Grant Details
Grant Number: |
1R01CA131332-01A2 Interpret this number |
Primary Investigator: |
Tamimi, Rulla |
Organization: |
Brigham And Women'S Hospital |
Project Title: |
Whole Genome Association Study of Mammographic Density |
Fiscal Year: |
2009 |
Abstract
DESCRIPTION (provided by applicant): Mammographic density is one of the strongest risk factors for breast cancer. Women with the highest mammographic density are at a four- to six-fold greater risk of breast cancer than women with the lowest density. Recently for other chronic diseases (e.g., coronary artery disease), we have seen proof-of-principle that utilizing a reliably measured, heritable quantitative trait (e.g., circulating lipids) that is a strong risk factor for the outcome can identify novel loci for the disease that were not identified through genome-wide association studies (GWASs) of the outcome. Thus, studies of heritable phenotypes can uncover biological pathways that will lead to a better understanding of basic mechanisms of disease and may identify targets for intervention. In a similar paradigm, mammographic density is a highly heritable, reliably measured, quantitative trait and a well-established strong predictor of breast cancer independent of known breast cancer risk factors. Identifying genes associated with mammographic density will identify mechanisms related to not only breast density, but has immense potential to detect genes involved with breast cancer. We propose to conduct a multi-stage GWAS of mammographic density among postmenopausal women (Aim 1). As part of the Cancer Genetic Markers of Susceptibility (CGEMS) project, postmenopausal breast cancer cases and controls in the Nurses' Health Study (NHS) have whole genome scans completed. We estimate that we will have mammographic density data on 1,800 of these women. Our initial analysis will examine the association between 2.5 million SNPs (includes 550,000 genotyped and the remainder imputed) and mammographic density among women included in the CGEMS project (Stage 1). To minimize false positive and negative associations, we will pursue the highest-ranking 7,600 SNPs from Stage 1 in an additional 1,200 postmenopausal women from the NHS (Stage 2). The 1,536 most promising SNPs will be genotyped in 3,000 postmenopausal participants in the Mayo Mammography Health Study (MMHS) (Stage 3).Validated SNPs that emerge from the multi-stage study will be evaluated for biologically plausible gene-environment interactions (Aim 2). The NHS and MMHS are both well established cohorts of demographically similar populations with blood samples, mammographic density data and extensive exposure information on breast cancer risk factors. We will also evaluate if validated SNPs from Aim 1 are associated with breast cancer risk in the NHS and in the Breast and Prostate Cancer Cohort Consortium (with over 6,000 breast cancer cases and controls). The results of the proposed study will complement those from breast cancer GWASs by increasing our understanding of breast biology and etiology of breast cancer. This is a unique, cost-efficient, and timely proposal to identify novel genetic pathways underlying breast density and breast cancer. Identification of genes associated with mammographic density will allow for study of their function as it relates to density and breast cancer and opens up the possibility for novel targets of breast cancer prevention and treatment. PUBLIC HEALTH RELEVANCE: Elucidating the genetic components of complex diseases with multifactorial causes such as breast cancer can be enhanced through concentration on heritable risk factors for the disease. Mammographic density is a highly heritable, reliably measured, quantitative trait and a well- established strong predictor of breast cancer independent of known breast cancer risk factors. This multi-stage genome-wide association study of mammographic density will not only identify novel loci associated with breast density, but will complement the studies of breast cancer by increasing our understanding of breast biology and etiology of breast cancer.
Publications
Plasma C-peptide mammographic features and risk of breast cancer.
Authors: Azam S.
, Peng C.
, Rosner B.A.
, Goncalves M.D.
, Phillips E.
, Eliassen H.
, Heine J.
, Hankinson S.E.
, Tamimi R.M.
.
Source: Npj Breast Cancer, 2024-10-17 00:00:00.0; 10(1), p. 91.
EPub date: 2024-10-17 00:00:00.0.
PMID: 39420200
Related Citations
Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies.
Authors: Yaghjyan L.
, Heng Y.J.
, Baker G.M.
, Murthy D.
, Mahoney M.B.
, Rosner B.
, Tamimi R.M.
.
Source: British Journal Of Cancer, 2024-06-07 00:00:00.0; , .
EPub date: 2024-06-07 00:00:00.0.
PMID: 38849477
Related Citations
Associations of early-life and adult anthropometric measures with the expression of stem cell markers CD44, CD24, and ALDH1A1 in women with benign breast biopsies.
Authors: Oh H.
, Yaghjyan L.
, Heng Y.J.
, Rosner B.
, Mahoney M.B.
, Murthy D.
, Baker G.M.
, Tamimi R.M.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2024-04-23 00:00:00.0; , .
EPub date: 2024-04-23 00:00:00.0.
PMID: 38652503
Related Citations
Reproductive factors related to childbearing and a novel automated mammographic measure, V.
Authors: Yaghjyan L.
, Wang Z.
, Warner E.T.
, Rosner B.
, Heine J.
, Tamimi R.M.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2024-03-18 00:00:00.0; , .
EPub date: 2024-03-18 00:00:00.0.
PMID: 38497795
Related Citations
Associations of reproductive breast cancer risk factors with expression of stem cell markers in benign breast tissue.
Authors: Yaghjyan L.
, Heng Y.J.
, Baker G.M.
, Bret-Mounet V.C.
, Murthy D.
, Mahoney M.B.
, Rosner B.
, Tamimi R.M.
.
Source: Frontiers In Oncology, 2024; 14, p. 1354094.
EPub date: 2024-03-21 00:00:00.0.
PMID: 38577336
Related Citations
Reproductive factors and expression of stem cell markers in women with incident benign breast disease.
Authors: Wang T.
, Heng Y.J.
, Sardella B.R.
, Rosner B.
, Tamimi R.M.
, Yaghjyan L.
.
Source: American Journal Of Cancer Research, 2024; 14(11), p. 5434-5445.
EPub date: 2024-11-15 00:00:00.0.
PMID: 39659919
Related Citations
Associations of stem cell markers in benign breast tissue with subsequent breast cancer risk.
Authors: Yaghjyan L.
, Heng Y.J.
, Baker G.M.
, Murthy D.
, Mahoney M.B.
, Rosner B.
, Tamimi R.M.
.
Source: American Journal Of Cancer Research, 2023; 13(12), p. 6280-6289.
EPub date: 2023-12-15 00:00:00.0.
PMID: 38187066
Related Citations
Associations of aspirin and other anti-inflammatory medications with breast cancer risk by the status of COX-2 expression.
Authors: Yaghjyan L.
, Eliassen A.H.
, Colditz G.
, Rosner B.
, Schedin P.
, Wijayabahu A.
, Tamimi R.M.
.
Source: Breast Cancer Research : Bcr, 2022-12-09 00:00:00.0; 24(1), p. 89.
EPub date: 2022-12-09 00:00:00.0.
PMID: 36494710
Related Citations
The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.
Authors: Ward S.V.
, Burton A.
, Tamimi R.M.
, Pereira A.
, Garmendia M.L.
, Pollan M.
, Boyd N.
, Dos-Santos-Silva I.
, Maskarinec G.
, Perez-Gomez B.
, et al.
.
Source: Breast Cancer Research : Bcr, 2022-07-14 00:00:00.0; 24(1), p. 49.
EPub date: 2022-07-14 00:00:00.0.
PMID: 35836268
Related Citations
Associations of oral contraceptives with mammographic breast density in premenopausal women.
Authors: Yaghjyan L.
, Smotherman C.
, Heine J.
, Colditz G.A.
, Rosner B.
, Tamimi R.M.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-12-03 00:00:00.0; , .
EPub date: 2021-12-03 00:00:00.0.
PMID: 34862209
Related Citations
Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density.
Authors: Garzia N.A.
, Cushing-Haugen K.
, Kensler T.W.
, Tamimi R.M.
, Harris H.R.
.
Source: Breast Cancer Research : Bcr, 2021-07-07 00:00:00.0; 23(1), p. 71.
EPub date: 2021-07-07 00:00:00.0.
PMID: 34233736
Related Citations
Associations of reproductive breast cancer risk factors with breast tissue composition.
Authors: Yaghjyan L.
, Austin-Datta R.J.
, Oh H.
, Heng Y.J.
, Vellal A.D.
, Sirinukunwattana K.
, Baker G.M.
, Collins L.C.
, Murthy D.
, Rosner B.
, et al.
.
Source: Breast Cancer Research : Bcr, 2021-07-05 00:00:00.0; 23(1), p. 70.
EPub date: 2021-07-05 00:00:00.0.
PMID: 34225771
Related Citations
Association of Interactions Between Mammographic Density Phenotypes and Established Risk Factors With Breast Cancer Risk, by Tumor Subtype and Menopausal Status.
Authors: Chen H.
, Yaghjyan L.
, Li C.
, Peters U.
, Rosner B.
, Lindström S.
, Tamimi R.M.
.
Source: American Journal Of Epidemiology, 2021-01-04 00:00:00.0; 190(1), p. 44-58.
PMID: 32639533
Related Citations
Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes.
Authors: Kleinstern G.
, Scott C.G.
, Tamimi R.M.
, Jensen M.R.
, Pankratz V.S.
, Bertrand K.A.
, Norman A.D.
, Visscher D.W.
, Couch F.J.
, Brandt K.
, et al.
.
Source: Breast Cancer Research And Treatment, 2021-01-04 00:00:00.0; , .
EPub date: 2021-01-04 00:00:00.0.
PMID: 33392844
Related Citations
Early-life and adult adiposity, adult height, and benign breast tissue composition.
Authors: Oh H.
, Yaghjyan L.
, Austin-Datta R.J.
, Heng Y.J.
, Baker G.M.
, Sirinukunwattana K.
, Vellal A.D.
, Collins L.C.
, Murthy D.
, Eliassen A.H.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-12-07 00:00:00.0; , .
EPub date: 2020-12-07 00:00:00.0.
PMID: 33288551
Related Citations
Associations of aspirin and other anti-inflammatory medications with mammographic breast density and breast cancer risk.
Authors: Yaghjyan L.
, Wijayabahu A.
, Eliassen A.H.
, Colditz G.
, Rosner B.
, Tamimi R.M.
.
Source: Cancer Causes & Control : Ccc, 2020-05-31 00:00:00.0; , .
EPub date: 2020-05-31 00:00:00.0.
PMID: 32476101
Related Citations
Early-life and adult anthropometrics in relation to mammographic image intensity variation in the Nurses' Health Studies.
Authors: Oh H.
, Rice M.S.
, Warner E.T.
, Bertrand K.A.
, Fowler E.
, Eliassen A.H.
, Rosner B.A.
, Heine J.
, Tamimi R.M.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019-12-11 00:00:00.0; , .
EPub date: 2019-12-11 00:00:00.0.
PMID: 31826913
Related Citations
Circulating lipids, mammographic density, and risk of breast cancer in the Nurses' Health Study and Nurses' Health Study II.
Authors: Lucht S.A.
, Eliassen A.H.
, Bertrand K.A.
, Ahern T.P.
, Borgquist S.
, Rosner B.
, Hankinson S.E.
, Tamimi R.M.
.
Source: Cancer Causes & Control : Ccc, 2019-07-01 00:00:00.0; , .
EPub date: 2019-07-01 00:00:00.0.
PMID: 31264139
Related Citations
Adolescent caffeine consumption and mammographic breast density in premenopausal women.
Authors: Yaghjyan L.
, Colditz G.
, Rosner B.
, Rich S.
, Egan K.
, Tamimi R.M.
.
Source: European Journal Of Nutrition, 2019-05-31 00:00:00.0; , .
EPub date: 2019-05-31 00:00:00.0.
PMID: 31152213
Related Citations
Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype.
Authors: Shieh Y.
, Scott C.G.
, Jensen M.R.
, Norman A.D.
, Bertrand K.A.
, Pankratz V.S.
, Brandt K.R.
, Visscher D.W.
, Shepherd J.A.
, Tamimi R.M.
, et al.
.
Source: Breast Cancer Research : Bcr, 2019-04-03 00:00:00.0; 21(1), p. 48.
EPub date: 2019-04-03 00:00:00.0.
PMID: 30944014
Related Citations
Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes.
Authors: Chung W.
, Chen J.
, Turman C.
, Lindstrom S.
, Zhu Z.
, Loh P.R.
, Kraft P.
, Liang L.
.
Source: Nature Communications, 2019-02-04 00:00:00.0; 10(1), p. 569.
EPub date: 2019-02-04 00:00:00.0.
PMID: 30718517
Related Citations
Interactions of alcohol and postmenopausal hormone use in regards to mammographic breast density.
Authors: Yaghjyan L.
, Colditz G.
, Eliassen H.
, Rosner B.
, Gasparova A.
, Tamimi R.M.
.
Source: Cancer Causes & Control : Ccc, 2018-06-25 00:00:00.0; , .
EPub date: 2018-06-25 00:00:00.0.
PMID: 29938357
Related Citations
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
Authors: Khawaja A.P.
, Cooke Bailey J.N.
, Wareham N.J.
, Scott R.A.
, Simcoe M.
, Igo R.P.
, Song Y.E.
, Wojciechowski R.
, Cheng C.Y.
, Khaw P.T.
, et al.
.
Source: Nature Genetics, 2018 Jun; 50(6), p. 778-782.
EPub date: 2018-05-21 00:00:00.0.
PMID: 29785010
Related Citations
Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics.
Authors: Rice M.S.
, Tamimi R.M.
, Bertrand K.A.
, Scott C.G.
, Jensen M.R.
, Norman A.D.
, Visscher D.W.
, Chen Y.Y.
, Brandt K.R.
, Couch F.J.
, et al.
.
Source: Breast Cancer Research And Treatment, 2018-03-03 00:00:00.0; , .
EPub date: 2018-03-03 00:00:00.0.
PMID: 29502324
Related Citations
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma.
Authors: Gharahkhani P.
, Burdon K.P.
, Cooke Bailey J.N.
, Hewitt A.W.
, Law M.H.
, Pasquale L.R.
, Kang J.H.
, Haines J.L.
, Souzeau E.
, Zhou T.
, et al.
.
Source: Scientific Reports, 2018-02-15 00:00:00.0; 8(1), p. 3124.
EPub date: 2018-02-15 00:00:00.0.
PMID: 29449654
Related Citations
Associations of coffee consumption and caffeine intake with mammographic breast density.
Authors: Yaghjyan L.
, Colditz G.
, Rosner B.
, Gasparova A.
, Tamimi R.M.
.
Source: Breast Cancer Research And Treatment, 2018-01-17 00:00:00.0; , .
EPub date: 2018-01-17 00:00:00.0.
PMID: 29340883
Related Citations
Percent mammographic density prediction: development of a model in the nurses' health studies.
Authors: Rice M.S.
, Rosner B.A.
, Tamimi R.M.
.
Source: Cancer Causes & Control : Ccc, 2017 Jul; 28(7), p. 677-684.
EPub date: 2017-05-06 00:00:00.0.
PMID: 28478536
Related Citations
Age At Natural Menopause Genetic Risk Score In Relation To Age At Natural Menopause And Primary Open-angle Glaucoma In A Us-based Sample
Authors: Pasquale L.R.
, Aschard H.
, Kang J.H.
, Bailey J.N.
, Lindström S.
, Chasman D.I.
, Christen W.G.
, Allingham R.R.
, Ashley-Koch A.
, Lee R.K.
, et al.
.
Source: Menopause (new York, N.y.), 2017 Feb; 24(2), p. 150-156.
PMID: 27760082
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A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts.
Authors: Lindström S.
, Loomis S.
, Turman C.
, Huang H.
, Huang J.
, Aschard H.
, Chan A.T.
, Choi H.
, Cornelis M.
, Curhan G.
, et al.
.
Source: Plos One, 2017; 12(3), p. e0173997.
EPub date: 2017-03-16 00:00:00.0.
PMID: 28301549
Related Citations
Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems.
Authors: Burton A.
, Byrnes G.
, Stone J.
, Tamimi R.M.
, Heine J.
, Vachon C.
, Ozmen V.
, Pereira A.
, Garmendia M.L.
, Scott C.
, et al.
.
Source: Breast Cancer Research : Bcr, 2016-12-19 00:00:00.0; 18(1), p. 130.
EPub date: 2016-12-19 00:00:00.0.
PMID: 27993168
Related Citations
Mammographic Texture And Risk Of Breast Cancer By Tumor Type And Estrogen Receptor Status
Authors: Malkov S.
, Shepherd J.A.
, Scott C.G.
, Tamimi R.M.
, Ma L.
, Bertrand K.A.
, Couch F.
, Jensen M.R.
, Mahmoudzadeh A.P.
, Fan B.
, et al.
.
Source: Breast Cancer Research : Bcr, 2016-12-06 00:00:00.0; 18(1), p. 122.
PMID: 27923387
Related Citations
Mammographic Density And Breast Cancer Risk: A Mediation Analysis
Authors: Rice M.S.
, Bertrand K.A.
, VanderWeele T.J.
, Rosner B.A.
, Liao X.
, Adami H.O.
, Tamimi R.M.
.
Source: Breast Cancer Research : Bcr, 2016-09-21 00:00:00.0; 18(1), p. 94.
PMID: 27654859
Related Citations
Adolescent fiber intake and mammographic breast density in premenopausal women.
Authors: Yaghjyan L.
, Ghita G.L.
, Rosner B.
, Farvid M.
, Bertrand K.A.
, Tamimi R.M.
.
Source: Breast Cancer Research : Bcr, 2016-08-12 00:00:00.0; 18(1), p. 85.
EPub date: 2016-08-12 00:00:00.0.
PMID: 27520794
Related Citations
Reproductive factors related to childbearing and mammographic breast density.
Authors: Yaghjyan L.
, Colditz G.A.
, Rosner B.
, Bertrand K.A.
, Tamimi R.M.
.
Source: Breast Cancer Research And Treatment, 2016 Jul; 158(2), p. 351-9.
EPub date: 2016-06-28 00:00:00.0.
PMID: 27351801
Related Citations
International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries.
Authors: McCormack V.A.
, Burton A.
, dos-Santos-Silva I.
, Hipwell J.H.
, Dickens C.
, Salem D.
, Kamal R.
, Hartman M.
, Lee C.P.
, Chia K.S.
, et al.
.
Source: Cancer Epidemiology, 2016 Feb; 40, p. 141-51.
PMID: 26724463
Related Citations
Postmenopausal mammographic breast density and subsequent breast cancer risk according to selected tissue markers.
Authors: Yaghjyan L.
, Pettersson A.
, Colditz G.A.
, Collins L.C.
, Schnitt S.J.
, Beck A.H.
, Rosner B.
, Vachon C.
, Tamimi R.M.
.
Source: British Journal Of Cancer, 2015-09-29 00:00:00.0; 113(7), p. 1104-13.
EPub date: 2015-09-29 00:00:00.0.
PMID: 26335607
Related Citations
Novel Associations Between Common Breast Cancer Susceptibility Variants And Risk-predicting Mammographic Density Measures
Authors: Stone J.
, Thompson D.J.
, Dos Santos Silva I.
, Scott C.
, Tamimi R.M.
, Lindstrom S.
, Kraft P.
, Hazra A.
, Li J.
, Eriksson L.
, et al.
.
Source: Cancer Research, 2015-06-15 00:00:00.0; 75(12), p. 2457-67.
PMID: 25862352
Related Citations
Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.
Authors: Bertrand K.A.
, Scott C.G.
, Tamimi R.M.
, Jensen M.R.
, Pankratz V.S.
, Norman A.D.
, Visscher D.W.
, Couch F.J.
, Shepherd J.
, Chen Y.Y.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2015 May; 24(5), p. 798-809.
PMID: 25716949
Related Citations
Mammographic breast density and breast cancer risk: interactions of percent density, absolute dense, and non-dense areas with breast cancer risk factors.
Authors: Yaghjyan L.
, Colditz G.A.
, Rosner B.
, Tamimi R.M.
.
Source: Breast Cancer Research And Treatment, 2015 Feb; 150(1), p. 181-9.
PMID: 25677739
Related Citations
Immunoassay and Nb2 lymphoma bioassay prolactin levels and mammographic density in premenopausal and postmenopausal women the Nurses' Health Studies.
Authors: Rice M.S.
, Tworoger S.S.
, Bertrand K.A.
, Hankinson S.E.
, Rosner B.A.
, Feeney Y.B.
, Clevenger C.V.
, Tamimi R.M.
.
Source: Breast Cancer Research And Treatment, 2015 Jan; 149(1), p. 245-53.
PMID: 25503962
Related Citations
Premenopausal plasma 25-hydroxyvitamin D, mammographic density, and risk of breast cancer.
Authors: Bertrand K.A.
, Rosner B.
, Eliassen A.H.
, Hankinson S.E.
, Rexrode K.M.
, Willett W.
, Tamimi R.M.
.
Source: Breast Cancer Research And Treatment, 2015 Jan; 149(2), p. 479-87.
PMID: 25543181
Related Citations
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
Authors: Lindström S.
, Thompson D.J.
, Paterson A.D.
, Li J.
, Gierach G.L.
, Scott C.
, Stone J.
, Douglas J.A.
, dos-Santos-Silva I.
, Fernandez-Navarro P.
, et al.
.
Source: Nature Communications, 2014-10-24 00:00:00.0; 5, p. 5303.
EPub date: 2014-10-24 00:00:00.0.
PMID: 25342443
Related Citations
Mammographic Density Phenotypes And Risk Of Breast Cancer: A Meta-analysis
Authors: Pettersson A.
, Graff R.E.
, Ursin G.
, Santos Silva I.D.
, McCormack V.
, Baglietto L.
, Vachon C.
, Bakker M.F.
, Giles G.G.
, Chia K.S.
, et al.
.
Source: Journal Of The National Cancer Institute, 2014 May; 106(5), .
PMID: 24816206
Related Citations
Mammographic Density And Risk Of Breast Cancer By Age And Tumor Characteristics
Authors: Bertrand K.A.
, Tamimi R.M.
, Scott C.G.
, Jensen M.R.
, Pankratz V.
, Visscher D.
, Norman A.
, Couch F.
, Shepherd J.
, Fan B.
, et al.
.
Source: Breast Cancer Research : Bcr, 2013-11-04 00:00:00.0; 15(6), p. R104.
PMID: 24188089
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Plasma C-peptide, Mammographic Breast Density, And Risk Of Invasive Breast Cancer
Authors: Ahern T.P.
, Hankinson S.E.
, Willett W.C.
, Pollak M.N.
, Eliassen A.H.
, Tamimi R.M.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2013 Oct; 22(10), p. 1786-96.
PMID: 24097198
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Mammographic Breast Density And Subsequent Risk Of Breast Cancer In Postmenopausal Women According To The Time Since The Mammogram
Authors: Yaghjyan L.
, Colditz G.A.
, Rosner B.
, Tamimi R.M.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2013 Jun; 22(6), p. 1110-7.
PMID: 23603205
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A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes.
Authors: Aschard H.
, Zaitlen N.
, Tamimi R.M.
, Lindström S.
, Kraft P.
.
Source: Genetic Epidemiology, 2013 May; 37(4), p. 323-33.
PMID: 23512279
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Insulin-like Growth Factor-1, Insulin-like Growth Factor-binding Protein-3, Growth Hormone, And Mammographic Density In The Nurses' Health Studies
Authors: Rice M.S.
, Tworoger S.S.
, Rosner B.A.
, Pollak M.N.
, Hankinson S.E.
, Tamimi R.M.
.
Source: Breast Cancer Research And Treatment, 2012 Dec; 136(3), p. 805-12.
PMID: 23085768
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Breast Fat And Breast Cancer
Authors: Pettersson A.
, Tamimi R.M.
.
Source: Breast Cancer Research And Treatment, 2012 Aug; 135(1), p. 321-3.
PMID: 22855239
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Identification of a novel percent mammographic density locus at 12q24.
Authors: Stevens K.N.
, Lindstrom S.
, Scott C.G.
, Thompson D.
, Sellers T.A.
, Wang X.
, Wang A.
, Atkinson E.
, Rider D.N.
, Eckel-Passow J.E.
, et al.
.
Source: Human Molecular Genetics, 2012-07-15 00:00:00.0; 21(14), p. 3299-305.
EPub date: 2012-07-15 00:00:00.0.
PMID: 22532574
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