Grant Number:	1R01CA143237-01 Interpret this number
Primary Investigator:	Casey, Graham
Organization:	University Of Southern California
Project Title:	Functional Analysis of Genome Wide Associations in Colorectal Cancer
Fiscal Year:	2010

DESCRIPTION (provided by applicant): Genome-wide association (GWA) studies of colorectal cancer (CRC) have led to the identification of a number of significantly associated hits that have been robustly replicated in other populations. The number of associations is likely to grow considerably over the next few years as larger GWA studies of CRC using higher density SNP arrays as well as meta- or pooled analyses of existing GWA studies are completed. To date there has been little emphasis on identifying the causal variant associated with these findings and even less effort directed towards developing an understanding of their biological impact. Without conducting studies designed to characterize the functional relevance of causal variants identified through GWA studies a complete understanding of the biological implications of such approaches will not be achieved. The goal of this proposal is to develop comprehensive strategies for the functional analysis of hits arising from CRC GWA studies using a multidisciplinary approach. This is not an insignificant challenge as most of the associations identified to date through GWA studies do not target non-synonymous variants in exons but instead involve variants that lie near genes or within gene-poor regions that require comprehensive analytical approaches. We will pursue validated hits arising from published CRC GWA studies by developing fine mapping information across these regions. We will incorporate state-of-the-art barcoded multiplex deep re-sequencing, and leverage information from ChIP-seq, RNA-seq and in silico analyses to identify candidate causal variants in genic or regulatory regions that will be functionally tested using biochemical analyses. Our goal is to identify the causal gene(s) identified through GWA studies and to characterize the functional significance of the causal variants. By doing so we aim to fully exploit the promise of GWA studies and provide a framework for a comprehensive understanding of the biological implications of associations identified through genome wide association (GWA) studies. Our work is motivated by the growing roadblock to fully exploiting the biological significance of GWA studies and if successful our approaches should be applicable to novel associations identified in ongoing GWA studies of CRC but also other complex genetic diseases. PUBLIC HEALTH RELEVANCE: The goal of our proposal is to develop comprehensive strategies for the functional analysis of hits arising from CRC genome wide association (GWA) studies using a multidisciplinary approach. Our work is motivated by the growing roadblock to fully exploiting the biological significance of GWA studies and if successful our approaches should be applicable to novel associations identified in ongoing GWA studies of CRC but also other complex genetic diseases.




Diet Impacts on Gene Expression in Healthy Colon Tissue: Insights from the BarcUVa-Seq Study.
Authors: Obón-Santacana M. , Moratalla-Navarro F. , Guinó E. , Carreras-Torres R. , Díez-Obrero V. , Bars-Cortina D. , Ibáñez-Sanz G. , Rodríguez-Alonso L. , Mata A. , García-Rodríguez A. , et al. .
Source: Nutrients, 2024-09-16 00:00:00.0; 16(18), .
EPub date: 2024-09-16 00:00:00.0.
PMID: 39339731
Related Citations

Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study.
Authors: Denos M. , Sun Y.Q. , Brumpton B. , Li Y. , Albanes D. , Burnett-Hartman A. , Campbell P.T. , Küry S. , Li C.I. , White E. , et al. .
Source: Research Square, 2024-04-10 00:00:00.0; , .
EPub date: 2024-04-10 00:00:00.0.
PMID: 38659935
Related Citations

Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk.
Authors: Stern M.C. , Sanchez Mendez J. , Kim A.E. , Obón-Santacana M. , Moratalla-Navarro F. , Martín V. , Moreno V. , Lin Y. , Bien S.A. , Qu C. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2024-03-01 00:00:00.0; 33(3), p. 400-410.
PMID: 38112776
Related Citations

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.
Authors: Yarmolinsky J. , Robinson J.W. , Mariosa D. , Karhunen V. , Huang J. , Dimou N. , Murphy N. , Burrows K. , Bouras E. , Smith-Byrne K. , et al. .
Source: Ebiomedicine, 2024 Feb; 100, p. 104991.
EPub date: 2024-02-01 00:00:00.0.
PMID: 38301482
Related Citations

DNA Mutational Profiling in Patients With Colorectal Cancer Treated With Standard of Care Reveals Differences in Outcome and Racial Distribution of Mutations.
Authors: Innocenti F. , Mu W. , Qu X. , Ou F.S. , Kabbarah O. , Blanke C.D. , Venook A.P. , Lenz H.J. , Rashid N.U. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2023-11-22 00:00:00.0; , p. JCO2300825.
EPub date: 2023-11-22 00:00:00.0.
PMID: 37992266
Related Citations

Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes.
Authors: Mahmood K. , Thomas M. , Qu C. , Gecco-Ccfr Consortium , Hsu L. , Buchanan D.D. , Peters U. .
Source: Gastroenterology, 2023 Oct; 165(4), p. 1070-1076.e3.
EPub date: 2023-07-14 00:00:00.0.
PMID: 37453563
Related Citations

Identifying metabolic features of colorectal cancer liability using Mendelian randomization.
Authors: Bull C.J. , Hazelwood E. , Bell J.A. , Tan V.Y. , Constantinescu A.E. , Borges M.C. , Legge D.N. , Burrows K. , Huyghe J.R. , Brenner H. , et al. .
Source: Medrxiv : The Preprint Server For Health Sciences, 2023-07-17 00:00:00.0; , .
EPub date: 2023-07-17 00:00:00.0.
PMID: 36945480
Related Citations

Assessment of Colorectal Cancer Risk Factors through the Application of Network-Based Approaches in a Racially Diverse Cohort of Colon Organoid Stem Cells.
Authors: Devall M. , Eaton S. , Yoshida C. , Powell S.M. , Casey G. , Li L. .
Source: Cancers, 2023-07-09 00:00:00.0; 15(14), .
EPub date: 2023-07-09 00:00:00.0.
PMID: 37509213
Related Citations

Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.
Authors: Dimou N. , Kim A.E. , Flanagan O. , Murphy N. , Diez-Obrero V. , Shcherbina A. , Aglago E.K. , Bouras E. , Campbell P.T. , Casey G. , et al. .
Source: British Journal Of Cancer, 2023-06-26 00:00:00.0; , .
EPub date: 2023-06-26 00:00:00.0.
PMID: 37365285
Related Citations

Multi-omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability.
Authors: Devall M. , Ali M.W. , Eaton S. , Weisenberger D.J. , Reilley M.J. , Powell S.M. , Li L. , Casey G. .
Source: Cancer Medicine, 2023-05-10 00:00:00.0; , .
EPub date: 2023-05-10 00:00:00.0.
PMID: 37162286
Related Citations

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis.
Authors: Yarmolinsky J. , Robinson J.W. , Mariosa D. , Karhunen V. , Huang J. , Dimou N. , Murphy N. , Burrows K. , Bouras E. , Smith-Byrne K. , et al. .
Source: Medrxiv : The Preprint Server For Health Sciences, 2023-05-05 00:00:00.0; , .
EPub date: 2023-05-05 00:00:00.0.
PMID: 37205426
Related Citations

A Race-Specific, DNA Methylation Analysis of Aging in Normal Rectum: Implications for the Biology of Aging and Its Relationship to Rectal Cancer.
Authors: Devall M.A. , Sun X. , Eaton S. , Cooper G.S. , Willis J.E. , Weisenberger D.J. , Casey G. , Li L. .
Source: Cancers, 2022-12-22 00:00:00.0; 15(1), .
EPub date: 2022-12-22 00:00:00.0.
PMID: 36612042
Related Citations

Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex.
Authors: Devall M.A.M. , Dampier C.H. , Eaton S. , Ali M.W. , Plummer S.J. , Bryant J. , Gauderman W.J. , Peters U. , Powell S.M. , Casey G. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2022-09-12 00:00:00.0; , p. OF1-OF10.
EPub date: 2022-09-12 00:00:00.0.
PMID: 36095330
Related Citations

Insights into Early Onset Colorectal Cancer through Analysis of Normal Colon Organoids of Familial Adenomatous Polyposis Patients.
Authors: Devall M.A. , Eaton S. , Ali M.W. , Powell S.M. , Li L. , Casey G. .
Source: Cancers, 2022-08-26 00:00:00.0; 14(17), .
EPub date: 2022-08-26 00:00:00.0.
PMID: 36077675
Related Citations

DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development.
Authors: Devall M.A. , Eaton S. , Ali M.W. , Dampier C.H. , Weisenberger D. , Powell S.M. , Li L. , Casey G. .
Source: Clinical Epigenetics, 2022-08-23 00:00:00.0; 14(1), p. 104.
EPub date: 2022-08-23 00:00:00.0.
PMID: 35999641
Related Citations

Transcriptome-Wide Association Study for Inflammatory Bowel Disease Reveals Novel Candidate Susceptibility Genes in Specific Colon Subsites and Tissue Categories.
Authors: Díez-Obrero V. , Moratalla-Navarro F. , Ibáñez-Sanz G. , Guardiola J. , Rodríguez-Moranta F. , Obón-Santacana M. , Díez-Villanueva A. , Dampier C.H. , Devall M. , Carreras-Torres R. , et al. .
Source: Journal Of Crohn's & Colitis, 2022-02-23 00:00:00.0; 16(2), p. 275-285.
PMID: 34286847
Related Citations

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis.
Authors: Yarmolinsky J. , Díez-Obrero V. , Richardson T.G. , Pigeyre M. , Sjaarda J. , Paré G. , Walker V.M. , Vincent E.E. , Tan V.Y. , Obón-Santacana M. , et al. .
Source: Plos Medicine, 2022 Feb; 19(2), p. e1003897.
EPub date: 2022-02-03 00:00:00.0.
PMID: 35113855
Related Citations

Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids.
Authors: Devall M. , Dampier C.H. , Eaton S. , Ali M.W. , Díez-Obrero V. , Moratalla-Navarro F. , Bryant J. , Jennelle L.T. , Moreno V. , Powell S.M. , et al. .
Source: Oncotarget, 2021-09-14 00:00:00.0; 12(19), p. 1863-1877.
EPub date: 2021-09-14 00:00:00.0.
PMID: 34548904
Related Citations

Transcriptome-wide in vitro effects of aspirin on patient-derived normal colon organoids.
Authors: Devall M.A. , Drew D.A. , Dampier C.H. , Plummer S.J. , Eaton S. , Bryant J. , Díez-Obrero V. , Mo J. , Kedrin D. , Zerjav D.C. , et al. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2021-08-13 00:00:00.0; , .
EPub date: 2021-08-13 00:00:00.0.
PMID: 34389629
Related Citations

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number of LGR5+ Ectopic Stem Cells.
Authors: Jennelle L.T. , Dampier C.H. , Tring S. , Powell S. , Casey G. .
Source: Clinical And Translational Gastroenterology, 2021-05-17 00:00:00.0; 12(5), p. e00353.
EPub date: 2021-05-17 00:00:00.0.
PMID: 33999013
Related Citations

Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability.
Authors: Devall M.A.M. , Casey G. .
Source: Oncotarget, 2021-04-13 00:00:00.0; 12(8), p. 767-782.
EPub date: 2021-04-13 00:00:00.0.
PMID: 33889300
Related Citations

Genetic architectures of proximal and distal colorectal cancer are partly distinct.
Authors: Huyghe J.R. , Harrison T.A. , Bien S.A. , Hampel H. , Figueiredo J.C. , Schmit S.L. , Conti D.V. , Chen S. , Qu C. , Lin Y. , et al. .
Source: Gut, 2021-02-25 00:00:00.0; , .
EPub date: 2021-02-25 00:00:00.0.
PMID: 33632709
Related Citations

SNPs associated with colorectal cancer at 15q13.3 affect risk enhancers that modulate GREM1 gene expression.
Authors: Fortini B.K. , Tring S. , Devall M.A. , Ali M.W. , Plummer S.J. , Casey G. .
Source: Human Mutation, 2021-01-21 00:00:00.0; , .
EPub date: 2021-01-21 00:00:00.0.
PMID: 33476087
Related Citations

Ethanol exposure drives colon location specific cell composition changes in a normal colon crypt 3D organoid model.
Authors: Devall M. , Plummer S.J. , Bryant J. , Jennelle L.T. , Eaton S. , Dampier C.H. , Huyghe J.R. , Peters U. , Powell S.M. , Casey G. .
Source: Scientific Reports, 2021-01-11 00:00:00.0; 11(1), p. 432.
EPub date: 2021-01-11 00:00:00.0.
PMID: 33432071
Related Citations

Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci.
Authors: Díez-Obrero V. , Dampier C.H. , Moratalla-Navarro F. , Devall M. , Plummer S.J. , Díez-Villanueva A. , Peters U. , Bien S. , Huyghe J.R. , Kundaje A. , et al. .
Source: Cellular And Molecular Gastroenterology And Hepatology, 2021; 12(1), p. 181-197.
EPub date: 2021-02-16 00:00:00.0.
PMID: 33601062
Related Citations

Racial Disparities in Epigenetic Aging of the Right vs Left Colon.
Authors: Devall M. , Sun X. , Yuan F. , Cooper G.S. , Willis J. , Weisenberger D.J. , Casey G. , Li L. .
Source: Journal Of The National Cancer Institute, 2020-12-30 00:00:00.0; , .
EPub date: 2020-12-30 00:00:00.0.
PMID: 33377907
Related Citations

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects.
Authors: Guo X. , Lin W. , Wen W. , Huyghe J. , Bien S. , Cai Q. , Harrison T. , Chen Z. , Qu C. , Bao J. , et al. .
Source: Gastroenterology, 2020-10-12 00:00:00.0; , .
EPub date: 2020-10-12 00:00:00.0.
PMID: 33058866
Related Citations

Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).
Authors: Innocenti F. , Sibley A.B. , Patil S.A. , Etheridge A.S. , Jiang C. , Ou F.S. , Howell S.D. , Plummer S.J. , Casey G. , Bertagnolli M.M. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2020-09-21 00:00:00.0; , .
EPub date: 2020-09-21 00:00:00.0.
PMID: 32958699
Related Citations

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.
Authors: Montazeri Z. , Li X. , Nyiraneza C. , Ma X. , Timofeeva M. , Svinti V. , Meng X. , He Y. , Bo Y. , Morgan S. , et al. .
Source: Gut, 2020 Aug; 69(8), p. 1460-1471.
EPub date: 2019-12-09 00:00:00.0.
PMID: 31818908
Related Citations

Oncogenic Features in Histologically Normal Mucosa: Novel Insights Into Field Effect From a Mega-Analysis of Colorectal Transcriptomes.
Authors: Dampier C.H. , Devall M. , Jennelle L.T. , Díez-Obrero V. , Plummer S.J. , Moreno V. , Casey G. .
Source: Clinical And Translational Gastroenterology, 2020 07; 11(7), p. e00210.
PMID: 32764205
Related Citations

Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases.
Authors: Lu L. , Liu X. , Huang W.K. , Giusti-Rodríguez P. , Cui J. , Zhang S. , Xu W. , Wen Z. , Ma S. , Rosen J.D. , et al. .
Source: Molecular Cell, 2020-06-20 00:00:00.0; , .
EPub date: 2020-06-20 00:00:00.0.
PMID: 32592681
Related Citations

Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies.
Authors: Phipps A.I. , Alwers E. , Harrison T. , Banbury B. , Brenner H. , Campbell P.T. , Chang-Claude J. , Buchanan D. , Chan A.T. , Farris A.B. , et al. .
Source: Gastroenterology, 2020-02-20 00:00:00.0; , .
EPub date: 2020-02-20 00:00:00.0.
PMID: 32088204
Related Citations

Modeling the effect of prolonged ethanol exposure on global gene expression and chromatin accessibility in normal 3D colon organoids.
Authors: Devall M. , Jennelle L.T. , Bryant J. , Bien S. , Peters U. , Powell S. , Casey G. .
Source: Plos One, 2020; 15(1), p. e0227116.
EPub date: 2020-01-17 00:00:00.0.
PMID: 31951625
Related Citations

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.
Authors: Morton A.R. , Dogan-Artun N. , Faber Z.J. , MacLeod G. , Bartels C.F. , Piazza M.S. , Allan K.C. , Mack S.C. , Wang X. , Gimple R.C. , et al. .
Source: Cell, 2019-11-27 00:00:00.0; 179(6), p. 1330-1341.e13.
EPub date: 2019-11-21 00:00:00.0.
PMID: 31761532
Related Citations

Genome-wide association study of circulating folate one-carbon metabolites.
Authors: Wang J. , Asante I. , Baron J.A. , Figueiredo J.C. , Haile R. , Joan Levine A. , Newcomb P.A. , Templeton A.S. , Schumacher F.R. , Louie S.G. , et al. .
Source: Genetic Epidemiology, 2019-09-10 00:00:00.0; , .
EPub date: 2019-09-10 00:00:00.0.
PMID: 31502714
Related Citations

Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history.
Authors: Jenkins M.A. , Win A.K. , Dowty J.G. , MacInnis R.J. , Makalic E. , Schmidt D.F. , Dite G.S. , Kapuscinski M. , Clendenning M. , Rosty C. , et al. .
Source: Familial Cancer, 2019-06-17 00:00:00.0; , .
EPub date: 2019-06-17 00:00:00.0.
PMID: 31209717
Related Citations

DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility.
Authors: Pardini B. , Corrado A. , Paolicchi E. , Cugliari G. , Berndt S.I. , Bezieau S. , Bien S.A. , Brenner H. , Caan B.J. , Campbell P.T. , et al. .
Source: International Journal Of Cancer, 2019-06-17 00:00:00.0; , .
EPub date: 2019-06-17 00:00:00.0.
PMID: 31209889
Related Citations

Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Authors: Law P.J. , Timofeeva M. , Fernandez-Rozadilla C. , Broderick P. , Studd J. , Fernandez-Tajes J. , Farrington S. , Svinti V. , Palles C. , Orlando G. , et al. .
Source: Nature Communications, 2019-05-14 00:00:00.0; 10(1), p. 2154.
EPub date: 2019-05-14 00:00:00.0.
PMID: 31089142
Related Citations

Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes.
Authors: Hung S. , Saiakhova A. , Faber Z.J. , Bartels C.F. , Neu D. , Bayles I. , Ojo E. , Hong E.S. , Pontius W.D. , Morton A.R. , et al. .
Source: Elife, 2019-02-13 00:00:00.0; 8, .
EPub date: 2019-02-13 00:00:00.0.
PMID: 30759065
Related Citations

Discovery of common and rare genetic risk variants for colorectal cancer.
Authors: Huyghe J.R. , Bien S.A. , Harrison T.A. , Kang H.M. , Chen S. , Schmit S.L. , Conti D.V. , Qu C. , Jeon J. , Edlund C.K. , et al. .
Source: Nature Genetics, 2019 01; 51(1), p. 76-87.
EPub date: 2018-12-03 00:00:00.0.
PMID: 30510241
Related Citations

Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.
Authors: Wang X. , Dai J.Y. , Albanes D. , Arndt V. , Berndt S.I. , Bézieau S. , Brenner H. , Buchanan D.D. , Butterbach K. , Caan B. , et al. .
Source: International Journal Of Epidemiology, 2018-11-21 00:00:00.0; , .
EPub date: 2018-11-21 00:00:00.0.
PMID: 30476131
Related Citations

Enhancers: bridging the gap between gene control and human disease.
Authors: Karnuta J.M. , Scacheri P.C. .
Source: Human Molecular Genetics, 2018-08-01 00:00:00.0; 27(R2), p. R219-R227.
PMID: 29726898
Related Citations

Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
Authors: Neumeyer S. , Banbury B.L. , Arndt V. , Berndt S.I. , Bezieau S. , Bien S.A. , Buchanan D.D. , Butterbach K. , Caan B.J. , Campbell P.T. , et al. .
Source: British Journal Of Cancer, 2018 Jun; 118(12), p. 1639-1647.
EPub date: 2018-05-24 00:00:00.0.
PMID: 29795306
Related Citations

Targeting Epigenetics to Prevent Obesity Promoted Cancers.
Authors: Berger N.A. , Scacheri P.C. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2018 03; 11(3), p. 125-128.
EPub date: 2018-02-23 00:00:00.0.
PMID: 29476043
Related Citations

Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC).
Authors: Jenkins M.A. , Win A.K. , Templeton A.S. , Angelakos M.S. , Buchanan D.D. , Cotterchio M. , Figueiredo J.C. , Thibodeau S.N. , Baron J.A. , Potter J.D. , et al. .
Source: International Journal Of Epidemiology, 2018-02-27 00:00:00.0; , .
EPub date: 2018-02-27 00:00:00.0.
PMID: 29490034
Related Citations

Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.
Authors: Tanskanen T. , van den Berg L. , Välimäki N. , Aavikko M. , Ness-Jensen E. , Hveem K. , Wettergren Y. , Bexe Lindskog E. , Tõnisson N. , Metspalu A. , et al. .
Source: International Journal Of Cancer, 2018-02-01 00:00:00.0; 142(3), p. 540-546.
EPub date: 2017-10-12 00:00:00.0.
PMID: 28960316
Related Citations

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations.
Authors: Sheth H. , Northwood E. , Ulrich C.M. , Scherer D. , Elliott F. , Barrett J.H. , Forman D. , Wolf C.R. , Smith G. , Jackson M.S. , et al. .
Source: Plos One, 2018; 13(2), p. e0192223.
EPub date: 2018-02-09 00:00:00.0.
PMID: 29425227
Related Citations

Genetic susceptibility markers for a breast-colorectal cancer phenotype: Exploratory results from genome-wide association studies.
Authors: Pande M. , Joon A. , Brewster A.M. , Chen W.V. , Hopper J.L. , Eng C. , Shete S. , Casey G. , Schumacher F. , Lin Y. , et al. .
Source: Plos One, 2018; 13(4), p. e0196245.
EPub date: 2018-04-26 00:00:00.0.
PMID: 29698419
Related Citations

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.
Authors: May-Wilson S. , Sud A. , Law P.J. , Palin K. , Tuupanen S. , Gylfe A. , Hänninen U.A. , Cajuso T. , Tanskanen T. , Kondelin J. , et al. .
Source: European Journal Of Cancer (oxford, England : 1990), 2017 Oct; 84, p. 228-238.
EPub date: 2017-08-19 00:00:00.0.
PMID: 28829991
Related Citations

Quantifying the genetic correlation between multiple cancer types.
Authors: Lindström S. , Finucane H. , Bulik-Sullivan B. , Schumacher F.R. , Amos C.I. , Hung R.J. , Rand K. , Gruber S.B. , Conti D. , Permuth J.B. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-06-21 00:00:00.0; , .
EPub date: 2017-06-21 00:00:00.0.
PMID: 28637796
Related Citations