Grant Number:	5R01CA124759-03 Interpret this number
Primary Investigator:	Cardis, Elisabeth
Organization:	Centre/Res/Environmental Epidemiology
Project Title:	Occupational Exposures and Brain Cancer
Fiscal Year:	2010

DESCRIPTION (provided by applicant): The International Agency for Research on Cancer has coordinated a multi-national prospective case-control study of cellular telephones and cancer risk. The INTERPHONE study was conducted in 13 countries using a common core protocol, and focused on the risk of glioma, meningioma, acoustic neurinoma and parotid gland tumors. A total of 2,613 glioma and 2,343 meningioma cases and 7 557 controls were recruited between 2000 and 2005, making INTERPHONE the largest analytical epidemiological study of brain cancer ever conducted. The current proposal aims to exploit the information on occupational exposures collected within the INTERPHONE study. It has three specific aims: 1. To evaluate the possible association between the occupational exposure to EMF and tumors of the brain and central nervous system (specifically, glioma and meningioma). 2. To evaluate the possible association between selected occupational chemical exposures and tumors of the brain and central nervous system (specifically, glioma and meningioma). 3. To investigate the possibility of synergism and/or confounding between chemical and EMF exposures on the risk of brain cancers. In order to achieve these substantive aims we will need to address the following operational objectives: To transform the occupational history and questionnaire data into meaningful indices of EMF. To devise and implement methods for transforming job histories into occupational chemical exposure information. Occupational exposure to EMF (both ELF and RF/MW) and selected chemicals will be assessed for all the study subjects using validated job-exposure matrices, which will be developed within this project. The assessment of EMF exposure will then be refined by consolidating information obtained from the JEM with data on exposure variations related to the specific industry in which a subject worked, to the tasks he or she performed and to the actual sources of exposure, available from the INTERPHONE questionnaire. For chemicals, the JEM based estimates will be compared to estimates derived by occupational hygienists using the more detailed occupational histories in Canada, France, New Zealand and the UK, thereby providing an indication of the validity of the classification. Finally, analyses of the relationship between brain tumor risk and exposure to EMF and to the chemicals of interest will be carried out. Further analyses of possible interactions between EMF and specific chemicals will also be conducted.




Comparison of a radiofrequency electric and magnetic field source-based job-exposure matrix with personal radiofrequency exposure measurements.
Authors: Turuban M. , Kromhout H. , Vila J. , de Vocht F. , Vallbona-Vistós M. , Baldi I. , Cardis E. , Turner M.C. .
Source: Annals Of Work Exposures And Health, 2024-09-26 00:00:00.0; , .
EPub date: 2024-09-26 00:00:00.0.
PMID: 39326006
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Occupational exposure to radiofrequency electromagnetic fields and brain tumor risk: Application of the INTEROCC job-exposure matrix.
Authors: Turuban M. , Kromhout H. , Vila J. , Vallbona-Vistós M. , De Vocht F. , Baldi I. , Richardson L. , Benke G. , Krewski D. , Parent M.E. , et al. .
Source: International Journal Of Cancer, 2024-09-20 00:00:00.0; , .
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Adjusting for Berkson error in exposure in ordinary and conditional logistic regression and in Poisson regression.
Authors: Oraby T. , Chakraborty S. , Sivaganesan S. , Kincl L. , Richardson L. , McBride M. , Siemiatycki J. , Cardis E. , Krewski D. .
Source: Bmc Medical Research Methodology, 2023-10-10 00:00:00.0; 23(1), p. 225.
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Occupational exposure to extremely low-frequency magnetic fields and follicular lymphoma risk: a family case-control study.
Authors: Odutola M.K. , van Leeuwen M.T. , Bruinsma F.J. , Benke G. , Turner M.C. , Trotman J. , Turner J. , Seymour J.F. , Prince H.M. , Milliken S.T. , et al. .
Source: Occupational And Environmental Medicine, 2023 Oct; 80(10), p. 599-602.
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Authors: Migault L. , Bowman J.D. , Kromhout H. , Figuerola J. , Baldi I. , Bouvier G. , Turner M.C. , Cardis E. , Vila J. .
Source: Annals Of Work Exposures And Health, 2019-11-13 00:00:00.0; 63(9), p. 1013-1028.
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Occupational exposure to high-frequency electromagnetic fields and brain tumor risk in the INTEROCC study: An individualized assessment approach.
Authors: Vila J. , Turner M.C. , Gracia-Lavedan E. , Figuerola J. , Bowman J.D. , Kincl L. , Richardson L. , Benke G. , Hours M. , Krewski D. , et al. .
Source: Environment International, 2018 10; 119, p. 353-365.
EPub date: 2018-07-08 00:00:00.0.
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Berkson error adjustment and other exposure surrogates in occupational case-control studies, with application to the Canadian INTEROCC study.
Authors: Oraby T. , Sivaganesan S. , Bowman J.D. , Kincl L. , Richardson L. , McBride M. , Siemiatycki J. , Cardis E. , Krewski D. .
Source: Journal Of Exposure Science & Environmental Epidemiology, 2018 05; 28(3), p. 251-258.
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Authors: McElvenny D.M. , van Tongeren M. , Turner M.C. , Benke G. , Figuerola J. , Fleming S. , Hours M. , Kincl L. , Krewski D. , McLean D. , et al. .
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Interactions between occupational exposure to extremely low frequency magnetic fields and chemicals for brain tumour risk in the INTEROCC study.
Authors: Turner M.C. , Benke G. , Bowman J.D. , Figuerola J. , Fleming S. , Hours M. , Kincl L. , Krewski D. , McLean D. , Parent M.E. , et al. .
Source: Occupational And Environmental Medicine, 2017 11; 74(11), p. 802-809.
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Occupational solvent exposure and risk of glioma in the INTEROCC study.
Authors: Benke G. , Turner M.C. , Fleming S. , Figuerola J. , Kincl L. , Richardson L. , Blettner M. , Hours M. , Krewski D. , McLean D. , et al. .
Source: British Journal Of Cancer, 2017-10-10 00:00:00.0; 117(8), p. 1246-1254.
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Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case-control study.
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Source: Environmental Health : A Global Access Science Source, 2017-08-25 00:00:00.0; 16(1), p. 90.
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Development of a source-exposure matrix for occupational exposure assessment of electromagnetic fields in the INTEROCC study.
Authors: Vila J. , Bowman J.D. , Figuerola J. , Moriña D. , Kincl L. , Richardson L. , Cardis E. .
Source: Journal Of Exposure Science & Environmental Epidemiology, 2017 Jul; 27(4), p. 398-408.
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Source: Journal Of Neuro-oncology, 2016 12; 130(3), p. 505-515.
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Authors: Vila J. , Bowman J.D. , Richardson L. , Kincl L. , Conover D.L. , McLean D. , Mann S. , Vecchia P. , van Tongeren M. , Cardis E. , et al. .
Source: The Annals Of Occupational Hygiene, 2016 Mar; 60(2), p. 184-204.
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Occupational Exposure To Extremely Low-frequency Magnetic Fields And Brain Tumor Risks In The Interocc Study
Authors: Turner M.C. , Benke G. , Bowman J.D. , Figuerola J. , Fleming S. , Hours M. , Kincl L. , Krewski D. , McLean D. , Parent M.E. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Sep; 23(9), p. 1863-72.
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