Grant Number:	1R01CA133015-01A2 Interpret this number
Primary Investigator:	Stone, Maureen
Organization:	University Of Maryland Baltimore
Project Title:	Predictors of Speech Quality After Tongue Cancer Surgery
Fiscal Year:	2009

DESCRIPTION (provided by applicant): Oral, head and neck cancer represents 3% of all cancers in the United States and is the 6th most common cancer worldwide. Recent studies have shown a five-fold increase in the incidence of squamous cell carcinomas of the oral portion of the tongue among young men and a six-fold increase among young women. Glossectomy is the surgical removal of a cancerous tumor. The amount of tongue tissue removed is not negotiable, because the surgeon must remove the entire tumor plus about 1 cm of tissue around it. The reconstructive phase focuses on maximizing the patient's post-operative quality of life, including the critical function of speech. Patients with poor speech avoid social situations, develop self-consciousness, and even depression. Surgeons must choose a reconstruction method, such as primary closure (suture the wound), or replacement with a 'flap' of tissue taken from elsewhere in the body. Larger tumors (above 4 cm in largest dimension) almost always require some type of flap. Among early stage tumors, however, there is no consensus as to the optimal closure procedure. We propose an objective study of patients for whom precise tumor-node-metastasis staging and specific surgical treatments have been established. We will study partial- to hemiglossectomy with primary closure, secondary healing and radial forearm free flap. We will focus on discovering the relationships between reconstruction technique and successful glossectomy speech as mediated by characteristics of tongue motion, kinematic properties of the residual muscles, and configurations of the vocal tract. We have research aims organized to address the following hypotheses. 1(a): Glossectomy speech quality will correlate with tongue motion pattern. 1(b): Tongue motion components that affect speech will vary by surgical type. 2(a): Glossectomy speech quality reflects the success of altered muscle mechanics. 2(b): Muscle mechanics that relate to speech quality will vary by surgical type. 3: A vocal tract model that maps geometry to acoustics can provide targeted speech therapy and can inform surgical decisions. In Aim 3 we will use the knowledge gained in Aims 1 and 2 along with both a 1D and a 3D acoustic model to represent post-glossectomy vocal tracts and then modify them to reflect changes in size and shape of flap or resected region. Results of the project will include a unique atlas of normal tongue deformation and patient comparisons, a better understanding of the impacts of tongue cancer surgery on the tongue and speech, and a tool to help understand speech outcomes of surgical modifications. PUBLIC HEALTH RELEVANCE: Tongue cancer surgery is a life saving procedure, but it typically leaves patients physically and mentally damaged, with speech communication difficulties that are in play every day. This research is an attempt to improve the speech outcome of tongue cancer surgery by minimizing the impact of the tongue reconstruction and understanding the contributions of patient and surgical factors, so patients can communicate more clearly. This will in turn diminish their own feelings of inadequacy, depression, and withdrawal from society.




Investigating muscle coordination patterns with Granger causality analysis in protrusive motion from tagged and diffusion MRI.
Authors: Park H. , Xing F. , Stone M. , Kang H. , Liu X. , Zhuo J. , Fels S. , Reese T.G. , Wedeen V.J. , Fakhri G.E. , et al. .
Source: Jasa Express Letters, 2024-09-01 00:00:00.0; 4(9), .
PMID: 39240196
Related Citations

Speech Motion Anomaly Detection via Cross-Modal Translation of 4D Motion Fields from Tagged MRI.
Authors: Liu X. , Xing F. , Zhuo J. , Stone M. , Prince J.L. , El Fakhri G. , Woo J. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2024 Feb; 12926, .
EPub date: 2024-05-01 00:00:00.0.
PMID: 39238547
Related Citations

Speech Audio Synthesis from Tagged MRI and Non-Negative Matrix Factorization via Plastic Transformer.
Authors: Liu X. , Xing F. , Stone M. , Zhuo J. , Fels S. , Prince J.L. , El Fakhri G. , Woo J. .
Source: Medical Image Computing And Computer-assisted Intervention : Miccai ... International Conference On Medical Image Computing And Computer-assisted Intervention, 2023 Oct; 14226, p. 435-445.
EPub date: 2023-10-01 00:00:00.0.
PMID: 38651032
Related Citations

Attentive continuous generative self-training for unsupervised domain adaptive medical image translation.
Authors: Liu X. , Prince J.L. , Xing F. , Zhuo J. , Reese T. , Stone M. , El Fakhri G. , Woo J. .
Source: Medical Image Analysis, 2023 Aug; 88, p. 102851.
EPub date: 2023-05-29 00:00:00.0.
PMID: 37329854
Related Citations

Attentive Continuous Generative Self-training for Unsupervised Domain Adaptive Medical Image Translation.
Authors: Liu X. , Prince J.L. , Xing F. , Zhuo J. , Reese T. , Stone M. , El Fakhri G. , Woo J. .
Source: Arxiv, 2023-05-23 00:00:00.0; , .
EPub date: 2023-05-23 00:00:00.0.
PMID: 37292465
Related Citations

Synthesizing Audio from Tongue Motion During Speech Using Tagged MRI Via Transformer.
Authors: Liu X. , Xing F. , Prince J.L. , Stone M. , Fakhri G.E. , Woo J. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2023 Feb; 12464, .
EPub date: 2023-04-03 00:00:00.0.
PMID: 38009135
Related Citations

Tagged-MRI Sequence to Audio Synthesis via Self Residual Attention Guided Heterogeneous Translator.
Authors: Liu X. , Xing F. , Prince J.L. , Zhuo J. , Stone M. , Fakhri G.E. , Woo J. .
Source: Medical Image Computing And Computer-assisted Intervention : Miccai ... International Conference On Medical Image Computing And Computer-assisted Intervention, 2022 Sep; 13436, p. 376-386.
EPub date: 2022-09-17 00:00:00.0.
PMID: 36820764
Related Citations

Structure-aware Unsupervised Tagged-to-Cine MRI Synthesis with Self Disentanglement.
Authors: Liu X. , Xing F. , Prince J.L. , Stone M. , El Fakhri G. , Woo J. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2022 Feb-Mar; 12032, .
EPub date: 2022-04-04 00:00:00.0.
PMID: 36203947
Related Citations

Structure-aware Unsupervised Tagged-to-Cine MRI Synthesis with Self Disentanglement.
Authors: Liu X. , Xing F. , Prince J.L. , Stone M. , El Fakhri G. , Woo J. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2022 Feb-Mar; 12032, .
EPub date: 2022-04-04 00:00:00.0.
PMID: 36203947
Related Citations

Measuring Strain in Diffusion-Weighted Data Using Tagged Magnetic Resonance Imaging.
Authors: Xing F. , Liu X. , Reese T.G. , Stone M. , Wedeen V.J. , Prince J.L. , El Fakhri G. , Woo J. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2022 Feb-Mar; 12032, .
EPub date: 2022-04-04 00:00:00.0.
PMID: 36777787
Related Citations

A deep joint sparse non-negative matrix factorization framework for identifying the common and subject-specific functional units of tongue motion during speech.
Authors: Woo J. , Xing F. , Prince J.L. , Stone M. , Gomez A.D. , Reese T.G. , Wedeen V.J. , El Fakhri G. .
Source: Medical Image Analysis, 2021 08; 72, p. 102131.
EPub date: 2021-06-12 00:00:00.0.
PMID: 34174748
Related Citations

DUAL-CYCLE CONSTRAINED BIJECTIVE VAE-GAN FOR TAGGED-TO-CINE MAGNETIC RESONANCE IMAGE SYNTHESIS.
Authors: Liu X. , Xing F. , Prince J.L. , Carass A. , Stone M. , Fakhri G.E. , Woo J. .
Source: Proceedings. Ieee International Symposium On Biomedical Imaging, 2021 Apr; 2021, .
EPub date: 2021-05-25 00:00:00.0.
PMID: 34707796
Related Citations

Floor-of-the-Mouth Muscle Function Analysis Using Dynamic Magnetic Resonance Imaging.
Authors: Xing F. , Stone M. , Prince J.L. , Liu X. , Fakhri G.E. , Woo J. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2021 Feb; 11596, .
EPub date: 2021-02-15 00:00:00.0.
PMID: 34012189
Related Citations

Generative Self-training for Cross-domain Unsupervised Tagged-to-Cine MRI Synthesis.
Authors: Liu X. , Xing F. , Stone M. , Zhuo J. , Reese T. , Prince J.L. , Fakhri G.E. , Woo J. .
Source: Medical Image Computing And Computer-assisted Intervention : Miccai ... International Conference On Medical Image Computing And Computer-assisted Intervention, 2021; 12903, p. 138-148.
EPub date: 2021-09-21 00:00:00.0.
PMID: 34734217
Related Citations

Identifying the Common and Subject-specific Functional Units of Speech Movements via a Joint Sparse Non-negative Matrix Factorization Framework.
Authors: Woo J. , Xing F. , Prince J.L. , Stone M. , Reese T.G. , Wedeen V.J. , El Fakhri G. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2020 Feb; 11313, .
EPub date: 2020-03-10 00:00:00.0.
PMID: 32454553
Related Citations

Quantifying Tongue Tip Shape in Apical and Laminal /s/: Contributions of Palate Shape.
Authors: Stone M. , Gomez A.D. , Zhuo J. , Tchouaga A.L. , Prince J.L. .
Source: Journal Of Speech, Language, And Hearing Research : Jslhr, 2019-09-20 00:00:00.0; 62(9), p. 3149-3159.
EPub date: 2019-08-29 00:00:00.0.
PMID: 31469967
Related Citations

Atlas-Based Tongue Muscle Correlation Analysis From Tagged and High-Resolution Magnetic Resonance Imaging.
Authors: Xing F. , Stone M. , Goldsmith T. , Prince J.L. , El Fakhri G. , Woo J. .
Source: Journal Of Speech, Language, And Hearing Research : Jslhr, 2019-07-15 00:00:00.0; 62(7), p. 2258-2269.
EPub date: 2019-07-02 00:00:00.0.
PMID: 31265364
Related Citations

Differentiating post-cancer from healthy tongue muscle coordination patterns during speech using deep learning.
Authors: Woo J. , Xing F. , Prince J.L. , Stone M. , Green J.R. , Goldsmith T. , Reese T.G. , Wedeen V.J. , El Fakhri G. .
Source: The Journal Of The Acoustical Society Of America, 2019 May; 145(5), p. EL423.
PMID: 31153323
Related Citations

Speech Map: A Statistical Multimodal Atlas of 4D Tongue Motion During Speech from Tagged and Cine MR Images.
Authors: Woo J. , Xing F. , Stone M. , Green J. , Reese T.G. , Brady T.J. , Wedeen V.J. , Prince J.L. , El Fakhri G. .
Source: Computer Methods In Biomechanics And Biomedical Engineering. Imaging & Visualization, 2019; 7(4), p. 361-373.
EPub date: 2017-10-09 00:00:00.0.
PMID: 31328049
Related Citations

A Sparse Non-negative Matrix Factorization Framework for Identifying Functional Units of Tongue Behavior from MRI.
Authors: Woo J. , Prince J.L. , Stone M. , Xing F. , Gomez A.D. , Green J.R. , Hartnick C.J. , Brady T.J. , Reese T.G. , Wedeen V.J. , et al. .
Source: Ieee Transactions On Medical Imaging, 2018-09-18 00:00:00.0; , .
EPub date: 2018-09-18 00:00:00.0.
PMID: 30235120
Related Citations

Strain Map of the Tongue in Normal and ALS Speech Patterns from Tagged and Diffusion MRI.
Authors: Xing F. , Prince J.L. , Stone M. , Reese T.G. , Atassi N. , Wedeen V.J. , El Fakhri G. , Woo J. .
Source: Proceedings Of Spie--the International Society For Optical Engineering, 2018 Feb; 10574, .
EPub date: 2018-03-02 00:00:00.0.
PMID: 29706684
Related Citations

A Spatio-Temporal Atlas and Statistical Model of the Tongue During Speech from Cine-MRI.
Authors: Woo J. , Xing F. , Lee J. , Stone M. , Prince J.L. .
Source: Computer Methods In Biomechanics And Biomedical Engineering. Imaging & Visualization, 2018; 6(5), p. 520-531.
EPub date: 2016-04-28 00:00:00.0.
PMID: 30034953
Related Citations

Structure and variability in human tongue muscle anatomy.
Authors: Stone M. , Woo J. , Lee J. , Poole T. , Seagraves A. , Chung M. , Kim E. , Murano E.Z. , Prince J.L. , Blemker S.S. .
Source: Computer Methods In Biomechanics And Biomedical Engineering. Imaging & Visualization, 2018; 6(5), p. 499-507.
EPub date: 2016-04-08 00:00:00.0.
PMID: 30135746
Related Citations

Variability in muscle activation of simple speech motions: A biomechanical modeling approach.
Authors: M Harandi N. , Woo J. , Stone M. , Abugharbieh R. , Fels S. .
Source: The Journal Of The Acoustical Society Of America, 2017 04; 141(4), p. 2579.
PMID: 28464688
Related Citations

Subject-Specific Biomechanical Modelling of the Oropharynx: Towards Speech Production.

Error Notice