Grant Number:	5U01CA115953-05 Interpret this number
Primary Investigator:	Zauber, Ann
Organization:	Sloan-Kettering Inst Can Research
Project Title:	Coordinating Center for Colorectal Microsimulation
Fiscal Year:	2009

DESCRIPTION (provided by applicant): Population based microsimulation models can provide a sensitive and informative tool for health policy to evaluate the population benefit and expenditures for interventions to reduce the burden of colorectal cancer. However the value of such models in the health policy area is often hampered by the uncertainty about what model outcomes stand for and why they differ between models. This proposal is to coordinate the activities of the investigators for the CISNET-Colon models to improve the dissemination of high quality models and thereby enhance our ability to inform the important policy issues to reduce the burden of colorectal cancer in the United States. A Clinical and Epidemiology Advisory Committee will provide additional insights into addressing the important pertinent issues for colorectal cancer. This proposal is from Memorial Sloan-Kettering Cancer Center in collaboration with Erasmus University MC who has developed the MISCAN-Colon model as a participant for the CISNET-Colon program. A multi-disciplinary team with experience in biostatistics, epidemiology, health policy, and microsimulation modeling will address the following aims for the coordinating center (COLON): 1. To create an optimal environment for a fruitful cooperation within the CISNET-Colon group 2. To formulate, prioritize and coordinate work on base case and other questions within the CISNET-Colon group. 3. To disseminate current policy related issues and the latest research results across the spectrum of prevention, screening and treatment for colorectal cancer in order to facilitate access to the latest information in these areas. 4. To serve as a spokesperson, first contact and disseminator for requests and collaborations from inside the CISNET groups and NCI and from outside the CISNET-Colon group. 5. Work cooperatively with the contractor, Lauren Clark of Cornerstone who maintains the Model Profiler/Interactive WebSite.




Cost Effectiveness of Screening Individuals With Cystic Fibrosis for Colorectal Cancer.
Authors: Gini A. , Zauber A.G. , Cenin D.R. , Omidvari A.H. , Hempstead S.E. , Fink A.K. , Lowenfels A.B. , Lansdorp-Vogelaar I. .
Source: Gastroenterology, 2018 Feb; 154(3), p. 556-567.e18.
EPub date: 2017-11-02 00:00:00.0.
PMID: 29102616
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Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Non-Invasive Colorectal Cancer Screening.
Authors: Lansdorp-Vogelaar I. , Goede S.L. , Bosch L.J.W. , Melotte V. , Carvalho B. , van Engeland M. , Meijer G.A. , de Koning H.J. , van Ballegooijen M. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2017-07-18 00:00:00.0; , .
EPub date: 2017-07-18 00:00:00.0.
PMID: 28733262
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Harms, benefits and costs of fecal immunochemical testing versus guaiac fecal occult blood testing for colorectal cancer screening.
Authors: Goede S.L. , Rabeneck L. , van Ballegooijen M. , Zauber A.G. , Paszat L.F. , Hoch J.S. , Yong J.H. , Kroep S. , Tinmouth J. , Lansdorp-Vogelaar I. .
Source: Plos One, 2017; 12(3), p. e0172864.
EPub date: 2017-03-15 00:00:00.0.
PMID: 28296927
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The impact of stratifying by family history in colorectal cancer screening programs.
Authors: Goede S.L. , Rabeneck L. , Lansdorp-Vogelaar I. , Zauber A.G. , Paszat L.F. , Hoch J.S. , Yong J.H. , van Hees F. , Tinmouth J. , van Ballegooijen M. .
Source: International Journal Of Cancer, 2015-09-01 00:00:00.0; 137(5), p. 1119-27.
EPub date: 2015-09-01 00:00:00.0.
PMID: 25663135
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Cost-Savings to Medicare From Pre-Medicare Colorectal Cancer Screening.
Authors: Goede S.L. , Kuntz K.M. , van Ballegooijen M. , Knudsen A.B. , Lansdorp-Vogelaar I. , Tangka F.K. , Howard D.H. , Chin J. , Zauber A.G. , Seeff L.C. .
Source: Medical Care, 2015 Jul; 53(7), p. 630-8.
PMID: 26067885
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The impact of screening on colorectal cancer mortality and incidence: has it really made a difference?
Authors: Zauber A.G. .
Source: Digestive Diseases And Sciences, 2015 Mar; 60(3), p. 681-91.
PMID: 25740556
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Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms and benefits.
Authors: Lansdorp-Vogelaar I. , Gulati R. , Mariotto A.B. , Schechter C.B. , de Carvalho T.M. , Knudsen A.B. , van Ravesteyn N.T. , Heijnsdijk E.A. , Pabiniak C. , van Ballegooijen M. , et al. .
Source: Annals Of Internal Medicine, 2014-07-15 00:00:00.0; 161(2), p. 104-12.
PMID: 25023249
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Utilization of surveillance after polypectomy in the medicare population--a cohort study.
Authors: Lansdorp-Vogelaar I. , Fedewa S. , Lin C.C. , Virgo K.S. , Jemal A. .
Source: Plos One, 2014; 9(11), p. e110937.
PMID: 25393312
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Multicohort models in cost-effectiveness analysis: why aggregating estimates over multiple cohorts can hide useful information.
Authors: O'Mahony J.F. , van Rosmalen J. , Zauber A.G. , van Ballegooijen M. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2013 Apr; 33(3), p. 407-14.
PMID: 22927697
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Derivation Of Background Mortality By Smoking And Obesity In Cancer Simulation Models
Authors: Wang Y.C. , Graubard B.I. , Rosenberg M.A. , Kuntz K.M. , Zauber A.G. , Kahle L. , Schechter C.B. , Feuer E.J. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2013 Feb; 33(2), p. 176-97.
PMID: 23132901
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Contribution of screening and survival differences to racial disparities in colorectal cancer rates.
Authors: Lansdorp-Vogelaar I. , Kuntz K.M. , Knudsen A.B. , van Ballegooijen M. , Zauber A.G. , Jemal A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 May; 21(5), p. 728-36.
PMID: 22514249
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Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.
Authors: Zauber A.G. , Winawer S.J. , O'Brien M.J. , Lansdorp-Vogelaar I. , van Ballegooijen M. , Hankey B.F. , Shi W. , Bond J.H. , Schapiro M. , Panish J.F. , et al. .
Source: The New England Journal Of Medicine, 2012-02-23 00:00:00.0; 366(8), p. 687-96.
PMID: 22356322
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Comparative economic evaluation of data from the ACRIN National CT Colonography Trial with three cancer intervention and surveillance modeling network microsimulations.
Authors: Vanness D.J. , Knudsen A.B. , Lansdorp-Vogelaar I. , Rutter C.M. , Gareen I.F. , Herman B.A. , Kuntz K.M. , Zauber A.G. , van Ballegooijen M. , Feuer E.J. , et al. .
Source: Radiology, 2011 Nov; 261(2), p. 487-98.
PMID: 21813740
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How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer?
Authors: Wilschut J.A. , Steyerberg E.W. , van Leerdam M.E. , Lansdorp-Vogelaar I. , Habbema J.D. , van Ballegooijen M. .
Source: Cancer, 2011-09-15 00:00:00.0; 117(18), p. 4166-74.
EPub date: 2011-09-15 00:00:00.0.
PMID: 21387272
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A systematic comparison of microsimulation models of colorectal cancer: the role of assumptions about adenoma progression.
Authors: Kuntz K.M. , Lansdorp-Vogelaar I. , Rutter C.M. , Knudsen A.B. , van Ballegooijen M. , Savarino J.E. , Feuer E.J. , Zauber A.G. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2011 Jul-Aug; 31(4), p. 530-9.
PMID: 21673186
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Clarifying differences in natural history between models of screening: the case of colorectal cancer.
Authors: van Ballegooijen M. , Rutter C.M. , Knudsen A.B. , Zauber A.G. , Savarino J.E. , Lansdorp-Vogelaar I. , Boer R. , Feuer E.J. , Habbema J.D. , Kuntz K.M. .
Source: Medical Decision Making : An International Journal Of The Society For Medical Decision Making, 2011 Jul-Aug; 31(4), p. 540-9.
PMID: 21673187
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Radiation-related cancer risks from CT colonography screening: a risk-benefit analysis.
Authors: Berrington de González A. , Kim K.P. , Knudsen A.B. , Lansdorp-Vogelaar I. , Rutter C.M. , Smith-Bindman R. , Yee J. , Kuntz K.M. , van Ballegooijen M. , Zauber A.G. , et al. .
Source: Ajr. American Journal Of Roentgenology, 2011 Apr; 196(4), p. 816-23.
PMID: 21427330
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Cost-effectiveness of colorectal cancer screening.
Authors: Lansdorp-Vogelaar I. , Knudsen A.B. , Brenner H. .
Source: Epidemiologic Reviews, 2011; 33, p. 88-100.
PMID: 21633092
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Cost-effectiveness of colonoscopy.
Authors: Zauber A.G. .
Source: Gastrointestinal Endoscopy Clinics Of North America, 2010 Oct; 20(4), p. 751-70.
PMID: 20889076
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Stool DNA testing to screen for colorectal cancer in the Medicare population: a cost-effectiveness analysis.
Authors: Lansdorp-Vogelaar I. , Kuntz K.M. , Knudsen A.B. , Wilschut J.A. , Zauber A.G. , van Ballegooijen M. .
Source: Annals Of Internal Medicine, 2010-09-21 00:00:00.0; 153(6), p. 368-77.
PMID: 20855801
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Cost-effectiveness of computed tomographic colonography screening for colorectal cancer in the medicare population.
Authors: Knudsen A.B. , Lansdorp-Vogelaar I. , Rutter C.M. , Savarino J.E. , van Ballegooijen M. , Kuntz K.M. , Zauber A.G. .
Source: Journal Of The National Cancer Institute, 2010-08-18 00:00:00.0; 102(16), p. 1238-52.
EPub date: 2010-08-18 00:00:00.0.
PMID: 20664028
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Simulation of colorectal cancer screening: what we do and do not know and does it matter.
Authors: van Ballegooijen M. , Boer R. , Zauber A.G. .
Source: Best Practice & Research. Clinical Gastroenterology, 2010 Aug; 24(4), p. 427-37.
PMID: 20833347
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Cost-effectiveness of colorectal cancer screening - an overview.
Authors: Lansdorp-Vogelaar I. , Knudsen A.B. , Brenner H. .
Source: Best Practice & Research. Clinical Gastroenterology, 2010 Aug; 24(4), p. 439-49.
PMID: 20833348
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Individualizing colonoscopy screening by sex and race.
Authors: Lansdorp-Vogelaar I. , van Ballegooijen M. , Zauber A.G. , Boer R. , Wilschut J. , Winawer S.J. , Habbema J.D. .
Source: Gastrointestinal Endoscopy, 2009 Jul; 70(1), p. 96-108, 108.e1-24.
PMID: 19467539
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A novel hypothesis on the sensitivity of the fecal occult blood test: Results of a joint analysis of 3 randomized controlled trials.
Authors: Lansdorp-Vogelaar I. , van Ballegooijen M. , Boer R. , Zauber A. , Habbema J.D. .
Source: Cancer, 2009-06-01 00:00:00.0; 115(11), p. 2410-9.
PMID: 19288570
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At what costs will screening with CT colonography be competitive? A cost-effectiveness approach.
Authors: Lansdorp-Vogelaar I. , van Ballegooijen M. , Zauber A.G. , Boer R. , Wilschut J. , Habbema J.D. .
Source: International Journal Of Cancer, 2009-03-01 00:00:00.0; 124(5), p. 1161-8.
PMID: 19048626
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Evaluating test strategies for colorectal cancer screening: a decision analysis for the U.S. Preventive Services Task Force.
Authors: Zauber A.G. , Lansdorp-Vogelaar I. , Knudsen A.B. , Wilschut J. , van Ballegooijen M. , Kuntz K.M. .
Source: Annals Of Internal Medicine, 2008-11-04 00:00:00.0; 149(9), p. 659-69.
EPub date: 2008-11-04 00:00:00.0.
PMID: 18838717
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