gorlova O.Y.
, Ying J.
, Qiao Y.
, Weng S.F.
, Lee A.T.
, Gregersen P.K.
, Spitz M.R.
, Amos C.I.
, Wei Q.
.
Source: Cancer Research, 2013-01-01 00:00:00.0; 73(1), p. 256-64.
EPub date: 2013-01-01 00:00:00.0.
PMID: 23108145
Related Citations
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
Authors: Timofeeva M.N.
, Hung R.J.
, Rafnar T.
, Christiani D.C.
, Field J.K.
, Bickeböller H.
, Risch A.
, McKay J.D.
, Wang Y.
, Dai J.
, et al.
.
Source: Human Molecular Genetics, 2012-11-15 00:00:00.0; 21(22), p. 4980-95.
EPub date: 2012-11-15 00:00:00.0.
PMID: 22899653
Related Citations
Association Study Of Nicotinic Acetylcholine Receptor Genes Identifies A Novel Lung Cancer Susceptibility Locus Near Chrna1 In African-americans
Authors: Walsh K.M.
, Amos C.I.
, Wenzlaff A.S.
, Gorlov I.P.
, Sison J.D.
, Wu X.
, Spitz M.R.
, Hansen H.M.
, Lu E.Y.
, Wei C.
, et al.
.
Source: Oncotarget, 2012 Nov; 3(11), p. 1428-38.
PMID: 23232035
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Genome-wide Gene-environment Interaction Analysis For Asbestos Exposure In Lung Cancer Susceptibility
Authors: Wei S.
, Wang L.E.
, McHugh M.K.
, Han Y.
, Xiong M.
, Amos C.I.
, Spitz M.R.
, Wei Q.W.
.
Source: Carcinogenesis, 2012 Aug; 33(8), p. 1531-7.
PMID: 22637743
Related Citations
Association Analyses Identify Multiple New Lung Cancer Susceptibility Loci And Their Interactions With Smoking In The Chinese Population
Authors: Dong,J.
, Hu,Z.
, Wu,C.
, Guo,H.
, Zhou,B.
, Lv,J.
, Lu,D.
, Chen,K.
, Shi,Y.
, Chu,M.
, et al.
.
Source: Nature Genetics, 2012 Aug; 44(8), p. 895-9.
PMID: 22797725
Related Citations
Multistage Analysis Of Variants In The Inflammation Pathway And Lung Cancer Risk In Smokers
Authors: Spitz M.R.
, Gorlov I.P.
, Dong Q.
, Wu X.
, Chen W.
, Chang D.W.
, Etzel C.J.
, Caporaso N.E.
, Zhao Y.
, Christiani D.C.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Jul; 21(7), p. 1213-21.
PMID: 22573796
Related Citations
Cotinine Conundrum--a Step Forward But Questions Remain
Authors: Spitz M.R.
, Amos C.I.
, Bierut L.J.
, Caporaso N.E.
.
Source: Journal Of The National Cancer Institute, 2012-05-16 00:00:00.0; 104(10), p. 720-2.
PMID: 22534783
Related Citations
Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.
Authors: VanderWeele T.J.
, Asomaning K.
, Tchetgen Tchetgen E.J.
, Han Y.
, Spitz M.R.
, Shete S.
, Wu X.
, Gaborieau V.
, Wang Y.
, McLaughlin J.
, et al.
.
Source: American Journal Of Epidemiology, 2012-05-15 00:00:00.0; 175(10), p. 1013-20.
EPub date: 2012-05-15 00:00:00.0.
PMID: 22306564
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Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.
Authors: Chen L.S.
, Saccone N.L.
, Culverhouse R.C.
, Bracci P.M.
, Chen C.H.
, Dueker N.
, Han Y.
, Huang H.
, Jin G.
, Kohno T.
, et al.
.
Source: Genetic Epidemiology, 2012 May; 36(4), p. 340-51.
PMID: 22539395
Related Citations
Genetic Determinants For Promoter Hypermethylation In The Lungs Of Smokers: A Candidate Gene-based Study
Authors: Leng,S.
, Stidley,C.A.
, Liu,Y.
, Edlund,C.K.
, Willink,R.P.
, Han,Y.
, Landi,M.T.
, Thun,M.
, Picchi,M.A.
, Bruse,S.E.
, et al.
.
Source: Cancer Research, 2012-02-01 00:00:00.0; 72(3), p. 707-15.
PMID: 22139380
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Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma.
Authors: Shi J.
, Chatterjee N.
, Rotunno M.
, Wang Y.
, Pesatori A.C.
, Consonni D.
, Li P.
, Wheeler W.
, Broderick P.
, Henrion M.
, et al.
.
Source: Cancer Discovery, 2012 Feb; 2(2), p. 131-9.
PMID: 22585858
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Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer.
Authors: Ma J.
, Xiao F.
, Xiong M.
, Andrew A.S.
, Brenner H.
, Duell E.J.
, Haugen A.
, Hoggart C.
, Hung R.J.
, Lazarus P.
, et al.
.
Source: Human Heredity, 2012; 73(4), p. 185-94.
PMID: 22889990
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Method For Evaluating Multiple Mediators: Mediating Effects Of Smoking And Copd On The Association Between The Chrna5-a3 Variant And Lung Cancer Risk
Authors: Wang J.
, Spitz M.R.
, Amos C.I.
, Wu X.
, Wetter D.W.
, Cinciripini P.M.
, Shete S.
.
Source: Plos One, 2012; 7(10), p. e47705.
PMID: 23077662
Related Citations
Genetic Association Analysis Of Complex Diseases Incorporating Intermediate Phenotype Information
Authors: Li Y.
, Huang J.
, Amos C.I.
.
Source: Plos One, 2012; 7(10), p. e46612.
PMID: 23094028
Related Citations
A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.
Authors: Wei C.
, Han Y.
, Spitz M.R.
, Wu X.
, Chancoco H.
, Akiva P.
, Rechavi G.
, Brand H.
, Wun I.
, Frazier M.L.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2011 Dec; 20(12), p. 2603-9.
PMID: 22028403
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Genome-wide Association And Large-scale Follow Up Identifies 16 New Loci Influencing Lung Function
Authors: Soler Artigas M.
, Loth D.W.
, Wain L.V.
, Gharib S.A.
, Obeidat M.
, Tang W.
, Zhai G.
, Zhao J.H.
, Smith A.V.
, Huffman J.E.
, et al.
.
Source: Nature Genetics, 2011 Nov; 43(11), p. 1082-90.
PMID: 21946350
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Novel Genetic Variants In The Chromosome 5p15.33 Region Associate With Lung Cancer Risk
Authors: Pande M.
, Spitz M.R.
, Wu X.
, Gorlov I.P.
, Chen W.V.
, Amos C.I.
.
Source: Carcinogenesis, 2011 Oct; 32(10), p. 1493-9.
PMID: 21771723
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Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke.
Authors: Spitz M.R.
, Gorlov I.P.
, Amos C.I.
, Dong Q.
, Chen W.
, Etzel C.J.
, Gorlova O.Y.
, Chang D.W.
, Pu X.
, Zhang D.
, et al.
.
Source: Cancer Discovery, 2011 Oct; 1(5), p. 420-9.
PMID: 22586632
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Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.
Authors: Wassenaar C.A.
, Dong Q.
, Wei Q.
, Amos C.I.
, Spitz M.R.
, Tyndale R.F.
.
Source: Journal Of The National Cancer Institute, 2011-09-07 00:00:00.0; 103(17), p. 1342-6.
EPub date: 2011-09-07 00:00:00.0.
PMID: 21747048
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Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer.
Authors: Chen J.
, Wu X.
, Pande M.
, Amos C.I.
, Killary A.M.
, Sen S.
, Frazier M.L.
.
Source: Pancreas, 2011 Aug; 40(6), p. 872-5.
PMID: 21697764
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The landscape of recombination in African Americans.
Authors: Hinch A.G.
, Tandon A.
, Patterson N.
, Song Y.
, Rohland N.
, Palmer C.D.
, Chen G.K.
, Wang K.
, Buxbaum S.G.
, Akylbekova E.L.
, et al.
.
Source: Nature, 2011-07-20 00:00:00.0; 476(7359), p. 170-5.
EPub date: 2011-07-20 00:00:00.0.
PMID: 21775986
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Genome-wide Association Study Of Survival In Non-small Cell Lung Cancer Patients Receiving Platinum-based Chemotherapy
Authors: Wu X.
, Ye Y.
, Rosell R.
, Amos C.I.
, Stewart D.J.
, Hildebrandt M.A.
, Roth J.A.
, Minna J.D.
, Gu J.
, Lin J.
, et al.
.
Source: Journal Of The National Cancer Institute, 2011-05-18 00:00:00.0; 103(10), p. 817-25.
PMID: 21483023
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An Analysis Of Single Nucleotide Polymorphisms Of 125 Dna Repair Genes In The Texas Genome-wide Association Study Of Lung Cancer With A Replication For The Xrcc4 Snps
Authors: Yu H.
, Zhao H.
, Wang L.E.
, Han Y.
, Chen W.V.
, Amos C.I.
, Rafnar T.
, Sulem P.
, Stefansson K.
, Landi M.T.
, et al.
.
Source: Dna Repair, 2011-04-03 00:00:00.0; 10(4), p. 398-407.
PMID: 21296624
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Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study.
Authors: Wei S.
, Niu J.
, Zhao H.
, Liu Z.
, Wang L.E.
, Han Y.
, Chen W.V.
, Amos C.I.
, Rafnar T.
, Sulem P.
, et al.
.
Source: Carcinogenesis, 2011 Apr; 32(4), p. 507-15.
PMID: 21292647
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Estimation Of Odds Ratios Of Genetic Variants For The Secondary Phenotypes Associated With Primary Diseases
Authors: Wang,J.
, Shete,S.
.
Source: Genetic Epidemiology, 2011 Apr; 35(3), p. 190-200.
PMID: 21308766
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A Genome-wide Association Study Identifies A Locus On Chromosome 14q21 As A Predictor Of Leukocyte Telomere Length And As A Marker Of Susceptibility For Bladder Cancer
Authors: Gu J.
, Chen M.
, Shete S.
, Amos C.I.
, Kamat A.
, Ye Y.
, Lin J.
, Dinney C.P.
, Wu X.
.
Source: Cancer Prevention Research (philadelphia, Pa.), 2011 Apr; 4(4), p. 514-21.
PMID: 21460395
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