Grant Number:	5R01CA114205-04 Interpret this number
Primary Investigator:	Michaud, Dominique
Organization:	Imperial College Of Science, Technology And Medicine
Project Title:	Allergies, Genetic Susceptibility and Adult Glioma Risk
Fiscal Year:	2009

Gliomas are the most common primary malignant brain tumors in adults and are often highly fatal. Little is known about the etiology of these tumors. Recent studies suggest that individuals with allergies may have a lower risk of glioma. Studies have also reported associations with detoxification genes, especially GSTT1 and GSTP1. However, most epidemiologic studies reporting these associations have been case- control studies, which are particularly prone to biases, given the high fatality of gliomas. To examine hypotheses related to allergies and genetic susceptibility, we propose to draw on five established prospective cohorts: the Health Professionals Follow-Up study, the Nurses' Health Study I, the Nurses' Health Study II, the Physicians' Health Study, and the Women's Health Study. Specifically, we propose to examine IgE levels (total, food and respiratory specific) in blood specimens, SNPs (both alleles and haplotypes) of genes strongly related to allergies or asthma (IL-4, IL-4Ralpha, IL-13, FceRI-p, IL-10, CTLA- 4), and known functional variants of two detoxification genes (GSTP1 and GSTT1) in relation to the risk of gliomas. In these five cohorts, blood samples were collected from participants prior to disease diagnosis. For the genetic polymorphism analyses, we will have 341 incident glioma cases with 3 matched controls, using a nested case-control design. In addition, we propose to obtain tissue blocks from all incident glioma cases to classify the different types of gliomas using molecular markers (TP53 mutations, EGFR amplification, chromosome loss of 1p and 10p). Use of molecular markers to identify subtypes of gliomas may enhance our ability to uncover etiologic risk factors. This will be the largest prospective study of gliomas to date, and with its considerable strengths, holds the promise of contributing substantially to our understanding of the relation between allergies, genetic susceptibility and adult glioma risk. Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer.




Single-nucleotide Polymorphisms Of Allergy-related Genes And Risk Of Adult Glioma
Authors: Backes D.M. , Siddiq A. , Cox D.G. , Calboli F.C. , Gaziano J.M. , Ma J. , Stampfer M. , Hunter D.J. , Camargo C.A. , Michaud D.S. .
Source: Journal Of Neuro-oncology, 2013 Jun; 113(2), p. 229-38.
PMID: 23525950
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Mannose-binding Lectin 2 Gene And Risk Of Adult Glioma
Authors: Michaud D.S. , Siddiq A. , Cox D.G. , Backes D.M. , Calboli F.C. , Sughrue M.E. , Gaziano J.M. , Ma J. , Stampfer M. , Tworoger S.S. , et al. .
Source: Plos One, 2013; 8(4), p. e61117.
PMID: 23637788
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Genome-wide Association Study Of Glioma And Meta-analysis
Authors: Rajaraman P. , Melin B.S. , Wang Z. , McKean-Cowdin R. , Michaud D.S. , Wang S.S. , Bondy M. , Houlston R. , Jenkins R.B. , Wrensch M. , et al. .
Source: Human Genetics, 2012 Dec; 131(12), p. 1877-88.
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Prediagnostic Plasma Ige Levels And Risk Of Adult Glioma In Four Prospective Cohort Studies
Authors: Calboli F.C. , Cox D.G. , Buring J.E. , Gaziano J.M. , Ma J. , Stampfer M. , Willett W.C. , Tworoger S.S. , Hunter D.J. , Camargo C.A. , et al. .
Source: Journal Of The National Cancer Institute, 2011-11-02 00:00:00.0; 103(21), p. 1588-95.
PMID: 22010181
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Anthropometric Measures, Physical Activity, And Risk Of Glioma And Meningioma In A Large Prospective Cohort Study
Authors: Michaud D.S. , Bové G. , Gallo V. , Schlehofer B. , Tjønneland A. , Olsen A. , Overvad K. , Dahm C.C. , Teucher B. , Boeing H. , et al. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2011 Sep; 4(9), p. 1385-92.
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Coffee, Tea, Caffeine Intake, And Risk Of Adult Glioma In Three Prospective Cohort Studies
Authors: Holick C.N. , Smith S.G. , Giovannucci E. , Michaud D.S. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2010 Jan; 19(1), p. 39-47.
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Periodontal Disease, Tooth Loss, And Cancer Risk In Male Health Professionals: A Prospective Cohort Study
Authors: Michaud D.S. , Liu Y. , Meyer M. , Giovannucci E. , Joshipura K. .
Source: The Lancet. Oncology, 2008 Jun; 9(6), p. 550-8.
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Atopy And Risk Of Brain Tumors: A Meta-analysis
Authors: Linos E. , Raine T. , Alonso A. , Michaud D. .
Source: Journal Of The National Cancer Institute, 2007-10-17 00:00:00.0; 99(20), p. 1544-50.
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