Grant Number:	1R01CA136859-01A1 Interpret this number
Primary Investigator:	Rogers, Laura
Organization:	Southern Illinois University Sch Of Med
Project Title:	Enhancing Physical Activity After Breast Cancer Diagnosis: Randomized Trial
Fiscal Year:	2009

DESCRIPTION (provided by applicant): Most breast cancer survivors do not engage in regular physical activity (PA). Our piloted PA behavior change intervention for breast cancer survivors significantly improved PA and health outcomes post-intervention. Testing in additional sites with longer follow-up is warranted to confirm program effectiveness short and longer term. Importantly, the pilot intervention resulted in changes in PA and social cognitive theory constructs, enhancing our potential for testing mechanisms mediating PA behavior change. Therefore, we propose a multi- center, randomized controlled trial enrolling 256 breast cancer survivors with the following study aims: Primary study aim: To examine intervention effectiveness, the primary study aim is to compare the effects of the BEAT Cancer PA behavior change intervention to usual care on short and longer term PA adherence among breast cancer survivors. We hypothesize that, compared with usual care, the intervention will result in a significant increase in PA adherence post-intervention that will be maintained 3 and 9 months post- intervention. Secondary study aim #1: To better understand the mechanisms of PA behavior change, secondary study aim #1 is to compare the effects of the BEAT Cancer PA behavior change intervention to usual care on social cognitive factors and examine if such changes mediate PA behavior change. We hypothesize that, compared with usual care, the intervention will result in significant improvements in social cognitive factors targeted by the intervention. We also hypothesize that social cognitive factors will mediate the intervention effect on PA with selected factors mediating the intervention effect on self-efficacy and the effect of self-efficacy on PA. Secondary study aim #2: Although the primary focus of this proposal is to achieve and understand PA behavior change, we also aim to compare the short and longer term health effects of the BEAT Cancer PA behavior change intervention when compared with usual care. We hypothesize that, compared with usual care, the intervention will result in significant improvements in fitness, muscle strength, waist-to-hip ratio, quality of life, fatigue, sleep quality, and joint dysfunction. Outcome measures obtained at baseline, 3 months (i.e., immediately post-intervention), 6 months, and 12 months will include accelerometer (PA and sleep), survey (social cognitive factors, quality of life, fatigue, perceived sleep, and joint dysfunction), submaximal treadmill test (fitness), dynamometer (muscle strength), and waist-to-hip ratio. The study aims will be analyzed with mixed-model analysis of variance (ANOVA) with the secondary study aim #1 also utilizing multivariate analysis of variance (MANOVA) and Freedman- Schatzkin difference-in-coefficients test of mediation. Identifying the effects and underlying mechanisms of PA behavior change interventions will facilitate translation to community settings for improving the health and well- being of breast cancer survivors. PUBLIC HEALTH RELEVANCE: It is important to develop programs that successfully assist breast cancer survivors in adapting and maintaining physically active lifestyles. Learning why such programs are able to help survivors exercise more regularly and identifying the health benefits that can be expected from these programs will guide program refinement and translation to clinical and community settings. Such information is expected to improve the health and quality of life while possibly reducing fatigue and risk of cancer recurrence in breast cancer survivors.




Associations between Symptoms and Exercise Barriers in Breast Cancer Survivors.
Authors: Scott H. , Brown N.I. , Schleicher E.A. , Oster R.A. , McAuley E. , Courneya K.S. , Anton P. , Ehlers D.K. , Phillips S.M. , Rogers L.Q. .
Source: Journal Of Clinical Medicine, 2023-10-14 00:00:00.0; 12(20), .
EPub date: 2023-10-14 00:00:00.0.
PMID: 37892669
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Breast cancer survivors' exercise preferences change during an exercise intervention are associated with post-intervention physical activity.
Authors: Schleicher E. , McAuley E. , Courneya K.S. , Anton P. , Ehlers D.K. , Phillips S.M. , Brown N.I. , Oster R.A. , Pekmezi D. , Rogers L.Q. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2023-04-29 00:00:00.0; , .
EPub date: 2023-04-29 00:00:00.0.
PMID: 37120460
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Physical activity intervention benefits persist months post-intervention: randomized trial in breast cancer survivors.
Authors: Rogers L.Q. , Courneya K.S. , Oster R.A. , Anton P.M. , Phillips S. , Ehlers D.K. , McAuley E. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2023-02-01 00:00:00.0; , .
EPub date: 2023-02-01 00:00:00.0.
PMID: 36723801
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Breast Cancer Survivors' Exercise Preferences Change During an Exercise Intervention and are associated with Post-Intervention Physical Activity.
Authors: Schleicher E. , McAuley E. , Courneya K.S. , Anton P. , Ehlers D.K. , Phillips S.M. , Brown N.I. , Oster R.A. , Pekmezi D. , Rogers L.Q. .
Source: Research Square, 2023-01-20 00:00:00.0; , .
EPub date: 2023-01-20 00:00:00.0.
PMID: 36711885
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Moderators of physical activity and quality of life response to a physical activity intervention for breast cancer survivors.
Authors: Schleicher E. , McAuley E. , Courneya K.S. , Anton P. , Ehlers D.K. , Phillips S.M. , Oster R.A. , Pekmezi D. , Rogers L.Q. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2022-12-17 00:00:00.0; 31(1), p. 53.
EPub date: 2022-12-17 00:00:00.0.
PMID: 36526826
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Comparative responsiveness and minimally important difference of Fatigue Symptom Inventory (FSI) scales and the FSI-3 in trials with cancer survivors.
Authors: Mosher C.E. , Secinti E. , Johns S.A. , Kroenke K. , Rogers L.Q. .
Source: Journal Of Patient-reported Outcomes, 2022-07-23 00:00:00.0; 6(1), p. 82.
EPub date: 2022-07-23 00:00:00.0.
PMID: 35870034
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Feasibility of Implementing Physical Activity Behavior Change Counseling in an Existing Cancer-Exercise Program.
Authors: McGinnis E.L. , Rogers L.Q. , Fruhauf C.A. , Jankowski C.M. , Crisafio M.E. , Leach H.J. .
Source: International Journal Of Environmental Research And Public Health, 2021-12-02 00:00:00.0; 18(23), .
EPub date: 2021-12-02 00:00:00.0.
PMID: 34886430
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Inverse association between changes in energetic cost of walking and vertical accelerations in non-metastatic breast cancer survivors.
Authors: Carter S.J. , Rogers L.Q. , Bowles H.R. , Norian L.A. , Hunter G.R. .
Source: European Journal Of Applied Physiology, 2019-09-13 00:00:00.0; , .
EPub date: 2019-09-13 00:00:00.0.
PMID: 31520215
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Gut microbiota diversity is associated with cardiorespiratory fitness in post-primary treatment breast cancer survivors.
Authors: Carter S.J. , Hunter G.R. , Blackston J.W. , Liu N. , Lefkowitz E.J. , Van Der Pol W.J. , Morrow C.D. , Paulsen J.A. , Rogers L.Q. .
Source: Experimental Physiology, 2019 Apr; 104(4), p. 529-539.
EPub date: 2019-02-27 00:00:00.0.
PMID: 30763983
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Acceptability of a Mobile Phone App for Measuring Time Use in Breast Cancer Survivors (Life in a Day): Mixed-Methods Study.
Authors: Ainsworth M.C. , Pekmezi D. , Bowles H. , Ehlers D. , McAuley E. , Courneya K.S. , Rogers L.Q. .
Source: Jmir Cancer, 2018-05-14 00:00:00.0; 4(1), p. e9.
EPub date: 2018-05-14 00:00:00.0.
PMID: 29759953
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Ease of walking associates with greater free-living physical activity and reduced depressive symptomology in breast cancer survivors: pilot randomized trial.
Authors: Carter S.J. , Hunter G.R. , Norian L.A. , Turan B. , Rogers L.Q. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2017-12-14 00:00:00.0; , .
EPub date: 2017-12-14 00:00:00.0.
PMID: 29243165
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Physical Activity and Sleep Quality in Breast Cancer Survivors: A Randomized Trial.
Authors: Rogers L.Q. , Courneya K.S. , Oster R.A. , Anton P.M. , Robbs R.S. , Forero A. , McAuley E. .
Source: Medicine And Science In Sports And Exercise, 2017-05-20 00:00:00.0; , .
EPub date: 2017-05-20 00:00:00.0.
PMID: 28538261
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Effects of BEAT Cancer randomized physical activity trial on subjective memory impairments in breast cancer survivors.
Authors: Ehlers D.K. , Rogers L.Q. , Courneya K.S. , Robbs R.S. , McAuley E. .
Source: Psycho-oncology, 2017-04-16 00:00:00.0; , .
EPub date: 2017-04-16 00:00:00.0.
PMID: 28414894
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Gut Microbiota Composition Associated With Alterations In Cardiorespiratory Fitness And Psychosocial Outcomes Among Breast Cancer Survivors
Authors: Paulsen J.A. , Ptacek T.S. , Carter S.J. , Liu N. , Kumar R. , Hyndman L. , Lefkowitz E.J. , Morrow C.D. , Rogers L.Q. .
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2017-01-07 00:00:00.0; , .
PMID: 28064384
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Social Cognitive Constructs Did Not Mediate The Beat Cancer Intervention Effects On Objective Physical Activity Behavior Based On Multivariable Path Analysis
Authors: Rogers L.Q. , Courneya K.S. , Anton P.M. , Hopkins-Price P. , Verhulst S. , Robbs R.S. , Vicari S.K. , McAuley E. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2016-10-17 00:00:00.0; , .
PMID: 27752993
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Lower rate-pressure product during submaximal walking: a link to fatigue improvement following a physical activity intervention among breast cancer survivors.
Authors: Carter S.J. , Hunter G.R. , McAuley E. , Courneya K.S. , Anton P.M. , Rogers L.Q. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2016 Oct; 10(5), p. 927-34.
PMID: 27061740
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Effects of a multicomponent physical activity behavior change intervention on breast cancer survivor health status outcomes in a randomized controlled trial.
Authors: Rogers L.Q. , Courneya K.S. , Carter S.J. , Anton P.M. , Verhulst S. , Vicari S.K. , Robbs R.S. , McAuley E. .
Source: Breast Cancer Research And Treatment, 2016 Sep; 159(2), p. 283-91.
PMID: 27539586
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Effects of a multicomponent physical activity behavior change intervention on fatigue, anxiety, and depressive symptomatology in breast cancer survivors: randomized trial.
Authors: Rogers L.Q. , Courneya K.S. , Anton P.M. , Verhulst S. , Vicari S.K. , Robbs R.S. , McAuley E. .
Source: Psycho-oncology, 2016-08-17 00:00:00.0; , .
EPub date: 2016-08-17 00:00:00.0.
PMID: 27530961
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Effects of the BEAT Cancer physical activity behavior change intervention on physical activity, aerobic fitness, and quality of life in breast cancer survivors: a multicenter randomized controlled trial.
Authors: Rogers L.Q. , Courneya K.S. , Anton P.M. , Hopkins-Price P. , Verhulst S. , Vicari S.K. , Robbs R.S. , Mocharnuk R. , McAuley E. .
Source: Breast Cancer Research And Treatment, 2015 Jan; 149(1), p. 109-19.
PMID: 25417174
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Meeting physical activity guidelines in rural breast cancer survivors.
Authors: Olson E.A. , Mullen S.P. , Rogers L.Q. , Courneya K.S. , Verhulst S. , McAuley E. .
Source: American Journal Of Health Behavior, 2014 Nov; 38(6), p. 890-9.
PMID: 25341266
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Effects of a physical activity behavior change intervention on inflammation and related health outcomes in breast cancer survivors: pilot randomized trial.
Authors: Rogers L.Q. , Fogleman A. , Trammell R. , Hopkins-Price P. , Vicari S. , Rao K. , Edson B. , Verhulst S. , Courneya K.S. , Hoelzer K. .
Source: Integrative Cancer Therapies, 2013 Jul; 12(4), p. 323-35.
PMID: 22831916
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Diet components associated with perceived fatigue in breast cancer survivors.
Authors: Guest D.D. , Evans E.M. , Rogers L.Q. .
Source: European Journal Of Cancer Care, 2013 Jan; 22(1), p. 51-9.
PMID: 22672363
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Better exercise adherence after treatment for cancer (BEAT Cancer) study: rationale, design, and methods.
Authors: Rogers L.Q. , McAuley E. , Anton P.M. , Courneya K.S. , Vicari S. , Hopkins-Price P. , Verhulst S. , Mocharnuk R. , Hoelzer K. .
Source: Contemporary Clinical Trials, 2012 Jan; 33(1), p. 124-37.
PMID: 21983625
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Reduced barriers mediated physical activity maintenance among breast cancer survivors.
Authors: Rogers L.Q. , Markwell S. , Hopkins-Price P. , Vicari S. , Courneya K.S. , Hoelzer K. , Verhulst S. .
Source: Journal Of Sport & Exercise Psychology, 2011 Apr; 33(2), p. 235-54.
PMID: 21558582
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Physical activity type and intensity among rural breast cancer survivors: patterns and associations with fatigue and depressive symptoms.
Authors: Rogers L.Q. , Markwell S.J. , Courneya K.S. , McAuley E. , Verhulst S. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2011 Mar; 5(1), p. 54-61.
PMID: 21110134
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Lessons learned in the trenches: facilitating exercise adherence among breast cancer survivors in a group setting.
Authors: Rogers L.Q. , Vicari S. , Courneya K.S. .
Source: Cancer Nursing, 2010 Nov-Dec; 33(6), p. E10-7.
PMID: 20562618
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Objective monitoring of physical activity after a cancer diagnosis: challenges and opportunities for enhancing cancer control.
Authors: Rogers L.Q. .
Source: Physical Therapy Reviews : Ptr, 2010-06-01 00:00:00.0; 15(3), p. 224-237.
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