Grant Details
Grant Number: |
1R01CA126831-01A2 Interpret this number |
Primary Investigator: |
Wiencke, John |
Organization: |
University Of California, San Francisco |
Project Title: |
Biomarkers of Survival in Glioma Epidemiology |
Fiscal Year: |
2008 |
Abstract
DESCRIPTION (provided by applicant): To address the great need for improved therapies for adult glioma, this project will evaluate molecular features of tumor tissue, serologic immune factors and genetic polymorphisms as biomarkers of patient surival. The proposed studies are additions to ongoing recruitment of patients in a 16 year R01 funded population-based case control study and 5 years of SPORE funded clinic-based research in the UCSF Neuro-oncology Clinic (NOC). Together these sources provide among the country s largest datasets of well-characterized adult glioma patients with polymorphism, serologic, tumor marker, demographic and other epidemiologic, treatment, and survival data. We will continue to determine vital status and relevant treatment information for population based adult onset glioma cases diagnosed 1997-99 and 2001-04 and patients accrued through the UCSF NOC 2002-2006 (total number ~1500) and (b) accrue ~720 patients (questionnaire, blood, buccal, and tumor specimens) in the UCSF NOC 2007-2011. (Another population based series to begin May 2006 will bring the total number of patients diagnosed from 2006-2011 to ~960). Several biomarkers identified in our ongoing and other studies warrant further research. In Aims 1,2 of this proposal we will obtain a greater understanding of the mechanisms of improved survival among glioblastoma cases with elevated versus normal or borderline serum IgE levels observed in our current series and validate and expand findings to other potentially related serum markers (sCD23 and sCD14), tumor markers (CD23 protein and IL13RA2 mRNA expression), and constitutive SNPs in IL4, IL13, IL4R, IL13RA1, and IL13RA2. These markers will also be assessed in relation to tumor TP53 mutation and expression and EGFR amplification and expression (markers measured in the parent R01 study). In Aim 3 we will determine whether polymorphisms in MGMT or tumor TP53 mutation or expression influence survival in the presence or absence of tumor MGMT methylation in patients treated or not treated with temozolomide. In Aim 4 we will validate promising markers obtained from Aims 2 and 3 in newly diagnosed patients seen at the UCSF NOC from July 1, 2007-June 30, 2011 in ~120 of these GM cases on clinical trial protocols. Identification of predictive biomarkers related glioma survival is likely to aid in choosing the best treatments for each glioma patient, in enhancing definition of homogeneous subgroups for clinical trials based on uniform prognosis for rapid treatment evaluation, and in providing better prognostic information to patients. PUBLIC HEALTH RELEVANCE: The proposed study will help identify markers that may be useful in the treatment of adult glioma brain tumors. Specific therapies may be more effective in some patient groups that display specific genetic, immulogical, and tumor characteristics. The relevance of individualizing brain tumor treatment to public health and cancer medicine lies in sparing patients ineffective and potentially toxic therapies while guideing newer experimental treatments to those patients who may benefit the most from such interventions.
Publications
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.
Authors: Kachuri L.
, Guerra G.A.
, Nakase T.
, Wendt G.A.
, Hansen H.M.
, Molinaro A.M.
, Bracci P.
, McCoy L.
, Rice T.
, Wiencke J.K.
, et al.
.
Source: Nature Communications, 2025-01-14 00:00:00.0; 16(1), p. 658.
EPub date: 2025-01-14 00:00:00.0.
PMID: 39809742
Related Citations
Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma.
Authors: Alpen K.
, Maclnnis R.J.
, Vajdic C.M.
, Lai J.
, Dowty J.G.
, Koh E.S.
, Hovey E.
, Harrup R.
, Nguyen T.L.
, Li S.
, et al.
.
Source: Cancer Research Communications, 2024-11-01 00:00:00.0; 4(11), p. 2933-2946.
PMID: 39387520
Related Citations
Functional germline variants in DNA damage repair pathways are associated with altered survival in adults with glioma treated with temozolomide.
Authors: Guerra G.
, Wendt G.
, McCoy L.
, Hansen H.M.
, Kachuri L.
, Molinaro A.M.
, Rice T.
, Guan V.
, Capistrano L.
, Hsieh A.
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-10-10 00:00:00.0; , .
EPub date: 2024-10-10 00:00:00.0.
PMID: 39417102
Related Citations
Association of immunoglobulin E levels with glioma risk and survival.
Authors: Guerra G.
, Nakase T.
, Kachuri L.
, McCoy L.
, Hansen H.M.
, Rice T.
, Wiemels J.L.
, Wiencke J.K.
, Molinaro A.M.
, Wrensch M.
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-05-09 00:00:00.0; , .
EPub date: 2024-05-09 00:00:00.0.
PMID: 38766059
Related Citations
Genome-wide Polygenic Risk Scores Predict Risk of Glioma and Molecular Subtypes.
Authors: Nakase T.
, Guerra G.
, Ostrom Q.T.
, Ge T.
, Melin B.
, Wrensch M.
, Wiencke J.K.
, Jenkins R.B.
, Eckel-Passow J.E.
, Glioma International Case-Control Study (GICC)
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-01-11 00:00:00.0; , .
EPub date: 2024-01-11 00:00:00.0.
PMID: 38260701
Related Citations
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.
Authors: Kachuri L.
, Guerra G.A.
, Wendt G.A.
, Hansen H.M.
, Molinaro A.M.
, Bracci P.
, McCoy L.
, Rice T.
, Wiencke J.K.
, Eckel-Passow J.E.
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2023-10-16 00:00:00.0; , .
EPub date: 2023-10-16 00:00:00.0.
PMID: 37905116
Related Citations
Inherited polymorphisms in the Human Leukocyte Antigen Region modify the association between varicella-zoster virus antibody reactivity and glioma prognosis.
Authors: Francis S.S.
, Guerra G.
, Hansen H.M.
, Wendt G.
, Kachuri L.
, Wiencke J.K.
, Wrensch M.
.
Source: Neuro-oncology, 2023-08-18 00:00:00.0; , .
EPub date: 2023-08-18 00:00:00.0.
PMID: 37595256
Related Citations
Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma.
Authors: Guerra G.
, McCoy L.
, Hansen H.M.
, Rice T.
, Molinaro A.M.
, Wiemels J.L.
, Wiencke J.K.
, Wrensch M.
, Francis S.S.
.
Source: Neuro-oncology, 2023-06-02 00:00:00.0; 25(6), p. 1047-1057.
PMID: 36610073
Related Citations
Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker.
Authors: Tang E.
, Wiencke J.K.
, Warrier G.
, Hansen H.
, McCoy L.
, Rice T.
, Bracci P.M.
, Wrensch M.
, Taylor J.W.
, Clarke J.L.
, et al.
.
Source: Clinical Epigenetics, 2022-10-28 00:00:00.0; 14(1), p. 136.
EPub date: 2022-10-28 00:00:00.0.
PMID: 36307860
Related Citations
Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes.
Authors: Zhang Y.
, Lucas C.G.
, Young J.S.
, Morshed R.A.
, McCoy L.
, Oberheim Bush N.A.
, Taylor J.W.
, Daras M.
, Butowski N.A.
, Villanueva-Meyer J.E.
, et al.
.
Source: Neuro-oncology, 2022-10-03 00:00:00.0; 24(10), p. 1749-1762.
PMID: 35395677
Related Citations
DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival.
Authors: Wiencke J.K.
, Molinaro A.M.
, Warrier G.
, Rice T.
, Clarke J.
, Taylor J.W.
, Wrensch M.
, Hansen H.
, McCoy L.
, Tang E.
, et al.
.
Source: Nature Communications, 2022-09-20 00:00:00.0; 13(1), p. 5505.
EPub date: 2022-09-20 00:00:00.0.
PMID: 36127421
Related Citations
The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival.
Authors: Guerra G.
, Kachuri L.
, Wendt G.
, Hansen H.M.
, Mack S.J.
, Molinaro A.M.
, Rice T.
, Bracci P.
, Wiencke J.K.
, Kasahara N.
, et al.
.
Source: American Journal Of Human Genetics, 2022-06-02 00:00:00.0; 109(6), p. 1105-1116.
EPub date: 2022-05-11 00:00:00.0.
PMID: 35550063
Related Citations
Interactions of Age and Blood Immune Factors and Non-Invasive Prediction of Glioma Survival.
Authors: Molinaro A.M.
, Wiencke J.K.
, Warrier G.
, Koestler D.C.
, Chunduru P.
, Lee J.Y.
, Hansen H.M.
, Lee S.
, Anguiano J.
, Rice T.
, et al.
.
Source: Journal Of The National Cancer Institute, 2021-10-01 00:00:00.0; , .
EPub date: 2021-10-01 00:00:00.0.
PMID: 34597382
Related Citations
Adult Diffuse Glioma GWAS by Molecular Subtype Identifies Variants in D2HGDH and FAM20C.
Authors: Eckel-Passow J.E.
, Drucker K.L.
, Kollmeyer T.M.
, Kosel M.L.
, Decker P.A.
, Molinaro A.M.
, Rice T.
, Praska C.E.
, Clark L.
, Caron A.
, et al.
.
Source: Neuro-oncology, 2020-05-09 00:00:00.0; , .
EPub date: 2020-05-09 00:00:00.0.
PMID: 32386320
Related Citations
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
Authors: Ostrom Q.T.
, Kinnersley B.
, Armstrong G.
, Rice T.
, Chen Y.
, Wiencke J.K.
, McCoy L.S.
, Hansen H.M.
, Amos C.I.
, Bernstein J.L.
, et al.
.
Source: International Journal Of Cancer, 2018-08-27 00:00:00.0; , .
EPub date: 2018-08-27 00:00:00.0.
PMID: 30152087
Related Citations
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
Authors: Ostrom Q.T.
, Kinnersley B.
, Wrensch M.R.
, Eckel-Passow J.E.
, Armstrong G.
, Rice T.
, Chen Y.
, Wiencke J.K.
, McCoy L.S.
, Hansen H.M.
, et al.
.
Source: Scientific Reports, 2018-05-09 00:00:00.0; 8(1), p. 7352.
EPub date: 2018-05-09 00:00:00.0.
PMID: 29743610
Related Citations
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
Authors: Melin B.S.
, Barnholtz-Sloan J.S.
, Wrensch M.R.
, Johansen C.
, Il'yasova D.
, Kinnersley B.
, Ostrom Q.T.
, Labreche K.
, Chen Y.
, Armstrong G.
, et al.
.
Source: Nature Genetics, 2017 May; 49(5), p. 789-794.
EPub date: 2017-03-27 00:00:00.0.
PMID: 28346443
Related Citations
Adult Infiltrating Gliomas With Who 2016 Integrated Diagnosis: Additional Prognostic Roles Of Atrx And Tert
Authors: Pekmezci M.
, Rice T.
, Molinaro A.M.
, Walsh K.M.
, Decker P.A.
, Hansen H.
, Sicotte H.
, Kollmeyer T.M.
, McCoy L.S.
, Sarkar G.
, et al.
.
Source: Acta Neuropathologica, 2017-03-02 00:00:00.0; , .
PMID: 28255664
Related Citations
Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival.
Authors: Wiencke J.K.
, Koestler D.C.
, Salas L.A.
, Wiemels J.L.
, Roy R.P.
, Hansen H.M.
, Rice T.
, McCoy L.S.
, Bracci P.M.
, Molinaro A.M.
, et al.
.
Source: Clinical Epigenetics, 2017; 9, p. 10.
EPub date: 2017-02-02 00:00:00.0.
PMID: 28184256
Related Citations
Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.
Authors: Ojha J.
, Codd V.
, Nelson C.P.
, Samani N.J.
, Smirnov I.V.
, Madsen N.R.
, Hansen H.M.
, de Smith A.J.
, Bracci P.M.
, Wiencke J.K.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2016 Jul; 25(7), p. 1043-9.
PMID: 27197291
Related Citations
Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.
Authors: Walsh K.M.
, Codd V.
, Rice T.
, Nelson C.P.
, Smirnov I.V.
, McCoy L.S.
, Hansen H.M.
, Elhauge E.
, Ojha J.
, Francis S.S.
, et al.
.
Source: Oncotarget, 2015-12-15 00:00:00.0; 6(40), p. 42468-77.
PMID: 26646793
Related Citations
Telomere Maintenance And The Etiology Of Adult Glioma
Authors: Walsh K.M.
, Wiencke J.K.
, Lachance D.H.
, Wiemels J.L.
, Molinaro A.M.
, Eckel-Passow J.E.
, Jenkins R.B.
, Wrensch M.R.
.
Source: Neuro-oncology, 2015 Nov; 17(11), p. 1445-52.
PMID: 26014050
Related Citations
Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time.
Authors: Zhou M.
, Bracci P.M.
, McCoy L.S.
, Hsuang G.
, Wiemels J.L.
, Rice T.
, Zheng S.
, Kelsey K.T.
, Wrensch M.R.
, Wiencke J.K.
.
Source: International Journal Of Cancer, 2015-08-15 00:00:00.0; 137(4), p. 826-36.
EPub date: 2015-08-15 00:00:00.0.
PMID: 25604093
Related Citations
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
Authors: Eckel-Passow J.E.
, Lachance D.H.
, Molinaro A.M.
, Walsh K.M.
, Decker P.A.
, Sicotte H.
, Pekmezci M.
, Rice T.
, Kosel M.L.
, Smirnov I.V.
, et al.
.
Source: The New England Journal Of Medicine, 2015-06-25 00:00:00.0; 372(26), p. 2499-508.
EPub date: 2015-06-25 00:00:00.0.
PMID: 26061753
Related Citations
CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.
Authors: Reis G.F.
, Pekmezci M.
, Hansen H.M.
, Rice T.
, Marshall R.E.
, Molinaro A.M.
, Phillips J.J.
, Vogel H.
, Wiencke J.K.
, Wrensch M.R.
, et al.
.
Source: Journal Of Neuropathology And Experimental Neurology, 2015 May; 74(5), p. 442-52.
PMID: 25853694
Related Citations
Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.
Authors: Jalali A.
, Amirian E.S.
, Bainbridge M.N.
, Armstrong G.N.
, Liu Y.
, Tsavachidis S.
, Jhangiani S.N.
, Plon S.E.
, Lau C.C.
, Claus E.B.
, et al.
.
Source: Scientific Reports, 2015-02-05 00:00:00.0; 5, p. 8278.
EPub date: 2015-02-05 00:00:00.0.
PMID: 25652157
Related Citations
Germline mutations in shelterin complex genes are associated with familial glioma.
Authors: Bainbridge M.N.
, Armstrong G.N.
, Gramatges M.M.
, Bertuch A.A.
, Jhangiani S.N.
, Doddapaneni H.
, Lewis L.
, Tombrello J.
, Tsavachidis S.
, Liu Y.
, et al.
.
Source: Journal Of The National Cancer Institute, 2015 Jan; 107(1), p. 384.
PMID: 25482530
Related Citations
Survival And Low-grade Glioma: The Emergence Of Genetic Information
Authors: Claus E.B.
, Walsh K.M.
, Wiencke J.K.
, Molinaro A.M.
, Wiemels J.L.
, Schildkraut J.M.
, Bondy M.L.
, Berger M.
, Jenkins R.
, Wrensch M.
.
Source: Neurosurgical Focus, 2015 Jan; 38(1), p. E6.
PMID: 25552286
Related Citations
Germline Rearrangements In Families With Strong Family History Of Glioma And Malignant Melanoma, Colon, And Breast Cancer
Authors: Andersson U.
, Wibom C.
, Cederquist K.
, Aradottir S.
, Borg A.
, Armstrong G.N.
, Shete S.
, Lau C.C.
, Bainbridge M.N.
, Claus E.B.
, et al.
.
Source: Neuro-oncology, 2014 Oct; 16(10), p. 1333-40.
PMID: 24723567
Related Citations
A comparison of DNA methylation specific droplet digital PCR (ddPCR) and real time qPCR with flow cytometry in characterizing human T cells in peripheral blood.
Authors: Wiencke J.K.
, Bracci P.M.
, Hsuang G.
, Zheng S.
, Hansen H.
, Wrensch M.R.
, Rice T.
, Eliot M.
, Kelsey K.T.
.
Source: Epigenetics, 2014 Oct; 9(10), p. 1360-5.
PMID: 25437051
Related Citations
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
Authors: Walsh K.M.
, Codd V.
, Smirnov I.V.
, Rice T.
, Decker P.A.
, Hansen H.M.
, Kollmeyer T.
, Kosel M.L.
, Molinaro A.M.
, McCoy L.S.
, et al.
.
Source: Nature Genetics, 2014 Jul; 46(7), p. 731-5.
PMID: 24908248
Related Citations
A Novel Approach To The Discovery Of Survival Biomarkers In Glioblastoma Using A Joint Analysis Of Dna Methylation And Gene Expression
Authors: Smith A.A.
, Huang Y.T.
, Eliot M.
, Houseman E.A.
, Marsit C.J.
, Wiencke J.K.
, Kelsey K.T.
.
Source: Epigenetics, 2014 Jun; 9(6), p. 873-83.
PMID: 24670968
Related Citations
Leukocyte-adjusted Epigenome-wide Association Studies Of Blood From Solid Tumor Patients
Authors: Langevin S.M.
, Houseman E.A.
, Accomando W.P.
, Koestler D.C.
, Christensen B.C.
, Nelson H.H.
, Karagas M.R.
, Marsit C.J.
, Wiencke J.K.
, Kelsey K.T.
.
Source: Epigenetics, 2014 Jun; 9(6), p. 884-95.
PMID: 24671036
Related Citations
Quantitative Reconstruction Of Leukocyte Subsets Using Dna Methylation
Authors: Accomando W.P.
, Wiencke J.K.
, Houseman E.A.
, Nelson H.H.
, Kelsey K.T.
.
Source: Genome Biology, 2014; 15(3), p. R50.
PMID: 24598480
Related Citations
Associations Between Genome-wide Native American Ancestry, Known Risk Alleles And B-cell All Risk In Hispanic Children
Authors: Walsh K.M.
, Chokkalingam A.P.
, Hsu L.I.
, Metayer C.
, de Smith A.J.
, Jacobs D.I.
, Dahl G.V.
, Loh M.L.
, Smirnov I.V.
, Bartley K.
, et al.
.
Source: Leukemia, 2013 Dec; 27(12), p. 2416-9.
PMID: 23615557
Related Citations
Blood-based Profiles Of Dna Methylation Predict The Underlying Distribution Of Cell Types: A Validation Analysis
Authors: Koestler D.C.
, Christensen B.
, Karagas M.R.
, Marsit C.J.
, Langevin S.M.
, Kelsey K.T.
, Wiencke J.K.
, Houseman E.A.
.
Source: Epigenetics, 2013 Aug; 8(8), p. 816-26.
PMID: 23903776
Related Citations
Inherited Variant On Chromosome 11q23 Increases Susceptibility To Idh-mutated But Not Idh-normal Gliomas Regardless Of Grade Or Histology
Authors: Rice T.
, Zheng S.
, Decker P.A.
, Walsh K.M.
, Bracci P.
, Xiao Y.
, McCoy L.S.
, Smirnov I.
, Patoka J.S.
, Hansen H.M.
, et al.
.
Source: Neuro-oncology, 2013 May; 15(5), p. 535-41.
PMID: 23361564
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A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma.
Authors: Sun X.
, Vengoechea J.
, Elston R.
, Chen Y.
, Amos C.I.
, Armstrong G.
, Bernstein J.L.
, Claus E.
, Davis F.
, Houlston R.S.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Dec; 21(12), p. 2242-51.
PMID: 22962404
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A Low-frequency Variant At 8q24.21 Is Strongly Associated With Risk Of Oligodendroglial Tumors And Astrocytomas With Idh1 Or Idh2 Mutation
Authors: Jenkins R.B.
, Xiao Y.
, Sicotte H.
, Decker P.A.
, Kollmeyer T.M.
, Hansen H.M.
, Kosel M.L.
, Zheng S.
, Walsh K.M.
, Rice T.
, et al.
.
Source: Nature Genetics, 2012 Oct; 44(10), p. 1122-5.
PMID: 22922872
Related Citations
Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.
Authors: Koestler D.C.
, Marsit C.J.
, Christensen B.C.
, Accomando W.
, Langevin S.M.
, Houseman E.A.
, Nelson H.H.
, Karagas M.R.
, Wiencke J.K.
, Kelsey K.T.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2012 Aug; 21(8), p. 1293-302.
PMID: 22714737
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Key Epigenetic Changes Associated With Lung Cancer Development: Results From Dense Methylation Array Profiling
Authors: Nelson H.H.
, Marsit C.J.
, Christensen B.C.
, Houseman E.A.
, Kontic M.
, Wiemels J.L.
, Karagas M.R.
, Wrensch M.R.
, Zheng S.
, Wiencke J.K.
, et al.
.
Source: Epigenetics, 2012-06-01 00:00:00.0; 7(6), p. 559-66.
PMID: 22522909
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Leveraging Ethnic Group Incidence Variation To Investigate Genetic Susceptibility To Glioma: A Novel Candidate Snp Approach
Authors: Jacobs,D.I.
, Walsh,K.M.
, Wrensch,M.
, Wiencke,J.
, Jenkins,R.
, Houlston,R.S.
, Bondy,M.
, Simon,M.
, Sanson,M.
, Gousias,K.
, et al.
.
Source: Frontiers In Genetics, 2012; 3, p. 203.
PMID: 23091480
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Genome-wide High-density Snp Linkage Search For Glioma Susceptibility Loci: Results From The Gliogene Consortium
Authors: Shete S.
, Lau C.C.
, Houlston R.S.
, Claus E.B.
, Barnholtz-Sloan J.
, Lai R.
, Il'yasova D.
, Schildkraut J.
, Sadetzki S.
, Johansen C.
, et al.
.
Source: Cancer Research, 2011-12-15 00:00:00.0; 71(24), p. 7568-75.
PMID: 22037877
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Dna Hypermethylation Profiles Associated With Glioma Subtypes And Ezh2 And Igfbp2 Mrna Expression
Authors: Zheng S.
, Houseman E.A.
, Morrison Z.
, Wrensch M.R.
, Patoka J.S.
, Ramos C.
, Haas-Kogan D.A.
, McBride S.
, Marsit C.J.
, Christensen B.C.
, et al.
.
Source: Neuro-oncology, 2011 Mar; 13(3), p. 280-9.
PMID: 21339190
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Dna Methylation, Isocitrate Dehydrogenase Mutation, And Survival In Glioma
Authors: Christensen B.C.
, Smith A.A.
, Zheng S.
, Koestler D.C.
, Houseman E.A.
, Marsit C.J.
, Wiemels J.L.
, Nelson H.H.
, Karagas M.R.
, Wrensch M.R.
, et al.
.
Source: Journal Of The National Cancer Institute, 2011-01-19 00:00:00.0; 103(2), p. 143-53.
PMID: 21163902
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Circulating Levels Of The Innate And Humoral Immune Regulators Cd14 And Cd23 Are Associated With Adult Glioma
Authors: Zhou M.
, Wiemels J.L.
, Bracci P.M.
, Wrensch M.R.
, McCoy L.S.
, Rice T.
, Sison J.D.
, Patoka J.S.
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