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Grant Details

Grant Number: 2R01CA067264-10A2 Interpret this number
Primary Investigator: Trentham-Dietz, Amy
Organization: University Of Wisconsin-Madison
Project Title: Breast Carcinoma in Situ: Predicting Risk and Outcomes
Fiscal Year: 2009


Abstract

DESCRIPTION (provided by applicant): As a consequence of widespread screening mammography, approximately 20% of breast cancer diagnosed today is breast carcinoma in situ (BCIS). To reduce the chance of a subsequent breast cancer diagnosis after BCIS, many patients now receive treatment as aggressive as that recommended for invasive breast cancer. Several issues argue for critical examination of the impact of current BCIS detection and treatment practices. These include uncertain risk factors, substantial treatment morbidity, low numbers of BCIS cases that subsequently develop invasive breast cancer, negative impact on quality of life, and importantly, excellent relative survival regardless of therapy choice. A population predictive model, such as the one we have developed for breast cancer epidemiology, can accommodate the multi-dimensional nature of breast cancer. We propose a formal and quantitative evaluation of the uncertainties surrounding BCIS that incorporates multi- level risk factor and screening data into an epidemiologic study and an integrated simulation model assessing the population burden of BCIS. Specifically, we aim to comprehensively examine individual- and geographic- level socioeconomic and screening factors in relation to BCIS disease-free survival and treatment (among cases) and risk (comparing cases and controls). We further aim to use simulation modeling to evaluate the effect of BCIS on breast cancer incidence and outcomes. To accomplish these aims, we will continue to actively follow a large, population-based cohort of BCIS women, comprised of 2,352 cases, for disease-free survival. BCIS cases will be recontacted to ascertain any new breast cancer diagnoses and to evaluate health status and risk factor changes as measured by validated questionnaires. Available data for over 5,000 healthy population controls previously enrolled for our case-control studies will be included in case-control analyses jointly considering individual-level and geographic factors. Using epidemiologic data from the BCIS cases and controls as inputs, we will enhance our validated breast cancer discrete-event simulation model with individual- level risk factors, geographic measures of screening and treatment, and tumor histology. We will use the model to assess the contribution of BCIS diagnosis and treatment towards recent declines in breast cancer incidence and mortality rates since the 1990s, and to evaluate quality-adjusted life years resulting from screening and treatment regimens. Records from Wisconsin's statewide tumor registry, interview information, and publicly available data linked to the BCIS cases and controls through their geocoded residential addresses will contribute to both the epidemiologic cohort and case-control analyses and the simulation model. Using epidemiologic studies and computer modeling, this study will address BCIS uncertainties by characterizing the multitude of factors related to BCIS incidence, choice of treatment, quality of life, disease-free survival, and mortality. This study will efficiently and validly provide broad perspectives on BCIS, an increasingly important public health concern. PUBLIC HEALTH RELEVANCE: Women who are diagnosed with breast carcinoma in situ (BCIS) - 20% of all breast cancer diagnoses - have an excellent prognosis regardless of the type of therapy they receive. However, since women with BCIS are often treated with aggressive therapy and suffer similar side effects as women with more invasive cancer, the overall impact of BCIS detection and treatment on length and quality of life is not clear. The long-term goal of this project is to reduce the public health impact of BCIS by quantifying both contextual and personal risk factors for the development of BCIS and the recurrence of breast cancer after a BCIS diagnosis.



Publications

Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast.
Authors: Yadav S. , Hu C. , Nathanson K.L. , Weitzel J.N. , Goldgar D.E. , Kraft P. , Gnanaolivu R.D. , Na J. , Huang H. , Boddicker N.J. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2021-12-10 00:00:00.0; 39(35), p. 3918-3926.
EPub date: 2021-10-21 00:00:00.0.
PMID: 34672684
Related Citations

Does margin width impact breast cancer recurrence rates in women with breast conserving surgery for ductal carcinoma in situ?
Authors: Livingston-Rosanoff D. , Trentham-Dietz A. , Hampton J.M. , Newcomb P.A. , Wilke L.G. .
Source: Breast Cancer Research And Treatment, 2021-06-15 00:00:00.0; , .
EPub date: 2021-06-15 00:00:00.0.
PMID: 34129117
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Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score.
Authors: Gao C. , Polley E.C. , Hart S.N. , Huang H. , Hu C. , Gnanaolivu R. , Lilyquist J. , Boddicker N.J. , Na J. , Ambrosone C.B. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2021-06-08 00:00:00.0; , p. JCO2001992.
EPub date: 2021-06-08 00:00:00.0.
PMID: 34101481
Related Citations

A Population-Based Study of Genes Previously Implicated in Breast Cancer.
Authors: Hu C. , Hart S.N. , Gnanaolivu R. , Huang H. , Lee K.Y. , Na J. , Gao C. , Lilyquist J. , Yadav S. , Boddicker N.J. , et al. .
Source: The New England Journal Of Medicine, 2021-01-20 00:00:00.0; , .
EPub date: 2021-01-20 00:00:00.0.
PMID: 33471974
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Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.
Authors: Palmer J.R. , Polley E.C. , Hu C. , John E.M. , Haiman C. , Hart S.N. , Gaudet M. , Pal T. , Anton-Culver H. , Trentham-Dietz A. , et al. .
Source: Journal Of The National Cancer Institute, 2020-05-19 00:00:00.0; , .
EPub date: 2020-05-19 00:00:00.0.
PMID: 32427313
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Evaluation of Long-Term Satisfaction with Breast Surgery in Patients Treated for Ductal Carcinoma In Situ: A Population-Based Longitudinal Cohort Study.
Authors: Livingston-Rosanoff D. , Trentham-Dietz A. , Hampton J.M. , Newcomb P.A. , Wilke L.G. .
Source: Annals Of Surgical Oncology, 2020-02-24 00:00:00.0; , .
EPub date: 2020-02-24 00:00:00.0.
PMID: 32095924
Related Citations

The association between post-diagnosis health behaviors and long-term quality of life in survivors of ductal carcinoma in situ: a population-based longitudinal cohort study.
Authors: Hart V. , Trentham-Dietz A. , Berkman A. , Fujii M. , Veal C. , Hampton J. , Gangnon R.E. , Newcomb P.A. , Gilchrist S.C. , Sprague B.L. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2018-02-07 00:00:00.0; , .
EPub date: 2018-02-07 00:00:00.0.
PMID: 29417425
Related Citations

Geographic access to mammography facilities and frequency of mammography screening.
Authors: Jewett P.I. , Gangnon R.E. , Elkin E. , Hampton J.M. , Jacobs E.A. , Malecki K. , LaGro J. , Newcomb P.A. , Trentham-Dietz A. .
Source: Annals Of Epidemiology, 2018 Feb; 28(2), p. 65-71.e2.
EPub date: 2017-12-07 00:00:00.0.
PMID: 29439783
Related Citations

Collagen alignment as a predictor of recurrence after ductal carcinoma in situ.
Authors: Conklin M.W. , Gangnon R.E. , Sprague B.L. , van Germert L. , Hampton J.M. , Eliceiri K.W. , Bredfeldt J.S. , Liu Y. , Surachaicharn N. , Newcomb P.A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-11-15 00:00:00.0; , .
EPub date: 2017-11-15 00:00:00.0.
PMID: 29141852
Related Citations

Emerging Trends in Family History of Breast Cancer and Associated Risk.
Authors: Shiyanbola O.O. , Arao R.F. , Miglioretti D.L. , Sprague B.L. , Hampton J.M. , Stout N.K. , Kerlikowske K. , Braithwaite D. , Buist D.S.M. , Egan K.M. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2017-10-06 00:00:00.0; , .
EPub date: 2017-10-06 00:00:00.0.
PMID: 28986348
Related Citations

Health-related Behaviors And Mortality Outcomes In Women Diagnosed With Ductal Carcinoma In Situ
Authors: Veal C.T. , Hart V. , Lakoski S.G. , Hampton J.M. , Gangnon R.E. , Newcomb P.A. , Higgins S.T. , Trentham-Dietz A. , Sprague B.L. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2017-01-05 00:00:00.0; , .
PMID: 28058695
Related Citations

Emerging trends in surgical and adjuvant radiation therapies among women diagnosed with ductal carcinoma in situ.
Authors: Shiyanbola O.O. , Sprague B.L. , Hampton J.M. , Dittus K. , James T.A. , Herschorn S. , Gangnon R.E. , Weaver D.L. , Trentham-Dietz A. .
Source: Cancer, 2016-09-15 00:00:00.0; 122(18), p. 2810-8.
EPub date: 2016-09-15 00:00:00.0.
PMID: 27244699
Related Citations

Cigarette Smoking Before and After Breast Cancer Diagnosis: Mortality From Breast Cancer and Smoking-Related Diseases.
Authors: Passarelli M.N. , Newcomb P.A. , Hampton J.M. , Trentham-Dietz A. , Titus L.J. , Egan K.M. , Baron J.A. , Willett W.C. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-04-20 00:00:00.0; 34(12), p. 1315-22.
EPub date: 2016-04-20 00:00:00.0.
PMID: 26811527
Related Citations

Trends in Health-Related Quality of Life After a Diagnosis of Ductal Carcinoma In Situ.
Authors: Hart V. , Sprague B.L. , Lakoski S.G. , Hampton J.M. , Newcomb P.A. , Gangnon R.E. , Trentham-Dietz A. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2016-04-20 00:00:00.0; 34(12), p. 1323-9.
EPub date: 2016-04-20 00:00:00.0.
PMID: 26884560
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The Role of Stage at Diagnosis in Colorectal Cancer Black-White Survival Disparities: A Counterfactual Causal Inference Approach.
Authors: Valeri L. , Chen J.T. , Garcia-Albeniz X. , Krieger N. , VanderWeele T.J. , Coull B.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016 Jan; 25(1), p. 83-9.
PMID: 26503034
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Partnership Status and Socioeconomic Factors in Relation to Health Behavior Changes after a Diagnosis of Ductal Carcinoma In Situ.
Authors: Khadanga S. , Lakoski S.G. , Hart V. , Sprague B.L. , Ba Y. , Hampton J.M. , Higgins S.T. , Ades P.A. , Newcomb P.A. , Trentham-Dietz A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016 Jan; 25(1), p. 76-82.
PMID: 26545402
Related Citations

Health behavior change following a diagnosis of ductal carcinoma in situ: An opportunity to improve health outcomes.
Authors: Berkman A.M. , Trentham-Dietz A. , Dittus K. , Hart V. , Vatovec C.M. , King J.G. , James T.A. , Lakoski S.G. , Sprague B.L. .
Source: Preventive Medicine, 2015 Nov; 80, p. 53-9.
PMID: 25858806
Related Citations

Lifestyle factors and the risk of a second breast cancer after ductal carcinoma in situ.
Authors: McLaughlin V.H. , Trentham-Dietz A. , Hampton J.M. , Newcomb P.A. , Sprague B.L. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2014 Mar; 23(3), p. 450-60.
PMID: 24403528
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Disease-free survival by treatment after a DCIS diagnosis in a population-based cohort study.
Authors: Sprague B.L. , McLaughlin V. , Hampton J.M. , Newcomb P.A. , Trentham-Dietz A. .
Source: Breast Cancer Research And Treatment, 2013 Aug; 141(1), p. 145-54.
PMID: 23979007
Related Citations

Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes.
Authors: Newcomb P.A. , Kampman E. , Trentham-Dietz A. , Egan K.M. , Titus L.J. , Baron J.A. , Hampton J.M. , Passarelli M.N. , Willett W.C. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2013-06-01 00:00:00.0; 31(16), p. 1939-46.
EPub date: 2013-06-01 00:00:00.0.
PMID: 23569314
Related Citations

Using propensity scores to reduce case-control selection bias.
Authors: Walsh M.C. , Trentham-Dietz A. , Newcomb P.A. , Gangnon R. , Palta M. .
Source: Epidemiology (cambridge, Mass.), 2012 Sep; 23(5), p. 772-3.
PMID: 22872122
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Selection bias in population-based cancer case-control studies due to incomplete sampling frame coverage.
Authors: Walsh M.C. , Trentham-Dietz A. , Gangnon R.E. , Nieto F.J. , Newcomb P.A. , Palta M. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Jun; 21(6), p. 881-6.
PMID: 22490319
Related Citations

To screen or not to screen women in their 40s for breast cancer: is personalized risk-based screening the answer?
Authors: Mandelblatt J.S. , Stout N. , Trentham-Dietz A. .
Source: Annals Of Internal Medicine, 2011-07-05 00:00:00.0; 155(1), p. 58-60.
PMID: 21727294
Related Citations

Availability of driver's license master lists for use in government-sponsored public health research.
Authors: Walsh M.C. , Trentham-Dietz A. , Palta M. .
Source: American Journal Of Epidemiology, 2011-06-15 00:00:00.0; 173(12), p. 1414-8.
EPub date: 2011-06-15 00:00:00.0.
PMID: 21571870
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Bilateral oophorectomy in relation to risk of postmenopausal breast cancer: confounding by nonmalignant indications for surgery?
Authors: Nichols H.B. , Visvanathan K. , Newcomb P.A. , Hampton J.M. , Egan K.M. , Titus-Ernstoff L. , Trentham-Dietz A. .
Source: American Journal Of Epidemiology, 2011-05-15 00:00:00.0; 173(10), p. 1111-20.
EPub date: 2011-05-15 00:00:00.0.
PMID: 21430192
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The contribution of postmenopausal hormone use cessation to the declining incidence of breast cancer.
Authors: Sprague B.L. , Trentham-Dietz A. , Remington P.L. .
Source: Cancer Causes & Control : Ccc, 2011 Jan; 22(1), p. 125-34.
PMID: 21080050
Related Citations

Change in lifestyle behaviors and medication use after a diagnosis of ductal carcinoma in situ.
Authors: Sprague B.L. , Trentham-Dietz A. , Nichols H.B. , Hampton J.M. , Newcomb P.A. .
Source: Breast Cancer Research And Treatment, 2010 Nov; 124(2), p. 487-95.
PMID: 20361251
Related Citations

Socioeconomic disparities in the decline in invasive breast cancer incidence.
Authors: Sprague B.L. , Trentham-Dietz A. , Burnside E.S. .
Source: Breast Cancer Research And Treatment, 2010 Aug; 122(3), p. 873-8.
PMID: 20087648
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Association of COMT haplotypes and breast cancer risk in caucasian women.
Authors: Peterson N.B. , Trentham-Dietz A. , Garcia-Closas M. , Newcomb P.A. , Titus-Ernstoff L. , Huang Y. , Chanock S.J. , Haines J.L. , Egan K.M. .
Source: Anticancer Research, 2010 Jan; 30(1), p. 217-20.
PMID: 20150638
Related Citations

Prevalence of breast carcinoma in situ in the United States.
Authors: Sprague B.L. , Trentham-Dietz A. .
Source: Jama, 2009-08-26 00:00:00.0; 302(8), p. 846-8.
PMID: 19706857
Related Citations

Tea consumption and risk of breast cancer.
Authors: Kumar N. , Titus-Ernstoff L. , Newcomb P.A. , Trentham-Dietz A. , Anic G. , Egan K.M. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2009 Jan; 18(1), p. 341-5.
PMID: 19124518
Related Citations

Prediagnostic use of hormone therapy and mortality after breast cancer.
Authors: Newcomb P.A. , Egan K.M. , Trentham-Dietz A. , Titus-Ernstoff L. , Baron J.A. , Hampton J.M. , Stampfer M.J. , Willett W.C. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Apr; 17(4), p. 864-71.
PMID: 18381475
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Oral contraceptive use and risk of breast carcinoma in situ.
Authors: Nichols H.B. , Trentham-Dietz A. , Egan K.M. , Titus-Ernstoff L. , Hampton J.M. , Newcomb P.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2007 Nov; 16(11), p. 2262-8.
PMID: 18006914
Related Citations

Cigarette smoking and risk of breast carcinoma in situ.
Authors: Trentham-Dietz A. , Nichols H.B. , Egan K.M. , Titus-Ernstoff L. , Hampton J.M. , Newcomb P.A. .
Source: Epidemiology (cambridge, Mass.), 2007 Sep; 18(5), p. 629-38.
PMID: 17700252
Related Citations

Genetic variation in TP53 and risk of breast cancer in a population-based case control study.
Authors: Sprague B.L. , Trentham-Dietz A. , Garcia-Closas M. , Newcomb P.A. , Titus-Ernstoff L. , Hampton J.M. , Chanock S.J. , Haines J.L. , Egan K.M. .
Source: Carcinogenesis, 2007 Aug; 28(8), p. 1680-6.
PMID: 17449902
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Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.
Authors: Gaudet M.M. , Egan K.M. , Lissowska J. , Newcomb P.A. , Brinton L.A. , Titus-Ernstoff L. , Yeager M. , Chanock S. , Welch R. , Peplonska B. , et al. .
Source: Human Genetics, 2007 May; 121(3-4), p. 483-90.
PMID: 17216494
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Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.
Authors: Breast Cancer Association Consortium .
Source: Journal Of The National Cancer Institute, 2006-10-04 00:00:00.0; 98(19), p. 1382-96.
PMID: 17018785
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Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses.
Authors: García-Closas M. , Egan K.M. , Newcomb P.A. , Brinton L.A. , Titus-Ernstoff L. , Chanock S. , Welch R. , Lissowska J. , Peplonska B. , Szeszenia-Dabrowska N. , et al. .
Source: Human Genetics, 2006 May; 119(4), p. 376-88.
PMID: 16485136
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Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
Authors: Zhang Y. , Newcomb P.A. , Egan K.M. , Titus-Ernstoff L. , Chanock S. , Welch R. , Brinton L.A. , Lissowska J. , Bardin-Mikolajczak A. , Peplonska B. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2006 Feb; 15(2), p. 353-8.
PMID: 16492928
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Collection of genomic DNA from adults in epidemiological studies by buccal cytobrush and mouthwash.
Authors: García-Closas M. , Egan K.M. , Abruzzo J. , Newcomb P.A. , Titus-Ernstoff L. , Franklin T. , Bender P.K. , Beck J.C. , Le Marchand L. , Lum A. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2001 Jun; 10(6), p. 687-96.
PMID: 11401920
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