No large-scale study within the United States has examined any aspect of the epidemiology of intracranial
meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to
conduct a population-based case/control study of meningioma within the states of Connecticut,
Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of
an integrated R01 (Note that identical applications are submitted for all five sites). Cases will beselected
using rapid case ascertainment and will include all male and female individuals diagnosed with a
histologically confirmed intra-cranial meningioma betweenthe ages of 20 and 79 years from 7/1/2006
through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial
methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category.Study
subjects will be administered a telephone questionnaire to collect information on the two primary categories
of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history
of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome
and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a
uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgenand
MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA
polymorphisms in DNA repair and cell cycle genes. This study represents the first concentratedeffort to
examine environmental and genetic risk factors for meningioma.
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