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Grant Details

Grant Number: 5R03CA132149-02 Interpret this number
Primary Investigator: Cooney, Robert
Organization: University Of Hawaii At Manoa
Project Title: Interactions of Coenzyme Q10 with Plasma Tocopherols and Their Role in Breast Can
Fiscal Year: 2008
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Abstract

DESCRIPTION (provided by applicant): Coenzyme Q10 is of critical importance to mitochondrial function and its deficiency is associated with impaired ATP synthesis, apoptosis, and immune function. Its decease in tissue levels with age is associated with mitochondrial dysfunction and aging. There have been no major epidemiologic studies exploring the relationship between Coenzyme Q10 and breast cancer incidence and all cause mortality. Indeed, prospective studies relating this major endogenous lipid-phase anti-oxidant and key element of the electron transport chain to any type of cancer are nonexistent. Intriguing small clinical studies have suggested a possible beneficial effect of Coenzyme Q10, however supportive epidemiologic data is not available. There is compelling evidence that Coenzyme Q10 may play an important general role in the development and progression of many tumor types and preliminary evidence for an association with prostate cancer incidence and all- cause mortality in men is presented. It is proposed to utilize stored extracts from 2,193 women (731 incident cases of breast cancer and 1,462 matched controls) from two large prospective cohorts to determine the association of plasma coenzyme Q10 with breast cancer risk and all-cause mortality. In addition we observe intriguing relationships between Coenzyme Q10 and plasma levels of alpha and gamma-tocopherols, as well as C-Reactive Protein that may have a significant impact on the interpretation of the role of these dietary lipid-phase antioxidants on cancer development and progression in general. Analysis of Coenzyme Q10 in tandem with the individual tocopherols should provide significant new insight into the possible role of these essential lipids in the etiology of breast cancer and aging, as well as the interpretation of the meaning of plasma levels of these molecules. We hypothesize that an optimal level of Coenzyme Q10 will be determined that is associated with reduced risk for breast cancer and all- cause mortality. The project will explore the relation between coenzyme Q10, alpha-tocopherol, and gamma-tocopherol with breast cancer incidence and all-cause mortality in women utilizing previously collected samples from 2,193 women. It will greatly benefit our understanding of the association of these essential lipids with breast cancer and help to elucidate the potential role of plasma coenzyme Q10 in human physiology.

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Publications

Serum coenzyme Q₁₀, α-tocopherol, γ-tocopherol, and C-reactive protein levels and body mass index in adolescent and premenopausal females.
Authors: Chai W. , Novotny R. , Maskarinec G. , Le Marchand L. , Franke A.A. , Cooney R.V. .
Source: Journal of the American College of Nutrition, 2014; 33(3), p. 192-7.
EPub date: 2014-05-08.
PMID: 24809382
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Effects of calcium and vitamin D supplementation on blood pressure and serum lipids and carotenoids: a randomized, double-blind, placebo-controlled, clinical trial.
Authors: Chai W. , Cooney R.V. , Franke A.A. , Bostick R.M. .
Source: Annals of epidemiology, 2013 Sep; 23(9), p. 564-70.
PMID: 23958407
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C-reactive protein, lipid-soluble micronutrients, and survival in colorectal cancer patients.
Authors: Cooney R.V. , Chai W. , Franke A.A. , Wilkens L.R. , Kolonel L.N. , Le Marchand L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013 Jul; 22(7), p. 1278-88.
EPub date: 2013-05-15.
PMID: 23677577
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Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites.
Authors: Chai W. , Bostick R.M. , Ahearn T.U. , Franke A.A. , Custer L.J. , Cooney R.V. .
Source: Nutrition and cancer, 2012; 64(1), p. 57-64.
EPub date: 2011-12-09.
PMID: 22149065
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Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women.
Authors: Cooney R.V. , Dai Q. , Gao Y.T. , Chow W.H. , Franke A.A. , Shu X.O. , Li H. , Ji B. , Cai Q. , Chai W. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Jun; 20(6), p. 1124-30.
EPub date: 2011-04-05.
PMID: 21467235
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Plasma coenzyme Q10 levels and prostate cancer risk: the multiethnic cohort study.
Authors: Chai W. , Cooney R.V. , Franke A.A. , Caberto C.P. , Wilkens L.R. , Le Marchand L. , Goodman M.T. , Henderson B.E. , Kolonel L.N. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011 Apr; 20(4), p. 708-10.
EPub date: 2011-02-04.
PMID: 21297042
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Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study.
Authors: Chai W. , Cooney R.V. , Franke A.A. , Shvetsov Y.B. , Caberto C.P. , Wilkens L.R. , Le Marchand L. , Henderson B.E. , Kolonel L.N. , Goodman M.T. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010 Sep; 19(9), p. 2351-6.
EPub date: 2010-07-28.
PMID: 20668119
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Coenzyme Q10 in human blood: native levels and determinants of oxidation during processing and storage.
Authors: Franke A.A. , Morrison C.M. , Bakke J.L. , Custer L.J. , Li X. , Cooney R.V. .
Source: Free radical biology & medicine, 2010-06-15; 48(12), p. 1610-7.
EPub date: 2010-03-11.
PMID: 20226852
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