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Grant Details

Grant Number: 5U01CA097416-09 Interpret this number
Primary Investigator: De Koning, Harry
Organization: Erasmus Medical Center
Project Title: Surveillance of Lung Cancer Trends in the Us with Miscan
Fiscal Year: 2009


Abstract

DESCRIPTION (provided by applicant): The proposed study is a continuation of a project to develop a comprehensive model of population trends in lung cancer. The model delivers estimates of the impact of cancer control interventions on observed trends in incidence and/or mortality; plausible ranges of estimates for the extent to which recommended interventions are having their expected population impact; the potential impact of new interventions on future national lung cancer trends; and the impact of targeted cancer control interventions on population outcome. The current project model is an adaptation of the Micro-simulation Screening ANalysis (MISCAN) simulation model that includes the Moolgavkar model on multistage carcinogenesis. The Moolgavkar model links exposure to risk factors to risk of lung cancer over time. The proposed project will extend our modeling effort to include explicitly the step from smoking-related interventions to expected level of exposure lo tobacco smoke. With this extension and after finishing the model development and validation, the project will perform evaluations across the full spectrum of possible interventions, including behavioral risk factors related to smoking and diet, early detection strategies, and various treatment modalities. Relative to existing efforts in the CISNET program, the proposed project will emphasize comprehensiveness of evaluated interventions and population trends; integration of different modeling approaches; and developing meaningful comparisons among models.



Publications

Chapter 15: Impact of tobacco control on lung cancer mortality in the United States over the period 1975-2000--summary and limitations.
Authors: Boer R. , Moolgavkar S.H. , Levy D.T. .
Source: Risk Analysis : An Official Publication Of The Society For Risk Analysis, 2012 Jul; 32 Suppl 1, p. S190-201.
PMID: 22882889
Related Citations

Chapter 1:The impact of the reduction in tobacco smoking on U.S. lung cancer mortality, 1975-2000: an introduction to the problem.
Authors: Feuer E.J. , Levy D.T. , McCarthy W.J. .
Source: Risk Analysis : An Official Publication Of The Society For Risk Analysis, 2012 Jul; 32 Suppl 1, p. S6-S13.
PMID: 22882893
Related Citations

Chapter 6: Lung cancer in never smokers: epidemiology and risk prediction models.
Authors: McCarthy W.J. , Meza R. , Jeon J. , Moolgavkar S.H. .
Source: Risk Analysis : An Official Publication Of The Society For Risk Analysis, 2012 Jul; 32 Suppl 1, p. S69-84.
PMID: 22882894
Related Citations

Chapter 7: Description Of Miscan-lung, The Erasmus Mc Lung Cancer Microsimulation Model For Evaluating Cancer Control Interventions
Authors: Schultz F.W. , Boer R. , de Koning H.J. .
Source: Risk Analysis : An Official Publication Of The Society For Risk Analysis, 2012 Jul; 32 Suppl 1, p. S85-98.
PMID: 22882895
Related Citations

Impact of reduced tobacco smoking on lung cancer mortality in the United States during 1975-2000.
Authors: Moolgavkar S.H. , Holford T.R. , Levy D.T. , Kong C.Y. , Foy M. , Clarke L. , Jeon J. , Hazelton W.D. , Meza R. , Schultz F. , et al. .
Source: Journal Of The National Cancer Institute, 2012-04-04 00:00:00.0; 104(7), p. 541-8.
EPub date: 2012-04-04 00:00:00.0.
PMID: 22423009
Related Citations

Exploring The Uncertainties Of Early Detection Results: Model-based Interpretation Of Mayo Lung Project
Authors: Shi L. , Tian H. , McCarthy W.J. , Berman B. , Wu S. , Boer R. .
Source: Bmc Cancer, 2011; 11, p. 92.
PMID: 21375784
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