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Grant Details

Grant Number: 7R03CA134204-02 Interpret this number
Primary Investigator: Nyitray, Alan
Organization: H. Lee Moffitt Cancer Ctr & Res Inst
Project Title: Prevalence and Risk Factors for Anal Human Papillomavirus in Heterosexual Men: Th
Fiscal Year: 2009
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Abstract

DESCRIPTION (provided by applicant): Human papillomavirus (HPV) is a sexually transmitted infection and primary cause of anal cancer. While male anal cancer incidence in the US has increased almost threefold in three decades, anal HPV prevalence and risk factors in men, especially heterosexual men, remain largely unknown. We have recently estimated an anal canal HPV prevalence of 16.6% in 222 men who denied any lifetime sex with another man. In our analysis of these data, we also found significant univariate associations between anal HPV and decreased age, increased lifetime number of female sexual partners, and frequency of sexual intercourse in the previous month. In multivariate analysis, number of lifetime sexual partners and frequency of sex was independently associated with anal HPV. Our long term goal is to increase our understanding of anal HPV in heterosexual men so that prevention approaches such as vaccination can be developed and implemented to reduce anal cancer burden. The focus of this application is to determine the prevalence and risk factors for anal HPV in heterosexual men. Our hypothesis is that anal HPV in heterosexual men is a common infection inversely associated with age. This hypothesis can be efficiently tested given the availability of anal canal specimens from a large multinational study conducted by our collaborators at the H. Lee Moffitt Cancer Center. Dr. Anna Giuliano and colleagues have collected and archived anal canal samples from 1200 men recruited in Tampa, Florida; Morelos state, Mexico; and Sao Paulo, Brazil. We propose to test these anal canal samples for HPV. The specific aims of this cross-sectional study are designed to exploit the availability of the anal canal specimens from the larger study of 1200 men: Specific Aim 1. Using archived anal canal samples, determine the type-specific anal HPV prevalence in 1200 men; and Specific Aim 2. Identify factors independently associated with anal HPV in the 1200 men. HPV is a common sexually transmitted infection responsible for a variety of anogenital cancers including anal cancers in men. However, a high anal HPV prevalence in heterosexual men, if confirmed, will challenge assumptions about the epidemiology of HPV in men. The dramatically increased incidence of anal cancers in men in the last three decades underscores the need to learn more about prevalence of anal HPV in men (Specific Aim 1) and the risk factors most commonly associated with anal HPV in these men (Specific Aim 2). The focus of this application is to determine the prevalence and risk factors for anal HPV in 1200 heterosexual men. Our hypothesis is that anal HPV in heterosexual men is a common infection inversely associated with age.

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Publications

An Examination of HPV16 Natural Immunity in Men Who Have Sex with Men (MSM) in the HPV in Men (HIM) Study.
Authors: Beachler D.C. , Pinto L.A. , Kemp T.J. , Nyitray A.G. , Hildesheim A. , Viscidi R. , Schussler J. , Kreimer A.R. , Giuliano A.R. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 04; 27(4), p. 496-502.
EPub date: 2018-02-23.
PMID: 29475967
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Men who purchase sex, who are they? An interurban comparison.
Authors: Ompad D.C. , Bell D.L. , Amesty S. , Nyitray A.G. , Papenfuss M. , Lazcano-Ponce E. , Villa L.L. , Giuliano A.R. .
Source: Journal of urban health : bulletin of the New York Academy of Medicine, 2013 Dec; 90(6), p. 1166-80.
PMID: 23719715
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Genital human papillomavirus (HPV) concordance in heterosexual couples.
Authors: Nyitray A.G. , Menezes L. , Lu B. , Lin H.Y. , Smith D. , Abrahamsen M. , Papenfuss M. , Gage C. , Giuliano A.R. .
Source: The Journal of infectious diseases, 2012-07-15; 206(2), p. 202-11.
EPub date: 2012-04-26.
PMID: 22539815
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Six-month incidence, persistence, and factors associated with persistence of anal human papillomavirus in men: the HPV in men study.
Authors: Nyitray A.G. , Carvalho da Silva R.J. , Baggio M.L. , Smith D. , Abrahamsen M. , Papenfuss M. , Lin H.Y. , Quiterio M. , Salmerón J. , Lazcano-Ponce E. , et al. .
Source: The Journal of infectious diseases, 2011-12-01; 204(11), p. 1711-22.
EPub date: 2011-09-30.
PMID: 21964400
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The prevalence of genital HPV and factors associated with oncogenic HPV among men having sex with men and men having sex with women and men: the HIM study.
Authors: Nyitray A.G. , da Silva R.J. , Baggio M.L. , Lu B. , Smith D. , Abrahamsen M. , Papenfuss M. , Quiterio M. , Villa L.L. , Giuliano A.R. .
Source: Sexually transmitted diseases, 2011 Oct; 38(10), p. 932-40.
PMID: 21934568
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Age-specific prevalence of and risk factors for anal human papillomavirus (HPV) among men who have sex with women and men who have sex with men: the HPV in men (HIM) study.
Authors: Nyitray A.G. , Carvalho da Silva R.J. , Baggio M.L. , Lu B. , Smith D. , Abrahamsen M. , Papenfuss M. , Villa L.L. , Lazcano-Ponce E. , Giuliano A.R. .
Source: The Journal of infectious diseases, 2011-01-01; 203(1), p. 49-57.
PMID: 21148496
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Prevalence of and risk factors for anal human papillomavirus infection in men who have sex with women: a cross-national study.
Authors: Nyitray A.G. , Smith D. , Villa L. , Lazcano-Ponce E. , Abrahamsen M. , Papenfuss M. , Giuliano A.R. .
Source: The Journal of infectious diseases, 2010-05-15; 201(10), p. 1498-508.
PMID: 20367457
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Epidemiology and pathology of HPV disease in males.
Authors: Giuliano A.R. , Anic G. , Nyitray A.G. .
Source: Gynecologic oncology, 2010 May; 117(2 Suppl), p. S15-9.
EPub date: 2010-02-06.
PMID: 20138345
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