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Grant Details

Grant Number: 5R21CA128965-02 Interpret this number
Primary Investigator: Calhoun, Patrick
Organization: Duke University
Project Title: Supplemental Nicotine Administration for Smoking Cessation in Ptsd
Fiscal Year: 2010
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Abstract

DESCRIPTION (provided by applicant): Cigarette smoking is highly prevalent among persons with posttraumatic stress disorder (PTSD) and individuals with PTSD have decreased odds of successfully quitting smoking. There is a need to develop more effective interventions and to evaluate factors associated with smoking abstinence in persons with PTSD. The use of supplemental nicotine administration during a "pre-treatment" phase before a targeted quit date is a recent innovative development in smoking cessation therapy and may be particularly helpful in treating smokers with PTSD. The use of supplemental nicotine administration during ad lib smoking for smokers with PTSD is predicted to reduce both the physiological and emotional dependence on inhaled nicotine, thereby increasing the odds of successful smoking cessation. Smokers with PTSD will be randomly assigned to 1 of 2 pre- cessation patch therapy conditions (active patch versus placebo patch) for 2 weeks before a target quit- smoking date. All participants will receive brief cognitive-behavioral therapy (CBT) and will begin standard nicotine replacement therapy (NRT) on their quit day. PTSD symptoms, mood, smoking craving and withdrawal symptoms will be carefully evaluated using electronic diary assessment. The study is designed to address the following aims: (1) To examine the effects of supplemental nicotine administration on PTSD symptoms, mood, craving, and withdrawal through electronic diary assessment, (2) To evaluate the effect of supplemental nicotine administration on quit rates among smokers with PTSD, and (3) To investigate potential predictors of relapse including individual differences in affective style including PTSD symptom severity, baseline mood, anxiety sensitivity, measures of distress tolerance, and self-efficacy. PUBLIC HEALTH RELEVANCE: This study may serve to inform development of easily portable smoking cessation strategies for smokers with PTSD by investigating: 1) the effects of supplemental nicotine administration on craving, mood, PTSD symptoms, and withdrawal; 2) the possible benefit of pre-treatment with nicotine patches on abstinence rates; and 3) risk- factors for smoking relapse in this at risk population.

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Publications

Examining the relationship between negative affect and posttraumatic stress disorder symptoms among smokers using ecological momentary assessment.
Authors: Erwin M.C. , Dennis P.A. , Coughlin L.N. , Calhoun P.S. , Beckham J.C. .
Source: Journal of affective disorders, 2019-06-15; 253, p. 285-291.
EPub date: 2019-04-09.
PMID: 31077971
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Supplemental nicotine preloading for smoking cessation in posttraumatic stress disorder: Results from a randomized controlled trial.
Authors: Dennis P.A. , Kimbrel N.A. , Dedert E.A. , Beckham J.C. , Dennis M.F. , Calhoun P.S. .
Source: Addictive behaviors, 2016 08; 59, p. 24-9.
EPub date: 2016-03-11.
PMID: 27046670
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Latent Factor Structure of DSM-5 Posttraumatic Stress Disorder.
Authors: Gentes E. , Dennis P.A. , Kimbrel N.A. , Kirby A.C. , Hair L.P. , Beckham J.C. , Calhoun P.S. .
Source: Psychopathology review, 2015; 2(1), p. 17-29.
PMID: 26366290
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Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse?
Authors: Wilson S.M. , Dedert E.A. , Dennis P.A. , Dennis M.F. , Calhoun P.S. , Kirby A.C. , Beckham J.C. .
Source: Addictive behaviors, 2014 Jul; 39(7), p. 1163-7.
EPub date: 2014-03-16.
PMID: 24727113
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The role of daily hassles and distress tolerance in predicting cigarette craving during a quit attempt.
Authors: Volz A.R. , Dennis P.A. , Dennis M.F. , Calhoun P.S. , Wilson S.M. , Beckham J.C. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014 Jun; 16(6), p. 872-5.
EPub date: 2014-01-28.
PMID: 24474304
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Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt.
Authors: Dedert E.A. , Dennis P.A. , Swinkels C.M. , Calhoun P.S. , Dennis M.F. , Beckham J.C. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014 Apr; 16(4), p. 430-6.
EPub date: 2013-11-05.
PMID: 24191981
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Associations between smoking and psychiatric comorbidity in U.S. Iraq- and Afghanistan-era veterans.
Authors: McClernon F.J. , Calhoun P.S. , Hertzberg J.S. , Dedert E.A. , Beckham J.C. , VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Registry Workgroup .
Source: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2013 Dec; 27(4), p. 1182-1188.
EPub date: 2013-05-27.
PMID: 23713569
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Predictors of lapse in first week of smoking abstinence in PTSD and non-PTSD smokers.
Authors: Beckham J.C. , Calhoun P.S. , Dennis M.F. , Wilson S.M. , Dedert E.A. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013 Jun; 15(6), p. 1122-9.
EPub date: 2012-11-22.
PMID: 23178322
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The impact of race on metabolic disease risk factors in women with and without posttraumatic stress disorder.
Authors: Dedert E.A. , Harper L.A. , Calhoun P.S. , Dennis M.F. , Beckham J.C. .
Source: Journal of clinical psychology in medical settings, 2013 Mar; 20(1), p. 46-55.
PMID: 23179072
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The effect of draft DSM-V criteria on posttraumatic stress disorder prevalence.
Authors: Calhoun P.S. , Hertzberg J.S. , Kirby A.C. , Dennis M.F. , Hair L.P. , Dedert E.A. , Beckham J.C. .
Source: Depression and anxiety, 2012 Dec; 29(12), p. 1032-42.
EPub date: 2012-10-26.
PMID: 23109002
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Consumer perspectives on genetic testing for psychiatric disorders: the attitudes of veterans with posttraumatic stress disorder and their families.
Authors: Dedert E.A. , Elbogen E.B. , Hauser M.A. , Hertzberg J.S. , Wilson S.M. , Dennis M.F. , Calhoun P.S. , Kirby A.C. , Beckham J.C. .
Source: Genetic testing and molecular biomarkers, 2012 Sep; 16(9), p. 1122-9.
EPub date: 2012-08-14.
PMID: 22891755
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The relationship between posttraumatic stress disorder and smoking outcome expectancies among U.S. military veterans who served since September 11, 2001.
Authors: Calhoun P.S. , Levin H.F. , Dedert E.A. , Johnson Y. , VA Mid-Atlantic Mental Illness Research, Education, Clinical Center Registry Workgroup , Beckham J.C. .
Source: Journal of traumatic stress, 2011 Jun; 24(3), p. 303-8.
EPub date: 2011-04-26.
PMID: 21523829
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The effect of nicotine and trauma context on acoustic startle in smokers with and without posttraumatic stress disorder.
Authors: Calhoun P.S. , Wagner H.R. , McClernon F.J. , Lee S. , Dennis M.F. , Vrana S.R. , Clancy C.P. , Collie C.F. , Johnson Y.C. , Beckham J.C. .
Source: Psychopharmacology, 2011 May; 215(2), p. 379-89.
EPub date: 2010-12-29.
PMID: 21188354
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