Grant Number:	5U01CA097414-09 Interpret this number
Primary Investigator:	Tsodikov, Alexander
Organization:	University Of Michigan At Ann Arbor
Project Title:	Population Impact of Cancer Control Processes
Fiscal Year:	2009

DESCRIPTION (provided by applicant): During the first two years of our active CISNET project "Survival Effects of Prostate Cancer Surveillance" a population model of prostate cancer incidence and mortality was developed and applied to analyze national population and cancer registry data. The new application will focus on using the model to understand, predict and optimize the population impact of cancer control processes in prostate cancer. Specifically, we will study the joint effect of progress in treatment of prostate cancer and dissemination of PSA on observed national incidence and mortality trends; make short- and long-term predictions of the trends; analyze racial disparities as they pertain to dissemination of PSA testing, natural history of prostate cancer, benign disorders in the prostate, dissemination of treatment, survival, incidence and mortality; assess the effect of misattribution bias on the patterns of prostate cancer mortality; evaluate the sensitivity of estimates of population impact of screening interventions and treatment on mortality; assess the impact of Transurethral Resection of the Prostate (TURP) on early detection of prostate cancer and population trends in the pre-PSA era; develop unbiased assessment of treatment effects from population data; translate the results of clinical and prevention trials, and retrospective analyses of clinical data in prostate cancer into the potential population impact of their dissemination; determine and evaluate optimal screening strategies and predict their effect on future national trends in prostate cancer incidence and mortality; develop a user-friendly interface for the model.




A Self-consistency Approach to Multinomial Logit Model with Random Effects.
Authors: Wang S. , Tsodikov A. .
Source: Journal Of Statistical Planning And Inference, 2010-07-01 00:00:00.0; 140(7), p. 1939-1947.
PMID: 20383288
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Effects of a high dose, aglycone-rich soy extract on prostate-specific antigen and serum isoflavone concentrations in men with localized prostate cancer.
Authors: deVere White R.W. , Tsodikov A. , Stapp E.C. , Soares S.E. , Fujii H. , Hackman R.M. .
Source: Nutrition And Cancer, 2010; 62(8), p. 1036-43.
PMID: 21058191
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Stage-specific cancer incidence: an artificially mixed multinomial logit model.
Authors: Chefo S. , Tsodikov A. .
Source: Statistics In Medicine, 2009-07-10 00:00:00.0; 28(15), p. 2054-76.
PMID: 19452568
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Lead Time And Overdiagnosis In Prostate-specific Antigen Screening: Importance Of Methods And Context
Authors: Draisma G. , Etzioni R. , Tsodikov A. , Mariotto A. , Wever E. , Gulati R. , Feuer E. , de Koning H. .
Source: Journal Of The National Cancer Institute, 2009-03-18 00:00:00.0; 101(6), p. 374-83.
PMID: 19276453
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Dr. Andrei Yakovlev: visionary, leader, iconoclast.
Authors: Gusev Y. , Hanin L. , Klebanov L. , Tsodikov A. , Yanev N.M. , Zorin A. .
Source: Biology Direct, 2008-03-26 00:00:00.0; 3, p. 10.
EPub date: 2008-03-26 00:00:00.0.
PMID: 18366793
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Quantifying the role of PSA screening in the US prostate cancer mortality decline.
Authors: Etzioni R. , Tsodikov A. , Mariotto A. , Szabo A. , Falcon S. , Wegelin J. , DiTommaso D. , Karnofski K. , Gulati R. , Penson D.F. , et al. .
Source: Cancer Causes & Control : Ccc, 2008 Mar; 19(2), p. 175-81.
PMID: 18027095
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A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer.
Authors: Laxman B. , Morris D.S. , Yu J. , Siddiqui J. , Cao J. , Mehra R. , Lonigro R.J. , Tsodikov A. , Wei J.T. , Tomlins S.A. , et al. .
Source: Cancer Research, 2008-02-01 00:00:00.0; 68(3), p. 645-9.
PMID: 18245462
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Generalized Self-Consistency: Multinomial logit model and Poisson likelihood.
Authors: Tsodikov A. , Chefo S. .
Source: Journal Of Statistical Planning And Inference, 2008; 138(8), p. 23802397.
PMID: 18709183
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Profile information matrix for nonlinear transformation models.
Authors: Tsodikov A. , Garibotti G. .
Source: Lifetime Data Analysis, 2007 Mar; 13(1), p. 139-59.
PMID: 17021958
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A population model of prostate cancer incidence.
Authors: Tsodikov A. , Szabo A. , Wegelin J. .
Source: Statistics In Medicine, 2006-08-30 00:00:00.0; 25(16), p. 2846-66.
PMID: 16397859
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Two-sample statistics for testing the equality of survival functions against improper semi-parametric accelerated failure time alternatives: an application to the analysis of a breast cancer clinical trial.
Authors: Broët P. , Tsodikov A. , De Rycke Y. , Moreau T. .
Source: Lifetime Data Analysis, 2004 Jun; 10(2), p. 103-20.
PMID: 15293627
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Estimating Cure Rates From Survival Data: An Alternative to Two-Component Mixture Models.
Authors: Tsodikov A.D. , Ibrahim J.G. , Yakovlev A.Y. .
Source: Journal Of The American Statistical Association, 2003-12-01 00:00:00.0; 98(464), p. 1063-1078.
PMID: 21151838
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Semiparametric models: a generalized self-consistency approach.
Authors: Tsodikov A. .
Source: Journal Of The Royal Statistical Society. Series B, Statistical Methodology, 2003-08-01 00:00:00.0; 65(3), p. 759-774.
PMID: 21127741
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