Grant Details
Grant Number: |
5R01CA112035-05 Interpret this number |
Primary Investigator: |
Ancoli-Israel, Sonia |
Organization: |
University Of California, San Diego |
Project Title: |
Contributions of Sleep/Rhythms/Fatigue to "Chemobrain" |
Fiscal Year: |
2009 |
Abstract
DESCRIPTION (provided by applicant): Patients treated with chemotherapy complain of decreased cognitive functioning before and during chemotherapy, as well as for some years after the end of therapy. Objective measures of cognitive functioning confirm that a large percentage of patients receiving chemotherapy show at least acute decrements in multiple domains of cognitive test performance. This phenomenon has been termed "chemobrain." Understanding the cause of the cognitive deficits is critical as these patients require increased care, experience impaired decision making ability, experience decreased quality of life and express concern about their ability to maintain employment. Fatigue and problems sleeping are also major complaints in this population, particularly in patients with breast cancer. Yet whether chemobrain is related just to the chemotherapy, or might be secondary to fatigue and/or sleep and circadian rhythm problems has not yet been explored. Clarification of the role of sleep disturbances, hormonal changes, anxiety and depression, and other proximal causes of cognitive impairment in chemotherapy patients may be helpful in identifying potential targets for secondary intervention. The specific aims are: to examine how much cognitive impairment occurs during chemotherapy and one year after the start of chemotherapy compared to before the start of treatment; to examine the relationship between cognitive impairment and fatigue; to examine the relationship between cognitive impairment and sleep and circadian rhythms; and to examine the relationship between inflammatory markers, cognitive functioning and sleep. Over 5 years, 80 women with breast cancer and 80 controls (women with no history of any cancer) will be studied. Women will have their sleep recorded for three days with actigraphy, a complete neuropsychological test battery, have blood drawn for inflammatory markers and complete questionnaires on fatigue, sleep, menopausal status, quality of life, depression, and anxiety. These procedures will be repeated before the start of chemotherapy, during week 2 of cycle 4 of chemotherapy and one year after chemotherapy. Control women will be tested at the same time points. Each woman will also have a complete overnight sleep recording. The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning.
Publications
Preventing Sleep Disruption With Bright Light Therapy During Chemotherapy for Breast Cancer: A Phase II Randomized Controlled Trial.
Authors: Rissling M.
, Liu L.
, Youngstedt S.D.
, Trofimenko V.
, Natarajan L.
, Neikrug A.B.
, Jeste N.
, Parker B.A.
, Ancoli-Israel S.
.
Source: Frontiers In Neuroscience, 2022; 16, p. 815872.
EPub date: 2022-03-09 00:00:00.0.
PMID: 35356054
Related Citations
Reductions in sleep quality and circadian activity rhythmicity predict longitudinal changes in objective and subjective cognitive functioning in women treated for breast cancer.
Authors: Ancoli-Israel S.
, Liu L.
, Natarajan L.
, Rissling M.
, Neikrug A.B.
, Youngstedt S.D.
, Mills P.J.
, Sadler G.R.
, Dimsdale J.E.
, Parker B.A.
, et al.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2021-12-26 00:00:00.0; , .
EPub date: 2021-12-26 00:00:00.0.
PMID: 34957532
Related Citations
Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy.
Authors: Fox R.S.
, Ancoli-Israel S.
, Roesch S.C.
, Merz E.L.
, Mills S.D.
, Wells K.J.
, Sadler G.R.
, Malcarne V.L.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2019-06-03 00:00:00.0; , .
EPub date: 2019-06-03 00:00:00.0.
PMID: 31161437
Related Citations
Cognition, quality-of-life, and symptom clusters in breast cancer: Using Bayesian networks to elucidate complex relationships.
Authors: Xu S.
, Thompson W.
, Ancoli-Israel S.
, Liu L.
, Palmer B.
, Natarajan L.
.
Source: Psycho-oncology, 2017-10-20 00:00:00.0; , .
EPub date: 2017-10-20 00:00:00.0.
PMID: 29055062
Related Citations
Measuring cognitive complaints in breast cancer survivors: psychometric properties of the patient's assessment of own functioning inventory.
Authors: Van Dyk K.
, Ganz P.A.
, Ercoli L.
, Petersen L.
, Crespi C.M.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2016 Dec; 24(12), p. 4939-4949.
PMID: 27432402
Related Citations
Sleep, fatigue, depression, and circadian activity rhythms in women with breast cancer before and after treatment: a 1-year longitudinal study.
Authors: Ancoli-Israel S.
, Liu L.
, Rissling M.
, Natarajan L.
, Neikrug A.B.
, Palmer B.W.
, Mills P.J.
, Parker B.A.
, Sadler G.R.
, Maglione J.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2014 Sep; 22(9), p. 2535-45.
PMID: 24733634
Related Citations
Prevention of quality-of-life deterioration with light therapy is associated with changes in fatigue in women with breast cancer undergoing chemotherapy.
Authors: Jeste N.
, Liu L.
, Rissling M.
, Trofimenko V.
, Natarajan L.
, Parker B.A.
, Ancoli-Israel S.
.
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2013 Aug; 22(6), p. 1239-44.
PMID: 22865153
Related Citations
Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance.
Authors: Ganz P.A.
, Kwan L.
, Castellon S.A.
, Oppenheim A.
, Bower J.E.
, Silverman D.H.
, Cole S.W.
, Irwin M.R.
, Ancoli-Israel S.
, Belin T.R.
.
Source: Journal Of The National Cancer Institute, 2013-06-05 00:00:00.0; 105(11), p. 791-801.
EPub date: 2013-06-05 00:00:00.0.
PMID: 23606729
Related Citations
Decreased health-related quality of life in women with breast cancer is associated with poor sleep.
Authors: Liu L.
, Fiorentino L.
, Rissling M.
, Natarajan L.
, Parker B.A.
, Dimsdale J.E.
, Mills P.J.
, Sadler G.R.
, Ancoli-Israel S.
.
Source: Behavioral Sleep Medicine, 2013; 11(3), p. 189-206.
PMID: 23205513
Related Citations
Fatigue and Circadian Activity Rhythms in Breast Cancer Patients Before and After Chemotherapy: A Controlled Study.
Authors: Liu L.
, Rissling M.
, Neikrug A.
, Fiorentino L.
, Natarajan L.
, Faierman M.
, Sadler G.R.
, Dimsdale J.E.
, Mills P.J.
, Parker B.A.
, et al.
.
Source: Fatigue : Biomedicine, Health & Behavior, 2013; 1(1-2), p. 12-26.
PMID: 23412418
Related Citations
Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy.
Authors: Liu L.
, Mills P.J.
, Rissling M.
, Fiorentino L.
, Natarajan L.
, Dimsdale J.E.
, Sadler G.R.
, Parker B.A.
, Ancoli-Israel S.
.
Source: Brain, Behavior, And Immunity, 2012 Jul; 26(5), p. 706-13.
PMID: 22406004
Related Citations
Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer.
Authors: Ancoli-Israel S.
, Rissling M.
, Neikrug A.
, Trofimenko V.
, Natarajan L.
, Parker B.A.
, Lawton S.
, Desan P.
, Liu L.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2012 Jun; 20(6), p. 1211-9.
PMID: 21660669
Related Citations
The longitudinal relationship between fatigue and sleep in breast cancer patients undergoing chemotherapy.
Authors: Liu L.
, Rissling M.
, Natarajan L.
, Fiorentino L.
, Mills P.J.
, Dimsdale J.E.
, Sadler G.R.
, Parker B.A.
, Ancoli-Israel S.
.
Source: Sleep, 2012-02-01 00:00:00.0; 35(2), p. 237-45.
EPub date: 2012-02-01 00:00:00.0.
PMID: 22294814
Related Citations
The consensus sleep diary: standardizing prospective sleep self-monitoring.
Authors: Carney C.E.
, Buysse D.J.
, Ancoli-Israel S.
, Edinger J.D.
, Krystal A.D.
, Lichstein K.L.
, Morin C.M.
.
Source: Sleep, 2012-02-01 00:00:00.0; 35(2), p. 287-302.
EPub date: 2012-02-01 00:00:00.0.
PMID: 22294820
Related Citations
Bright light therapy protects women from circadian rhythm desynchronization during chemotherapy for breast cancer.
Authors: Neikrug A.B.
, Rissling M.
, Trofimenko V.
, Liu L.
, Natarajan L.
, Lawton S.
, Parker B.A.
, Ancoli-Israel S.
.
Source: Behavioral Sleep Medicine, 2012; 10(3), p. 202-16.
PMID: 22742438
Related Citations
The Symptom Cluster of Sleep, Fatigue and Depressive Symptoms in Breast Cancer Patients: Severity of the Problem and Treatment Options.
Authors: Fiorentino L.
, Rissling M.
, Liu L.
, Ancoli-Israel S.
.
Source: Drug Discovery Today. Disease Models, 2011 Winter; 8(4), p. 167-173.
PMID: 22140397
Related Citations
Relationship of menopausal status and climacteric symptoms to sleep in women undergoing chemotherapy.
Authors: Rissling M.B.
, Liu L.
, Natarajan L.
, He F.
, Ancoli-Israel S.
.
Source: Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2011 Aug; 19(8), p. 1107-15.
PMID: 20508951
Related Citations
Number of lapses during the psychomotor vigilance task as an objective measure of fatigue.
Authors: Lee I.S.
, Bardwell W.A.
, Ancoli-Israel S.
, Dimsdale J.E.
.
Source: Journal Of Clinical Sleep Medicine : Jcsm : Official Publication Of The American Academy Of Sleep Medicine, 2010-04-15 00:00:00.0; 6(2), p. 163-8.
PMID: 20411694
Related Citations
Sleep disturbances in nursing homes.
Authors: Neikrug A.B.
, Ancoli-Israel S.
.
Source: The Journal Of Nutrition, Health & Aging, 2010 Mar; 14(3), p. 207-11.
PMID: 20191255
Related Citations
Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program.
Authors: Palesh O.G.
, Roscoe J.A.
, Mustian K.M.
, Roth T.
, Savard J.
, Ancoli-Israel S.
, Heckler C.
, Purnell J.Q.
, Janelsins M.C.
, Morrow G.R.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2010-01-10 00:00:00.0; 28(2), p. 292-8.
EPub date: 2010-01-10 00:00:00.0.
PMID: 19933917
Related Citations
Sleep disorders in the older adult - a mini-review.
Authors: Neikrug A.B.
, Ancoli-Israel S.
.
Source: Gerontology, 2010; 56(2), p. 181-9.
PMID: 19738366
Related Citations
Individual Cognitive Behavioral Therapy For Insomnia In Breast Cancer Survivors: A Randomized Controlled Crossover Pilot Study
Authors: Fiorentino L.
, McQuaid J.R.
, Liu L.
, Natarajan L.
, He F.
, Cornejo M.
, Lawton S.
, Parker B.A.
, Sadler G.R.
, Ancoli-Israel S.
.
Source: Nature And Science Of Sleep, 2010; 2, p. 1-8.
PMID: 23616695
Related Citations
Recognition and treatment of sleep disturbances in cancer.
Authors: Ancoli-Israel S.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2009-12-10 00:00:00.0; 27(35), p. 5864-6.
EPub date: 2009-12-10 00:00:00.0.
PMID: 19884528
Related Citations
Arousal frequency is associated with increased fatigue in obstructive sleep apnea.
Authors: Yue H.J.
, Bardwell W.
, Ancoli-Israel S.
, Loredo J.S.
, Dimsdale J.E.
.
Source: Sleep & Breathing = Schlaf & Atmung, 2009 Nov; 13(4), p. 331-9.
PMID: 19319586
Related Citations
Breast cancer patients have progressively impaired sleep-wake activity rhythms during chemotherapy.
Authors: Savard J.
, Liu L.
, Natarajan L.
, Rissling M.B.
, Neikrug A.B.
, He F.
, Dimsdale J.E.
, Mills P.J.
, Parker B.A.
, Sadler G.R.
, et al.
.
Source: Sleep, 2009 Sep; 32(9), p. 1155-60.
PMID: 19750920
Related Citations
The roles of TNF-alpha and the soluble TNF receptor I on sleep architecture in OSA.
Authors: Yue H.J.
, Mills P.J.
, Ancoli-Israel S.
, Loredo J.S.
, Ziegler M.G.
, Dimsdale J.E.
.
Source: Sleep & Breathing = Schlaf & Atmung, 2009 Aug; 13(3), p. 263-9.
PMID: 19148690
Related Citations
Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapy.
Authors: Liu L.
, Fiorentino L.
, Natarajan L.
, Parker B.A.
, Mills P.J.
, Sadler G.R.
, Dimsdale J.E.
, Rissling M.
, He F.
, Ancoli-Israel S.
.
Source: Psycho-oncology, 2009 Feb; 18(2), p. 187-94.
PMID: 18677716
Related Citations
Does effective management of sleep disorders reduce cancer-related fatigue?
Authors: Zee P.C.
, Ancoli-Israel S.
, Workshop Participants
.
Source: Drugs, 2009; 69 Suppl 2, p. 29-41.
PMID: 20047349
Related Citations
Sleep problems and associated daytime fatigue in community-dwelling older individuals.
Authors: Goldman S.E.
, Ancoli-Israel S.
, Boudreau R.
, Cauley J.A.
, Hall M.
, Stone K.L.
, Rubin S.M.
, Satterfield S.
, Simonsick E.M.
, Newman A.B.
, et al.
.
Source: The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences, 2008 Oct; 63(10), p. 1069-75.
PMID: 18948557
Related Citations
Sleep Disturbances in Cancer.
Authors: Liu L.
, Ancoli-Israel S.
.
Source: Psychiatric Annals, 2008-09-01 00:00:00.0; 38(9), p. 627-634.
PMID: 21243092
Related Citations
Association between nighttime sleep and napping in older adults.
Authors: Goldman S.E.
, Hall M.
, Boudreau R.
, Matthews K.A.
, Cauley J.A.
, Ancoli-Israel S.
, Stone K.L.
, Rubin S.M.
, Satterfield S.
, Simonsick E.M.
, et al.
.
Source: Sleep, 2008 May; 31(5), p. 733-40.
PMID: 18517043
Related Citations
Breast Cancer and Fatigue.
Authors: Bardwell W.A.
, Ancoli-Israel S.
.
Source: Sleep Medicine Clinics, 2008 Mar; 3(1), p. 61-71.
PMID: 18769530
Related Citations
Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer.
Authors: Miller A.H.
, Ancoli-Israel S.
, Bower J.E.
, Capuron L.
, Irwin M.R.
.
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2008-02-20 00:00:00.0; 26(6), p. 971-82.
PMID: 18281672
Related Citations
Sleep disturbances in long-term care.
Authors: Martin J.L.
, Ancoli-Israel S.
.
Source: Clinics In Geriatric Medicine, 2008 Feb; 24(1), p. 39-50, vi.
PMID: 18035230
Related Citations
The relative importance of specific risk factors for insomnia in women treated for early-stage breast cancer.
Authors: Bardwell W.A.
, Profant J.
, Casden D.R.
, Dimsdale J.E.
, Ancoli-Israel S.
, Natarajan L.
, Rock C.L.
, Pierce J.P.
, Women's Healthy Eating & Living (WHEL) Study Group
.
Source: Psycho-oncology, 2008 Jan; 17(1), p. 9-18.
PMID: 17428006
Related Citations
Predictors of inflammation in response to anthracycline-based chemotherapy for breast cancer.
Authors: Mills P.J.
, Ancoli-Israel S.
, Parker B.
, Natarajan L.
, Hong S.
, Jain S.
, Sadler G.R.
, von Känel R.
.
Source: Brain, Behavior, And Immunity, 2008 Jan; 22(1), p. 98-104.
PMID: 17706918
Related Citations
Sleep in the elderly: normal variations and common sleep disorders.
Authors: Ancoli-Israel S.
, Ayalon L.
, Salzman C.
.
Source: Harvard Review Of Psychiatry, 2008; 16(5), p. 279-86.
PMID: 18803103
Related Citations
Sleep and Its Disorders in Seniors.
Authors: Stepnowsky C.J.
, Ancoli-Israel S.
.
Source: Sleep Medicine Clinics, 2008; 3(2), p. 281-293.
PMID: 19122865
Related Citations
Sleep dysfunction in patients with cancer.
Authors: Fiorentino L.
, Ancoli-Israel S.
.
Source: Current Treatment Options In Neurology, 2007 Sep; 9(5), p. 337-46.
PMID: 17716597
Related Citations
Taking fatigue seriously, II: variability in fatigue levels in cancer patients.
Authors: Dimsdale J.E.
, Ancoli-Israel S.
, Ayalon L.
, Elsmore T.F.
, Gruen W.
.
Source: Psychosomatics, 2007 May-Jun; 48(3), p. 247-52.
PMID: 17478594
Related Citations
Sleep apnea in older adults--is it real and should age be the determining factor in the treatment decision matrix?
Authors: Ancoli-Israel S.
.
Source: Sleep Medicine Reviews, 2007 Apr; 11(2), p. 83-5.
PMID: 17317240
Related Citations
Insomnia and its treatment in women with breast cancer.
Authors: Fiorentino L.
, Ancoli-Israel S.
.
Source: Sleep Medicine Reviews, 2006 Dec; 10(6), p. 419-29.
PMID: 16963293
Related Citations
Sleep and its disorders in older adults.
Authors: Cooke J.R.
, Ancoli-Israel S.
.
Source: The Psychiatric Clinics Of North America, 2006 Dec; 29(4), p. 1077-93; abstract x-xi.
PMID: 17118283
Related Citations
The impact and prevalence of chronic insomnia and other sleep disturbances associated with chronic illness.
Authors: Ancoli-Israel S.
.
Source: The American Journal Of Managed Care, 2006 May; 12(8 Suppl), p. S221-9.
PMID: 16686592
Related Citations
Continuous positive airway pressure reduces subjective daytime sleepiness in patients with mild to moderate Alzheimer's disease with sleep disordered breathing.
Authors: Chong M.S.
, Ayalon L.
, Marler M.
, Loredo J.S.
, Corey-Bloom J.
, Palmer B.W.
, Liu L.
, Ancoli-Israel S.
.
Source: Journal Of The American Geriatrics Society, 2006 May; 54(5), p. 777-81.
PMID: 16696743
Related Citations